6.10411 % | Viking Global Investors LP | 2,456,292 | 0 | |
4.18792 % | BVF Partners L.P. | 1,685,219 | 0 | |
3.82321 % | Vivo Capital, LLC | 1,538,461 | 0 | |
3.82321 % | Deerfield Management Company, L.P. | 1,538,461 | 0 | |
3.79999 % | OrbiMed Advisors, LLC | 1,529,115 | 0 | |
3.54283 % | Soleus Capital Management, L.P. | 1,425,634 | 78,265 | |
3.23062 % | Adage Capital Management, L.P. | 1,300,000 | 0 | |
2.85848 % | The Vanguard Group, Inc. | 1,150,253 | 0 | |
1.84273 % | Tang Capital Management, LLC | 741,514 | -150,000 | |
1.43199 % | Citadel Advisors LLC | 576,231 | -317,554 | |
0.74865 % | BlackRock Institutional Trust Company, N.A. | 301,255 | 2,659 | |
0.57716 % | Acuta Capital Partners, LLC | 232,249 | 2,249 | |
0.57686 % | Geode Capital Management, L.L.C. | 232,128 | 12,213 | |
0.52535 % | Opaleye Management Inc. | 211,400 | 0 | |
0.50529 % | Sectoral Asset Management Inc. | 203,327 | 0 | |
0.50529 % | Bank Vontobel AG | 203,327 | 0 | |
0.40336 % | Susquehanna International Group, LLP | 162,312 | 140,042 | |
0.39647 % | Jefferies LLC | 159,541 | 0 | |
0.37276 % | LifeSci Fund Management LLC | 150,000 | 0 | |
0.37276 % | AlphaCentric Advisors LLC. | 150,000 | 0 | |
0.35235 % | Morgan Stanley & Co. LLC | 141,786 | 132,584 | |
0.20772 % | State Street Global Advisors (US) | 83,587 | 23,700 | |
0.20655 % | Millennium Management LLC | 83,114 | 83,114 | |
0.18367 % | Citi Investment Research (US) | 73,908 | 43,833 | |
0.18198 % | Stuglik (Brian M) | 73,227 | 2,142 | |
0.15359 % | UBS O'Connor LLC | 61,803 | -94,101 | |
0.13436 % | RBC Capital Markets Wealth Management | 54,066 | 12,085 | |
0.12768 % | ExodusPoint Capital Management, LP | 51,379 | 51,379 | |
0.11151 % | Northern Trust Investments, Inc. | 44,873 | 255 | |
0.10897 % | Paterson (Daniel W) | 43,849 | 1,227 | |
0.09797 % | Dimensional Fund Advisors, L.P. | 39,423 | 1,268 | |
0.07794 % | Renaissance Technologies LLC | 31,365 | -15,000 | |
0.06433 % | NewEdge Wealth, LLC | 25,885 | 0 | |
0.06281 % | CornerCap Investment Counsel, Inc. | 25,274 | 0 | |
0.05619 % | Two Sigma Investments, LP | 22,612 | -37,957 | |
0.05417 % | Goldman Sachs & Company, Inc. | 21,799 | -15,278 | |
0.05198 % | Gagnon (Robert E) | 20,918 | 714 | |
0.04800 % | BofA Global Research (US) | 19,315 | -3,161 | |
0.04660 % | Telemetry Investments, L.L.C. | 18,750 | 3,125 | |
0.04335 % | Stifel, Nicolaus & Company, Incorporated | 17,445 | 4,984 | |
0.03728 % | Abaris Investment Management AG | 15,000 | 6,667 | |
0.03251 % | Aries Wealth Management, LLC | 13,081 | 0 | |
0.03068 % | Avantis Investors | 12,345 | 6,972 | |
0.02858 % | BNY Mellon Asset Management | 11,499 | -11,259 | |
0.02834 % | BlackRock (Netherlands) B.V. | 11,403 | 11,403 | |
0.02758 % | Cannon Global Investment Management, LLC | 11,100 | 11,100 | |
0.02511 % | Jacobs Levy Equity Management, Inc. | 10,103 | 0 | |
0.01779 % | Charles Schwab Investment Management, Inc. | 7,159 | 0 | |
0.01522 % | Calkins (Daniel) | 6,125 | -6 | |
0.01519 % | Dimensional Fund Advisors, Ltd. | 6,114 | 0 | |
0.01497 % | BlackRock Advisors (UK) Limited | 6,023 | 6,023 | |
0.01305 % | Wells Fargo Advisors | 5,252 | 700 | |
0.00919 % | BlackRock Financial Management, Inc. | 3,699 | 0 | |
0.00769 % | Advisory Services Network, LLC | 3,094 | 3,094 | |
0.00733 % | Loring, Wolcott & Coolidge Fiduciary Advisors, LLP | 2,949 | 0 | |
0.00724 % | UBS Financial Services, Inc. | 2,914 | 1,273 | |
0.00629 % | BlackRock Investment Management (UK) Ltd. | 2,530 | 2,530 | |
0.00588 % | Qube Research & Technologies Ltd | 2,367 | 2,367 | |
0.00552 % | Welzia Management SGIIC S.A. | 2,222 | 2,222 | |
0.00468 % | American Century Investment Management, Inc. | 1,884 | 0 | |
0.00451 % | Morgan Stanley Smith Barney LLC | 1,814 | -123 | |
0.00398 % | BlackRock Investment Management, LLC | 1,602 | 1,602 | |
0.00383 % | Osaic Holdings, Inc. | 1,542 | -1,562 | |
0.00360 % | Blackstone Alternative Investment Advisors LLC | 1,450 | -567 | |
0.00344 % | Fidelity Management & Research Company LLC | 1,386 | 0 | |
0.00321 % | Simplex Trading, LLC | 1,292 | 730 | |
0.00320 % | IFAM Capital | 1,286 | 0 | |
0.00264 % | Barclays Bank PLC | 1,061 | -3,701 | |
0.00167 % | Rhumbline Advisers Ltd. Partnership | 674 | 0 | |
0.00137 % | RBC Capital Partners | 551 | 32 | |
0.00137 % | Kauffman (Michael G) | 550 | 0 | |
0.00085 % | J.P. Morgan Securities plc | 341 | 0 | |
0.00062 % | American Portfolios Advisors, Inc | 249 | 0 | |
0.00050 % | Tower Research Capital LLC | 200 | -921 | |
0.00045 % | Wells Fargo Bank, N.A. | 183 | 10 | |
0.00041 % | Northwestern Mutual Capital, LLC | 166 | 166 | |
0.00031 % | 1919 Investment Counsel, LLC | 125 | 125 | |
0.00023 % | Group One Trading, L.P. | 92 | -21 | |
0.00021 % | Guggenheim Investments | 85 | 0 | |
0.00020 % | First Manhattan Co. LLC | 81 | 0 | |
0.00015 % | L2 Asset Management, LLC | 59 | 0 | |
0.00013 % | Northern Trust Global Investments | 51 | 0 | |
0.00011 % | RBC Brewin Dolphin Ireland | 44 | 0 | |
0.00007 % | PSI Advisors, L.L.C. | 27 | 0 | |
0.00004 % | Concourse Financial Group Securities, Inc | 16 | 0 | |
0.00003 % | Harbour Investments, Inc | 14 | 0 | |
0.00002 % | Global Retirement Partners, LLC | 8 | 0 | |
0.00000 % | TimeScale Financial, Inc. | 1 | 0 | |
0 % | Ellevest, Inc. | 0 | -29 | |
0 % | McAdam, LLC | 0 | -2,697 | |
0 % | Ergoteles Capital | 0 | -5,323 | |
0 % | LUNIS Vermögensmanagement AG | 0 | -5,833 | |
0 % | Romano Wealth management | 0 | -83 | |
0 % | Valeo Financial Advisors LLC | 0 | -1,958 | |
0 % | AdvisorNet Wealth Partners | 0 | -9 | |
0 % | Acuitas Investments LLC | 0 | -5,258 | |
0 % | Susquehanna Fundamental Investments, LLC | 0 | -15,775 | |
0 % | ACCI Capital Investments SGIIC, SA | 0 | -11,667 | |
0 % | AJ Wealth Strategies, LLC | 0 | -2,847 | |
0 % | Altium Capital Management LP | 0 | -250,000 | |