9.75356 % | BVF Partners L.P. | 5,744,848 | 0 | |
9.73587 % | Farallon Capital Management, L.L.C. | 5,734,430 | 288,000 | |
9.02464 % | RTW Investments L.P. | 5,315,514 | -100,000 | |
7.13136 % | BlackRock Institutional Trust Company, N.A. | 4,200,370 | 305,219 | |
5.33685 % | The Vanguard Group, Inc. | 3,143,402 | -74,478 | |
4.63485 % | State Street Global Advisors (US) | 2,729,929 | -1,212,209 | |
4.43710 % | Point72 Asset Management, L.P. | 2,613,453 | 1,505,313 | |
4.15821 % | Johnson & Johnson Innovation-JJDC, Inc. | 2,449,183 | 0 | |
3.40386 % | Kynam Capital Management LP | 2,004,875 | 186,218 | |
2.19304 % | Adage Capital Management, L.P. | 1,291,701 | 591,701 | |
2.15715 % | Jefferies LLC | 1,270,561 | 435,000 | |
2.11933 % | Geode Capital Management, L.L.C. | 1,248,284 | 67,028 | |
1.95189 % | Morgan Stanley & Co. LLC | 1,149,666 | 910,385 | |
1.71173 % | BlackRock Financial Management, Inc. | 1,008,210 | -6,185 | |
1.38631 % | Dimensional Fund Advisors, L.P. | 816,537 | -124,737 | |
1.34772 % | DWS Investment S.A. | 793,806 | 793,806 | |
1.34409 % | T. Rowe Price Associates, Inc. | 791,669 | -7,919 | |
1.21392 % | 683 Capital Management LLC | 715,000 | -17,784 | |
0.91354 % | Eversept Partners, LP | 538,074 | 251,326 | |
0.91171 % | Candriam Belgium S.A. | 537,000 | -93,000 | |
0.87212 % | StemPoint Capital LP | 513,681 | 513,681 | |
0.87157 % | Patel (Dinesh V) | 513,355 | -25,000 | |
0.83837 % | Northern Trust Investments, Inc. | 493,797 | 25,007 | |
0.79109 % | Fidelity Management & Research Company LLC | 465,952 | -43,290 | |
0.78106 % | Sio Capital Management, LLC | 460,044 | 211,917 | |
0.77537 % | Goldman Sachs & Company, Inc. | 456,693 | 47,580 | |
0.77304 % | Charles Schwab Investment Management, Inc. | 455,321 | 16,219 | |
0.74586 % | Mangrove Partners | 439,314 | 0 | |
0.69949 % | Candriam Luxembourg S.A. | 412,000 | 0 | |
0.67499 % | Gratus Capital LLC | 397,571 | 104,702 | |
0.65070 % | Perceptive Advisors LLC | 383,260 | -671,013 | |
0.64659 % | Two Sigma Investments, LP | 380,843 | -272,365 | |
0.64371 % | Superstring Capital Management LP | 379,143 | 379,143 | |
0.54160 % | Ikarian Capital LLC | 319,000 | 319,000 | |
0.51747 % | Kennedy Capital Management LLC | 304,790 | -14,744 | |
0.51608 % | Nuveen LLC | 303,970 | -231,569 | |
0.46723 % | Deep Track Capital LP | 275,201 | 275,201 | |
0.45307 % | Checkpoint Capital L.P. | 266,856 | 266,856 | |
0.36327 % | Renaissance Technologies LLC | 213,967 | -12,301 | |
0.34102 % | Adar1 Capital Management LLC | 200,859 | 200,859 | |
0.33733 % | Driehaus Capital Management, LLC | 198,689 | 198,689 | |
0.33261 % | UBS Asset Management (Americas), Inc. | 195,908 | 195,908 | |
0.31481 % | Walleye Capital LLC | 185,426 | 51,610 | |
0.30644 % | Silvercrest Asset Management Group LLC | 180,496 | 34 | |
0.29953 % | JP Morgan Asset Management | 176,422 | -34,211 | |
0.29599 % | J.P. Morgan Securities LLC | 174,340 | 174,340 | |
0.29210 % | Gupta (Suneel) | 172,046 | -4,282 | |
0.28488 % | Rafferty Asset Management LLC | 167,795 | -182,486 | |
0.27680 % | BlackRock Investment Management, LLC | 163,035 | 2,615 | |
0.26067 % | BNY Mellon Asset Management | 153,532 | 2,948 | |
0.26046 % | BofA Global Research (US) | 153,409 | -85,629 | |
0.25614 % | UBS Financial Services, Inc. | 150,867 | 60,141 | |
0.25325 % | Millennium Management LLC | 149,163 | 149,163 | |
0.25293 % | Barclays Bank PLC | 148,974 | -27,863 | |
0.24565 % | Liu (David Y.) | 144,687 | 3,011 | |
0.24188 % | Marshall Wace LLP | 142,470 | 120,723 | |
0.21903 % | Jacobs Levy Equity Management, Inc. | 129,011 | 0 | |
0.21222 % | Ghost Tree Capital, LLC | 125,000 | -275,000 | |
0.20260 % | HSBC Global Asset Management (UK) Limited | 119,334 | -434,971 | |
0.19134 % | Opaleye Management Inc. | 112,700 | 112,700 | |
0.19073 % | Artia Global Partners LP | 112,340 | 0 | |
0.18812 % | TD Asset Management Inc. | 110,800 | 0 | |
0.18622 % | Susquehanna International Group, LLP | 109,683 | 52,438 | |
0.18258 % | Connor, Clark & Lunn Investment Management Ltd. | 107,542 | -31,952 | |
0.18023 % | UBS O'Connor LLC | 106,154 | -30,114 | |
0.15723 % | BlackRock Advisors (UK) Limited | 92,607 | 3,784 | |
0.15476 % | Great Lakes Advisors, LLC | 91,153 | -50,406 | |
0.15399 % | Schweizerische Nationalbank | 90,700 | -9,900 | |
0.15280 % | DWS Investment GmbH | 90,000 | 45,000 | |
0.15130 % | Schonfeld Strategic Advisors LLC | 89,113 | -64,985 | |
0.14499 % | AllianceBernstein L.P. | 85,400 | -1,872 | |
0.14141 % | Rhumbline Advisers Ltd. Partnership | 83,292 | 483 | |
0.14092 % | Soleus Capital Management, L.P. | 83,000 | 83,000 | |
0.13685 % | Boothbay Fund Management, LLC | 80,607 | 80,607 | |
0.12862 % | Algert Global LLC | 75,760 | 2,930 | |
0.12415 % | HRT Financial LP | 73,126 | 73,126 | |
0.12382 % | Jane Street Capital, L.L.C. | 72,931 | 34,425 | |
0.12343 % | Citi Investment Research (US) | 72,703 | -75,125 | |
0.12296 % | BlackRock Asset Management Ireland Limited | 72,422 | 2,559 | |
0.12207 % | BNP Paribas Securities Corp. North America | 71,898 | -72,066 | |
0.11618 % | Manulife Investment Management (North America) Limited | 68,432 | -5,691 | |
0.10686 % | Twin Lakes Capital | 62,941 | -148 | |
0.10614 % | Credit Suisse Funds AG | 62,517 | 14,832 | |
0.10582 % | Moody Aldrich Partners, LLC | 62,327 | -6,641 | |
0.10037 % | UBS Asset Management (Switzerland) | 59,118 | 16,718 | |
0.09937 % | Goldman Sachs Asset Management, L.P. | 58,527 | 437 | |
0.09712 % | Readystate Asset Management LP | 57,206 | -127,141 | |
0.08919 % | BlackRock Investment Management (UK) Ltd. | 52,535 | -4,700 | |
0.08891 % | Knott Partners Management, LLC | 52,368 | 0 | |
0.08574 % | Balyasny Asset Management LP | 50,503 | 50,503 | |
0.08559 % | MFS Investment Management | 50,410 | -1,862 | |
0.08556 % | California State Teachers Retirement System | 50,392 | -2,688 | |
0.08336 % | JPMorgan Private Bank (United States) | 49,097 | 38,226 | |
0.08209 % | Molina (Arturo MD) | 48,350 | 25,823 | |
0.08149 % | Birchview Capital, LP | 48,000 | 10,000 | |
0.08126 % | Citadel Advisors LLC | 47,864 | -2,932 | |
0.07689 % | Legal & General Investment Management Ltd. | 45,289 | 524 | |
0.07555 % | Azimut Capital Management Sgr SpA | 44,497 | -18,578 | |
0.07381 % | Mellon Investments Corporation | 43,475 | 0 | |
0.07342 % | Voya Investment Management LLC | 43,245 | 282 | |