4.13022 % | Shefferman (Jesse M) | 852,065 | 39,611 | |
2.91023 % | Heights Capital Management, Inc. | 600,380 | 600,380 | |
2.83858 % | Marshall (Randall S) | 585,600 | 0 | |
2.07277 % | The Vanguard Group, Inc. | 427,612 | 0 | |
13.05184 % | Opaleye Management Inc. | 2,692,594 | 0 | |
1.01419 % | Boxer Capital, L.L.C. | 209,227 | 0 | |
0.96787 % | Baker Bros. Advisors LP | 199,671 | 0 | |
0.95977 % | Beshar (Luke M) | 198,000 | 0 | |
0.91451 % | Ikarian Capital LLC | 188,664 | 0 | |
0.58037 % | Privium Fund Management (UK) Ltd | 119,730 | 0 | |
0.54920 % | Renaissance Technologies LLC | 113,300 | 53,200 | |
0.38060 % | Geode Capital Management, L.L.C. | 78,518 | 0 | |
0.31023 % | Bridgeway Capital Management, LLC | 64,000 | 0 | |
0.30840 % | Zummo (Jacqueline) | 63,622 | 12,823 | |
0.27219 % | Medical Strategy GmbH | 56,153 | 0 | |
0.25285 % | Two Sigma Investments, LP | 52,163 | -3,000 | |
0.18437 % | Citadel Advisors LLC | 38,035 | 15,892 | |
0.15996 % | Garceau (Roger J) | 33,000 | 0 | |
0.15272 % | BlackRock Institutional Trust Company, N.A. | 31,506 | -286 | |
0.15027 % | Levy (Richard S) | 31,000 | 0 | |
0.15027 % | Sargen (Gregory P) | 31,000 | 0 | |
0.14978 % | State Street Global Advisors (US) | 30,900 | 0 | |
0.14462 % | Fry (Hannah) | 29,836 | 6,772 | |
0.12845 % | Solomon (Michael Edward) | 26,500 | 0 | |
0.12361 % | Abaris Investment Management AG | 25,500 | -6,500 | |
0.11272 % | Bandari (Jathin) | 23,255 | 18,244 | |
0.10664 % | Fabbio (Patrick) | 22,000 | 22,000 | |
0.09144 % | Boothbay Fund Management, LLC | 18,864 | 0 | |
0.08787 % | Northern Trust Investments, Inc. | 18,127 | -2,460 | |
0.07674 % | Assenagon Asset Management S.A. | 15,831 | 0 | |
0.06922 % | Newton Investment Management North America, LLC | 14,280 | 0 | |
0.05817 % | LPL Financial LLC | 12,000 | 2,000 | |
0.05577 % | Millennium Management LLC | 11,506 | -6,541 | |
0.03151 % | Gesiuris Asset Management S.G.I.I.C., S.A. | 6,500 | 0 | |
0.03061 % | Acadian Asset Management LLC | 6,314 | 0 | |
0.02103 % | Tower Research Capital LLC | 4,338 | -456 | |
0.01758 % | BNY Mellon Asset Management | 3,627 | 0 | |
0.01074 % | Dimensional Fund Advisors, Ltd. | 2,216 | 0 | |
0.01063 % | Adar1 Capital Management LLC | 2,194 | 2,194 | |
0.00848 % | BlackRock Investment Management, LLC | 1,750 | 0 | |
0.00718 % | Davis (Blaine) | 1,481 | 0 | |
0.00514 % | BlackRock Financial Management, Inc. | 1,060 | 0 | |
0.00444 % | UBS Financial Services, Inc. | 916 | 795 | |
0.00242 % | RBC Dominion Securities, Inc. | 500 | 0 | |
0.00242 % | Wells Fargo Advisors | 500 | 0 | |
0.00194 % | Blackstone Alternative Investment Advisors LLC | 400 | -300 | |
0.00111 % | RBC Capital Partners | 228 | 228 | |
0.00048 % | American Portfolios Advisors, Inc | 100 | 0 | |
0.00048 % | Osaic Holdings, Inc. | 100 | 0 | |
0.00033 % | Wells Fargo Bank, N.A. | 69 | 4 | |
0.00008 % | J.P. Morgan Securities LLC | 16 | 5 | |
0.00003 % | BofA Global Research (US) | 6 | 6 | |
0.00001 % | Qube Research & Technologies Ltd | 2 | 0 | |
0 % | ACCI Capital Investments SGIIC, SA | 0 | -60,000 | |
0 % | Financial Advocates Investment Management | 0 | -6,187 | |
0 % | Simplex Trading, LLC | 0 | -195 | |
0 % | DLD Asset Management, LP | 0 | -157,349 | |
0 % | Morgan Stanley Smith Barney LLC | 0 | -25 | |
0 % | Virtu Americas LLC | 0 | -12,465 | |
0 % | Susquehanna International Group, LLP | 0 | -34,971 | |
0 % | Perceptive Advisors LLC | 0 | -290,051 | |
0 % | Apo Asset Management GmbH | 0 | -7,535 | |
0 % | OrbiMed Advisors, LLC | 0 | -772,584 | |
0 % | Federated MDTA LLC | 0 | -124 | |
0 % | Morgan Stanley & Co. LLC | 0 | -58,339 | |
0 % | Manulife Investment Management (North America) Limited | 0 | -372 | |
0 % | Fidelity Management & Research Company LLC | 0 | -9 | |
0 % | Dimensional Fund Advisors, L.P. | 0 | -13,821 | |