7.62170 % | Pfizer Inc | 5,376,344 | 0 | |
7.49322 % | Nextech Invest, Ltd. | 5,285,714 | 0 | |
6.97436 % | Fidelity Management & Research Company LLC | 4,919,713 | -104,240 | |
6.22984 % | VR Adviser, LLC | 4,394,527 | 0 | |
5.87306 % | Frazier Life Sciences Management, L.P. | 4,142,855 | 0 | |
5.80298 % | BlackRock Institutional Trust Company, N.A. | 4,093,420 | 1,200,147 | |
5.67054 % | Viking Global Investors LP | 4,000,000 | 0 | |
5.01953 % | The Column Group LP | 3,540,777 | 0 | |
4.84557 % | EcoR1 Capital, LLC | 3,418,068 | 0 | |
4.52231 % | The Vanguard Group, Inc. | 3,190,034 | 307,979 | |
4.47989 % | Alkeon Capital Management LLC | 3,160,112 | 71,526 | |
3.19851 % | State Street Global Advisors (US) | 2,256,228 | 540,147 | |
2.83527 % | Commodore Capital LP | 2,000,000 | 0 | |
2.45615 % | Boxer Capital, L.L.C. | 1,732,571 | 0 | |
2.14908 % | First Turn Management, LLC | 1,515,960 | 418,389 | |
2.12645 % | New Enterprise Associates (NEA) | 1,500,000 | 0 | |
1.88148 % | Norges Bank Investment Management (NBIM) | 1,327,195 | 1,327,195 | |
1.80539 % | ArrowMark Colorado Holdings, LLC | 1,273,522 | -237,339 | |
1.79994 % | Vivo Capital, LLC | 1,269,676 | 419,995 | |
1.73333 % | Geode Capital Management, L.L.C. | 1,222,692 | 311,059 | |
1.63790 % | T. Rowe Price Associates, Inc. | 1,155,372 | -390,441 | |
1.52511 % | SilverArc Capital Management, LLC | 1,075,812 | -37,195 | |
1.42837 % | Invus Financial Advisors, LLC | 1,007,575 | 0 | |
1.40262 % | Euclidean Capital, L.L.C. | 989,410 | 0 | |
1.10901 % | Millennium Management LLC | 782,299 | 585,447 | |
1.10632 % | Adage Capital Management, L.P. | 780,400 | -250,000 | |
1.06815 % | Franklin Advisers, Inc. | 753,475 | 3,139 | |
1.03281 % | Chacko (Jacob M) | 728,544 | -32,236 | |
0.91293 % | Oppenheimer Asset Management Inc. | 643,984 | 28,474 | |
0.85380 % | Memorial Sloan-Kettering Cancer Center | 602,272 | 0 | |
0.66156 % | Dimensional Fund Advisors, L.P. | 466,662 | 305,860 | |
0.59471 % | BlackRock Financial Management, Inc. | 419,508 | 299,294 | |
0.57414 % | Altium Capital Management LP | 405,000 | 0 | |
0.54428 % | Morgan Stanley & Co. LLC | 383,938 | 183,650 | |
0.48570 % | Two Sigma Investments, LP | 342,614 | 204,505 | |
0.45936 % | Northern Trust Investments, Inc. | 324,033 | 6,900 | |
0.42763 % | Monaco asset management S.A.M. | 301,650 | 171,650 | |
0.40700 % | OrbiMed Advisors, LLC | 287,100 | 0 | |
0.39196 % | BofA Global Research (US) | 276,489 | 75,367 | |
0.34014 % | Goldman Sachs & Company, Inc. | 239,934 | 96,635 | |
0.32432 % | Heyman (Richard A) | 228,772 | 0 | |
0.25696 % | BlackRock Investment Management, LLC | 181,263 | 74,011 | |
0.23450 % | Nuveen LLC | 165,415 | 30,406 | |
0.23107 % | Soleus Capital Management, L.P. | 163,000 | -258,000 | |
0.23018 % | Charles Schwab Investment Management, Inc. | 162,366 | 57,822 | |
0.22103 % | Fred Alger Management, LLC | 155,912 | -64,031 | |
0.20406 % | Driehaus Capital Management, LLC | 143,943 | 0 | |
0.19762 % | TD Asset Management Inc. | 139,400 | -69,200 | |
0.19558 % | Hennion & Walsh Asset Management, Inc. | 137,962 | 35,528 | |
0.18621 % | Manulife Investment Management (North America) Limited | 131,350 | 9,424 | |
0.18565 % | BNY Mellon Asset Management | 130,958 | 49,258 | |
0.17412 % | Wellington Management Company, LLP | 122,823 | 10,850 | |
0.16474 % | Rafferty Asset Management LLC | 116,208 | 5,062 | |
0.16213 % | UBS O'Connor LLC | 114,366 | 22,000 | |
0.14565 % | Jane Street Capital, L.L.C. | 102,741 | 102,741 | |
0.13609 % | Acuta Capital Partners, LLC | 96,000 | -7,992 | |
0.13588 % | Victory Capital Management Inc. | 95,850 | 7,310 | |
0.13142 % | Rhumbline Advisers Ltd. Partnership | 92,702 | 32,402 | |
0.11937 % | American Century Investment Management, Inc. | 84,201 | 11,034 | |
0.11881 % | Piscitelli (Dominic G.) | 83,809 | 7,764 | |
0.11515 % | Qube Research & Technologies Ltd | 81,227 | 28,184 | |
0.11455 % | UBS Financial Services, Inc. | 80,807 | -13,254 | |
0.10102 % | Wilmington Trust Investment Advisors, Inc. | 71,259 | 12 | |
0.10018 % | BlackRock Investment Management (UK) Ltd. | 70,664 | 62,389 | |
0.09870 % | SG Americas Securities, L.L.C. | 69,620 | 69,620 | |
0.09399 % | Schweizerische Nationalbank | 66,300 | 66,300 | |
0.09037 % | Avantis Investors | 63,749 | 23,617 | |
0.07872 % | Mellon Investments Corporation | 55,526 | 28,052 | |
0.07200 % | Barclays Bank PLC | 50,787 | 17,633 | |
0.06891 % | Dimensional Fund Advisors, Ltd. | 48,612 | 2,990 | |
0.06663 % | Renaissance Technologies LLC | 47,000 | -63,900 | |
0.06245 % | AllianceBernstein L.P. | 44,050 | 13,890 | |
0.05581 % | BlackRock Advisors (UK) Limited | 39,367 | 867 | |
0.05511 % | Goldman Sachs Asset Management, L.P. | 38,876 | 12,497 | |
0.05383 % | Legal & General Investment Management Ltd. | 37,972 | 34,719 | |
0.05231 % | Atom Investors LP | 36,901 | 5,506 | |
0.05195 % | Corton Capital Inc | 36,643 | 36,643 | |
0.05172 % | BlackRock Asset Management Ireland Limited | 36,482 | 693 | |
0.05135 % | State of Wisconsin Investment Board | 36,223 | 36,223 | |
0.05115 % | MetLife Investment Management, LLC | 36,078 | 15,341 | |
0.05103 % | Dafna Capital Management, LLC | 36,000 | 36,000 | |
0.05088 % | UBS Fund Management (Switzerland) AG | 35,889 | 8,294 | |
0.04976 % | California State Teachers Retirement System | 35,104 | 31,180 | |
0.04961 % | Northern Trust Global Investments | 34,993 | -1,215 | |
0.04852 % | Verition Fund Management LLC | 34,228 | 34,228 | |
0.04826 % | Susquehanna International Group, LLP | 34,045 | 34,045 | |
0.04818 % | Squarepoint Capital LLP | 33,984 | 16,613 | |
0.04799 % | T. Rowe Price International Ltd | 33,855 | 12,932 | |
0.04734 % | Tudor Investment Corporation | 33,391 | 4,186 | |
0.04696 % | Corebridge Financial Inc | 33,124 | 33,124 | |
0.04519 % | Parametric Portfolio Associates LLC | 31,877 | -61,321 | |
0.04158 % | Aperio Group, LLC | 29,331 | 7,886 | |
0.04017 % | Assenagon Asset Management S.A. | 28,338 | 926 | |
0.03897 % | Citi Investment Research (US) | 27,490 | -106,416 | |
0.03720 % | JPMorgan Private Bank (United States) | 26,239 | 10,935 | |
0.03673 % | Mirae Asset Global Investments (USA) LLC | 25,912 | 25,912 | |
0.03598 % | Wells Fargo Bank, N.A. | 25,379 | 11,562 | |
0.03510 % | DWS Investments UK Limited | 24,759 | 4,036 | |
0.03375 % | Multani Pratik S | 23,809 | 7,764 | |
0.03234 % | Alpine Global Management, LLC | 22,815 | 22,815 | |