6.28920 % | BlackRock Institutional Trust Company, N.A. | 6,614,350 | 419,633 | |
5.46640 % | Millennium Management LLC | 5,749,015 | 736,732 | |
5.36740 % | Cadian Capital Management LP | 5,644,898 | 5,644,898 | |
5.01084 % | The Vanguard Group, Inc. | 5,269,902 | 243,261 | |
4.79543 % | Vitruvian Partners LLP | 5,043,356 | 0 | |
4.38404 % | Sofinnova Partners | 4,610,693 | -365,803 | |
2.78171 % | Morgan Stanley Investment Management Inc. (US) | 2,925,528 | 2,012,145 | |
2.62171 % | Portolan Capital Management, L.L.C. | 2,757,249 | 613,583 | |
2.49048 % | Fidelity Management & Research Company LLC | 2,619,243 | 2,616,840 | |
2.41239 % | MFS Investment Management | 2,537,114 | 584,372 | |
1.99344 % | Geode Capital Management, L.L.C. | 2,096,497 | 123,060 | |
1.84843 % | State Street Global Advisors (US) | 1,943,997 | 103,823 | |
1.79234 % | Blue Water Life Science Advisors, LP. | 1,885,000 | 0 | |
1.78886 % | Mudita Advisors LLP | 1,881,349 | 490,491 | |
1.66397 % | Canaccord Genuity Wealth Management | 1,750,000 | 0 | |
1.52135 % | Swedbank Robur Fonder AB | 1,600,000 | 0 | |
1.44399 % | River Global Investors LLP | 1,518,646 | 45,392 | |
1.35823 % | Granahan Investment Management, LLC | 1,428,449 | -547,398 | |
1.30624 % | ArrowMark Colorado Holdings, LLC | 1,373,777 | -1,035,261 | |
1.25581 % | Berenberg Bank (Asset Management) | 1,320,732 | -54,500 | |
1.22749 % | Columbia Threadneedle Investments (US) | 1,290,949 | 138,080 | |
0.96986 % | Chelverton Asset Management Ltd. | 1,020,000 | -30,000 | |
0.69757 % | Northern Trust Investments, Inc. | 733,632 | 19,568 | |
0.66080 % | Dimensional Fund Advisors, L.P. | 694,961 | 218,356 | |
0.63600 % | Silvercrest Asset Management Group LLC | 668,880 | -591,743 | |
0.62462 % | Grandeur Peak Global Advisors, LLC | 656,916 | -777,903 | |
0.56178 % | Crux Asset Management Limited | 590,820 | -28,000 | |
0.52296 % | Willis Investment Counsel Inc. | 550,000 | 550,000 | |
0.45149 % | Octopus Investments Limited | 474,835 | -70,000 | |
0.42974 % | North Run Capital, LP | 451,960 | -105,000 | |
0.42788 % | AWM Investment Company, Inc. | 450,000 | 450,000 | |
0.42395 % | Morgan Stanley & Co. LLC | 445,871 | 223,174 | |
0.38708 % | Fred Alger Management, LLC | 407,096 | 46,222 | |
0.36722 % | Roubaix Capital, LLC | 386,201 | 386,201 | |
0.35607 % | Mandell (Arthur M) | 374,484 | 0 | |
0.34908 % | Lazard Asset Management, L.L.C. | 367,132 | -90,236 | |
0.31682 % | Doerfler (Douglas A.) | 333,197 | 0 | |
0.31125 % | Royce Investment Partners | 327,338 | -95,222 | |
0.29285 % | Apollo Capital Management, L.P. | 307,987 | 0 | |
0.28619 % | Rathbones Investment Management Limited | 300,988 | -2,730 | |
0.27113 % | Allspring Global Investments, LLC | 285,146 | -5,406 | |
0.25344 % | BNY Mellon Asset Management | 266,538 | 42,459 | |
0.25228 % | BlackRock Financial Management, Inc. | 265,320 | 2,233 | |
0.24205 % | William Blair & Company, L.L.C. (Research) | 254,563 | 2,712 | |
0.23866 % | Jacobs Levy Equity Management, Inc. | 251,001 | 251,001 | |
0.23771 % | Bleichroeder LP | 250,000 | 0 | |
0.23636 % | BlackRock Investment Management, LLC | 248,581 | -6,763 | |
0.23557 % | Erck (Stanley C) | 247,751 | 0 | |
0.23358 % | Nuveen LLC | 245,655 | 0 | |
0.23176 % | Charles Schwab Investment Management, Inc. | 243,743 | 5,271 | |
0.20393 % | Fidelity Institutional Asset Management | 214,472 | 214,472 | |
0.18196 % | ARIAD Asset Management GmbH | 191,370 | 0 | |
0.17980 % | Renaissance Technologies LLC | 189,100 | -22,000 | |
0.16855 % | JPMorgan Private Bank (United States) | 177,259 | 123,676 | |
0.16626 % | Two Sigma Investments, LP | 174,860 | 174,860 | |
0.16497 % | Schweizerische Nationalbank | 173,500 | -16,900 | |
0.14027 % | BlackRock Advisors (UK) Limited | 147,520 | 4,849 | |
0.13811 % | BofA Global Research (US) | 145,249 | 64,352 | |
0.13687 % | Conestoga Capital Advisors, LLC | 143,945 | 0 | |
0.13471 % | UBS Asset Management (Americas), Inc. | 141,676 | 0 | |
0.13312 % | Toscafund Asset Management LLP | 140,000 | 0 | |
0.13070 % | Barclays Bank PLC | 137,460 | 106,266 | |
0.12944 % | Alberta Investment Management Corporation | 136,135 | -63,688 | |
0.12842 % | Citadel Advisors LLC | 135,055 | 86,981 | |
0.12632 % | Rhumbline Advisers Ltd. Partnership | 132,851 | 1,443 | |
0.12338 % | Goldman Sachs Asset Management, L.P. | 129,755 | 33,694 | |
0.12290 % | BlackRock Asset Management Ireland Limited | 129,250 | 8,896 | |
0.11466 % | Johnston (John Joseph) | 120,583 | 0 | |
0.10963 % | Mellon Investments Corporation | 115,295 | 0 | |
0.10940 % | Avantis Investors | 115,055 | 46,070 | |
0.10925 % | State Teachers Retirement System of Ohio | 114,900 | -6,300 | |
0.10590 % | Squarepoint Capital LLP | 111,375 | 111,375 | |
0.10422 % | Parametric Portfolio Associates LLC | 109,611 | -79,248 | |
0.09508 % | Lauxera Capital Partners | 100,000 | 0 | |
0.09508 % | Douglas (Richard H) | 100,000 | 80,000 | |
0.09088 % | UBS Financial Services, Inc. | 95,574 | 30,643 | |
0.08814 % | California State Teachers Retirement System | 92,693 | -4,004 | |
0.08757 % | UBS Asset Management (UK) Ltd. | 92,100 | 0 | |
0.08626 % | Columbia Threadneedle Management Limited | 90,718 | 1,147 | |
0.08301 % | Wilmington Trust Investment Advisors, Inc. | 87,304 | -76,058 | |
0.08000 % | American Century Investment Management, Inc. | 84,136 | -1,621,992 | |
0.07980 % | ValMark Advisers, Inc. | 83,927 | 83,927 | |
0.07726 % | Swirsky (Douglas J) | 81,250 | 81,250 | |
0.07696 % | Credit Suisse Funds AG | 80,934 | 11,573 | |
0.07685 % | Legal & General Investment Management Ltd. | 80,822 | 6,718 | |
0.06985 % | SEI Investments Management Corporation | 73,460 | -1,488 | |
0.06755 % | Assenagon Asset Management S.A. | 71,038 | 5,145 | |
0.06678 % | Citi Investment Research (US) | 70,228 | 11,170 | |
0.06589 % | Ohio Public Employees Retirement System | 69,300 | 69,300 | |
0.06529 % | Jane Street Capital, L.L.C. | 68,662 | 51,983 | |
0.06435 % | Goldman Sachs & Company, Inc. | 67,673 | -4,731 | |
0.05999 % | AllianceBernstein L.P. | 63,090 | -4,530 | |
0.05894 % | Ensign Peak Advisors, Inc. | 61,990 | 3,600 | |
0.05703 % | Aperio Group, LLC | 59,983 | 40,786 | |
0.05576 % | Northern Trust Global Investments | 58,645 | -764 | |
0.05469 % | Susquehanna International Group, LLP | 57,521 | 38,251 | |
0.05439 % | State Street Global Advisors Ireland Limited | 57,204 | -208 | |
0.05400 % | Chevy Chase Trust Company | 56,795 | 543 | |
0.05391 % | Gagnon Securities LLC | 56,701 | 1,264 | |
0.05360 % | Salem Investment Counselors, Inc. | 56,375 | 28,741 | |