8.98 % | Avoro Capital Advisors LLC | 2,565,555 | 0 | |
8.52 % | The Vanguard Group, Inc. | 2,432,038 | 35,632 | |
8.34 % | Fidelity Management & Research Company LLC | 2,381,205 | -82,166 | |
6.14 % | Krishnan (Krish S) | 1,752,262 | -25,000 | |
6.07 % | Redmile Group, LLC | 1,733,189 | -270,178 | |
5.75 % | Krishnan (Suma M) | 1,640,882 | -25,000 | |
5.74 % | BlackRock Institutional Trust Company, N.A. | 1,639,280 | 120,409 | |
4.33 % | State Street Global Advisors (US) | 1,237,497 | 205,670 | |
3.46 % | Frazier Healthcare Partners | 988,460 | 0 | |
2.54 % | Jennison Associates LLC | 724,344 | 383,495 | |
2.17 % | Lord, Abbett & Co. LLC | 618,458 | -52,853 | |
1.93 % | Dimensional Fund Advisors, L.P. | 550,806 | 30,169 | |
1.79 % | Geode Capital Management, L.L.C. | 511,246 | 28,011 | |
1.69 % | Woodline Partners LP | 481,979 | 160,035 | |
1.66 % | Credit Suisse Funds AG | 474,484 | 241,361 | |
1.61 % | Hood River Capital Management LLC | 458,513 | -1,976 | |
1.45 % | T. Rowe Price Associates, Inc. | 413,813 | 169,616 | |
0.96 % | Morgan Stanley & Co. LLC | 275,124 | 36,452 | |
0.93 % | Medical Strategy GmbH | 265,798 | 2,000 | |
0.90 % | Balyasny Asset Management LP | 256,604 | 223,962 | |
0.88 % | TimesSquare Capital Management, LLC | 250,470 | 127,435 | |
0.85 % | SEB Investment Management AB | 244,061 | 0 | |
0.85 % | Nuveen LLC | 243,733 | 10,080 | |
0.85 % | First Turn Management, LLC | 242,185 | 242,185 | |
0.69 % | Driehaus Capital Management, LLC | 196,386 | -2,297 | |
0.69 % | Braidwell LP | 196,200 | 118,703 | |
0.68 % | Pictet Asset Management Ltd. | 192,875 | -180,937 | |
0.67 % | Northern Trust Investments, Inc. | 191,560 | 5,440 | |
0.65 % | C WorldWide Asset Management Fondsmaeglerselskab A/S | 185,809 | 0 | |
0.65 % | Charles Schwab Investment Management, Inc. | 185,038 | 5,258 | |
0.63 % | JPMorgan Asset Management U.K. Limited | 179,444 | -8,734 | |
0.61 % | Victory Capital Management Inc. | 172,879 | -36,608 | |
0.60 % | Fidelity Investments Canada ULC | 170,459 | -4,066 | |
0.60 % | Baker Bros. Advisors LP | 169,934 | 0 | |
0.56 % | Fred Alger Management, LLC | 160,335 | -7,150 | |
0.55 % | Allspring Global Investments, LLC | 158,425 | 99,101 | |
0.48 % | Goldman Sachs & Company, Inc. | 137,265 | 32,011 | |
0.48 % | Eventide Asset Management, LLC | 136,485 | 136,485 | |
0.43 % | Handelsbanken Kapitalförvaltning AB | 123,200 | 10,400 | |
0.39 % | S Squared Technology, LLC | 110,215 | 2,000 | |
0.38 % | Janney (Daniel Spencer) | 107,362 | -125,000 | |
0.36 % | Rock Springs Capital Management LP | 103,969 | 13,409 | |
0.36 % | OrbiMed Advisors, LLC | 103,700 | 103,700 | |
0.34 % | Capital Research Global Investors | 97,147 | 97,147 | |
0.34 % | Verition Fund Management LLC | 95,958 | -31,112 | |
0.32 % | Goldman Sachs Asset Management, L.P. | 90,788 | 11,698 | |
0.30 % | Integral Health Asset Management, LLC | 85,000 | 15,000 | |
0.29 % | Rafferty Asset Management LLC | 84,021 | 12,215 | |
0.29 % | Rossi (Dino A) | 83,691 | 0 | |
0.28 % | BofA Global Research (US) | 81,233 | 18,008 | |
0.28 % | Eversept Partners, LP | 80,798 | -27,973 | |
0.26 % | Schroder Investment Management Ltd. (SIM) | 74,945 | 74,945 | |
0.25 % | Nuveen Asset Management, LLC | 71,732 | 43,151 | |
0.25 % | Marshall Wace LLP | 70,901 | 61,373 | |
0.24 % | D. E. Shaw & Co., L.P. | 67,141 | 11,384 | |
0.23 % | Decheng Capital LLC | 65,772 | 65,772 | |
0.22 % | Barclays Bank PLC | 64,062 | 24,542 | |
0.22 % | Wellington Management Company, LLP | 63,799 | -96 | |
0.22 % | BlackRock Financial Management, Inc. | 61,986 | -3,167 | |
0.21 % | BNY Mellon Asset Management | 60,419 | 871 | |
0.20 % | ACT Capital Management, L.L.C. | 58,300 | -700 | |
0.19 % | Candriam Luxembourg S.A. | 55,000 | 0 | |
0.19 % | Candriam Belgium S.A. | 55,000 | -15,000 | |
0.19 % | BlackRock Investment Management, LLC | 54,308 | 390 | |
0.19 % | Monarch Partners Asset Management LLC | 53,905 | 7,411 | |
0.18 % | AHL Partners LLP | 50,836 | 50,836 | |
0.18 % | Jane Street Capital, L.L.C. | 50,618 | -24,508 | |
0.18 % | Ghost Tree Capital, LLC | 50,000 | -30,000 | |
0.17 % | Nicholas Investment Partners, L.P. | 49,073 | -306,538 | |
0.16 % | International Biotechnology Trust PLC | 46,092 | 147 | |
0.16 % | Voya Investment Management LLC | 45,853 | 17,413 | |
0.16 % | Invesco Advisers, Inc. | 44,544 | 33,720 | |
0.15 % | ExodusPoint Capital Management, LP | 42,502 | 14,752 | |
0.15 % | Arctic Fund Management AS | 42,154 | 8,180 | |
0.14 % | TD Asset Management Inc. | 40,962 | 18,542 | |
0.14 % | Soleus Capital Management, L.P. | 40,000 | -77,892 | |
0.14 % | Putnam Investment Management, L.L.C. | 39,322 | 4,529 | |
0.14 % | BNP Paribas Securities Corp. North America | 39,072 | 10,057 | |
0.13 % | PGIM Securities Investment Trust Enterprise | 37,800 | -200 | |
0.13 % | Citi Investment Research (US) | 36,566 | 779 | |
0.13 % | Mutual of America Capital Management LLC | 36,388 | -1,151 | |
0.13 % | Schweizerische Nationalbank | 35,900 | -3,500 | |
0.12 % | Mellon Investments Corporation | 35,287 | 2,873 | |
0.12 % | Hennion & Walsh Asset Management, Inc. | 33,154 | 1,756 | |
0.11 % | BlackRock Advisors (UK) Limited | 32,616 | 1,224 | |
0.11 % | CastleArk Management, LLC | 32,350 | 20,930 | |
0.11 % | Rhumbline Advisers Ltd. Partnership | 31,785 | -618 | |
0.11 % | Parametric Portfolio Associates LLC | 31,232 | -8,113 | |
0.11 % | UBS Financial Services, Inc. | 30,760 | 30,760 | |
0.10 % | Kennedy Capital Management LLC | 29,673 | 29,673 | |
0.10 % | Manulife Investment Management (North America) Limited | 29,250 | 8,813 | |
0.10 % | BlackRock Asset Management Ireland Limited | 27,592 | -3,944 | |
0.09 % | AllianceBernstein L.P. | 25,900 | 0 | |
0.09 % | Schonfeld Strategic Advisors LLC | 25,566 | -58,069 | |
0.09 % | Affinity Asset Advisors LLC | 25,000 | -32,500 | |
0.09 % | Franklin Advisers, Inc. | 24,866 | 370 | |
0.09 % | New Jersey Division of Investment | 24,804 | 4,475 | |
0.08 % | Carson Wealth Management Group | 23,850 | -6,719 | |
0.08 % | Scout Investments, Inc. | 23,611 | 23,611 | |
0.08 % | GW&K Investment Management, LLC | 23,600 | 23,600 | |