17.01247 % | RA Capital Management, LP | 4,472,120 | 629,297 | |
16.68702 % | OrbiMed Advisors, LLC | 4,386,568 | 0 | |
10.87978 % | BML Capital Management LLC | 2,860,000 | 2,860,000 | |
8.91713 % | Arix Bioscience Holdings Ltd. | 2,344,072 | 0 | |
5.92576 % | Pfizer Inc | 1,557,722 | 0 | |
5.69823 % | Commodore Capital LP | 1,497,910 | 1,497,910 | |
5.45024 % | Lundbeckfond Ventures | 1,432,722 | 0 | |
3.29591 % | Woodline Partners LP | 866,405 | -84,888 | |
3.20460 % | Rock Springs Capital Management LP | 842,402 | 0 | |
2.67574 % | Bay City Capital L.L.C. | 703,380 | 0 | |
1.25279 % | Renaissance Technologies LLC | 329,324 | -78,196 | |
1.15704 % | The Vanguard Group, Inc. | 304,155 | 38,468 | |
0.87495 % | Leonard (Braden Michael) | 230,000 | -90,000 | |
0.87200 % | Mott (David M) | 229,224 | 0 | |
0.79886 % | JBF Capital, Inc. | 210,000 | 210,000 | |
0.64670 % | Caption Management, LLC | 170,000 | 170,000 | |
0.53339 % | Janus Henderson Investors | 140,213 | 0 | |
0.48122 % | Bridgeway Capital Management, LLC | 126,500 | 0 | |
0.40733 % | BlackRock Institutional Trust Company, N.A. | 107,076 | -13,166 | |
0.39972 % | Geode Capital Management, L.L.C. | 105,075 | 49,336 | |
0.39676 % | Jefferies LLC | 104,298 | 104,298 | |
0.37698 % | Parallax Volatility Advisers, L.P. | 99,099 | 99,099 | |
0.36269 % | Citadel Advisors LLC | 95,342 | 95,342 | |
0.35376 % | Group One Trading, L.P. | 92,994 | 92,994 | |
0.23305 % | Morgan Stanley Smith Barney LLC | 61,263 | -30,831 | |
0.19941 % | BNY Mellon Asset Management | 52,419 | 0 | |
0.15216 % | MYDA Advisors LLC | 40,000 | 40,000 | |
0.14359 % | Marquette Wealth Management | 37,745 | -13,822 | |
0.10787 % | Anson Funds Management LP. | 28,356 | 28,356 | |
0.10752 % | Dimensional Fund Advisors, L.P. | 28,265 | 28,265 | |
0.09321 % | Tudor Investment Corporation | 24,502 | -27,390 | |
0.08064 % | State Street Global Advisors (US) | 21,198 | 0 | |
0.07993 % | Great Valley Advisor Group, Inc. | 21,011 | 0 | |
0.06847 % | Rockefeller Capital Management | 18,000 | 0 | |
0.06007 % | HRT Financial LP | 15,792 | 15,792 | |
0.05826 % | Northern Trust Investments, Inc. | 15,314 | 0 | |
0.03804 % | AE Wealth Management LLC | 10,000 | 10,000 | |
0.03146 % | Dimensional Fund Advisors, Ltd. | 8,270 | 8,270 | |
0.02092 % | Dorsey, Wright & Associates, LLC | 5,500 | 5,500 | |
0.01040 % | Lord, Abbett & Co. LLC | 2,735 | -276 | |
0.00651 % | Gray (Michael P) | 1,712 | 0 | |
0.00599 % | Federated Hermes MDTA LLC | 1,575 | -2,167 | |
0.00599 % | BlackRock Investment Management, LLC | 1,574 | 0 | |
0.00436 % | BlackRock Financial Management, Inc. | 1,145 | 0 | |
0.00232 % | Ballal (Rahul D.) | 609 | 0 | |
0.00036 % | Wells Fargo Bank, N.A. | 94 | 10 | |
0.00033 % | RBC Capital Partners | 87 | 55 | |
0.00003 % | J.P. Morgan Securities LLC | 9 | 9 | |
0.00001 % | RBC Capital Markets Wealth Management | 2 | 2 | |
0 % | Ergoteles Capital | 0 | -31,546 | |
0 % | Simplex Trading, LLC | 0 | -337 | |
0 % | Trexquant Investment LP | 0 | -19,646 | |
0 % | Lion Point Capital, L.P. | 0 | -834,780 | |
0 % | Cubist Systematic Strategies, LLC | 0 | -11,983 | |
0 % | Blackstone Alternative Investment Advisors LLC | 0 | -2,700 | |
0 % | Altfest Personal Wealth Management | 0 | -15,234 | |
0 % | Advisory Services Network, LLC | 0 | -11,680 | |
0 % | Pura Vida Investments, LLC | 0 | -196,635 | |
0 % | Tibra Equities Europe, Ltd. | 0 | -37,500 | |
0 % | Principal Funds, Inc. | 0 | -1,445 | |
0 % | DWS Investments UK Limited | 0 | -4,906 | |
0 % | Assenagon Asset Management S.A. | 0 | -170 | |
0 % | Russell Investments Trust Company | 0 | -193,904 | |
0 % | ProShare Advisors LLC | 0 | -2,125 | |
0 % | Walleye Trading, LLC | 0 | -43,233 | |
0 % | Laurion Capital Management LP | 0 | -155,183 | |
0 % | Susquehanna International Group, LLP | 0 | -98,209 | |
0 % | Prelude Capital Management, LLC | 0 | -19,545 | |
0 % | Tower Research Capital LLC | 0 | -830 | |
0 % | Northern Trust Global Investments | 0 | -7,604 | |
0 % | Two Sigma Investments, LP | 0 | -301,937 | |
0 % | Ancora Advisors, L.L.C. | 0 | -112 | |
0 % | Morgan Stanley & Co. International Plc | 0 | -209 | |
0 % | Millennium Management LLC | 0 | -10,307 | |
0 % | ProFund Advisors LLC | 0 | -167 | |
0 % | Deerfield Management Company, L.P. | 0 | -79,465 | |
0 % | D. E. Shaw & Co., L.P. | 0 | -83,866 | |
0 % | New Enterprise Associates (NEA) | 0 | -1,006,722 | |
0 % | PGIM Quantitative Solutions LLC | 0 | -1,865 | |
0 % | Acadian Asset Management LLC | 0 | -8,592 | |
0 % | Charles Schwab Investment Management, Inc. | 0 | -18,284 | |
0 % | Legal & General Investment Management Ltd. | 0 | -976 | |
0 % | Principal Global Investors (Equity) | 0 | -1,445 | |
0 % | DWS Investment Management Americas, Inc. | 0 | -15,180 | |
0 % | Citi Investment Research (US) | 0 | -508 | |
0 % | T. Rowe Price Associates, Inc. | 0 | -68 | |
0 % | Morgan Stanley Investment Management Inc. (US) | 0 | -64 | |
0 % | Morgan Stanley & Co. LLC | 0 | -741 | |
0 % | BofA Global Research (US) | 0 | -9,478 | |
0 % | Manulife Investment Management (North America) Limited | 0 | -1,879 | |
0 % | SunAmerica Asset Management, LLC | 0 | -4,462 | |
0 % | Goldman Sachs & Company, Inc. | 0 | -872,581 | |
0 % | Fidelity Management & Research Company LLC | 0 | -370,159 | |
0 % | Nuveen LLC | 0 | -14,913 | |
0 % | JPMorgan Private Bank (United States) | 0 | -3,072 | |
0 % | California Public Employees' Retirement System | 0 | -15,979 | |
0 % | Deutsche Asset Management Americas | 0 | -100 | |
0 % | Ameritas Investment Partners, Inc. | 0 | -437 | |
0 % | AllianceBernstein L.P. | 0 | -4,200 | |
0 % | Jacobs Levy Equity Management, Inc. | 0 | -13,794 | |