11.22588 % | BlackRock Institutional Trust Company, N.A. | 13,247,666 | 2,057,377 | |
9.67466 % | The Vanguard Group, Inc. | 11,417,065 | 1,438,904 | |
8.33158 % | Fidelity Management & Research Company LLC | 9,832,098 | 137,240 | |
6.89660 % | T. Rowe Price Investment Management, Inc. | 8,138,677 | 3,017,088 | |
6.36347 % | Wellington Management Company, LLP | 7,509,530 | 3,528,070 | |
5.54914 % | State Street Global Advisors (US) | 6,548,536 | 2,028,178 | |
3.87726 % | Darwin Global Management Ltd | 4,575,558 | 4,575,558 | |
3.61361 % | BofA Global Research (US) | 4,264,418 | -399,755 | |
2.32069 % | Geode Capital Management, L.L.C. | 2,738,646 | 491,481 | |
2.30587 % | RTW Investments L.P. | 2,721,158 | 196,078 | |
2.08005 % | Polar Capital LLP | 2,454,665 | 849,089 | |
1.93857 % | T. Rowe Price Associates, Inc. | 2,287,709 | -585,162 | |
1.77951 % | Boxer Capital, L.L.C. | 2,100,000 | 0 | |
1.75833 % | Vestal Point Capital, LP | 2,075,000 | -75,000 | |
1.75069 % | Armistice Capital LLC | 2,065,991 | 540,303 | |
1.59237 % | AllianceBernstein L.P. | 1,879,161 | 109,096 | |
1.49832 % | Pictet Asset Management Ltd. | 1,768,162 | 14,516 | |
1.48902 % | PFM Health Sciences, LP | 1,757,192 | 0 | |
1.43295 % | Fidelity Institutional Asset Management | 1,691,030 | 484,745 | |
1.42205 % | Marshall Wace LLP | 1,678,159 | -878,644 | |
1.42004 % | Melqart Asset Management (UK) Limited | 1,675,785 | 692,390 | |
0.94822 % | Pentwater Capital Management LP | 1,119,000 | 39,000 | |
0.94060 % | Sarissa Capital Management, L.P. | 1,110,000 | 810,000 | |
0.87934 % | Northern Trust Investments, Inc. | 1,037,704 | 76,490 | |
0.84739 % | Integral Health Asset Management, LLC | 1,000,000 | 550,000 | |
0.83077 % | RP Management, LLC | 980,392 | 980,392 | |
0.82733 % | Janus Henderson Investors | 976,329 | 178,957 | |
0.78441 % | Charles Schwab Investment Management, Inc. | 925,682 | 150,126 | |
0.74797 % | Morgan Stanley & Co. LLC | 882,675 | 187,204 | |
0.74020 % | Westfield Capital Management Company, L.P. | 873,513 | 142,127 | |
0.72788 % | Citadel Advisors LLC | 858,973 | 298,071 | |
0.72355 % | Adar1 Capital Management LLC | 853,862 | 534,352 | |
0.71574 % | JP Morgan Asset Management | 844,650 | 480,894 | |
0.68885 % | OrbiMed Advisors, LLC | 812,906 | 130,206 | |
0.67762 % | Norges Bank Investment Management (NBIM) | 799,664 | 77,435 | |
0.64617 % | Brown Advisory | 762,549 | 3,015 | |
0.63049 % | Fidelity Investments Canada ULC | 744,038 | 10,601 | |
0.62506 % | Hood River Capital Management LLC | 737,637 | 40,990 | |
0.57719 % | Medical Strategy GmbH | 681,145 | -42,471 | |
0.57416 % | Goldman Sachs & Company, Inc. | 677,566 | 212,369 | |
0.50959 % | Balyasny Asset Management LP | 601,367 | -73,695 | |
0.47039 % | Voloridge Investment Management, LLC | 555,110 | -205,209 | |
0.46507 % | BlackRock Financial Management, Inc. | 548,824 | 81,175 | |
0.45294 % | Fisher Investments | 534,520 | -4,277 | |
0.41897 % | Invus Public Equities Advisors, LLC | 494,421 | -12,163 | |
0.41597 % | Mellon Investments Corporation | 490,888 | 102,806 | |
0.41501 % | Invesco Advisers, Inc. | 489,749 | -765,335 | |
0.41141 % | BNY Mellon Asset Management | 485,505 | 69,017 | |
0.40183 % | Great Point Partners, LLC | 474,202 | 272,000 | |
0.39909 % | Renaissance Technologies LLC | 470,967 | 105,000 | |
0.39270 % | Ensign Peak Advisors, Inc. | 463,431 | 39,172 | |
0.38640 % | Goldman Sachs Asset Management, L.P. | 455,985 | 248,866 | |
0.38451 % | BlackRock Investment Management, LLC | 453,759 | 85,268 | |
0.33734 % | Dafna Capital Management, LLC | 398,100 | 0 | |
0.33402 % | Readystate Asset Management LP | 394,175 | -71,323 | |
0.33351 % | Principal Global Investors (Equity) | 393,579 | -37,977 | |
0.32618 % | Sphera Funds Management Ltd. | 384,924 | 103,253 | |
0.32138 % | Rhumbline Advisers Ltd. Partnership | 379,257 | 72,618 | |
0.31764 % | Point72 Asset Management, L.P. | 374,848 | 10,139 | |
0.30557 % | TD Asset Management Inc. | 360,598 | 76,078 | |
0.29787 % | BNP Paribas Asset Management USA, Inc. | 351,521 | 25,850 | |
0.29494 % | abrdn Inc. | 348,056 | -21,181 | |
0.29205 % | Nuveen LLC | 344,644 | -125,943 | |
0.28086 % | American Century Investment Management, Inc. | 331,444 | -84,410 | |
0.25388 % | UBS Financial Services, Inc. | 299,604 | 860 | |
0.24855 % | First Turn Management, LLC | 293,318 | -137,031 | |
0.23394 % | MFS Investment Management | 276,067 | 251,389 | |
0.23052 % | Saturn V Capital Management LP | 272,036 | 8,335 | |
0.22600 % | Kingdon Capital Management, L.L.C. | 266,700 | 150,700 | |
0.22462 % | Rafferty Asset Management LLC | 265,069 | 125,592 | |
0.22456 % | Jane Street Capital, L.L.C. | 265,002 | -42,565 | |
0.21731 % | Finepoint Capital LP | 256,449 | 18,403 | |
0.21536 % | Eventide Asset Management, LLC | 254,148 | 0 | |
0.21512 % | Pinnacle Associates Ltd. | 253,864 | -3,303 | |
0.21480 % | Schroder Investment Management Ltd. (SIM) | 253,487 | 0 | |
0.21423 % | Thornburg Investment Management, Inc. | 252,811 | 169,050 | |
0.20075 % | Cutter Capital Management, LP | 236,900 | 236,900 | |
0.20048 % | BlackRock Advisors (UK) Limited | 236,587 | 4,072 | |
0.19490 % | Prosight Capital | 230,000 | -15,000 | |
0.19387 % | Blum (Robert I) | 228,785 | 0 | |
0.19291 % | Columbia Threadneedle Investments (US) | 227,654 | 69,324 | |
0.19240 % | Northern Trust Global Investments | 227,046 | 96,245 | |
0.17795 % | Segantii Capital Management Limited | 210,000 | 210,000 | |
0.17601 % | BlackRock Asset Management Ireland Limited | 207,712 | 7,365 | |
0.17600 % | Clearline Capital LP | 207,695 | 159,660 | |
0.17307 % | Corebridge Financial Inc | 204,245 | 204,245 | |
0.16998 % | Putnam Investment Management, L.L.C. | 200,598 | -164,512 | |
0.16964 % | Franklin Advisers, Inc. | 200,195 | 6,977 | |
0.16821 % | Opaleye Management Inc. | 198,500 | 198,500 | |
0.16794 % | Woodline Partners LP | 198,181 | 198,181 | |
0.16737 % | Rhenman & Partners Asset Management AB | 197,515 | 0 | |
0.16609 % | Ghisallo Capital Management LLC | 196,000 | 196,000 | |
0.16566 % | Schweizerische Nationalbank | 195,500 | 21,300 | |
0.16100 % | Checkpoint Capital L.P. | 190,000 | 0 | |
0.15900 % | Superstring Capital Management LP | 187,633 | -91,282 | |
0.15231 % | California Public Employees' Retirement System | 179,737 | 48,596 | |
0.15185 % | Candriam Luxembourg S.A. | 179,200 | 0 | |
0.15185 % | Candriam Belgium S.A. | 179,200 | -313,829 | |
0.15107 % | JPMorgan Private Bank (United States) | 178,272 | 38,472 | |
0.14920 % | SunAmerica Asset Management, LLC | 176,072 | 125,172 | |