6.59 % | Nippon Shinyaku Co Ltd | 2,145,922 | 2,145,922 | |
3.58 % | The Vanguard Group, Inc. | 1,165,404 | 13,086 | |
2.80 % | Woodline Partners LP | 909,542 | 909,542 | |
1.09 % | BlackRock Institutional Trust Company, N.A. | 355,730 | 1,099 | |
0.97 % | Geode Capital Management, L.L.C. | 316,198 | 47,570 | |
0.61 % | Marban (Linda) | 199,524 | -177,855 | |
0.46 % | Susquehanna International Group, LLP | 149,115 | 19,840 | |
0.45 % | Renaissance Technologies LLC | 146,321 | 103,700 | |
0.41 % | Litvack (Frank) | 133,269 | 0 | |
0.36 % | Osaic Holdings, Inc. | 116,550 | 110,550 | |
0.32 % | Northern Trust Investments, Inc. | 105,009 | 22,269 | |
0.26 % | State Street Global Advisors (US) | 85,224 | 300 | |
0.24 % | LPL Financial LLC | 78,238 | -3,000 | |
0.19 % | Newton Investment Management North America, LLC | 60,440 | 0 | |
0.17 % | Qube Research & Technologies Ltd | 55,009 | 49,380 | |
0.16 % | Jump Financial, LLC | 52,800 | 52,800 | |
0.13 % | Simplex Trading, LLC | 42,740 | 5,959 | |
0.12 % | Jane Street Capital, L.L.C. | 40,039 | 40,039 | |
0.12 % | Musket (David B) | 38,632 | 0 | |
0.12 % | Morgan Stanley Smith Barney LLC | 37,632 | 5,000 | |
0.10 % | GSA Capital Partners LLP | 32,970 | -10,835 | |
0.10 % | Commonwealth Financial Network | 30,990 | 0 | |
0.08 % | Collier (Earl M Jr) | 26,856 | 0 | |
0.07 % | BNY Mellon Asset Management | 24,318 | 412 | |
0.07 % | Citi Investment Research (US) | 23,798 | -37,793 | |
0.07 % | BofA Global Research (US) | 23,728 | 8,989 | |
0.07 % | Northern Trust Global Investments | 22,220 | 0 | |
0.06 % | Millennium Management LLC | 21,038 | -23,750 | |
0.06 % | Krasney Karen | 20,047 | 0 | |
0.06 % | Two Sigma Investments, LP | 19,700 | 19,700 | |
0.05 % | Goldman Sachs Asset Management, L.P. | 15,240 | -9,309 | |
0.05 % | Dimensional Fund Advisors, L.P. | 14,839 | -9,246 | |
0.04 % | Charles Schwab Investment Management, Inc. | 13,479 | 0 | |
0.03 % | Coastal Bridge Advisors, LLC | 10,894 | 0 | |
0.03 % | Dunbar (George W Jr) | 10,556 | 0 | |
0.03 % | Y-Intercept (Hong Kong) Ltd | 10,263 | 10,263 | |
0.03 % | Morgan Stanley & Co. LLC | 10,056 | 0 | |
0.03 % | RBC Capital Markets Wealth Management | 8,500 | 8,500 | |
0.02 % | U.S. Bancorp Asset Management, Inc. | 7,462 | 0 | |
0.02 % | Auwaerter (Paul Gisbert) | 5,000 | 0 | |
0.01 % | BlackRock Investment Management, LLC | 3,943 | 0 | |
0.01 % | Bergmann (Anthony) | 2,381 | 0 | |
0.01 % | BlackRock Fund Advisors | 2,030 | 2,030 | |
0.01 % | Group One Trading, L.P. | 2,006 | -33,962 | |
0.00 % | Householder Group Estate and Retirement Specialist LLC | 1,500 | 0 | |
0.00 % | RBC Dominion Securities, Inc. | 1,400 | 0 | |
0.00 % | Tower Research Capital LLC | 1,360 | -7,562 | |
0.00 % | Manulife Investment Management (North America) Limited | 749 | 0 | |
0.00 % | Harel Insurance Investments and Financial Services Ltd | 689 | 0 | |
0.00 % | Wells Fargo Bank, N.A. | 236 | 48 | |
0.00 % | RBC Capital Partners | 78 | 78 | |
0.00 % | New Millennium Group LLC | 59 | 0 | |
0.00 % | Wipfli Financial Advisors, LLC | 4 | 4 | |
0.00 % | Mellon Investments Corporation | 1 | 0 | |
0 % | Cubist Systematic Strategies, LLC | 0 | -29,387 | |
0 % | Belvedere Trading, LLC | 0 | -8,053 | |
0 % | Belpointe Asset Management LLC | 0 | -2,070 | |
0 % | Dimensional Fund Advisors, Ltd. | 0 | -5,200 | |
0 % | Virtu Americas LLC | 0 | -16,895 | |
0 % | Hightower Advisors, LLC | 0 | -19,885 | |
0 % | Cutler Group, LP | 0 | -1,000 | |
0 % | Dorsey, Wright & Associates, LLC | 0 | -3,600 | |
0 % | Morgan Stanley & Co. International Plc | 0 | -276 | |
0 % | BNP Paribas Securities Corp. North America | 0 | -100 | |
0 % | Wells Fargo Advisors | 0 | -1,000 | |
0 % | Marshall Wace LLP | 0 | -28,359 | |
0 % | Roffman Miller Associates, Inc. | 0 | -500 | |
0 % | Citadel Advisors LLC | 0 | -20,861 | |
0 % | Highbridge Capital Management, LLC | 0 | -2,789,699 | |
0 % | Federated MDTA LLC | 0 | -111 | |
0 % | Northwestern Mutual Capital, LLC | 0 | -500 | |
0 % | Bailard, Inc. | 0 | -33,601 | |
0 % | Parametric Portfolio Associates LLC | 0 | -20 | |
0 % | UBS Financial Services, Inc. | 0 | -4,439 | |
0 % | McGlone Suttner Wealth Management, Inc. | 0 | -423 | |
0 % | Avat (Xavier) | 0 | -3,000 | |