13.36630 % | Kohlberg Kravis Roberts & Co. L.P. | 25,260,971 | -5,800,000 | |
13.29223 % | Viking Global Investors LP | 25,120,991 | 0 | |
7.42506 % | The Vanguard Group, Inc. | 14,032,613 | 832,622 | |
5.44447 % | BlackRock Institutional Trust Company, N.A. | 10,289,510 | 1,576,038 | |
3.65408 % | Kumar (Neil) | 6,905,851 | 0 | |
3.21082 % | Aisling Capital Management LP | 6,068,125 | 0 | |
3.09759 % | State Street Global Advisors (US) | 5,854,140 | 461,278 | |
2.32228 % | Laurion Capital Management LP | 4,388,873 | -787,455 | |
2.28188 % | Janus Henderson Investors | 4,312,531 | 999,825 | |
1.92211 % | Frazier Life Sciences Management, L.P. | 3,632,604 | 217,000 | |
1.74105 % | Geode Capital Management, L.L.C. | 3,290,409 | 427,564 | |
1.40164 % | Pictet Asset Management Ltd. | 2,648,957 | -283,472 | |
1.29764 % | AllianceBernstein L.P. | 2,452,404 | -391,895 | |
1.17048 % | Capital Research Global Investors | 2,212,085 | 0 | |
1.14104 % | Citadel Advisors LLC | 2,156,449 | 1,273,174 | |
0.98437 % | Sequoia Capital Partners Inc. | 1,860,364 | 0 | |
0.98331 % | Cormorant Asset Management, LP | 1,858,351 | -1,344,678 | |
0.98146 % | Emerald Advisers LLC | 1,854,863 | 690,265 | |
0.88984 % | Medical Strategy GmbH | 1,681,701 | 0 | |
0.87105 % | Ensign Peak Advisors, Inc. | 1,646,202 | 506,845 | |
0.81935 % | Goldman Sachs & Company, Inc. | 1,548,488 | 314,000 | |
0.81481 % | Fidelity Management & Research Company LLC | 1,539,913 | -785,699 | |
0.81220 % | Manulife Investment Management (North America) Limited | 1,534,972 | 442,248 | |
0.77788 % | Wellington Management Company, LLP | 1,470,110 | -71,775 | |
0.73583 % | HHLR Advisors, Ltd. | 1,390,653 | 23,164 | |
0.69598 % | Citi Investment Research (US) | 1,315,339 | -474,731 | |
0.66912 % | Adar1 Capital Management LLC | 1,264,570 | 714,766 | |
0.65087 % | Homcy (Charles J) | 1,230,085 | 2,089 | |
0.64307 % | Perceptive Advisors LLC | 1,215,346 | -196,687 | |
0.62924 % | Charles Schwab Investment Management, Inc. | 1,189,197 | 141,160 | |
0.61131 % | Morgan Stanley & Co. LLC | 1,155,313 | 180,534 | |
0.59535 % | Principal Global Investors (Equity) | 1,125,145 | 51,958 | |
0.58732 % | BlackRock Financial Management, Inc. | 1,109,978 | 269,822 | |
0.58208 % | McCormick (Frank) | 1,100,065 | -100,000 | |
0.58031 % | American Century Investment Management, Inc. | 1,096,734 | 182,623 | |
0.57797 % | UBS Financial Services, Inc. | 1,092,314 | -7,232 | |
0.57648 % | Paradigm BioCapital Advisors LP | 1,089,492 | 1,089,492 | |
0.56100 % | Invesco Advisers, Inc. | 1,060,241 | 88,183 | |
0.51409 % | Northern Trust Investments, Inc. | 971,571 | -2,992 | |
0.50244 % | Woodline Partners LP | 949,570 | 248,821 | |
0.49045 % | PRIMECAP Management Company | 926,900 | -330 | |
0.48154 % | Sphera Funds Management Ltd. | 910,070 | 324,114 | |
0.47290 % | Norges Bank Investment Management (NBIM) | 893,729 | -266,613 | |
0.43297 % | Two Sigma Investments, LP | 818,272 | -228,183 | |
0.42330 % | Prosight Capital | 800,000 | 210,470 | |
0.39661 % | Goldman Sachs Asset Management, L.P. | 749,551 | 358,280 | |
0.39060 % | T. Rowe Price Associates, Inc. | 738,193 | 5,208 | |
0.38519 % | PanAgora Asset Management Inc. | 727,963 | 312,686 | |
0.37948 % | Jane Street Capital, L.L.C. | 717,185 | 487,609 | |
0.37935 % | Eventide Asset Management, LLC | 716,927 | 0 | |
0.36510 % | Octagon Capital Advisors LP | 690,000 | 0 | |
0.35803 % | Susquehanna International Group, LLP | 676,649 | 618,296 | |
0.32802 % | AHL Partners LLP | 619,927 | 619,927 | |
0.31678 % | BofA Global Research (US) | 598,677 | -180,125 | |
0.31656 % | MFS Investment Management | 598,263 | 219,257 | |
0.30385 % | UBS Asset Management (Switzerland) | 574,241 | -5,898 | |
0.29745 % | Nuveen LLC | 562,154 | 258,876 | |
0.28996 % | Adage Capital Management, L.P. | 548,000 | 272,000 | |
0.24788 % | BlackRock Advisors (UK) Limited | 468,468 | 311 | |
0.23643 % | BlackRock Asset Management Ireland Limited | 446,825 | 14,009 | |
0.22078 % | Pictet Asset Management (Japan) Ltd. | 417,255 | -131,851 | |
0.21867 % | Barclays Bank PLC | 413,265 | 8,353 | |
0.21483 % | Caption Management, LLC | 406,000 | 95,566 | |
0.21048 % | BlackRock Investment Management, LLC | 397,783 | 98,146 | |
0.20949 % | Trimarchi (Thomas) | 395,923 | 1,067 | |
0.20251 % | Victory Capital Management Inc. | 382,717 | 34,360 | |
0.19423 % | BNY Mellon Asset Management | 367,076 | 59,767 | |
0.18729 % | Voloridge Investment Management, LLC | 353,961 | -1,042,458 | |
0.18285 % | Braidwell LP | 345,571 | 744 | |
0.18056 % | TwinBeech Capital LP | 341,247 | 341,247 | |
0.17568 % | Ikarian Capital LLC | 332,013 | 50,000 | |
0.17529 % | Stanford Management Company | 331,283 | 0 | |
0.16493 % | Cutter Capital Management, LP | 311,700 | 311,700 | |
0.16292 % | Melqart Asset Management (UK) Limited | 307,911 | 307,911 | |
0.14623 % | T. Rowe Price Investment Management, Inc. | 276,369 | -1,168,748 | |
0.14372 % | Rafferty Asset Management LLC | 271,607 | -44,835 | |
0.13947 % | Eagle Asset Management, Inc. | 263,584 | -46,575 | |
0.13849 % | Fernwood Investment Management, LLC. | 261,735 | 6,200 | |
0.13423 % | Lo (Andrew W.) | 253,682 | 0 | |
0.13376 % | Squarepoint Capital LLP | 252,793 | 252,793 | |
0.13309 % | Granahan Investment Management, LLC | 251,525 | -205,461 | |
0.12793 % | Millennium Management LLC | 241,780 | 125,178 | |
0.12699 % | Matrix Capital Management Company, LP | 240,000 | 70,000 | |
0.12562 % | Mellon Investments Corporation | 237,402 | 58,820 | |
0.12077 % | Nomura Securities Co., Ltd. | 228,234 | -153,411 | |
0.11859 % | D. E. Shaw & Co., L.P. | 224,128 | -193,760 | |
0.11715 % | Rhumbline Advisers Ltd. Partnership | 221,403 | 36,199 | |
0.11632 % | Superstring Capital Management LP | 219,837 | -133,670 | |
0.11477 % | Schweizerische Nationalbank | 216,900 | 10,900 | |
0.10968 % | Balyasny Asset Management LP | 207,280 | 207,280 | |
0.10649 % | Hightower Advisors, LLC | 201,254 | 1,992 | |
0.10583 % | 683 Capital Management LLC | 200,000 | 110,000 | |
0.09762 % | Rhenman & Partners Asset Management AB | 184,500 | 80,000 | |
0.09467 % | Parametric Portfolio Associates LLC | 178,913 | -12,355 | |
0.09349 % | WCM Investment Management | 176,692 | 2,766 | |
0.08934 % | Legal & General Investment Management Ltd. | 168,843 | 11,856 | |
0.08881 % | Susquehanna Fundamental Investments, LLC | 167,839 | 167,839 | |
0.07879 % | Northern Trust Global Investments | 148,898 | 1,984 | |
0.07851 % | Frontier Capital Management Company, LLC | 148,368 | -301,168 | |
0.07839 % | Nomura Asset Management Co., Ltd. | 148,143 | 8,943 | |