7.21712 % | RTW Investments L.P. | 6,947,918 | -188,497 | |
7.01338 % | Polar Capital LLP | 6,751,782 | 2,238,818 | |
5.83292 % | Tontine Asset Management, LLC | 5,615,350 | 0 | |
4.25514 % | Vivo Capital, LLC | 4,096,428 | 0 | |
3.86023 % | Kotler (Kevin) | 3,716,242 | -1,010,094 | |
2.50995 % | Wealth Effects LLC | 2,416,326 | 7,037 | |
11.55638 % | Janus Henderson Investors | 11,125,330 | 487,023 | |
1.92418 % | Woodline Partners LP | 1,852,412 | -50,431 | |
1.70598 % | Cowen & Co., LLC | 1,642,347 | -695,955 | |
1.59303 % | Brandes Investment Partners, L.P. | 1,533,614 | 84,842 | |
1.12135 % | Tang Capital Management, LLC | 1,079,528 | 79,528 | |
1.00501 % | Samsara BioCapital, LLC | 967,527 | 0 | |
0.87248 % | Tri Locum Partners LP | 839,933 | -143,669 | |
0.81179 % | Balyasny Asset Management LP | 781,515 | 781,515 | |
0.69075 % | BioImpact Capital LLC | 664,986 | 762 | |
0.67742 % | Morgan Stanley & Co. LLC | 652,150 | 537,192 | |
0.67090 % | Kennedy Capital Management LLC | 645,874 | -69,550 | |
0.64954 % | SEB Investment Management AB | 625,310 | -316 | |
0.64933 % | Renaissance Technologies LLC | 625,106 | -113,800 | |
0.63694 % | Citadel Advisors LLC | 613,185 | 150,080 | |
0.62325 % | Knoll Capital Management, LLC | 600,000 | 0 | |
0.62158 % | Modera Wealth Management, LLC | 598,392 | 4,392 | |
0.50613 % | Goldman Sachs & Company, Inc. | 487,251 | 125,799 | |
0.36048 % | Ally Bridge Group NY LLC | 347,036 | 347,036 | |
0.33759 % | Checkpoint Capital L.P. | 325,000 | 325,000 | |
0.31682 % | Candriam Luxembourg S.A. | 305,000 | 185,000 | |
0.31421 % | Driehaus Capital Management, LLC | 302,494 | 212,578 | |
0.31345 % | Morgan Stanley Smith Barney LLC | 301,761 | 1,764 | |
0.31162 % | DWS Investment Management Americas, Inc. | 300,000 | 0 | |
0.30032 % | Columbia Threadneedle Investments (US) | 289,114 | 4,101 | |
0.29689 % | Point72 Asset Management, L.P. | 285,816 | 285,816 | |
0.27350 % | UBS Switzerland AG | 263,297 | 0 | |
0.26161 % | Knott Partners Management, LLC | 251,850 | 30,000 | |
0.23372 % | Adage Capital Management, L.P. | 225,000 | -1,500,000 | |
0.22103 % | Arctic Fund Management AS | 212,788 | 5,600 | |
0.21246 % | Millennium Management LLC | 204,534 | 149,808 | |
0.20417 % | D. E. Shaw & Co., L.P. | 196,554 | -352,816 | |
0.17763 % | McCamish (Mark Anthony) | 171,000 | 0 | |
0.17441 % | Ende (Eric J) | 167,900 | 13,000 | |
0.16057 % | Marshall Wace LLP | 154,585 | -306,218 | |
0.14542 % | DWS Investment GmbH | 140,000 | 0 | |
0.12821 % | Susquehanna International Group, LLP | 123,425 | 123,425 | |
0.11416 % | Jane Street Capital, L.L.C. | 109,905 | 88,225 | |
0.11123 % | MAI Capital Management, LLC | 107,080 | 61,857 | |
0.11060 % | Investors Asset Management of Georgia, Inc. | 106,475 | 106,475 | |
0.10871 % | Advisory Research, Inc. | 104,654 | -96,455 | |
0.09972 % | Schulhoff & Company, Inc. | 96,000 | 0 | |
0.09617 % | Geode Capital Management, L.L.C. | 92,583 | -1,822 | |
0.08776 % | Cetera Advisors LLC | 84,486 | -3,385 | |
0.08666 % | Azimut Capital Management Sgr SpA | 83,423 | -8,803 | |
0.08627 % | Thornton (Peter J) | 83,055 | 0 | |
0.08362 % | McHugh (Thomas S) | 80,500 | 2,000 | |
0.08329 % | Commonwealth Financial Network | 80,182 | 969 | |
0.08310 % | Lion Point Capital, L.P. | 80,000 | 0 | |
0.08015 % | Polen Capital Management, LLC | 77,165 | 77,165 | |
0.07778 % | MML Investors Services, LLC | 74,881 | 2,294 | |
0.07749 % | Two Sigma Investments, LP | 74,600 | 0 | |
0.07271 % | Gendell (Jeffrey L) | 70,000 | 0 | |
0.06763 % | Caption Management, LLC | 65,108 | -15,992 | |
0.06609 % | CIBC Private Wealth Management | 63,629 | -29,799 | |
0.06559 % | GTS Securities LLC | 63,146 | 45,982 | |
0.06523 % | Group One Trading, L.P. | 62,799 | 56,616 | |
0.06181 % | Polar Asset Management Partners Inc. | 59,500 | 59,500 | |
0.06168 % | Assenagon Asset Management S.A. | 59,380 | 4,362 | |
0.06139 % | Divis (Gregory J. Jr.) | 59,100 | 10,000 | |
0.05552 % | Iridian Asset Management LLC | 53,451 | 7,865 | |
0.05059 % | State of Wyoming | 48,704 | 6,903 | |
0.04916 % | BlackRock Advisors (UK) Limited | 47,330 | 2,223 | |
0.04674 % | Glass (Geoffrey Michael) | 45,000 | -20,700 | |
0.04606 % | Palczuk (Linda S) | 44,343 | 2,500 | |
0.04560 % | BlackRock Asset Management Ireland Limited | 43,897 | 5,579 | |
0.04374 % | State Street Global Advisors (US) | 42,106 | 11,800 | |
0.04321 % | Wells Fargo Advisors | 41,600 | 24,315 | |
0.04155 % | Edge Wealth Management LLC | 40,000 | -110,000 | |
0.03938 % | Oppenheimer Asset Management Inc. | 37,911 | -2,000 | |
0.03882 % | Morgan Stanley AIP GP LP | 37,373 | 18,470 | |
0.03712 % | Diametric Capital | 35,739 | 35,739 | |
0.03535 % | PENN Capital Management Company, Inc. | 34,034 | 11,161 | |
0.03493 % | Dorsey, Wright & Associates, LLC | 33,630 | 530 | |
0.03128 % | Aperio Group, LLC | 30,110 | -167 | |
0.02992 % | Managed Account Advisors LLC | 28,801 | 3,787 | |
0.02586 % | Avantax Advisory Services, Inc. | 24,900 | 900 | |
0.02566 % | J.P. Morgan Securities LLC | 24,700 | -403,914 | |
0.02447 % | LPL Financial LLC | 23,557 | 3,427 | |
0.02405 % | Kestra Advisory Services, LLC | 23,150 | 1,200 | |
0.02352 % | Aaron Wealth Advisors LLC | 22,642 | 0 | |
0.02181 % | Carmichael Hill & Associates Inc | 21,000 | 0 | |
0.02179 % | Royce Investment Partners | 20,981 | 20,981 | |
0.02158 % | Wolverine Trading, LLC | 20,776 | 5,984 | |
0.02077 % | Northwestern Mutual Capital, LLC | 20,000 | 20,000 | |
0.02068 % | Jump Financial, LLC | 19,912 | -33,659 | |
0.02011 % | OneDigital Investment Advisors LLC | 19,360 | -28 | |
0.01920 % | U.S. Bancorp Asset Management, Inc. | 18,482 | 163 | |
0.01870 % | Blue Zone Wealth Advisors, LLC | 18,000 | 1,000 | |
0.01849 % | Creative Planning, Inc. | 17,802 | -1,676 | |
0.01792 % | J.P. Morgan Securities plc | 17,253 | 156 | |
0.01692 % | Advisory Services Network, LLC | 16,285 | 0 | |
0.01605 % | Algert Global LLC | 15,450 | 15,450 | |
0.01454 % | Shay Capital LLC | 14,000 | 14,000 | |
0.01424 % | Buckingham Strategic Wealth, LLC | 13,710 | -800 | |