5.55443 % | Boxer Capital, L.L.C. | 2,202,333 | 0 | |
5.49180 % | Baker Bros. Advisors LP | 2,177,499 | 0 | |
2.30175 % | Bill & Melinda Gates Foundation | 912,642 | 0 | |
2.29332 % | The Vanguard Group, Inc. | 909,300 | -419,623 | |
1.54352 % | BlackRock Institutional Trust Company, N.A. | 612,007 | -295,985 | |
1.11640 % | Redmile Group, LLC | 442,653 | 0 | |
0.97769 % | Aisling Capital Management LP | 387,653 | 0 | |
0.93051 % | Robinson (William Hewitt) | 368,948 | 0 | |
0.89792 % | Renaissance Technologies LLC | 356,024 | 14,100 | |
0.81339 % | Serafini (Tito A) | 322,511 | -20,788 | |
0.74520 % | Geode Capital Management, L.L.C. | 295,471 | 32,548 | |
0.52167 % | HRT Financial LP | 206,842 | 206,842 | |
0.26553 % | Ensign Peak Advisors, Inc. | 105,283 | 0 | |
0.26409 % | Susquehanna International Group, LLP | 104,712 | 104,712 | |
0.24668 % | Berger (Franklin Milan) | 97,808 | 0 | |
0.23064 % | Millennium Management LLC | 91,447 | 35,023 | |
0.22527 % | State Street Global Advisors (US) | 89,320 | -2,200 | |
0.19556 % | Orwin (John A) | 77,541 | 57,700 | |
0.18916 % | Bridgeway Capital Management, LLC | 75,000 | -75,000 | |
0.18365 % | Cross (Herbert C) | 72,817 | -5,487 | |
0.14894 % | Northern Trust Investments, Inc. | 59,055 | 0 | |
0.12719 % | Courtney (Phillips) | 50,431 | -7,061 | |
0.12523 % | Atwood (Brian G) | 49,654 | 0 | |
0.11977 % | Barclays Bank PLC | 47,487 | 0 | |
0.11559 % | Goldman Sachs & Company, Inc. | 45,831 | -24,324 | |
0.11125 % | Acadian Asset Management LLC | 44,110 | 0 | |
0.08822 % | Ruiz (Roger Richard) | 34,980 | 34,980 | |
0.08406 % | Fidelity Management & Research Company LLC | 33,331 | -76,848 | |
0.05790 % | Charles Schwab Investment Management, Inc. | 22,959 | 0 | |
0.05549 % | Abaris Investment Management AG | 22,000 | 0 | |
0.05330 % | XTX Markets LLC | 21,133 | 21,133 | |
0.05312 % | BlackRock Financial Management, Inc. | 21,064 | -208,760 | |
0.05244 % | BlackRock Advisors, LLC | 20,793 | 0 | |
0.04437 % | Baader Bank AG | 17,593 | 17,593 | |
0.03822 % | BNY Mellon Asset Management | 15,155 | 0 | |
0.03079 % | UBS Financial Services, Inc. | 12,210 | 5,779 | |
0.02876 % | Jane Street Capital, L.L.C. | 11,403 | 11,403 | |
0.02673 % | Endurance Wealth Management, Inc. | 10,600 | 0 | |
0.02046 % | Parallel Advisors, LLC | 8,114 | 0 | |
0.01704 % | Gould (Stephen E Ph.D.) | 6,757 | -391,536 | |
0.01237 % | BlackRock Investment Management, LLC | 4,903 | 0 | |
0.00963 % | Morgan Stanley & Co. LLC | 3,817 | 0 | |
0.00865 % | Osaic Holdings, Inc. | 3,429 | -3,034 | |
0.00504 % | Wells Fargo Advisors | 2,000 | 0 | |
0.00358 % | Mackenzie Financial Corporation | 1,419 | -185 | |
0.00167 % | RBC Capital Partners | 663 | 663 | |
0.00145 % | BofA Global Research (US) | 575 | 574 | |
0.00111 % | Parametric Portfolio Associates LLC | 441 | 0 | |
0.00075 % | Morgan Stanley Smith Barney LLC | 298 | 58 | |
0.00063 % | Wells Fargo Bank, N.A. | 251 | 14 | |
0.00050 % | IRC Wealth | 200 | 0 | |
0.00039 % | Guggenheim Investments | 154 | 0 | |
0.00029 % | Tower Research Capital LLC | 115 | 115 | |
0.00028 % | Northern Trust Global Investments | 113 | 0 | |
0.00027 % | RBC Capital Markets Wealth Management | 107 | 107 | |
0.00025 % | Simplex Trading, LLC | 100 | 100 | |
0.00013 % | Qube Research & Technologies Ltd | 52 | 0 | |
0.00006 % | J.P. Morgan Securities plc | 23 | 0 | |
0.00003 % | Carson Wealth Management Group | 10 | 0 | |
0.00003 % | Advisory Services Network, LLC | 10 | 10 | |
0.00001 % | Mellon Investments Corporation | 3 | 2 | |
0 % | ExodusPoint Capital Management, LP | 0 | -466,828 | |
0 % | Tidal Investments LLC | 0 | -624 | |
0 % | Crewe Advisors LLC | 0 | -824 | |
0 % | Global Trust Asset Management, LLC | 0 | -963 | |
0 % | Samsara BioCapital, LLC | 0 | -262,827 | |
0 % | LUNIS Vermögensmanagement AG | 0 | -40,000 | |
0 % | Ergoteles Capital | 0 | -107,783 | |
0 % | IHT Wealth Management, LLC | 0 | -13,010 | |
0 % | Ellevest, Inc. | 0 | -316 | |
0 % | Schonfeld Strategic Advisors LLC | 0 | -19,700 | |
0 % | GWM Advisors LLC | 0 | -125 | |
0 % | McDonald Partners LLC | 0 | -10,700 | |
0 % | Cubist Systematic Strategies, LLC | 0 | -12,587 | |
0 % | Cormorant Asset Management, LP | 0 | -319,057 | |
0 % | Rock Springs Capital Management LP | 0 | -362,530 | |
0 % | DLK Investment Management, LLC | 0 | -89,000 | |
0 % | Group One Trading, L.P. | 0 | -5,000 | |
0 % | Belpointe Asset Management LLC | 0 | -2,300 | |
0 % | Dimensional Fund Advisors, Ltd. | 0 | -4,950 | |
0 % | Assenagon Asset Management S.A. | 0 | -476 | |
0 % | Virtu Americas LLC | 0 | -14,239 | |
0 % | Hightower Advisors, LLC | 0 | -24,811 | |
0 % | BG Fund Management Luxembourg S.A. | 0 | -146,133 | |
0 % | Credit Suisse International | 0 | -14 | |
0 % | CAPTRUST Financial Advisors | 0 | -539 | |
0 % | GSA Capital Partners LLP | 0 | -191,442 | |
0 % | Laurion Capital Management LP | 0 | -142,824 | |
0 % | RBC Dominion Securities, Inc. | 0 | -874 | |
0 % | Two Sigma Investments, LP | 0 | -26,181 | |
0 % | Morgan Stanley & Co. International Plc | 0 | -123 | |
0 % | BNP Paribas Securities Corp. North America | 0 | -474 | |
0 % | Letko, Brosseau & Associates Inc. | 0 | -17,800 | |
0 % | Marshall Wace LLP | 0 | -26,839 | |
0 % | AQR Capital Management, LLC | 0 | -10,211 | |
0 % | ProFund Advisors LLC | 0 | -553 | |
0 % | Stifel, Nicolaus & Company, Incorporated | 0 | -10,191 | |
0 % | Citadel Advisors LLC | 0 | -440 | |
0 % | Signal Iduna Asset Management GmbH | 0 | -21,880 | |
0 % | Sand Hill Global Advisors, LLC | 0 | -12,500 | |