9.01362 % | RA Capital Management, LP | 18,472,503 | 0 | |
8.24299 % | RTW Investments L.P. | 16,893,185 | 0 | |
5.08094 % | VR Adviser, LLC | 10,412,872 | -4,031,572 | |
4.46664 % | Session (R. A. II) | 9,153,927 | 0 | |
3.54559 % | Audentes Therapeutics Inc | 7,266,342 | 0 | |
3.02311 % | The Vanguard Group, Inc. | 6,195,567 | 867,703 | |
2.12528 % | Avoro Capital Advisors LLC | 4,355,555 | 430,555 | |
11.42665 % | Manning (Paul B.) | 23,417,778 | 0 | |
10.94912 % | Fidelity Management & Research Company LLC | 22,439,124 | -2,088,677 | |
1.95411 % | Baker Bros. Advisors LP | 4,004,756 | 1,500,000 | |
1.84479 % | Eversept Partners, LP | 3,780,714 | 2,074,940 | |
1.80541 % | Tybourne Capital Management (HK) Limited | 3,700,000 | 2,200,000 | |
1.78740 % | Invus Public Equities Advisors, LLC | 3,663,104 | 0 | |
1.75141 % | Acuta Capital Partners, LLC | 3,589,333 | -238,593 | |
1.64952 % | Millennium Management LLC | 3,380,532 | 3,380,532 | |
1.42132 % | TCG Crossover Management, LLC | 2,912,861 | -8,198,250 | |
1.31160 % | Point72 Asset Management, L.P. | 2,688,000 | 1,751,450 | |
1.22910 % | Polar Capital LLP | 2,518,909 | -11,091 | |
1.18503 % | BlackRock Institutional Trust Company, N.A. | 2,428,609 | 1,686,434 | |
1.12109 % | Citadel Advisors LLC | 2,297,556 | 2,297,556 | |
1.02469 % | Ghost Tree Capital, LLC | 2,100,000 | 775,000 | |
0.94353 % | Stalfort (John A III) | 1,933,671 | 884,290 | |
0.74927 % | Nolan Capital LLC | 1,535,545 | 444,444 | |
0.69686 % | Susquehanna International Group, LLP | 1,428,146 | 1,225,529 | |
0.59887 % | T. Rowe Price Associates, Inc. | 1,227,333 | -20,138 | |
0.57864 % | Nolan (Sean Patrick) | 1,185,858 | 1,184,688 | |
0.54620 % | Schonfeld Strategic Advisors LLC | 1,119,375 | 399,332 | |
0.53547 % | Renaissance Technologies LLC | 1,097,400 | 499,400 | |
0.48083 % | Geode Capital Management, L.L.C. | 985,421 | 523,755 | |
0.43810 % | Nagendran (Sukumar) | 897,843 | 863,617 | |
0.36386 % | Alam (Kamran CPA) | 745,695 | -1,288 | |
0.35370 % | Sands Capital Ventures LLC | 724,873 | 0 | |
0.33829 % | Exome Asset Management LLC | 693,300 | 693,300 | |
0.31272 % | Alphabet, Inc. | 640,882 | 0 | |
0.31205 % | Quantum Private Wealth, LLC | 639,520 | 64,140 | |
0.25854 % | Palo Alto Investors LP | 529,861 | 529,861 | |
0.22449 % | Acadian Asset Management LLC | 460,066 | 460,066 | |
0.20494 % | Adage Capital Management, L.P. | 420,000 | -1,080,000 | |
0.16151 % | Medical Strategy GmbH | 330,995 | 164,000 | |
0.15173 % | Citi Investment Research (US) | 310,963 | 29,844 | |
0.14394 % | Monaco asset management S.A.M. | 295,000 | 295,000 | |
0.14229 % | Entrypoint Capital LLC | 291,616 | 291,616 | |
0.13554 % | Kovitz Investment Group Partners, LLC | 277,778 | 252,778 | |
0.10198 % | Adar1 Capital Management LLC | 209,000 | 209,000 | |
0.09469 % | Northern Trust Investments, Inc. | 194,067 | 127,877 | |
0.09265 % | Prelude Capital Management, LLC | 189,876 | -50,375 | |
0.09110 % | Polar Asset Management Partners Inc. | 186,700 | 186,700 | |
0.08568 % | TD Asset Management Inc. | 175,600 | 0 | |
0.07523 % | Two Sigma Investments, LP | 154,175 | 126,538 | |
0.06988 % | State Street Global Advisors (US) | 143,220 | 3,200 | |
0.06709 % | Morgan Stanley Smith Barney LLC | 137,497 | -700 | |
0.06580 % | Chicago Partners Wealth Advisors | 134,851 | 23,740 | |
0.06065 % | Assenagon Asset Management S.A. | 124,298 | 9,131 | |
0.05969 % | BofA Global Research (US) | 122,328 | 84,148 | |
0.05783 % | Qube Research & Technologies Ltd | 118,521 | 118,521 | |
0.05568 % | Donenberg (Phillip Brian) | 114,111 | 0 | |
0.05476 % | BlackRock Asset Management Ireland Limited | 112,235 | 112,235 | |
0.04073 % | Goldman Sachs & Company, Inc. | 83,474 | 83,474 | |
0.03813 % | BlackRock (Netherlands) B.V. | 78,150 | 78,150 | |
0.03759 % | Morgan Stanley & Co. LLC | 77,042 | 43,170 | |
0.03361 % | Diametric Capital | 68,871 | -691,143 | |
0.03097 % | Squarepoint Capital LLP | 63,477 | 34,909 | |
0.03003 % | Manulife Investment Management (North America) Limited | 61,547 | 0 | |
0.02837 % | BNY Mellon Asset Management | 58,140 | 32,066 | |
0.02833 % | LPL Financial LLC | 58,060 | 1,125 | |
0.02363 % | Cubist Systematic Strategies, LLC | 48,434 | 48,434 | |
0.02196 % | Dynamic Wealth Advisors | 45,000 | 0 | |
0.02196 % | Williams & Novak, LLC | 45,000 | 45,000 | |
0.02079 % | Redwood Wealth Management Group, LLC | 42,600 | 4,400 | |
0.02063 % | Jane Street Capital, L.L.C. | 42,278 | 42,278 | |
0.02012 % | BlackRock Advisors (UK) Limited | 41,224 | 41,224 | |
0.01780 % | J.P. Morgan Securities plc | 36,484 | 36,347 | |
0.01727 % | Connor, Clark & Lunn Investment Management Ltd. | 35,400 | 35,400 | |
0.01417 % | Prasad (Suyash) | 29,030 | -36,784 | |
0.01390 % | Graham Capital Management, L.P. | 28,477 | 28,477 | |
0.01306 % | Commonwealth Financial Network | 26,769 | -202 | |
0.01272 % | Virtu Americas LLC | 26,070 | 26,070 | |
0.01181 % | Cannon Global Investment Management, LLC | 24,200 | 24,200 | |
0.01059 % | Engineers Gate Manager, L.P. | 21,696 | 21,696 | |
0.01055 % | China Universal Asset Management Co., Ltd. | 21,622 | 21,622 | |
0.00976 % | Lee Financial Company, L.L.C. | 20,000 | 0 | |
0.00959 % | Northern Trust Global Investments Limited | 19,654 | 19,654 | |
0.00930 % | PGIM Quantitative Solutions LLC | 19,050 | 1,800 | |
0.00848 % | Dynamic Technology Lab Pte. Ltd. | 17,389 | 17,389 | |
0.00846 % | BlackRock Investment Management (UK) Ltd. | 17,342 | 17,342 | |
0.00810 % | T. Rowe Price International Ltd | 16,600 | 0 | |
0.00795 % | XTX Markets LLC | 16,285 | 16,285 | |
0.00788 % | Charles Schwab Investment Management, Inc. | 16,140 | 0 | |
0.00761 % | Victory Capital Management Inc. | 15,600 | 15,600 | |
0.00691 % | Howard Capital Management, Inc. | 14,165 | 14,165 | |
0.00643 % | Texas Capital Bank Private Wealth Advisors | 13,185 | 0 | |
0.00587 % | Group One Trading, L.P. | 12,032 | 6,410 | |
0.00583 % | ProShare Advisors LLC | 11,946 | 11,946 | |
0.00553 % | BlackRock Investment Management, LLC | 11,331 | 11,331 | |
0.00537 % | Camelot Portfolios, LLC | 11,000 | 11,000 | |
0.00520 % | Royal Capital Wealth Management LLC | 10,665 | 10,665 | |
0.00505 % | Aperio Group, LLC | 10,347 | 4,454 | |
0.00488 % | Capital Investment Advisors, LLC | 10,000 | 0 | |
0.00430 % | Lazard Asset Management, L.L.C. | 8,805 | 8,805 | |
0.00390 % | The Quarry LP | 8,000 | 8,000 | |