12.07725 % | Manning (Paul B.) | 24,751,111 | 1,333,333 | |
10.34968 % | Fidelity Management & Research Company LLC | 21,210,636 | 1,099,919 | |
9.17356 % | RTW Investments L.P. | 18,800,299 | 207,114 | |
9.10022 % | Avoro Capital Advisors LLC | 18,650,000 | 0 | |
5.30521 % | RA Capital Management, LP | 10,872,503 | 0 | |
5.26234 % | BlackRock Institutional Trust Company, N.A. | 10,784,648 | 8,291,921 | |
4.39153 % | VR Adviser, LLC | 9,000,000 | 0 | |
3.54559 % | Audentes Therapeutics Inc | 7,266,342 | 0 | |
3.49729 % | The Vanguard Group, Inc. | 7,167,337 | 1,249,923 | |
3.09922 % | Morgan Stanley & Co. LLC | 6,351,537 | 3,181,251 | |
2.23101 % | Octagon Capital Advisors LP | 4,572,222 | 1,542,222 | |
2.12463 % | Invus Public Equities Advisors, LLC | 4,354,214 | 666,666 | |
1.95411 % | Baker Bros. Advisors LP | 4,004,756 | 0 | |
1.80541 % | Tybourne Capital Management (HK) Limited | 3,700,000 | 0 | |
1.61922 % | State Street Global Advisors (US) | 3,318,421 | 2,978,901 | |
1.47604 % | Polar Capital LLP | 3,025,000 | 506,091 | |
1.40553 % | Geode Capital Management, L.L.C. | 2,880,485 | 1,860,694 | |
1.30100 % | JP Morgan Asset Management | 2,666,262 | 1,715,808 | |
1.23622 % | DWS Investments UK Limited | 2,533,502 | 2,533,502 | |
1.13738 % | Acuta Capital Partners, LLC | 2,330,937 | -1,002,396 | |
0.96755 % | Stalfort (John A III) | 1,982,891 | 49,220 | |
0.84053 % | Eagle Asset Management, Inc. | 1,722,586 | -66,808 | |
0.74927 % | Nolan Capital LLC | 1,535,545 | 0 | |
0.60993 % | Ghost Tree Capital, LLC | 1,250,000 | 300,000 | |
0.59797 % | T. Rowe Price Associates, Inc. | 1,225,474 | 126,145 | |
0.57954 % | Medical Strategy GmbH | 1,187,719 | 0 | |
0.50742 % | Nuveen LLC | 1,039,911 | 1,039,911 | |
0.50077 % | Woodline Partners LP | 1,026,269 | 1,026,269 | |
0.47111 % | Morgan Stanley Investment Management Inc. (US) | 965,500 | -878,300 | |
0.39586 % | Palo Alto Investors LP | 811,268 | 0 | |
0.39509 % | Granahan Investment Management, LLC | 809,691 | 809,691 | |
0.38357 % | Marshall Wace LLP | 786,094 | -244,563 | |
0.37533 % | Schonfeld Strategic Advisors LLC | 769,200 | 216,605 | |
0.35646 % | Quantum Private Wealth, LLC | 730,520 | 32,000 | |
0.35370 % | Sands Capital Ventures LLC | 724,873 | 0 | |
0.34686 % | Goldman Sachs & Company, Inc. | 710,853 | -348,109 | |
0.31272 % | Alphabet, Inc. | 640,882 | 0 | |
0.30863 % | Qube Research & Technologies Ltd | 632,500 | -439,570 | |
0.25001 % | Diametric Capital | 512,361 | 358,883 | |
0.20969 % | Charles Schwab Investment Management, Inc. | 429,744 | 378,282 | |
0.20901 % | BlackRock Investment Management, LLC | 428,343 | 428,343 | |
0.20031 % | BlackRock Financial Management, Inc. | 410,508 | 410,508 | |
0.16943 % | BNY Mellon Asset Management | 347,227 | 347,227 | |
0.16626 % | Millennium Management LLC | 340,724 | -2,794,593 | |
0.15786 % | Invesco Capital Management LLC | 323,520 | 317,289 | |
0.15427 % | Goldman Sachs Asset Management, L.P. | 316,165 | 316,165 | |
0.14286 % | Kovitz Investment Group Partners, LLC | 292,778 | 15,000 | |
0.13480 % | JPMorgan Private Bank (United States) | 276,262 | 276,262 | |
0.12574 % | Jefferies LLC | 257,694 | 209,594 | |
0.12436 % | Northern Trust Investments, Inc. | 254,862 | 60,375 | |
0.12238 % | Adar1 Capital Management LLC | 250,800 | 207,300 | |
0.09437 % | Bellecapital AG | 193,394 | 0 | |
0.09105 % | Prelude Capital Management, LLC | 186,591 | 130,698 | |
0.08992 % | Rhumbline Advisers Ltd. Partnership | 184,284 | 184,284 | |
0.08568 % | TD Asset Management Inc. | 175,600 | 0 | |
0.07970 % | Donenberg (Phillip Brian) | 163,331 | 49,220 | |
0.07807 % | Abaris Investment Management AG | 160,000 | 160,000 | |
0.07724 % | Alam (Kamran CPA) | 158,297 | -587,398 | |
0.07392 % | Alpine Global Management, LLC | 151,483 | 151,483 | |
0.07074 % | Morgan Stanley Smith Barney LLC | 144,977 | -2,515 | |
0.06919 % | GSA Capital Partners LLP | 141,805 | 141,805 | |
0.06500 % | Manulife Investment Management (North America) Limited | 133,213 | 69,487 | |
0.06304 % | Susquehanna International Group, LLP | 129,200 | -1,180,427 | |
0.06252 % | Jane Street Capital, L.L.C. | 128,124 | 69,238 | |
0.06049 % | BofA Global Research (US) | 123,974 | -1,739 | |
0.05766 % | Chicago Partners Wealth Advisors | 118,175 | 1,270 | |
0.05370 % | BlackRock Asset Management Ireland Limited | 110,047 | 10,851 | |
0.05233 % | Mellon Investments Corporation | 107,237 | 107,237 | |
0.04806 % | Privium Fund Management BV | 98,500 | 98,500 | |
0.04665 % | AllianceBernstein L.P. | 95,600 | 95,600 | |
0.04199 % | SunAmerica Asset Management, LLC | 86,058 | 0 | |
0.04199 % | Corebridge Financial Inc | 86,058 | 86,058 | |
0.03952 % | Assenagon Asset Management S.A. | 80,994 | 5,723 | |
0.03916 % | Squarepoint Capital LLP | 80,255 | -133,691 | |
0.03622 % | Invesco Advisers, Inc. | 74,230 | 74,230 | |
0.03122 % | SG Americas Securities, L.L.C. | 63,984 | 63,984 | |
0.02791 % | Virtu Americas LLC | 57,191 | 57,191 | |
0.02736 % | UBS Financial Services, Inc. | 56,079 | -133,205 | |
0.02646 % | Barclays Bank PLC | 54,234 | 54,234 | |
0.02632 % | Metropolitan Life Insurance Co. (US) | 53,946 | 53,946 | |
0.02632 % | Voya Investment Management LLC | 53,934 | 53,934 | |
0.02499 % | Wells Fargo Bank, N.A. | 51,213 | 50,497 | |
0.02494 % | T. Rowe Price International Ltd | 51,104 | 34,504 | |
0.02402 % | Long (Alison S) | 49,220 | 49,220 | |
0.02402 % | Sepp-Lorenzino (Laura) | 49,220 | 49,220 | |
0.02396 % | Los Angeles Capital Management LLC | 49,102 | 9,836 | |
0.02345 % | LPL Financial LLC | 48,060 | 5,998 | |
0.02286 % | Citadel Advisors LLC | 46,854 | 46,657 | |
0.02264 % | Redwood Wealth Management Group, LLC | 46,400 | 46,400 | |
0.02212 % | Marathon Trading Investment Management LLC | 45,340 | -178,560 | |
0.02196 % | Williams & Novak Wealth Management, LLC | 45,000 | 0 | |
0.02144 % | Citi Investment Research (US) | 43,935 | -211,268 | |
0.02115 % | Scientech Research LLC | 43,350 | 43,350 | |
0.02039 % | MetLife Investment Management, LLC | 41,794 | 41,794 | |
0.02005 % | Renaissance Technologies LLC | 41,100 | -287,400 | |
0.01923 % | China Universal Asset Management Co., Ltd. | 39,417 | 17,446 | |
0.01912 % | Nuveen Asset Management, LLC | 39,188 | 39,188 | |
0.01894 % | Goldman Sachs Asset Management International | 38,825 | 13,656 | |
0.01670 % | Nagendran (Sukumar) | 34,226 | -863,617 | |
0.01424 % | LSV Asset Management | 29,186 | 0 | |