7.06626 % | Point72 Asset Management, L.P. | 5,791,505 | 5,504,011 | |
7.05001 % | Suvretta Capital Management, LLC | 5,778,188 | -105,505 | |
5.64371 % | BlackRock Institutional Trust Company, N.A. | 4,625,582 | -91,654 | |
5.45119 % | Adage Capital Management, L.P. | 4,467,796 | 1,362,664 | |
4.21160 % | Millennium Management LLC | 3,451,825 | 1,915,956 | |
4.08485 % | BVF Partners L.P. | 3,347,946 | 0 | |
4.08103 % | Rubric Capital Management LP | 3,344,810 | 0 | |
3.52611 % | The Vanguard Group, Inc. | 2,890,000 | 21,238 | |
3.34204 % | Franklin Advisers, Inc. | 2,739,136 | -71,973 | |
2.44232 % | Kynam Capital Management LP | 2,001,727 | 449,052 | |
2.27776 % | Baillie Gifford & Co. | 1,866,850 | -804 | |
2.04439 % | Samsara BioCapital, LLC | 1,675,579 | 0 | |
1.53640 % | Geode Capital Management, L.L.C. | 1,259,237 | 62,085 | |
1.46709 % | Parkman Healthcare Partners LLC | 1,202,431 | 20,263 | |
1.41711 % | State Street Global Advisors (US) | 1,161,465 | 55,680 | |
1.39185 % | Dimensional Fund Advisors, L.P. | 1,140,760 | 10,937 | |
1.28900 % | Eversept Partners, LP | 1,056,461 | 286,823 | |
1.18521 % | Goldman Sachs Asset Management, L.P. | 971,401 | -15,626 | |
1.12619 % | Acadian Asset Management LLC | 923,029 | 149,162 | |
1.09594 % | Candriam Belgium S.A. | 898,234 | -640,000 | |
1.09588 % | Candriam Luxembourg S.A. | 898,181 | 0 | |
1.02301 % | BlackRock Financial Management, Inc. | 838,459 | -389 | |
0.80014 % | Renaissance Technologies LLC | 655,797 | 352,900 | |
0.78292 % | Bank Vontobel AG | 641,684 | 191,345 | |
0.76096 % | Sectoral Asset Management Inc. | 623,684 | 191,345 | |
0.75997 % | Verition Fund Management LLC | 622,873 | -1,878,803 | |
0.68691 % | Two Sigma Investments, LP | 562,992 | 377,792 | |
0.55111 % | PanAgora Asset Management Inc. | 451,692 | 82,544 | |
0.54905 % | Pentwater Capital Management LP | 450,000 | 20,000 | |
0.53768 % | Northern Trust Investments, Inc. | 440,682 | -4,460 | |
0.51324 % | Aquilo Capital Management, LLC | 420,649 | 420,649 | |
0.46162 % | UBS O'Connor LLC | 378,340 | 48,340 | |
0.43183 % | Jacobs Levy Equity Management, Inc. | 353,931 | -85,313 | |
0.41313 % | Schonfeld Strategic Advisors LLC | 338,600 | -16,400 | |
0.41084 % | Newell (William J) | 336,728 | 47,271 | |
0.36785 % | Opaleye Management Inc. | 301,491 | 301,491 | |
0.34539 % | Dafna Capital Management, LLC | 283,079 | 0 | |
0.27691 % | Tejara Capital Ltd. | 226,953 | 138,271 | |
0.25884 % | Nuveen LLC | 212,145 | 0 | |
0.23977 % | Asset Management One Co., Ltd. | 196,517 | 196,517 | |
0.23977 % | Fisher Investments | 196,517 | 0 | |
0.23792 % | Propel Bio Management, LLC | 195,000 | 75,000 | |
0.22880 % | Morgan Stanley & Co. LLC | 187,528 | 96,848 | |
0.22607 % | BlackRock Investment Management, LLC | 185,284 | -1,602 | |
0.21352 % | Aju IB Investment Co., Ltd. | 175,000 | 0 | |
0.20766 % | Bridgeway Capital Management, LLC | 170,200 | 170,200 | |
0.19629 % | Charles Schwab Investment Management, Inc. | 160,876 | 0 | |
0.18741 % | Exome Asset Management LLC | 153,600 | 153,600 | |
0.18206 % | PGIM Quantitative Solutions LLC | 149,220 | 81,930 | |
0.18180 % | Conestoga Capital Advisors, LLC | 149,005 | 14,763 | |
0.18163 % | BNY Mellon Asset Management | 148,867 | 630 | |
0.17536 % | BlackRock Asset Management Ireland Limited | 143,727 | -43,893 | |
0.17253 % | Cubist Systematic Strategies, LLC | 141,403 | 65,277 | |
0.16113 % | Barclays Bank PLC | 132,059 | 69,480 | |
0.16096 % | Citadel Advisors LLC | 131,925 | 83,336 | |
0.16013 % | Columbia Threadneedle Investments (US) | 131,242 | 25,662 | |
0.15497 % | BlackRock Advisors (UK) Limited | 127,011 | -6,997 | |
0.14641 % | Simplify Asset Management Inc | 120,000 | 0 | |
0.14530 % | Numeric Investors LLC | 119,088 | 17,277 | |
0.14369 % | Goldman Sachs Asset Management International | 117,771 | 0 | |
0.13554 % | BofA Global Research (US) | 111,090 | 21,098 | |
0.13024 % | Albini (Edward C) | 106,743 | 15,951 | |
0.12895 % | Jane Street Capital, L.L.C. | 105,687 | 92,408 | |
0.12002 % | Hallam (Trevor C) | 98,368 | 2,454 | |
0.12000 % | Tekla Capital Management LLC_NLE | 98,354 | 0 | |
0.11175 % | Rhumbline Advisers Ltd. Partnership | 91,589 | -309 | |
0.10881 % | Goldman Sachs & Company, Inc. | 89,181 | -15,183 | |
0.10274 % | Fidelity Management & Research Company LLC | 84,203 | 4,784 | |
0.10203 % | AQR Capital Management, LLC | 83,626 | 59,868 | |
0.10125 % | XTX Markets LLC | 82,988 | 62,542 | |
0.09187 % | AllianceBernstein L.P. | 75,300 | 0 | |
0.08940 % | Walleye Capital LLC | 73,271 | 73,271 | |
0.08913 % | Dimensional Fund Advisors, Ltd. | 73,051 | 0 | |
0.08670 % | Exchange Traded Concepts, LLC | 71,056 | 35,200 | |
0.08466 % | abrdn Inc. | 69,389 | 69,389 | |
0.07789 % | Avantis Investors | 63,842 | 30,141 | |
0.07538 % | Ohio Public Employees Retirement System | 61,778 | 0 | |
0.07271 % | UBS Financial Services, Inc. | 59,591 | 23,618 | |
0.06903 % | Engineers Gate Manager, L.P. | 56,580 | 56,580 | |
0.06872 % | Freund (John Gordon) | 56,327 | 0 | |
0.06704 % | Newton Investment Management North America, LLC | 54,950 | 0 | |
0.06532 % | Prelude Capital Management, LLC | 53,535 | 34,600 | |
0.06393 % | HSBC Global Asset Management (UK) Limited | 52,399 | 24,628 | |
0.06159 % | Aristides Capital, L.L.C. | 50,476 | 50,476 | |
0.06116 % | Mellon Investments Corporation | 50,124 | 0 | |
0.05304 % | American Century Investment Management, Inc. | 43,474 | 6,256 | |
0.05203 % | JPMorgan Private Bank (United States) | 42,640 | 40,987 | |
0.05149 % | Chung (Jane) | 42,201 | 10,503 | |
0.04981 % | Shabbir (Anik) | 40,827 | 10,403 | |
0.04975 % | SG Americas Securities, L.L.C. | 40,779 | 8,314 | |
0.04942 % | Northern Trust Global Investments | 40,502 | -178 | |
0.04543 % | Susquehanna International Group, LLP | 37,237 | -83,168 | |
0.04355 % | CornerCap Investment Counsel, Inc. | 35,690 | 0 | |
0.04227 % | Parametric Portfolio Associates LLC | 34,648 | -22,562 | |
0.03974 % | DWS Investments UK Limited | 32,568 | -1,214 | |
0.03709 % | State of Wisconsin Investment Board | 30,400 | -85,600 | |
0.03675 % | Srinivasan (Venkatesh) | 30,122 | 13,668 | |
0.03648 % | SunAmerica Asset Management, LLC | 29,896 | -121 | |
0.03641 % | Kennedy Capital Management LLC | 29,845 | 29,845 | |
0.03463 % | MetLife Investment Management, LLC | 28,380 | 0 | |