19.50597 % | BVF Partners L.P. | 8,291,988 | 0 | |
7.81578 % | OrbiMed Advisors, LLC | 3,322,488 | 0 | |
6.98107 % | Versant Ventures | 2,967,652 | -577,210 | |
6.58698 % | Cowen Investment Management LLC | 2,800,126 | -269,721 | |
6.41639 % | Deep Track Capital LP | 2,727,606 | -400,061 | |
6.31474 % | Redmile Group, LLC | 2,684,396 | 0 | |
5.71173 % | ARK Investment Management LLC | 2,428,055 | -203,973 | |
5.27555 % | MPM Capital Inc. | 2,242,636 | 0 | |
4.51194 % | T. Rowe Price Investment Management, Inc. | 1,918,026 | 155,283 | |
3.85756 % | BioImpact Capital LLC | 1,639,849 | 0 | |
1.64826 % | Fidelity Institutional Asset Management | 700,676 | 698,406 | |
1.64667 % | Invus Public Equities Advisors, LLC | 700,000 | 0 | |
1.50911 % | Medical Strategy GmbH | 641,524 | 0 | |
1.42387 % | Millennium Management LLC | 605,287 | 357,966 | |
0.66603 % | BlackRock Institutional Trust Company, N.A. | 283,131 | 30,064 | |
0.61371 % | BofA Global Research (US) | 260,886 | 247,926 | |
0.45278 % | Citadel Advisors LLC | 192,478 | -120,798 | |
0.42141 % | Segal (Lloyd Mitchell) | 179,143 | 78,550 | |
0.41393 % | Koehler (Maria) | 175,963 | 26,450 | |
0.41285 % | Fidelity Management & Research Company LLC | 175,502 | 542 | |
0.40939 % | Nikko Asset Management Co., Ltd. | 174,033 | -13,004 | |
0.38789 % | HighVista Strategies LLC | 164,890 | -139,291 | |
0.38438 % | Renaissance Technologies LLC | 163,400 | 28,279 | |
0.37579 % | BlackRock Advisors (UK) Limited | 159,749 | -14 | |
0.36792 % | BlackRock Asset Management Ireland Limited | 156,402 | 10,160 | |
0.31319 % | UBS Asset Management (Americas), Inc. | 133,138 | 22,986 | |
0.30233 % | BMO Private Investment Counsel Inc. | 128,519 | -5,000 | |
0.25235 % | D. E. Shaw & Co., L.P. | 107,274 | 41,890 | |
0.19902 % | Ensign Peak Advisors, Inc. | 84,603 | -6,200 | |
0.17294 % | The Vanguard Group, Inc. | 73,515 | 1,260 | |
0.17083 % | Trexquant Investment LP | 72,618 | -7,056 | |
0.16606 % | Zinda (Michael) | 70,591 | 24,550 | |
0.15227 % | Versant Venture Capital V (Canada), LP. | 64,731 | -80,148 | |
0.12545 % | State Street Global Advisors (US) | 53,330 | -145 | |
0.12511 % | Dimensional Fund Advisors, L.P. | 53,185 | 40,206 | |
0.10883 % | Parametric Portfolio Associates LLC | 46,262 | -25,315 | |
0.10703 % | Schweizerische Nationalbank | 45,500 | 1,200 | |
0.09289 % | Marshall Wace LLP | 39,489 | 39,489 | |
0.09143 % | Goldman Sachs & Company, Inc. | 38,867 | 10,762 | |
0.08133 % | Harbor Capital Advisors, Inc. | 34,572 | 32,255 | |
0.07219 % | Forte (Steve) | 30,687 | 24,530 | |
0.07102 % | Susquehanna International Group, LLP | 30,189 | 30,189 | |
0.06857 % | Tekla Capital Management LLC | 29,150 | 0 | |
0.06670 % | Algert Global LLC | 28,355 | 0 | |
0.06662 % | Versant Ophthalmic Affiliates Fund I, L.P. | 28,322 | -35,065 | |
0.06633 % | Jane Street Capital, L.L.C. | 28,197 | 28,197 | |
0.06587 % | Jump Financial, LLC | 28,000 | 9,800 | |
0.06327 % | T. Rowe Price Associates, Inc. | 26,894 | 8,567 | |
0.06244 % | Geode Capital Management, L.L.C. | 26,544 | 5,142 | |
0.06155 % | Acadian Asset Management LLC | 26,165 | 26,165 | |
0.06019 % | Versant Affiliates Fund V, L.P. | 25,587 | -31,677 | |
0.06017 % | Goldman Sachs Asset Management, L.P. | 25,577 | 4,372 | |
0.05912 % | Davis (Jerel C) | 25,131 | 4,254 | |
0.05874 % | XTX Markets LLC | 24,969 | 24,969 | |
0.05762 % | Assenagon Asset Management S.A. | 24,495 | -1,010 | |
0.05354 % | TD Asset Management Inc. | 22,758 | -6,505 | |
0.05315 % | The Blackstone Group | 22,595 | 3,427 | |
0.05300 % | HRT Financial LP | 22,529 | 22,529 | |
0.05088 % | Nuveen LLC | 21,630 | -188 | |
0.05009 % | Credit Suisse Asset Management | 21,293 | 7,043 | |
0.04718 % | Fred Alger Management, LLC | 20,055 | -4,256 | |
0.04659 % | Black (Cameron) | 19,804 | 729 | |
0.04608 % | Cubist Systematic Strategies, LLC | 19,590 | 19,590 | |
0.04363 % | Apo Asset Management GmbH | 18,545 | 0 | |
0.04268 % | Morgan Stanley & Co. LLC | 18,143 | -10,765 | |
0.04189 % | AQR Capital Management, LLC | 17,807 | 17,807 | |
0.04007 % | Tudor Investment Corporation | 17,034 | 17,034 | |
0.03855 % | California State Teachers Retirement System | 16,386 | 164 | |
0.03824 % | State of Wisconsin Investment Board | 16,256 | -1,141 | |
0.03682 % | Two Sigma Investments, LP | 15,653 | 15,653 | |
0.03626 % | Difesa Capital Management, LP | 15,416 | 0 | |
0.03621 % | Northern Trust Investments, Inc. | 15,392 | 1,046 | |
0.03434 % | Deka Investment GmbH | 14,600 | 1,300 | |
0.03434 % | Deka Vermögensmanagement GmbH | 14,600 | 0 | |
0.03399 % | BlackRock Financial Management, Inc. | 14,450 | 7,237 | |
0.02896 % | SETH KIM | 12,312 | 11,625 | |
0.02888 % | HarbourVest Partners, L.L.C. | 12,276 | 0 | |
0.02887 % | DuPont Capital Management Corporation | 12,271 | 12,271 | |
0.02780 % | Emerge Canada Inc | 11,816 | -1,204 | |
0.02655 % | UBS Asset Management (Switzerland) | 11,286 | -906 | |
0.02652 % | Morgan Stanley Smith Barney LLC | 11,273 | -35,203 | |
0.02588 % | Abaris Investment Management AG | 11,000 | 0 | |
0.02509 % | Qube Research & Technologies Ltd | 10,664 | -1,569 | |
0.02217 % | Virtus Etf Advisers LLC | 9,426 | 1,789 | |
0.01882 % | Schafer (Carol Anne) | 8,000 | 0 | |
0.01832 % | Lazard Asset Management, L.L.C. | 7,788 | 7,788 | |
0.01764 % | Civik (Thomas) | 7,500 | 0 | |
0.01599 % | Simplex Trading, LLC | 6,797 | 6,775 | |
0.01294 % | Handelsbanken Kapitalförvaltning AB | 5,500 | 0 | |
0.01186 % | UBS Financial Services, Inc. | 5,042 | 1,491 | |
0.01129 % | Morrison Briggs W | 4,800 | 0 | |
0.01090 % | Legal & General Investment Management Ltd. | 4,633 | 0 | |
0.01027 % | American Century Investment Management, Inc. | 4,367 | 2,848 | |
0.00972 % | BlackRock Investment Management (UK) Ltd. | 4,133 | 179 | |
0.00970 % | Dimensional Fund Advisors, Ltd. | 4,124 | 0 | |
0.00941 % | KLP Fondsforvaltning AS | 4,000 | 0 | |
0.00941 % | Rhoads (Ann D) | 4,000 | 0 | |
0.00936 % | Northern Trust Global Investments | 3,977 | 0 | |
0.00842 % | Northern Trust Global Investments Limited | 3,578 | 0 | |
0.00762 % | ProShare Advisors LLC | 3,239 | -345 | |