6.71405 % | Opaleye Management Inc. | 2,304,262 | -274,647 | |
5.53613 % | RA Capital Management, LP | 1,900,000 | 0 | |
2.86746 % | StemPoint Capital LP | 984,113 | 815,671 | |
2.41318 % | Shefferman (Jesse M) | 828,203 | -8,563 | |
2.36488 % | Boxer Capital, L.L.C. | 811,627 | 602,400 | |
1.93873 % | Citadel Advisors LLC | 665,372 | 52,240 | |
1.56420 % | Baker Bros. Advisors LP | 536,832 | 337,161 | |
1.51515 % | Armistice Capital LLC | 520,000 | -580,000 | |
1.39860 % | Velan Capital Investment Management LP | 480,000 | 480,000 | |
1.24596 % | The Vanguard Group, Inc. | 427,612 | 0 | |
0.88213 % | Heights Capital Management, Inc. | 302,746 | -297,634 | |
0.68849 % | Two Sigma Investments, LP | 236,291 | 172,132 | |
0.57692 % | Beshar (Luke M) | 198,000 | 0 | |
0.52655 % | Ikarian Capital LLC | 180,712 | -21,989 | |
0.43823 % | Renaissance Technologies LLC | 150,400 | 65,800 | |
0.40946 % | Geode Capital Management, L.L.C. | 140,526 | 57,619 | |
0.37057 % | Oppenheimer Asset Management Inc. | 127,181 | 117,181 | |
0.36422 % | ACCI Capital Investments SGIIC, SA | 125,000 | 40,000 | |
0.33423 % | Privium Fund Management (UK) Ltd | 114,708 | -5,022 | |
0.32469 % | BlackRock Institutional Trust Company, N.A. | 111,434 | 82,884 | |
0.29138 % | Woodline Partners LP | 100,001 | 100,001 | |
0.22538 % | Marshall Wace LLP | 77,351 | 77,351 | |
0.18453 % | Zummo (Jacqueline) | 63,331 | -291 | |
0.14860 % | Abaris Investment Management AG | 51,000 | 25,500 | |
0.12821 % | LPL Financial LLC | 44,000 | 16,000 | |
0.10781 % | CIBC World Markets Inc. | 37,000 | 37,000 | |
0.09615 % | Garceau (Roger J) | 33,000 | 0 | |
0.09033 % | Levy (Richard S) | 31,000 | 0 | |
0.09033 % | Sargen (Gregory P) | 31,000 | 0 | |
0.08693 % | Fry (Hannah) | 29,836 | 6,772 | |
0.08443 % | Northern Trust Investments, Inc. | 28,976 | 11,385 | |
0.07751 % | State Street Global Advisors (US) | 26,600 | 0 | |
0.07721 % | Solomon (Michael Edward) | 26,500 | 0 | |
0.07051 % | Bridgeway Capital Management, LLC | 24,200 | -34,800 | |
0.06776 % | Bandari (Jathin) | 23,255 | 18,244 | |
0.05883 % | Boothbay Fund Management, LLC | 20,191 | -2,456 | |
0.05828 % | Truist Bank | 20,000 | 0 | |
0.05661 % | Commonwealth Financial Network | 19,428 | 0 | |
0.04161 % | Newton Investment Management North America, LLC | 14,280 | 0 | |
0.03744 % | Jane Street Capital, L.L.C. | 12,850 | 12,850 | |
0.02924 % | Susquehanna International Group, LLP | 10,036 | -1,149 | |
0.01894 % | Gesiuris Asset Management S.G.I.I.C., S.A. | 6,500 | 0 | |
0.01171 % | Tower Research Capital LLC | 4,019 | 1,439 | |
0.01119 % | BlackRock Investment Management, LLC | 3,839 | 2,585 | |
0.01057 % | BNY Mellon Asset Management | 3,627 | 0 | |
0.01020 % | RBC Dominion Securities, Inc. | 3,500 | 0 | |
0.00816 % | RBC Capital Partners | 2,802 | 2,316 | |
0.00743 % | Group One Trading, L.P. | 2,550 | 2,550 | |
0.00646 % | Dimensional Fund Advisors, Ltd. | 2,216 | 0 | |
0.00260 % | Blackstone Alternative Investment Advisors LLC | 894 | 494 | |
0.00146 % | Wells Fargo Advisors | 500 | 0 | |
0.00043 % | BofA Global Research (US) | 149 | 149 | |
0.00029 % | Osaic Holdings, Inc. | 100 | 0 | |
0.00001 % | Qube Research & Technologies Ltd | 2 | 0 | |
0 % | Fabbio (Patrick) | 0 | -22,000 | |
0 % | Simplex Trading, LLC | 0 | -17,850 | |
0 % | Morgan Stanley Smith Barney LLC | 0 | -25 | |
0 % | Assenagon Asset Management S.A. | 0 | -15,831 | |
0 % | Perceptive Advisors LLC | 0 | -290,051 | |
0 % | Apo Asset Management GmbH | 0 | -7,535 | |
0 % | Medical Strategy GmbH | 0 | -56,153 | |
0 % | Millennium Management LLC | 0 | -11,506 | |
0 % | OrbiMed Advisors, LLC | 0 | -772,584 | |
0 % | Federated MDTA LLC | 0 | -124 | |
0 % | Acadian Asset Management LLC | 0 | -6,314 | |
0 % | Wells Fargo Bank, N.A. | 0 | -70 | |
0 % | BlackRock Financial Management, Inc. | 0 | -1,060 | |
0 % | Morgan Stanley & Co. LLC | 0 | -58,339 | |
0 % | Manulife Investment Management (North America) Limited | 0 | -372 | |
0 % | Fidelity Management & Research Company LLC | 0 | -9 | |
0 % | Dimensional Fund Advisors, L.P. | 0 | -12,126 | |
0 % | J.P. Morgan Securities LLC | 0 | -22 | |
0 % | UBS Financial Services, Inc. | 0 | -3,725 | |
0 % | Adar1 Capital Management LLC | 0 | -2,000 | |