11.37506 % | Novo Holdings A/S | 12,048,802 | 0 | |
10.86684 % | Institut Merieux SA | 11,510,481 | 5,201,107 | |
7.95520 % | Vulpes Investment Management Private Limited | 8,426,390 | 0 | |
6.76938 % | M&G Investment Management Ltd. | 7,170,330 | 119,809 | |
5.73888 % | Liontrust Investment Partners LLP | 6,078,799 | -838,958 | |
3.87615 % | Fidelity Management & Research Company LLC | 4,105,735 | 4,016,621 | |
3.64259 % | BlackRock Advisors (UK) Limited | 3,858,339 | 231,470 | |
3.48356 % | Hargreaves Lansdown Asset Management Limited | 3,689,888 | 256,641 | |
3.19378 % | Serum Life Sciences Ltd | 3,382,950 | 0 | |
3.06391 % | Columbia Threadneedle Investments (UK) | 3,245,381 | 61,653 | |
2.91322 % | Lansdowne Partners (UK) LLP | 3,085,765 | 2,382,375 | |
2.83656 % | Vitruvian Partners LLP | 3,004,567 | 0 | |
2.81839 % | The Vanguard Group, Inc. | 2,985,324 | -171,167 | |
2.74034 % | Shah (Sobhagchand Meghji Hirji) | 2,902,652 | -7,731 | |
2.46931 % | BlackRock Investment Management (UK) Ltd. | 2,615,567 | 28,206 | |
1.40461 % | Norges Bank Investment Management (NBIM) | 1,487,803 | 70,298 | |
0.63218 % | Acadian Asset Management LLC | 669,623 | 324,780 | |
0.53352 % | Lombard Odier Asset Management (Europe) Ltd | 565,118 | 565,118 | |
0.42484 % | Oaktree Capital Management, L.P. | 450,000 | -150,000 | |
0.41995 % | Vanguard Global Advisers LLC | 444,825 | 0 | |
0.41016 % | Legal & General Investment Management Ltd. | 434,451 | 0 | |
0.35101 % | Doliveux (Roch Frederic) | 371,805 | 0 | |
0.24461 % | BlackRock Life, Ltd. | 259,098 | 259,098 | |
0.23602 % | Royce Investment Partners | 250,000 | 250,000 | |
0.23542 % | Dawson (John) | 249,366 | 0 | |
0.22658 % | Sir A M D & Lady E V Gormley | 240,000 | 80,000 | |
0.22567 % | Close Brothers Asset Management | 239,037 | 0 | |
0.22239 % | Freeman (Robert M) | 235,566 | 13,500 | |
0.19138 % | River Global Investors LLP | 202,713 | 39,326 | |
0.16773 % | Watts (T) | 177,662 | 177,662 | |
0.16413 % | Janus Henderson Investors | 173,852 | 111,596 | |
0.15294 % | Crawford (Ward) | 162,000 | 162,000 | |
0.14161 % | Canaccord Genuity Wealth Management | 150,000 | 0 | |
0.13991 % | Mitrophanous (Kyriacos) | 148,200 | 159 | |
0.13838 % | Berry (Alexander) | 146,580 | 146,580 | |
0.13054 % | DZ PRIVATBANK S.A. | 138,275 | 0 | |
0.13054 % | Bellecapital AG | 138,275 | 0 | |
0.12962 % | abrdn Alternative Investments Limited | 137,300 | 0 | |
0.12509 % | LGT Bank (Schweiz) AG | 132,500 | 0 | |
0.11960 % | Platinum Asset Management | 126,689 | 0 | |
0.11497 % | Geode Capital Management, L.L.C. | 121,776 | 2,156 | |
0.11423 % | EFG Bank SA | 121,000 | 105,000 | |
0.11280 % | DBS Bank Ltd. | 119,483 | -8,717 | |
0.10549 % | JPMorgan Asset Management U.K. Limited | 111,733 | -98 | |
0.09632 % | Pine (Elliot) | 102,027 | 29,302 | |
0.09441 % | Lauxera Capital Partners | 100,000 | 0 | |
0.09164 % | Kilbey (Graham) | 97,073 | 17,473 | |
0.08261 % | Charnock (Colin) | 87,500 | 21,500 | |
0.07850 % | AFH Wealth Management | 83,151 | 0 | |
0.06769 % | Batchelor (Jeffery Tudor) | 71,698 | 0 | |
0.06722 % | California State Teachers Retirement System | 71,199 | 2,799 | |
0.06303 % | Birtles (Russell) | 66,760 | 0 | |
0.06254 % | Hopkins (Stephen Laurence) | 66,246 | 0 | |
0.05704 % | Page (Nicholas) | 60,417 | 38,525 | |
0.05677 % | Da'Silva (Carlos) | 60,129 | 0 | |
0.05599 % | State Street Global Advisors (UK) Ltd. | 59,309 | 6,475 | |
0.05558 % | abrdn Investments Limited | 58,873 | 0 | |
0.05191 % | Tallarigo (Lorenzo) | 54,988 | 0 | |
0.04725 % | Foster (Edward David) | 50,046 | 7,209 | |
0.04664 % | First Sentier Investors | 49,406 | 49,406 | |
0.04527 % | Hignett (Philip) | 47,950 | 4,971 | |
0.04453 % | DWS Investment GmbH | 47,165 | 13,969 | |
0.04386 % | Brompton Asset Management LLP | 46,458 | 8,680 | |
0.04366 % | Margetts Fund Management Limited | 46,247 | 6,305 | |
0.04340 % | Pink (Daemon Joseph) | 45,967 | 45,967 | |
0.04259 % | Pass (M) | 45,114 | 0 | |
0.03964 % | Harris (E) | 41,993 | -29,007 | |
0.03832 % | Ninety One SA Pty Ltd. | 40,590 | 40,590 | |
0.03782 % | McKenzie (I) | 40,063 | -5,937 | |
0.03776 % | Ostrum Asset Management | 40,000 | 40,000 | |
0.03774 % | Hayden (Michael Reuben) | 39,973 | 0 | |
0.03731 % | St. Galler Kantonalbank AG | 39,516 | 0 | |
0.03450 % | McKay (James Patrick) | 36,546 | 5,415 | |
0.03266 % | Da Silva (Carl) | 34,596 | 16,545 | |
0.03253 % | Cruickshank (N) | 34,462 | -4,718 | |
0.03239 % | State Street Global Advisors (US) | 34,309 | -3,719 | |
0.03210 % | Allspring Global Investments, LLC | 33,997 | 0 | |
0.03016 % | Calnan (Terence Arthur) | 31,942 | 7,175 | |
0.02997 % | Rose (William Marcus Henderson) | 31,746 | 0 | |
0.02864 % | Khan (Naheed) | 30,333 | 30,333 | |
0.02847 % | Abdul-Rahman (Ibrahim) | 30,153 | 0 | |
0.02818 % | Prescott (Ian Charles) | 29,850 | 29,850 | |
0.02749 % | Black (L) | 29,113 | 0 | |
0.02643 % | Birrell (Donald John) | 28,000 | 0 | |
0.02600 % | Harrop (Richard Oliver) | 27,543 | 0 | |
0.02509 % | Mc-Kay (James) | 26,571 | 0 | |
0.02502 % | Rodrigues (B) | 26,500 | 26,500 | |
0.02387 % | Moukheibir (Catherine) | 25,287 | 0 | |
0.02360 % | Bank Vontobel AG (Private Banking) | 25,000 | 25,000 | |
0.02292 % | Maybury (Andrew Leighton) | 24,279 | 1,190 | |
0.02237 % | University of Massachusetts Medical School | 23,698 | 0 | |
0.02223 % | Toomey (J J) | 23,547 | 903 | |
0.02192 % | State Street Global Advisors Ireland Limited | 23,218 | -6,088 | |
0.02128 % | Brown (Rebecca Ann) | 22,540 | 0 | |
0.02111 % | Yogarajah (Sinnappah) | 22,358 | 0 | |
0.02060 % | Harvey (Richard) | 21,820 | 0 | |
0.02051 % | Glass (Clive) | 21,721 | 0 | |
0.02007 % | Royal London Asset Management Ltd. | 21,264 | 0 | |
0.01980 % | Chesworth (David) | 20,972 | 0 | |
0.01888 % | Holmes (L) | 20,000 | -100 | |