| 9.11 % | RTW Investments L.P. | 2,327,403 | -500 | |
| 4.95 % | Healthinvest Partners AB | 1,265,000 | 558,000 | |
| 37.60 % | Tang Capital Management, LLC | 9,607,934 | -240,000 | |
| 3.23 % | The Vanguard Group, Inc. | 825,481 | -3,962 | |
| 2.70 % | Medical Strategy GmbH | 689,585 | -58,567 | |
| 2.35 % | D. E. Shaw & Co., L.P. | 600,070 | 11,268 | |
| 1.87 % | Acadian Asset Management LLC | 477,688 | 42,301 | |
| 1.61 % | BlackRock Institutional Trust Company, N.A. | 410,200 | -1,919 | |
| 1.38 % | Tang (Kevin C) | 352,000 | 112,000 | |
| 1.02 % | Norges Bank Investment Management (NBIM) | 259,676 | 259,676 | |
| 0.79 % | Geode Capital Management, L.L.C. | 202,816 | -81,054 | |
| 0.54 % | Millennium Management LLC | 138,889 | -612 | |
| 0.39 % | Ramsay (David) | 100,000 | 52,000 | |
| 0.39 % | State Street Global Advisors (US) | 98,941 | 3,962 | |
| 0.36 % | GlobeFlex Capital, L.P. | 92,799 | 0 | |
| 0.35 % | Fidelity Management & Research Company LLC | 90,441 | 90,441 | |
| 0.31 % | Hollencrest Capital Management | 80,355 | -2,000 | |
| 0.31 % | Northern Trust Investments, Inc. | 78,088 | 4,047 | |
| 0.24 % | Two Sigma Investments, LP | 62,444 | -86,068 | |
| 0.23 % | Newton Investment Management North America, LLC | 58,300 | 0 | |
| 0.23 % | Mellon Investments Corporation | 57,590 | 5,781 | |
| 0.20 % | Citadel Advisors LLC | 50,873 | -11,104 | |
| 0.16 % | First Midwest Trust Company | 41,731 | 0 | |
| 0.16 % | Old National Wealth Management | 41,284 | 41,284 | |
| 0.13 % | O'Shaughnessy Asset Management, LLC | 33,632 | 33,632 | |
| 0.11 % | Los Angeles Capital Management And Equity Research, Inc. | 29,075 | 22,175 | |
| 0.10 % | Schonfeld Strategic Advisors LLC | 26,100 | 10,400 | |
| 0.10 % | Renaissance Technologies LLC | 26,100 | -9,400 | |
| 0.10 % | Axiom Asset Management | 25,400 | 0 | |
| 0.10 % | Morgan Stanley Smith Barney LLC | 24,788 | 81 | |
| 0.08 % | Morgan Stanley & Co. LLC | 19,277 | -23,692 | |
| 0.07 % | Ritholtz Wealth Management LLC | 16,716 | 1,685 | |
| 0.05 % | Goldman Sachs Asset Management, L.P. | 13,718 | -301 | |
| 0.05 % | Occudo Quantitative Strategies LP | 13,541 | -3,635 | |
| 0.05 % | Johnson (Craig A) | 12,000 | 12,000 | |
| 0.05 % | Edwards (Larry G) | 11,969 | 296 | |
| 0.05 % | Susquehanna International Group, LLP | 11,546 | -36 | |
| 0.04 % | BNY Mellon Asset Management | 11,194 | 0 | |
| 0.04 % | BlackRock Financial Management, Inc. | 10,301 | 0 | |
| 0.04 % | Hearne (Michael S.) | 10,186 | 472 | |
| 0.04 % | Running Point Capital Advisors, LLC | 10,000 | 10,000 | |
| 0.03 % | PNC Wealth Management | 7,000 | 0 | |
| 0.03 % | BofA Global Research (US) | 6,592 | -7,564 | |
| 0.02 % | Apo Asset Management GmbH | 6,100 | -18,012 | |
| 0.02 % | Barclays Bank PLC | 5,352 | -12 | |
| 0.02 % | Meeder Asset Management, Inc | 4,312 | 4,312 | |
| 0.01 % | Tower Research Capital LLC | 3,569 | -5,183 | |
| 0.01 % | BlackRock Investment Management, LLC | 3,447 | -309 | |
| 0.01 % | Lord, Abbett & Co. LLC | 3,447 | 0 | |
| 0.01 % | Ellis Investment Partners, LLC | 2,800 | 0 | |
| 0.01 % | BlackRock Japan Co., Ltd. | 2,565 | -28 | |
| 0.01 % | Wells Fargo Advisors | 2,451 | -2,500 | |
| 0.01 % | UBS Financial Services, Inc. | 2,218 | -2,209 | |
| 0.01 % | Northern Trust Global Investments | 1,965 | 0 | |
| 0.00 % | Seasons of Advice Wealth Management | 1,045 | 0 | |
| 0.00 % | Group One Trading, L.P. | 594 | -7,533 | |
| 0.00 % | Johnson (Laura Laura) | 500 | 0 | |
| 0.00 % | Tyler-Stone Wealth Management LLC | 500 | 0 | |
| 0.00 % | J.P. Morgan Securities LLC | 341 | -1,163 | |
| 0.00 % | Simplex Trading, LLC | 330 | -1,758 | |
| 0.00 % | RBC Private Counsel (USA) Inc. | 225 | 0 | |
| 0.00 % | Blackstone Alternative Investment Advisors LLC | 200 | 0 | |
| 0.00 % | Wells Fargo Bank, N.A. | 161 | 1 | |
| 0.00 % | J.P. Morgan Securities plc | 47 | 0 | |
| 0.00 % | BNP Paribas Securities Corp. North America | 1 | -30,733 | |
| 0 % | ExodusPoint Capital Management, LP | 0 | -10,073 | |
| 0 % | Ergoteles Capital | 0 | -57,083 | |
| 0 % | Summit Global Investments, LLC | 0 | -48,500 | |
| 0 % | Ellevest, Inc. | 0 | -41 | |
| 0 % | L2 Asset Management, LLC | 0 | -15 | |
| 0 % | Squarepoint Capital LLP | 0 | -13,227 | |
| 0 % | Advisor Group, Inc | 0 | -1,150 | |
| 0 % | Powell Investment Advisors, LLC | 0 | -12,000 | |
| 0 % | Engineers Gate Manager, L.P. | 0 | -16,400 | |
| 0 % | Trexquant Investment LP | 0 | -25,006 | |
| 0 % | HRT Financial LP | 0 | -45,461 | |
| 0 % | Cubist Systematic Strategies, LLC | 0 | -16,218 | |
| 0 % | PDT Partners, LLC | 0 | -10,585 | |
| 0 % | Tibra Equities Europe, Ltd. | 0 | -72,600 | |
| 0 % | LMR Partners LLP | 0 | -11,515 | |
| 0 % | Principal Funds, Inc. | 0 | -2,623 | |
| 0 % | Quantbot Technologies, LP | 0 | -495 | |
| 0 % | HighVista Strategies LLC | 0 | -25,493 | |
| 0 % | DWS Investments UK Limited | 0 | -11,709 | |
| 0 % | Assenagon Asset Management S.A. | 0 | -401 | |
| 0 % | Boxer Capital, L.L.C. | 0 | -890,700 | |
| 0 % | Virtu Americas LLC | 0 | -21,258 | |
| 0 % | Signaturefd, LLC | 0 | -10,000 | |
| 0 % | Alyeska Investment Group, L.P. | 0 | -536,847 | |
| 0 % | ProShare Advisors LLC | 0 | -5,011 | |
| 0 % | Premier Asset Management, LLC | 0 | -51,305 | |
| 0 % | CAPTRUST Financial Advisors | 0 | -2,600 | |
| 0 % | Grimes & Company, Inc. | 0 | -25,270 | |
| 0 % | GSA Capital Partners LLP | 0 | -26,143 | |
| 0 % | Broadfin Capital, L.L.C. | 0 | -2,688,068 | |
| 0 % | Jane Street Capital, L.L.C. | 0 | -35,924 | |
| 0 % | Aperio Group, LLC | 0 | -15 | |
| 0 % | Barclays Capital Inc. | 0 | -1,982 | |
| 0 % | Morgan Stanley & Co. International Plc | 0 | -493 | |
| 0 % | RBC Capital Partners | 0 | -4,185 | |
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