11.37323 % | Novo Holdings A/S | 12,048,802 | 0 | |
10.86509 % | Institut Merieux SA | 11,510,481 | 5,201,107 | |
7.95393 % | Vulpes Investment Management Private Limited | 8,426,390 | 0 | |
6.76829 % | M&G Investment Management Ltd. | 7,170,330 | 119,809 | |
5.73796 % | Liontrust Investment Partners LLP | 6,078,799 | -838,958 | |
3.87553 % | Fidelity Management & Research Company LLC | 4,105,735 | 4,016,621 | |
3.64200 % | BlackRock Advisors (UK) Limited | 3,858,339 | 231,470 | |
3.48300 % | Hargreaves Lansdown Asset Management Limited | 3,689,888 | 256,641 | |
3.19327 % | Serum Life Sciences Ltd | 3,382,950 | 0 | |
3.06341 % | Columbia Threadneedle Investments (UK) | 3,245,381 | 61,653 | |
2.91275 % | Lansdowne Partners (UK) LLP | 3,085,765 | 2,382,375 | |
2.83610 % | Vitruvian Partners LLP | 3,004,567 | 0 | |
2.81794 % | The Vanguard Group, Inc. | 2,985,324 | -171,167 | |
2.73990 % | Shah (Sobhagchand Meghji Hirji) | 2,902,652 | -7,731 | |
2.46891 % | BlackRock Investment Management (UK) Ltd. | 2,615,567 | 28,206 | |
1.40438 % | Norges Bank Investment Management (NBIM) | 1,487,803 | 70,298 | |
0.63208 % | Acadian Asset Management LLC | 669,623 | 324,780 | |
0.53343 % | Lombard Odier Asset Management (Europe) Ltd | 565,118 | 565,118 | |
0.42477 % | Oaktree Capital Management, L.P. | 450,000 | -150,000 | |
0.41988 % | Vanguard Global Advisers LLC | 444,825 | 0 | |
0.41009 % | Legal & General Investment Management Ltd. | 434,451 | 0 | |
0.35096 % | Doliveux (Roch Frederic) | 371,805 | 0 | |
0.24457 % | BlackRock Life, Ltd. | 259,098 | 259,098 | |
0.23598 % | Royce Investment Partners | 250,000 | 250,000 | |
0.23538 % | Dawson (John) | 249,366 | 0 | |
0.22654 % | Sir A M D & Lady E V Gormley | 240,000 | 80,000 | |
0.22563 % | Close Brothers Asset Management | 239,037 | 0 | |
0.22236 % | Freeman (Robert M) | 235,566 | 13,500 | |
0.19135 % | River Global Investors LLP | 202,713 | 39,326 | |
0.16770 % | Watts (T) | 177,662 | 177,662 | |
0.16410 % | Janus Henderson Investors | 173,852 | 111,596 | |
0.15292 % | Crawford (Ward) | 162,000 | 162,000 | |
0.14159 % | Canaccord Genuity Wealth Management | 150,000 | 0 | |
0.13989 % | Mitrophanous (Kyriacos) | 148,200 | 159 | |
0.13836 % | Berry (Alexander) | 146,580 | 146,580 | |
0.13052 % | DZ PRIVATBANK S.A. | 138,275 | 0 | |
0.13052 % | Bellecapital AG | 138,275 | 0 | |
0.12960 % | abrdn Alternative Investments Limited | 137,300 | 0 | |
0.12507 % | LGT Bank (Schweiz) AG | 132,500 | 0 | |
0.11959 % | Platinum Asset Management | 126,689 | 0 | |
0.11495 % | Geode Capital Management, L.L.C. | 121,776 | 2,156 | |
0.11422 % | EFG Bank SA | 121,000 | 105,000 | |
0.11278 % | DBS Bank Ltd. | 119,483 | -8,717 | |
0.10547 % | JPMorgan Asset Management U.K. Limited | 111,733 | -98 | |
0.09631 % | Pine (Elliot) | 102,027 | 29,302 | |
0.09439 % | Lauxera Capital Partners | 100,000 | 0 | |
0.09163 % | Kilbey (Graham) | 97,073 | 17,473 | |
0.08259 % | Charnock (Colin) | 87,500 | 21,500 | |
0.07849 % | AFH Wealth Management | 83,151 | 0 | |
0.06768 % | Batchelor (Jeffery Tudor) | 71,698 | 0 | |
0.06721 % | California State Teachers Retirement System | 71,199 | 2,799 | |
0.06302 % | Birtles (Russell) | 66,760 | 0 | |
0.06253 % | Hopkins (Stephen Laurence) | 66,246 | 0 | |
0.05703 % | Page (Nicholas) | 60,417 | 38,525 | |
0.05676 % | Da'Silva (Carlos) | 60,129 | 0 | |
0.05598 % | State Street Global Advisors (UK) Ltd. | 59,309 | 6,475 | |
0.05557 % | abrdn Investments Limited | 58,873 | 0 | |
0.05190 % | Tallarigo (Lorenzo) | 54,988 | 0 | |
0.04724 % | Foster (Edward David) | 50,046 | 7,209 | |
0.04664 % | First Sentier Investors | 49,406 | 49,406 | |
0.04526 % | Hignett (Philip) | 47,950 | 4,971 | |
0.04452 % | DWS Investment GmbH | 47,165 | 13,969 | |
0.04385 % | Brompton Asset Management LLP | 46,458 | 8,680 | |
0.04365 % | Margetts Fund Management Limited | 46,247 | 6,305 | |
0.04339 % | Pink (Daemon Joseph) | 45,967 | 45,967 | |
0.04258 % | Pass (M) | 45,114 | 0 | |
0.03964 % | Harris (E) | 41,993 | -29,007 | |
0.03831 % | Ninety One SA Pty Ltd. | 40,590 | 40,590 | |
0.03782 % | McKenzie (I) | 40,063 | -5,937 | |
0.03776 % | Ostrum Asset Management | 40,000 | 40,000 | |
0.03773 % | Hayden (Michael Reuben) | 39,973 | 0 | |
0.03730 % | St. Galler Kantonalbank AG | 39,516 | 0 | |
0.03450 % | McKay (James Patrick) | 36,546 | 5,415 | |
0.03266 % | Da Silva (Carl) | 34,596 | 16,545 | |
0.03253 % | Cruickshank (N) | 34,462 | -4,718 | |
0.03239 % | State Street Global Advisors (US) | 34,309 | -3,719 | |
0.03209 % | Allspring Global Investments, LLC | 33,997 | 0 | |
0.03015 % | Calnan (Terence Arthur) | 31,942 | 7,175 | |
0.02997 % | Rose (William Marcus Henderson) | 31,746 | 0 | |
0.02863 % | Khan (Naheed) | 30,333 | 30,333 | |
0.02846 % | Abdul-Rahman (Ibrahim) | 30,153 | 0 | |
0.02818 % | Prescott (Ian Charles) | 29,850 | 29,850 | |
0.02748 % | Black (L) | 29,113 | 0 | |
0.02643 % | Birrell (Donald John) | 28,000 | 0 | |
0.02600 % | Harrop (Richard Oliver) | 27,543 | 0 | |
0.02508 % | Mc-Kay (James) | 26,571 | 0 | |
0.02501 % | Rodrigues (B) | 26,500 | 26,500 | |
0.02387 % | Moukheibir (Catherine) | 25,287 | 0 | |
0.02360 % | Bank Vontobel AG (Private Banking) | 25,000 | 25,000 | |
0.02292 % | Maybury (Andrew Leighton) | 24,279 | 1,190 | |
0.02237 % | University of Massachusetts Medical School | 23,698 | 0 | |
0.02223 % | Toomey (J J) | 23,547 | 903 | |
0.02192 % | State Street Global Advisors Ireland Limited | 23,218 | -6,088 | |
0.02128 % | Brown (Rebecca Ann) | 22,540 | 0 | |
0.02110 % | Yogarajah (Sinnappah) | 22,358 | 0 | |
0.02060 % | Harvey (Richard) | 21,820 | 0 | |
0.02050 % | Glass (Clive) | 21,721 | 0 | |
0.02007 % | Royal London Asset Management Ltd. | 21,264 | 0 | |
0.01980 % | Chesworth (David) | 20,972 | 0 | |
0.01888 % | Holmes (L) | 20,000 | -100 | |