19.70856 % | BVF Partners L.P. | 8,748,629 | 0 | |
17.77333 % | Bellevue Asset Management AG | 7,889,583 | 0 | |
9.48533 % | Soleus Capital Management, L.P. | 4,210,537 | 620,979 | |
9.40831 % | Morgan Stanley & Co. LLC | 4,176,348 | -700 | |
6.68043 % | PFM Health Sciences, LP | 2,965,442 | -14,978 | |
5.17833 % | RTW Investments L.P. | 2,298,662 | 0 | |
3.32094 % | Adage Capital Management, L.P. | 1,474,165 | -106,210 | |
2.26673 % | Janus Henderson Investors | 1,006,202 | -169,040 | |
1.81585 % | Rhenman & Partners Asset Management AB | 806,054 | -105,766 | |
1.76707 % | Berger (Franklin Milan) | 784,404 | 22,770 | |
1.52513 % | Rock Springs Capital Management LP | 677,005 | 0 | |
0.71128 % | Schonfeld Strategic Advisors LLC | 315,736 | -52,764 | |
0.58866 % | Medical Strategy GmbH | 261,304 | 15,000 | |
0.56786 % | Parkman Healthcare Partners LLC | 252,072 | 377 | |
0.18080 % | CIBC World Markets Inc. | 80,257 | -600 | |
0.14815 % | Parkinson (David Ross M.D.) | 65,765 | 0 | |
0.14301 % | D. E. Shaw & Co., L.P. | 63,481 | -1,600 | |
0.13553 % | Glickman (Richard M) | 60,160 | 3,750 | |
0.10531 % | American Century Investment Management, Inc. | 46,748 | 572 | |
0.10402 % | Avantis Investors | 46,176 | 26,132 | |
0.09821 % | BNP Paribas Securities Corp. North America | 43,595 | 1,100 | |
0.07885 % | RBC Capital Markets Wealth Management | 35,000 | 5,000 | |
0.07764 % | Kennedy Capital Management LLC | 34,465 | 34,465 | |
0.07511 % | Wood (David Sidney) | 33,343 | 0 | |
0.06759 % | Requadt (Scott) | 30,002 | 0 | |
0.06050 % | Geode Capital Management, L.L.C. | 26,858 | 0 | |
0.05660 % | Citadel Advisors LLC | 25,125 | -11,393 | |
0.03626 % | Tucker Asset Management LLC | 16,097 | 16,097 | |
0.03205 % | Martin (John Alexander) | 14,229 | 0 | |
0.02323 % | Two Sigma Investments, LP | 10,313 | 10,313 | |
0.01752 % | Virsik (Peter) | 7,776 | -694 | |
0.01352 % | Osaic Holdings, Inc. | 6,000 | 0 | |
0.01264 % | BlackRock Financial Management, Inc. | 5,609 | 0 | |
0.01154 % | Cesano (Alessandra) | 5,124 | 0 | |
0.00649 % | Thorell (Marella) | 2,881 | 0 | |
0.00563 % | CIBC Private Wealth Management | 2,500 | 0 | |
0.00462 % | Desjardins Securities Inc. | 2,050 | 2,000 | |
0.00353 % | UBS Financial Services, Inc. | 1,565 | -2,061 | |
0.00338 % | Morgan Stanley Smith Barney LLC | 1,500 | 0 | |
0.00203 % | TD Waterhouse Canada, Inc. | 900 | 0 | |
0.00175 % | RBC Dominion Securities, Inc. | 775 | 0 | |
0.00135 % | Laurel Wealth Advisors, LLC | 600 | 0 | |
0.00121 % | RBC Capital Partners | 537 | 537 | |
0.00011 % | TD Securities, Inc. | 48 | 0 | |
0.00005 % | J.P. Morgan Securities plc | 21 | 0 | |
0.00002 % | BofA Global Research (US) | 8 | 0 | |
0 % | ACCI Capital Investments SGIIC, SA | 0 | -47,500 | |
0 % | One Wealth Advisors, LLC | 0 | -8,333 | |
0 % | Crewe Advisors LLC | 0 | -265 | |
0 % | Simplex Trading, LLC | 0 | -4,329 | |
0 % | Cubist Systematic Strategies, LLC | 0 | -34,086 | |
0 % | Blackstone Alternative Investment Advisors LLC | 0 | -800 | |
0 % | Hunting Hill Global Capital, LLC | 0 | -10,000 | |
0 % | Barclays Bank PLC | 0 | -971 | |
0 % | Group One Trading, L.P. | 0 | -11,175 | |
0 % | Kapitalo Investimentos Ltda | 0 | -33,400 | |
0 % | Quantbot Technologies, LP | 0 | -1,751 | |
0 % | Susquehanna International Group, LLP | 0 | -95,758 | |
0 % | Connective Capital Management, LLC | 0 | -84,578 | |
0 % | Tower Research Capital LLC | 0 | -27 | |
0 % | Northern Trust Global Investments | 0 | -4,661 | |
0 % | Millennium Management LLC | 0 | -14,052 | |
0 % | Renaissance Technologies LLC | 0 | -24,234 | |
0 % | OrbiMed Advisors, LLC | 0 | -842,366 | |
0 % | Acadian Asset Management LLC | 0 | -15,903 | |
0 % | Driehaus Capital Management, LLC | 0 | -28,300 | |
0 % | Wellington Management Company, LLP | 0 | -562 | |
0 % | State Street Global Advisors (US) | 0 | -24,414 | |
0 % | Morgan Stanley Investment Management Inc. (US) | 0 | -7 | |
0 % | Thrivent Asset Management, LLC | 0 | -33,389 | |
0 % | Bessemer Trust Company, N.A. (US) | 0 | -6,852 | |
0 % | Northern Trust Investments, Inc. | 0 | -7,828 | |
0 % | J.P. Morgan Securities LLC | 0 | -29,406 | |
0 % | Entrypoint Capital LLC | 0 | -4,420 | |
0 % | Frazier Life Sciences Management, L.P. | 0 | -605,141 | |
0 % | Privium Fund Management (UK) Ltd | 0 | -20,032 | |
0 % | Ally Bridge Group NY LLC | 0 | -236,583 | |
0 % | Jump Financial, LLC | 0 | -27,500 | |
0 % | Avidity Partners Management LP | 0 | -1,855,400 | |
0 % | Walleye Capital LLC | 0 | -20,784 | |