6.61455 % | Adage Capital Management, L.P. | 796,392 | 796,392 | |
4.52056 % | Millennium Management LLC | 544,276 | 124,569 | |
3.57294 % | RA Capital Management, LP | 430,182 | 430,182 | |
3.54003 % | Tang Capital Management, LLC | 426,220 | 426,220 | |
3.31942 % | Paradigm BioCapital Advisors LP | 399,658 | 399,658 | |
3.22821 % | Point72 Asset Management, L.P. | 388,676 | 388,676 | |
16.81894 % | Cormorant Asset Management, LP | 2,025,000 | 550,000 | |
1.62707 % | Ikarian Capital LLC | 195,899 | 0 | |
1.54273 % | K2 HealthVentures LLC | 185,745 | 185,745 | |
1.49050 % | The Vanguard Group, Inc. | 179,456 | 0 | |
1.24585 % | Sio Capital Management, LLC | 150,000 | 0 | |
0.65692 % | BlackRock Institutional Trust Company, N.A. | 79,093 | -119 | |
0.41528 % | Smethurst (Dominic) | 50,000 | 50,000 | |
0.34564 % | Boothbay Fund Management, LLC | 41,615 | 0 | |
0.31682 % | Geode Capital Management, L.L.C. | 38,145 | 964 | |
0.26578 % | Healthinvest Partners AB | 32,000 | 32,000 | |
0.17451 % | RBC Capital Markets Wealth Management | 21,011 | 21,011 | |
0.13864 % | Dimensional Fund Advisors, L.P. | 16,692 | -12,531 | |
0.10946 % | State Street Global Advisors (US) | 13,179 | 0 | |
0.08682 % | Cohen (Yuval) | 10,453 | -73,947 | |
0.07001 % | Moran (Sean F) | 8,429 | 1,787 | |
0.04272 % | abrdn Inc. | 5,143 | 5,143 | |
0.04272 % | Tekla Capital Management LLC_NLE | 5,143 | 0 | |
0.02785 % | Fidelity Management & Research Company LLC | 3,353 | 0 | |
0.02752 % | Charles Schwab Investment Management, Inc. | 3,313 | 0 | |
0.02213 % | T. Rowe Price International Ltd | 2,664 | 2,664 | |
0.01608 % | Morgan Stanley & Co. LLC | 1,936 | -1,232 | |
0.01495 % | Group One Trading, L.P. | 1,800 | -230 | |
0.01301 % | Catlin (Avery W) | 1,567 | 0 | |
0.01145 % | Holmer (Alan F) | 1,379 | 0 | |
0.01025 % | BlackRock Financial Management, Inc. | 1,234 | 0 | |
0.00988 % | Tower Research Capital LLC | 1,190 | 1,190 | |
0.00933 % | Kingsbury Capital Investment Advisors, LLC | 1,123 | 1,123 | |
0.00919 % | JTC Employer Solutions Trusteee Ltd | 1,106 | 0 | |
0.00903 % | RBC Capital Partners | 1,087 | -231 | |
0.00748 % | Millian (Craig Stuart) | 900 | 167 | |
0.00664 % | Cutler Group, LP | 800 | 800 | |
0.00613 % | BlackRock Investment Management, LLC | 738 | 0 | |
0.00470 % | Citi Investment Research (US) | 566 | 566 | |
0.00448 % | J.P. Morgan Securities LLC | 539 | -1,163 | |
0.00267 % | UBS Financial Services, Inc. | 321 | -861 | |
0.00204 % | Osaic Holdings, Inc. | 246 | -185 | |
0.00100 % | Morgan Stanley Smith Barney LLC | 121 | 0 | |
0.00083 % | Carmichael Hill & Associates Inc | 100 | 0 | |
0.00064 % | American Portfolios Advisors, Inc | 77 | 3 | |
0.00051 % | Benefit Financial Services Group, LLC | 61 | 61 | |
0.00034 % | HighMark Wealth Management LLC | 41 | 0 | |
0.00028 % | Wells Fargo Bank, N.A. | 34 | 2 | |
0.00027 % | Jenkins (John Kenneth M.D.) | 33 | 0 | |
0.00027 % | NBC Securities, Inc. | 33 | 33 | |
0.00023 % | Fortis Group Advisors, L.L.C. | 28 | 14 | |
0.00019 % | Carson Wealth Management Group | 23 | 20 | |
0.00013 % | Baystate Wealth Management LLC | 16 | 16 | |
0.00007 % | Studio Investment Management, LLC | 9 | 0 | |
0.00007 % | GWM Advisors LLC | 8 | 0 | |
0.00005 % | Keener Financial Planning LLC | 6 | 6 | |
0.00005 % | Scarborough Capital Management | 6 | 6 | |
0.00003 % | J.P. Morgan Securities plc | 4 | 0 | |
0.00003 % | BofA Global Research (US) | 4 | 4 | |
0.00002 % | Independent Financial Partners | 3 | 0 | |
0.00001 % | Sandy Spring Bank | 1 | 0 | |
0.00001 % | Comerica, Inc. | 1 | 0 | |
0 % | ExodusPoint Capital Management, LP | 0 | -562 | |
0 % | Aries Wealth Management, LLC | 0 | -513 | |
0 % | McAdam, LLC | 0 | -334 | |
0 % | Parallel Advisors, LLC | 0 | -7 | |
0 % | ETF Managers Group, LLC | 0 | -157,011 | |
0 % | Vident Investment Advisory, LLC | 0 | -8,920 | |
0 % | HRT Financial LP | 0 | -877 | |
0 % | LPL Financial LLC | 0 | -5,116 | |
0 % | Andbank Wealth Management, SGIIC, S.A.U. | 0 | -22,328 | |
0 % | The MassMutual Trust Company, FSB | 0 | -17 | |
0 % | Creative Planning, Inc. | 0 | -6,901 | |
0 % | Belpointe Asset Management LLC | 0 | -22 | |
0 % | Mirae Asset Global Investments (USA) LLC | 0 | -13,298 | |
0 % | B. Riley Wealth Advisors, Inc. | 0 | -713 | |
0 % | Sigma Planning Corporation | 0 | -1,067 | |
0 % | Virtu Americas LLC | 0 | -10,077 | |
0 % | Hightower Advisors, LLC | 0 | -503 | |
0 % | Verition Fund Management LLC | 0 | -2,202 | |
0 % | Synovus Securities, Inc. | 0 | -2,200 | |
0 % | Envestnet Asset Management, Inc. | 0 | -1,133 | |
0 % | Cambridge Investment Research Advisors, Inc. | 0 | -2,225 | |
0 % | HBKS Wealth Advisors | 0 | -458 | |
0 % | Laurie J. Hall Trustee | 0 | -25 | |
0 % | Mercer Global Advisors, Inc. | 0 | -1,058 | |
0 % | CAPTRUST Financial Advisors | 0 | -25 | |
0 % | Jane Street Capital, L.L.C. | 0 | -2,780 | |
0 % | Susquehanna International Group, LLP | 0 | -5,247 | |
0 % | Dorsey, Wright & Associates, LLC | 0 | -2,555 | |
0 % | IQ EQ Fund Management (Ireland) Limited | 0 | -15,240 | |
0 % | Horizons ETFs Management (Canada) Inc. | 0 | -9,641 | |
0 % | Aperio Group, LLC | 0 | -13 | |
0 % | Northern Trust Global Investments | 0 | -11 | |
0 % | Two Sigma Investments, LP | 0 | -21,823 | |
0 % | Neuberger Berman, LLC | 0 | -667 | |
0 % | TD Securities, Inc. | 0 | -143 | |
0 % | Knoll Capital Management, LLC | 0 | -168,196 | |
0 % | BNP Paribas Securities Corp. North America | 0 | -3 | |
0 % | Wells Fargo Advisors | 0 | -583 | |