9.20 % | Kynam Capital Management LP | 4,420,349 | 2,747,308 | |
7.56 % | BVF Partners L.P. | 3,629,000 | 0 | |
3.98 % | The Vanguard Group, Inc. | 1,910,984 | 69,214 | |
3.61 % | Nantahala Capital Management, LLC | 1,732,388 | -54,771 | |
3.00 % | Millennium Management LLC | 1,441,735 | 122,227 | |
2.90 % | Citadel Advisors LLC | 1,391,302 | 269,873 | |
2.79 % | Point72 Asset Management, L.P. | 1,340,300 | 1,069,700 | |
2.72 % | BofA Global Research (US) | 1,308,386 | 4,391 | |
2.70 % | Ingalls & Snyder LLC (Asset Management) | 1,295,833 | -34,600 | |
2.51 % | Parkman Healthcare Partners LLC | 1,203,484 | 65,897 | |
2.46 % | BlackRock Institutional Trust Company, N.A. | 1,182,032 | 380,848 | |
2.39 % | Tang Capital Management, LLC | 1,150,000 | 146,983 | |
2.27 % | RA Capital Management, LP | 1,088,296 | 0 | |
2.09 % | Sphera Funds Management Ltd. | 1,002,783 | 50,000 | |
2.04 % | Medical Strategy GmbH | 979,309 | 0 | |
1.61 % | Dimensional Fund Advisors, L.P. | 774,922 | 112,822 | |
1.60 % | Assenagon Asset Management S.A. | 769,336 | -140,554 | |
1.57 % | Acadian Asset Management LLC | 753,140 | 123,841 | |
1.39 % | AWM Investment Company, Inc. | 666,661 | 0 | |
1.14 % | Barclays Bank PLC | 548,155 | 97,922 | |
1.14 % | NewEdge Wealth, LLC | 547,501 | 0 | |
1.13 % | BMO Capital Markets (US) | 543,200 | 543,200 | |
1.12 % | Alyeska Investment Group, L.P. | 538,579 | 38,579 | |
1.09 % | Goldman Sachs & Company, Inc. | 523,630 | 189,551 | |
1.08 % | Morgan Stanley & Co. LLC | 519,782 | -32,140 | |
1.05 % | Schonfeld Strategic Advisors LLC | 503,674 | 244,574 | |
1.04 % | Renaissance Technologies LLC | 500,605 | -142,000 | |
1.02 % | Two Sigma Investments, LP | 491,105 | -365,147 | |
0.96 % | IndexIQ Advisors LLC | 460,165 | 460,165 | |
0.87 % | Geode Capital Management, L.L.C. | 417,858 | 9,369 | |
0.61 % | Connor, Clark & Lunn Investment Management Ltd. | 290,595 | -9,763 | |
0.57 % | J.P. Morgan Securities LLC | 274,240 | 186,915 | |
0.50 % | Susquehanna International Group, LLP | 240,190 | 202,781 | |
0.44 % | Stuart Nancy | 210,654 | -6,048 | |
0.43 % | Pura Vida Investments, LLC | 206,525 | 206,525 | |
0.42 % | International Biotechnology Trust PLC | 200,800 | 0 | |
0.40 % | Citi Investment Research (US) | 194,090 | 73,373 | |
0.32 % | Manulife Investment Management (North America) Limited | 152,947 | 151,883 | |
0.31 % | Bridgeway Capital Management, LLC | 148,200 | 0 | |
0.29 % | State Street Global Advisors (US) | 140,898 | 20,300 | |
0.24 % | D. E. Shaw & Co., L.P. | 113,848 | 113,848 | |
0.24 % | Aberdeen Asset Managers Ltd. | 113,600 | -105,700 | |
0.23 % | Northern Trust Investments, Inc. | 108,079 | -437 | |
0.22 % | ClariVest Asset Management LLC | 103,300 | -1,500 | |
0.21 % | BZ Bank AG (Asset Management) | 100,000 | 0 | |
0.18 % | Florida State Board of Administration | 88,400 | 88,400 | |
0.18 % | Ensign Peak Advisors, Inc. | 88,341 | 0 | |
0.18 % | City National Rochdale, LLC | 87,200 | 87,200 | |
0.17 % | Caxton Associates LP | 83,993 | -40,122 | |
0.16 % | Walleye Capital LLC | 74,548 | 74,548 | |
0.15 % | Black Diamond Financial, LLC | 71,000 | 0 | |
0.15 % | Morgan Stanley Smith Barney LLC | 70,221 | 0 | |
0.13 % | BG Fund Management Luxembourg S.A. | 60,092 | 0 | |
0.12 % | Kensington Investment Counsel, LLC | 58,599 | -18,202 | |
0.10 % | RBF Capital, LLC | 49,122 | -15,781 | |
0.10 % | Qube Research & Technologies Ltd | 47,137 | 13,399 | |
0.10 % | Cubist Systematic Strategies, LLC | 46,167 | -26,901 | |
0.08 % | Aldrich (Richard H) | 39,226 | -358,500 | |
0.08 % | Cassella (James V) | 38,690 | -3,762 | |
0.08 % | 683 Capital Management LLC | 38,058 | 38,058 | |
0.08 % | van Heek (Christine) | 36,926 | 26,926 | |
0.07 % | Lake Street Advisors | 35,398 | 0 | |
0.07 % | Alps Advisors, Inc. | 32,516 | 6,319 | |
0.06 % | BlackRock Advisors (UK) Limited | 30,710 | 8,243 | |
0.06 % | ACCI Capital Investments SGIIC, SA | 30,000 | -10,000 | |
0.06 % | Jane Street Capital, L.L.C. | 29,404 | 18,992 | |
0.06 % | Dimensional Fund Advisors, Ltd. | 29,215 | 4,867 | |
0.06 % | Marshall Wace LLP | 29,030 | 29,030 | |
0.06 % | Auchincloss (Thomas G Jr) | 28,900 | 22,400 | |
0.06 % | Apo Asset Management GmbH | 28,215 | 0 | |
0.05 % | AHL Partners LLP | 25,987 | 25,987 | |
0.05 % | Occudo Quantitative Strategies LP | 24,418 | -38,386 | |
0.05 % | Hutt (Peter Barton) | 24,363 | 0 | |
0.05 % | BlackRock Financial Management, Inc. | 24,259 | 8,692 | |
0.05 % | Barclays Capital Inc. | 23,835 | 21,314 | |
0.05 % | BlackRock Asset Management Ireland Limited | 22,668 | 22,668 | |
0.04 % | Northern Trust Global Investments | 20,813 | -5 | |
0.04 % | Lighthouse Partners | 20,746 | 20,746 | |
0.04 % | SG Americas Securities, L.L.C. | 20,361 | 3,352 | |
0.04 % | Birchview Capital, LP | 20,000 | 0 | |
0.04 % | Boothbay Fund Management, LLC | 18,414 | 18,414 | |
0.04 % | Becker (Marc A) | 18,392 | -3,762 | |
0.04 % | BNY Mellon Asset Management | 17,278 | 0 | |
0.04 % | Alpine Associates Management Inc. | 17,000 | -17,700 | |
0.03 % | Hoeiland (Jesper) | 16,400 | 16,400 | |
0.03 % | Jaeger (Wilfred E) | 16,400 | 16,400 | |
0.03 % | Acuitas Investments LLC | 15,800 | -600 | |
0.03 % | Charles Schwab Investment Management, Inc. | 15,686 | 0 | |
0.03 % | HSBC Global Asset Management (UK) Limited | 15,571 | 0 | |
0.03 % | Tung (Roger D) | 15,411 | -814,343 | |
0.03 % | Mirabella Financial Services LLP | 15,410 | 15,410 | |
0.03 % | Jump Financial, LLC | 14,418 | -21,782 | |
0.02 % | Cantor Fitzgerald, L.P | 12,000 | -30,100 | |
0.02 % | Flagship Harbor Advisors LLC | 10,350 | 0 | |
0.02 % | Roanoke Asset Management Corp. | 10,000 | 0 | |
0.02 % | Blackstone Alternative Investment Advisors LLC | 9,800 | 8,000 | |
0.02 % | Lord, Abbett & Co. LLC | 7,992 | 0 | |
0.02 % | BlackRock Investment Management, LLC | 7,992 | 242 | |
0.02 % | Tower Research Capital LLC | 7,398 | 5,351 | |
0.02 % | UBS Financial Services, Inc. | 7,301 | -6,560 | |