7.23536 % | BlackRock Institutional Trust Company, N.A. | 5,132,038 | -79,492 | |
6.47526 % | Nantahala Capital Management, LLC | 4,592,903 | -476,540 | |
5.82043 % | The Vanguard Group, Inc. | 4,128,428 | 89,683 | |
5.78812 % | Fidelity Management & Research Company LLC | 4,105,517 | -2,898 | |
4.82038 % | Baillie Gifford & Co. | 3,419,093 | -630,474 | |
4.29371 % | Opaleye Management Inc. | 3,045,525 | 1,926,625 | |
3.80151 % | Telemark Asset Management, LLC | 2,696,411 | 171,911 | |
2.86489 % | Nuveen LLC | 2,032,069 | -992 | |
2.81968 % | Casdin Capital, LLC | 2,000,000 | 1,700,000 | |
2.14125 % | Two Sigma Investments, LP | 1,518,789 | -340,031 | |
2.13505 % | Geode Capital Management, L.L.C. | 1,514,392 | 121,250 | |
2.10968 % | BlackRock Financial Management, Inc. | 1,496,398 | -55,669 | |
2.09393 % | State Street Global Advisors (US) | 1,485,228 | 209,302 | |
2.05377 % | Assenagon Asset Management S.A. | 1,456,739 | -296,704 | |
2.03780 % | Jacobs Levy Equity Management, Inc. | 1,445,410 | -268,746 | |
1.88979 % | Federated MDTA LLC | 1,340,430 | -57,601 | |
1.73717 % | Columbia Threadneedle Investments (US) | 1,232,173 | -555,469 | |
1.28456 % | D. E. Shaw & Co., L.P. | 911,138 | -689,746 | |
1.26886 % | Paradigm Capital Management, Inc. | 900,000 | 400,000 | |
1.18009 % | GSA Capital Partners LLP | 837,036 | 420,977 | |
1.10527 % | Nicols (John J) | 783,965 | 0 | |
1.10270 % | Acadian Asset Management LLC | 782,147 | -167,769 | |
0.87263 % | Millennium Management LLC | 618,955 | -352,416 | |
0.81223 % | Medical Strategy GmbH | 576,112 | 0 | |
0.78888 % | Northern Trust Investments, Inc. | 559,556 | 47,939 | |
0.74792 % | Prescott Group Capital Management, LLC | 530,500 | 530,500 | |
0.72414 % | Baillie Gifford Overseas Ltd. | 513,629 | 0 | |
0.61045 % | Fred Alger Management, LLC | 432,989 | 432,989 | |
0.59619 % | MacKay Shields LLC | 422,877 | 0 | |
0.56394 % | ACATIS Investment Kapitalverwaltungsgesellschaft GmbH | 400,000 | 0 | |
0.54722 % | Vivo Capital, LLC | 388,144 | 0 | |
0.45862 % | Dilly (Stephen George) | 325,301 | 143,425 | |
0.45115 % | ARIAD Asset Management GmbH | 320,000 | 0 | |
0.43328 % | BlackRock Investment Management (UK) Ltd. | 307,328 | -30,898 | |
0.36792 % | Fidelity Institutional Asset Management | 260,965 | 33,800 | |
0.35598 % | State Teachers Retirement System of Ohio | 252,500 | -42,900 | |
0.34376 % | Morgan Stanley & Co. LLC | 243,827 | 106,377 | |
0.31016 % | Trellus Management Company, LLC | 220,000 | -31,460 | |
0.30372 % | Barclays Bank PLC | 215,427 | 60,372 | |
0.30316 % | BlackRock Investment Management, LLC | 215,033 | -2,364 | |
0.29851 % | Charles Schwab Investment Management, Inc. | 211,734 | 59,327 | |
0.29785 % | Engineers Gate Manager, L.P. | 211,267 | 10,097 | |
0.29722 % | Dimensional Fund Advisors, L.P. | 210,817 | 55,832 | |
0.27774 % | Bridgeway Capital Management, LLC | 197,000 | -33,000 | |
0.27642 % | BNY Mellon Asset Management | 196,067 | 20,861 | |
0.27275 % | Dorgan (Byron L) | 193,461 | -20,000 | |
0.26715 % | Private Advisor Group LLC | 189,486 | 7,065 | |
0.26642 % | AQR Capital Management, LLC | 188,969 | -524,899 | |
0.25730 % | Empire Financial Management Company, LLC | 182,500 | 8,500 | |
0.24784 % | Ryali (Sriram) | 175,791 | 52,350 | |
0.22911 % | BofA Global Research (US) | 162,507 | -43,109 | |
0.22639 % | abrdn Inc. | 160,581 | 160,581 | |
0.20899 % | White Pine Capital, L.L.C. | 148,240 | -48,029 | |
0.19719 % | Goldman Sachs Asset Management, L.P. | 139,868 | 44,423 | |
0.18472 % | Jacob Asset Management of New York, LLC | 131,021 | -67,450 | |
0.17989 % | Citadel Advisors LLC | 127,593 | 20,856 | |
0.16885 % | Envestnet Asset Management, Inc. | 119,762 | 81,819 | |
0.16290 % | Parametric Portfolio Associates LLC | 115,542 | -67,496 | |
0.16225 % | Goldman Sachs & Company, Inc. | 115,081 | -176,395 | |
0.15996 % | Susquehanna International Group, LLP | 113,462 | 96,560 | |
0.15776 % | Smith (David V) | 111,899 | 23,329 | |
0.15524 % | AllianceBernstein L.P. | 110,110 | 0 | |
0.14911 % | Squarepoint Capital LLP | 105,761 | 11,614 | |
0.14343 % | Rhumbline Advisers Ltd. Partnership | 101,733 | 659 | |
0.13551 % | RBC Capital Markets Wealth Management | 96,120 | 23,675 | |
0.13172 % | UBS Asset Management (Americas), Inc. | 93,432 | 0 | |
0.12345 % | LPL Financial LLC | 87,566 | 1,456 | |
0.12285 % | Fitzgerald (Margaret Nell) | 87,134 | 52,350 | |
0.12156 % | Norrett (Kevin) | 86,224 | 52,350 | |
0.11940 % | Conestoga Capital Advisors, LLC | 84,693 | 0 | |
0.11692 % | Avantis Investors | 82,932 | 41,966 | |
0.10828 % | Wolf (Dennis P) | 76,800 | 34,602 | |
0.10219 % | Parker (H Stewart) | 72,480 | 34,602 | |
0.10005 % | Alphacrest Capital Management LLC | 70,965 | 70,965 | |
0.09861 % | UBS Financial Services, Inc. | 69,945 | 53,617 | |
0.09856 % | XTX Markets LLC | 69,910 | -121,552 | |
0.09746 % | Tekla Capital Management LLC_NLE | 69,125 | 0 | |
0.09668 % | Moore (Alison) | 68,576 | 34,602 | |
0.09653 % | Mellon Investments Corporation | 68,472 | 5,108 | |
0.09335 % | Aaker (Jennifer) | 66,211 | 34,602 | |
0.09298 % | Singhvi (Rahul) | 65,949 | 34,602 | |
0.09280 % | Cubist Systematic Strategies, LLC | 65,820 | 1,587 | |
0.08892 % | Algert Global LLC | 63,070 | -44,010 | |
0.08727 % | Aristides Capital, L.L.C. | 61,900 | 61,900 | |
0.08168 % | Martinborough (Esther) | 57,933 | 34,602 | |
0.08057 % | J.P. Morgan Securities LLC | 57,149 | -171,673 | |
0.07952 % | Numeric Investors LLC | 56,400 | 56,400 | |
0.07736 % | RBC Wealth Management, International | 54,872 | 4,036 | |
0.07583 % | Yang (Patrick Y) | 53,785 | 0 | |
0.07574 % | Northern Trust Global Investments | 53,720 | -906 | |
0.07379 % | Jane Street Capital, L.L.C. | 52,339 | 25,258 | |
0.07352 % | Dimensional Fund Advisors, Ltd. | 52,149 | 0 | |
0.07113 % | Thrivent Asset Management, LLC | 50,456 | -2,464 | |
0.07057 % | JPMorgan Private Bank (United States) | 50,052 | 50,052 | |
0.06570 % | Perkins Capital Management, Inc. | 46,600 | 24,000 | |
0.06544 % | DWS Investments UK Limited | 46,414 | 46,414 | |
0.06027 % | American Century Investment Management, Inc. | 42,749 | 14,748 | |
0.05983 % | Wellington Management Company, LLP | 42,437 | -22,163 | |
0.05655 % | Simplex Trading, LLC | 40,114 | 38,016 | |
0.05486 % | BlackRock Japan Co., Ltd. | 38,914 | 0 | |