5.37324 % | Paradigm BioCapital Advisors LP | 3,707,001 | 64,694 | |
5.05944 % | Deep Track Capital LP | 3,490,506 | 0 | |
2.82360 % | Jefferies LLC | 1,948,000 | 0 | |
2.53868 % | Cambridge Innovation Capital Jersey Ltd | 1,751,437 | 0 | |
2.39211 % | Tybourne Capital Management (HK) Limited | 1,650,320 | 368,500 | |
2.24739 % | First Light Asset Management, LLC | 1,550,471 | -520,382 | |
2.22641 % | Armistice Capital LLC | 1,536,000 | 536,000 | |
10.17129 % | Baker Bros. Advisors LP | 7,017,176 | 4,966,996 | |
1.45606 % | Polar Capital LLP | 1,004,535 | -6,965 | |
1.32962 % | Westfield Capital Management Company, L.P. | 917,304 | 917,304 | |
1.32552 % | Suvretta Capital Management, LLC | 914,476 | -96,500 | |
1.31473 % | SV Health Investors, LLC | 907,032 | 0 | |
1.25998 % | Candriam Belgium S.A. | 869,258 | -384,003 | |
1.22371 % | Ridgeback Capital Management, L.P. | 844,235 | -1,420,566 | |
1.20196 % | Candriam Luxembourg S.A. | 829,229 | 0 | |
1.15959 % | RA Capital Management, LP | 800,000 | 0 | |
1.13494 % | BNP Paribas Asset Management USA, Inc. | 782,998 | 142,116 | |
1.09443 % | Morgan Stanley & Co. LLC | 755,047 | -313,404 | |
1.07340 % | Verition Fund Management LLC | 740,539 | -175,843 | |
0.92895 % | BNP Paribas Asset Management UK Limited | 640,882 | 83,336 | |
0.80314 % | AXA Investment Managers UK Ltd. | 554,086 | -20,981 | |
0.66869 % | BofA Global Research (US) | 461,331 | 458,389 | |
0.65227 % | Camber Capital Management LP | 450,000 | 50,000 | |
0.60369 % | Kennedy Capital Management LLC | 416,485 | 259,780 | |
0.57979 % | Nomura Securities Co., Ltd. | 400,000 | 0 | |
0.52483 % | Platinum Asset Management | 362,080 | 76,601 | |
0.45353 % | Parkman Healthcare Partners LLC | 312,889 | 190,168 | |
0.42682 % | Citadel Advisors LLC | 294,465 | 158,768 | |
0.40335 % | BlackRock Financial Management, Inc. | 278,270 | 278,270 | |
0.40127 % | T. Rowe Price Associates, Inc. | 276,837 | -316,216 | |
0.39713 % | AXA Investment Managers Paris | 273,983 | 0 | |
0.39318 % | Morgan Stanley Investment Management Inc. (US) | 271,256 | -278,600 | |
0.38607 % | Fidelity Management & Research Company LLC | 266,347 | 0 | |
0.36112 % | Millennium Management LLC | 249,135 | -65,958 | |
0.33131 % | Lee (Kevin) | 228,568 | -3,158 | |
0.32743 % | Point72 Asset Management, L.P. | 225,895 | -1,073,605 | |
0.29776 % | Rubric Capital Management LP | 205,423 | 0 | |
0.29436 % | BlackRock Institutional Trust Company, N.A. | 203,080 | 20,668 | |
0.28457 % | Trexquant Investment LP | 196,323 | 125,604 | |
0.25232 % | Numeric Investors LLC | 174,074 | 174,074 | |
0.24902 % | Winter (Gregory Paul) | 171,802 | -2,875 | |
0.24038 % | Two Sigma Investments, LP | 165,835 | 72,205 | |
0.22979 % | Medical Strategy GmbH | 158,530 | 0 | |
0.22944 % | HighVista Strategies LLC | 158,293 | 65,859 | |
0.21761 % | Walleye Capital LLC | 150,126 | 150,126 | |
0.20264 % | Handelsbanken Kapitalförvaltning AB | 139,800 | 5,300 | |
0.19250 % | Legal & General Investment Management Ltd. | 132,805 | 40,342 | |
0.17713 % | Dafna Capital Management, LLC | 122,200 | 0 | |
0.16510 % | Cubist Systematic Strategies, LLC | 113,901 | 48,356 | |
0.16401 % | Voya Investment Management LLC | 113,150 | -205 | |
0.15509 % | Schonfeld Strategic Advisors LLC | 107,000 | 54,900 | |
0.15292 % | Renaissance Technologies LLC | 105,500 | 23,500 | |
0.14469 % | Allianz Global Investors GmbH | 99,820 | 0 | |
0.13770 % | Soleus Capital Management, L.P. | 95,000 | -296,800 | |
0.13045 % | LifeSci Fund Management LLC | 90,000 | 31,500 | |
0.12023 % | Jane Street Capital, L.L.C. | 82,950 | 33,576 | |
0.11864 % | Comerica, Inc. | 81,850 | 81,400 | |
0.11209 % | Jump Financial, LLC | 77,332 | 40,265 | |
0.10846 % | Adar1 Capital Management LLC | 74,825 | 74,825 | |
0.10668 % | UBS O'Connor LLC | 73,601 | -4,301 | |
0.08312 % | Keen (Nicholas) | 57,345 | -790 | |
0.07890 % | Azimut Capital Management Sgr SpA | 54,434 | -24,682 | |
0.07282 % | Walleye Trading, LLC | 50,241 | 50,241 | |
0.06569 % | Milnes (Alistair) | 45,321 | -955 | |
0.06427 % | Tekla Capital Management LLC_NLE | 44,338 | -44,338 | |
0.06249 % | Skynner (Michael) | 43,111 | -451 | |
0.05341 % | BNP Paribas Securities Corp. North America | 36,851 | 36,503 | |
0.05100 % | TD Asset Management Inc. | 35,186 | -46,600 | |
0.05075 % | SBI Okasan Asset Management Co., Ltd. | 35,012 | -22,988 | |
0.05056 % | Wexford Capital LP | 34,879 | 34,879 | |
0.05001 % | Jay A. Fishman, Ltd. | 34,500 | -3,000 | |
0.04915 % | Crockett (Nigel) | 33,910 | 19,357 | |
0.04450 % | Smethurst (Dominic) | 30,699 | 15,699 | |
0.04435 % | Allianz Global Investors Taiwan Ltd. | 30,600 | 13,600 | |
0.04348 % | Deka Vermögensmanagement GmbH | 30,000 | 0 | |
0.04286 % | State Street Global Advisors (US) | 29,566 | -6,300 | |
0.03868 % | Harbor Capital Advisors, Inc. | 26,688 | 2,478 | |
0.03807 % | Group One Trading, L.P. | 26,264 | -54,962 | |
0.03621 % | Woodstock Corporation | 24,981 | 3,502 | |
0.03556 % | Susquehanna International Group, LLP | 24,535 | -41,146 | |
0.03385 % | Tocqueville Asset Management LP | 23,350 | 23,350 | |
0.03383 % | Thompson (Travis Alvin) | 23,338 | -152 | |
0.03332 % | Assenagon Asset Management S.A. | 22,989 | 1,689 | |
0.02899 % | Bellevue Asset Management AG | 20,000 | -19,200 | |
0.02886 % | HRT Financial LP | 19,913 | 19,913 | |
0.02816 % | BlackRock Advisors (UK) Limited | 19,429 | 1,983 | |
0.02730 % | Geode Capital Management, L.L.C. | 18,837 | 1,693 | |
0.02681 % | Entrypoint Capital LLC | 18,495 | 18,495 | |
0.02463 % | BlackRock Asset Management Ireland Limited | 16,993 | 5,321 | |
0.02283 % | Legault (Pierre) | 15,750 | -5,750 | |
0.02265 % | Citi Investment Research (US) | 15,628 | 15,096 | |
0.02167 % | Barclays Bank PLC | 14,948 | 14,948 | |
0.02087 % | Horizon Kinetics LLC | 14,396 | -604 | |
0.02029 % | Erste Asset Management GmbH | 14,000 | 0 | |
0.02011 % | Jordan (Veronica G H) | 13,875 | 6,000 | |
0.02011 % | Kender (Richard N) | 13,875 | 6,000 | |
0.02011 % | Gutierrez-Ramos (Jose-Carlos) | 13,875 | 6,000 | |
0.01913 % | Deka Investment GmbH | 13,200 | 0 | |
0.01909 % | Manulife Investment Management (North America) Limited | 13,173 | -22,919 | |
0.01800 % | Exchange Traded Concepts, LLC | 12,421 | 5,694 | |