16.66953 % | RA Capital Management, LP | 10,108,400 | 0 | |
8.18408 % | Westfield Capital Management Company, L.P. | 4,962,824 | 887,610 | |
7.57589 % | Fidelity Management & Research Company LLC | 4,594,018 | -15,506 | |
7.08283 % | Artisan Partners Limited Partnership | 4,295,029 | -1,376,905 | |
6.92062 % | Avoro Capital Advisors LLC | 4,196,661 | 229,995 | |
6.46242 % | Janus Henderson Investors | 3,918,813 | 151,610 | |
4.30880 % | Wellington Management Company, LLP | 2,612,856 | -133,016 | |
3.47015 % | Capital International Investors | 2,104,298 | -87,014 | |
2.94220 % | T. Rowe Price Associates, Inc. | 1,784,148 | 2,222 | |
2.81879 % | MFS Investment Management | 1,709,315 | 92,577 | |
2.70955 % | Capital Research Global Investors | 1,643,074 | 0 | |
2.17389 % | Franklin Advisers, Inc. | 1,318,244 | 127,711 | |
1.75385 % | Invesco Advisers, Inc. | 1,063,536 | 151,825 | |
1.35309 % | Adage Capital Management, L.P. | 820,512 | 611,000 | |
1.26375 % | Putnam Investment Management, L.L.C. | 766,339 | -19,729 | |
1.23681 % | Vestal Point Capital, LP | 750,000 | 225,000 | |
1.21089 % | Sofinnova Investments, Inc | 734,284 | -19,748 | |
1.09549 % | Paradigm BioCapital Advisors LP | 664,307 | 156,355 | |
1.09315 % | Spyglass Capital Management LLC | 662,888 | 48,781 | |
1.08948 % | Columbia Threadneedle Investments (US) | 660,662 | 605,496 | |
0.98337 % | TimesSquare Capital Management, LLC | 596,314 | 20,616 | |
0.88681 % | Citadel Advisors LLC | 537,762 | 80,258 | |
0.86721 % | Medical Strategy GmbH | 525,874 | 6,780 | |
0.78937 % | Brown Advisory | 478,676 | -205,396 | |
0.78331 % | AllianceBernstein L.P. | 475,001 | 1,248 | |
0.78075 % | Millennium Management LLC | 473,449 | 111,389 | |
0.75416 % | Two Sigma Investments, LP | 457,320 | 81,720 | |
0.73367 % | Capital World Investors | 444,896 | 0 | |
0.72973 % | Fidelity International | 442,508 | 431,781 | |
0.69802 % | Mikkelsen Jan Moller | 423,279 | 423,279 | |
0.69517 % | Goldman Sachs & Company, Inc. | 421,551 | -15,541 | |
0.59803 % | BlackRock Institutional Trust Company, N.A. | 362,645 | -1,838 | |
0.57094 % | Voloridge Investment Management, LLC | 346,218 | 38,719 | |
0.54178 % | Fidelity Institutional Asset Management | 328,537 | -400 | |
0.51047 % | The Vanguard Group, Inc. | 309,552 | 0 | |
0.50639 % | Fred Alger Management, LLC | 307,073 | 120,952 | |
0.50457 % | American Century Investment Management, Inc. | 305,974 | -167 | |
0.47823 % | Rock Springs Capital Management LP | 290,000 | 0 | |
0.46559 % | Candriam Luxembourg S.A. | 282,331 | 0 | |
0.46428 % | D. E. Shaw & Co., L.P. | 281,537 | -58,581 | |
0.43630 % | SEI Investments Management Corporation | 264,571 | -81,615 | |
0.43389 % | ARS Investment Partners LLC | 263,111 | 9,972 | |
0.39128 % | BofA Global Research (US) | 237,273 | -17,107 | |
0.38534 % | Summit Partners Public Asset Management, LLC | 233,673 | 8,562 | |
0.37560 % | Tri Locum Partners LP | 227,762 | 115,092 | |
0.36190 % | Q Global Advisors, LLC | 219,459 | -65,541 | |
0.32778 % | Woodline Partners LP | 198,766 | 2,736 | |
0.32214 % | Candriam Belgium S.A. | 195,347 | 95,972 | |
0.31212 % | Finepoint Capital LP | 189,272 | 13,600 | |
0.30769 % | First Turn Management, LLC | 186,581 | 34,994 | |
0.29853 % | DWS Investment GmbH | 181,029 | -80,000 | |
0.29571 % | New York State Common Retirement Fund | 179,318 | -20,083 | |
0.26928 % | Norges Bank Investment Management (NBIM) | 163,290 | 163,290 | |
0.26898 % | BNP Paribas Asset Management USA, Inc. | 163,110 | 76,908 | |
0.26618 % | Allspring Global Investments, LLC | 161,410 | -17,842 | |
0.26486 % | Rice Hall James & Associates, LLC | 160,614 | 8,958 | |
0.26091 % | abrdn Inc. | 158,213 | -2,389 | |
0.24130 % | Pictet Asset Management Ltd. | 146,327 | -124,443 | |
0.23444 % | Acadian Asset Management LLC | 142,165 | -108,327 | |
0.22165 % | Victory Capital Management Inc. | 134,409 | -155 | |
0.21562 % | Pictet Asset Management (Japan) Ltd. | 130,751 | 49,552 | |
0.21120 % | BNP Paribas Securities Corp. North America | 128,074 | 52,534 | |
0.20052 % | Loomis, Sayles & Company, L.P. | 121,594 | 113,829 | |
0.18672 % | Saturn V Capital Management LP | 113,224 | 9,796 | |
0.16672 % | Invus Public Equities Advisors, LLC | 101,100 | 101,100 | |
0.16505 % | Morgan Stanley & Co. LLC | 100,086 | 15,919 | |
0.16491 % | Soros Fund Management, L.L.C. | 100,000 | 96,568 | |
0.16482 % | TD Asset Management Inc. | 99,946 | -136,924 | |
0.16184 % | Schonfeld Strategic Advisors LLC | 98,141 | -3,859 | |
0.14397 % | Harbor Capital Advisors, Inc. | 87,302 | 35,102 | |
0.14301 % | Ghost Tree Capital, LLC | 86,721 | 86,721 | |
0.13423 % | Driehaus Capital Management, LLC | 81,396 | -18,924 | |
0.13353 % | Dafna Capital Management, LLC | 80,972 | -11,500 | |
0.12918 % | Principal Global Investors (Equity) | 78,334 | -7,283 | |
0.12903 % | Thrivent Asset Management, LLC | 78,245 | -36,156 | |
0.12383 % | Mellon Investments Corporation | 75,093 | -35,108 | |
0.11720 % | Baillie Gifford & Co. | 71,071 | -10,135 | |
0.09894 % | Alyeska Investment Group, L.P. | 60,000 | 60,000 | |
0.09529 % | Geode Capital Management, L.L.C. | 57,786 | 1,684 | |
0.09412 % | AEGON Investment Management B.V. | 57,076 | 2,920 | |
0.09028 % | Qube Research & Technologies Ltd | 54,748 | 54,748 | |
0.08526 % | Gray Foundation | 51,700 | 0 | |
0.08454 % | Adar1 Capital Management LLC | 51,263 | 2,679 | |
0.08245 % | Altium Capital Management LP | 50,000 | 25,000 | |
0.07919 % | Goldman Sachs Asset Management International | 48,019 | 0 | |
0.07868 % | Manulife Investment Management (North America) Limited | 47,712 | -6,814 | |
0.07751 % | Resolute Capital Asset Partners LLC | 47,000 | 0 | |
0.07407 % | Schroder Investment Management Ltd. (SIM) | 44,918 | 44,918 | |
0.06914 % | Diversified Trust Company | 41,924 | 41,924 | |
0.05963 % | First Light Asset Management, LLC | 36,157 | 36,157 | |
0.05781 % | State Street Global Advisors (US) | 35,057 | 705 | |
0.05664 % | INVESCO Asset Management Limited | 34,346 | -10,124 | |
0.05558 % | Parametric Portfolio Associates LLC | 33,704 | -5,315 | |
0.05555 % | Matisse Capital | 33,684 | -1,045 | |
0.05504 % | Tudor Investment Corporation | 33,375 | 33,375 | |
0.05435 % | BlackRock Advisors (UK) Limited | 32,957 | 693 | |
0.05435 % | BlackRock Asset Management Ireland Limited | 32,957 | 2,018 | |
0.05040 % | T. Rowe Price Investment Management, Inc. | 30,564 | -2,538,339 | |
0.04996 % | Neuberger Berman, LLC | 30,296 | 30,296 | |
0.04995 % | Marshall Wace LLP | 30,289 | 5,205 | |