25.82835 % | EcoR1 Capital, LLC | 7,794,996 | 273,972 | |
7.25193 % | Fidelity Management & Research Company LLC | 2,188,633 | 2,047,887 | |
7.17558 % | Frazier Life Sciences Management, L.P. | 2,165,591 | 329,212 | |
5.12720 % | BlackRock Institutional Trust Company, N.A. | 1,547,389 | 61,248 | |
4.71108 % | The Vanguard Group, Inc. | 1,421,804 | 70,403 | |
4.40980 % | Tang Capital Management, LLC | 1,330,879 | 0 | |
4.30749 % | Boxer Capital, L.L.C. | 1,300,000 | 0 | |
3.20362 % | State Street Global Advisors (US) | 966,852 | -240,552 | |
2.66283 % | Palo Alto Investors LP | 803,641 | 3,735 | |
2.58170 % | First Light Asset Management, LLC | 779,158 | -164,952 | |
2.28470 % | Mangrove Partners | 689,521 | 0 | |
2.25972 % | Fidelity Institutional Asset Management | 681,985 | 681,985 | |
1.88311 % | Eventide Asset Management, LLC | 568,324 | 141,324 | |
1.65673 % | Camber Capital Management LP | 500,000 | 500,000 | |
1.57537 % | Assenagon Asset Management S.A. | 475,446 | 168,813 | |
1.54199 % | Franklin Advisers, Inc. | 465,373 | 0 | |
1.49790 % | Geode Capital Management, L.L.C. | 452,065 | 30,362 | |
1.33083 % | Faga (Daniel R) | 401,646 | 390,662 | |
1.23844 % | Millennium Management LLC | 373,762 | -273,363 | |
1.18533 % | 5AM Ventures | 357,733 | 0 | |
1.11310 % | Dimensional Fund Advisors, L.P. | 335,934 | -133,926 | |
0.97409 % | T. Rowe Price Associates, Inc. | 293,981 | 127,681 | |
0.87111 % | Two Sigma Investments, LP | 262,901 | 11,230 | |
0.84926 % | Parkman Healthcare Partners LLC | 256,307 | 256,307 | |
0.83620 % | Woodline Partners LP | 252,366 | -256,473 | |
0.82707 % | Saturn V Capital Management LP | 249,609 | -336,422 | |
0.56857 % | Schonfeld Strategic Advisors LLC | 171,593 | 171,593 | |
0.56809 % | D. E. Shaw & Co., L.P. | 171,450 | -15,354 | |
0.55982 % | Northern Trust Investments, Inc. | 168,953 | -4,485 | |
0.52059 % | Goldman Sachs & Company, Inc. | 157,113 | 40,621 | |
0.51623 % | Adar1 Capital Management LLC | 155,799 | 154,799 | |
0.51451 % | Charles Schwab Investment Management, Inc. | 155,278 | 9,007 | |
0.50597 % | Renaissance Technologies LLC | 152,702 | 52,502 | |
0.46554 % | ExodusPoint Capital Management, LP | 140,499 | 140,499 | |
0.44935 % | Nordea Funds Oy | 135,614 | 68,613 | |
0.36353 % | Jennison Associates LLC | 109,714 | 0 | |
0.34460 % | BofA Global Research (US) | 104,001 | 49,476 | |
0.31058 % | Macquarie Investment Management | 93,732 | 0 | |
0.27898 % | BlackRock Advisors (UK) Limited | 84,197 | 1,504 | |
0.27303 % | Platinum Asset Management | 82,401 | 16,247 | |
0.26833 % | Citadel Advisors LLC | 80,981 | -243,764 | |
0.26777 % | Topper (James N) | 80,812 | 0 | |
0.26456 % | UBS O'Connor LLC | 79,844 | -3,181 | |
0.26105 % | BlackRock Asset Management Ireland Limited | 78,786 | -13,181 | |
0.25101 % | Ensign Peak Advisors, Inc. | 75,755 | 32,313 | |
0.23877 % | Susquehanna Fundamental Investments, LLC | 72,060 | 17,855 | |
0.21535 % | Fisher Investments | 64,992 | -5,662 | |
0.20839 % | Wellington Management Company, LLP | 62,891 | 3,843 | |
0.19483 % | Morgan Stanley & Co. LLC | 58,799 | -544,168 | |
0.18998 % | BlackRock Financial Management, Inc. | 57,336 | -1,994 | |
0.18387 % | Nuveen LLC | 55,493 | -8,228 | |
0.18224 % | Hudson Bay Capital Management LP | 55,000 | -77,500 | |
0.17983 % | Cubist Systematic Strategies, LLC | 54,273 | 54,273 | |
0.17274 % | BlackRock Investment Management, LLC | 52,134 | 3,753 | |
0.17222 % | BNY Mellon Asset Management | 51,975 | 5,718 | |
0.16458 % | Rafferty Asset Management LLC | 49,671 | -41,023 | |
0.16142 % | Asset Management One Co., Ltd. | 48,718 | -6,886 | |
0.15640 % | Jacobs Levy Equity Management, Inc. | 47,203 | -2,186 | |
0.14368 % | Jane Street Capital, L.L.C. | 43,362 | 4,674 | |
0.12525 % | TD Asset Management Inc. | 37,800 | 15,200 | |
0.12401 % | Goldman Sachs Asset Management, L.P. | 37,426 | 3,487 | |
0.11947 % | Federated MDTA LLC | 36,057 | 16 | |
0.11829 % | Jump Financial, LLC | 35,700 | 35,700 | |
0.11793 % | FMB Wealth Management | 35,592 | 0 | |
0.11457 % | UBS Financial Services, Inc. | 34,578 | -29,588 | |
0.10113 % | AllianceBernstein L.P. | 30,520 | 1,990 | |
0.10106 % | Victory Capital Management Inc. | 30,500 | -6,180 | |
0.09936 % | Parametric Portfolio Associates LLC | 29,986 | -275 | |
0.09846 % | Rhumbline Advisers Ltd. Partnership | 29,715 | 525 | |
0.09488 % | Martingale Asset Management, L.P. | 28,635 | 0 | |
0.08852 % | Trexquant Investment LP | 26,714 | -5,803 | |
0.08387 % | Manulife Investment Management (North America) Limited | 25,312 | 8,418 | |
0.08284 % | Great Point Partners, LLC | 25,000 | -951,981 | |
0.07467 % | Mellon Investments Corporation | 22,535 | 4,705 | |
0.07419 % | Northern Trust Global Investments | 22,390 | -2,406 | |
0.07331 % | Aperio Group, LLC | 22,124 | 67 | |
0.07067 % | Alps Advisors, Inc. | 21,329 | 2,582 | |
0.06958 % | Schweizerische Nationalbank | 21,000 | 0 | |
0.06778 % | Y-Intercept (Hong Kong) Ltd | 20,455 | 20,455 | |
0.06726 % | Wells Fargo Advisors | 20,299 | 20,237 | |
0.06630 % | Barclays Bank PLC | 20,009 | -945 | |
0.06374 % | UBS Asset Management (Switzerland) | 19,236 | 2,315 | |
0.06125 % | Nordea Investment Management AB (Denmark) | 18,484 | -42,798 | |
0.05931 % | Point72 Asset Management, L.P. | 17,900 | -846,200 | |
0.05340 % | Legal & General Investment Management Ltd. | 16,115 | 2,315 | |
0.05275 % | Alpha DNA Investment Management LLC | 15,920 | 15,920 | |
0.05191 % | UBS Asset Management (UK) Ltd. | 15,666 | 159 | |
0.04605 % | Lizzul (Paul F.) | 13,898 | 3,780 | |
0.04589 % | PDT Partners, LLC | 13,850 | -2,439 | |
0.04507 % | XTX Markets LLC | 13,603 | -2,101 | |
0.04418 % | Tower Research Capital LLC | 13,334 | 12,087 | |
0.04125 % | Mirae Asset Global Investments (USA) LLC | 12,448 | 317 | |
0.04061 % | Invesco Capital Management LLC | 12,257 | -1,411 | |
0.04060 % | MetLife Investment Management, LLC | 12,254 | 1,211 | |
0.04003 % | Engineers Gate Manager, L.P. | 12,082 | 12,082 | |
0.04001 % | SG Americas Securities, L.L.C. | 12,076 | 12,076 | |
0.03895 % | BlackRock Investment Management (UK) Ltd. | 11,756 | 0 | |
0.03709 % | California State Teachers Retirement System | 11,194 | -254 | |
0.03706 % | Squarepoint Capital LLP | 11,185 | -482 | |
0.03660 % | Cresset Asset Management, LLC | 11,047 | 11,047 | |