9.55329 % | The Vanguard Group, Inc. | 28,546,190 | 384,297 | |
9.38973 % | Perceptive Advisors LLC | 28,057,456 | 0 | |
9.16971 % | Avoro Capital Advisors LLC | 27,400,000 | 0 | |
7.17328 % | BlackRock Institutional Trust Company, N.A. | 21,434,490 | 1,019,701 | |
7.06400 % | Wellington Management Company, LLP | 21,107,943 | 2,304,298 | |
4.42803 % | Janus Henderson Investors | 13,231,394 | -583,120 | |
4.35172 % | William Blair Investment Management, LLC | 13,003,363 | 1,477,084 | |
3.68695 % | State Street Global Advisors (US) | 11,016,963 | -1,425,538 | |
3.64629 % | JP Morgan Asset Management | 10,895,485 | -311,708 | |
3.54576 % | Redmile Group, LLC | 10,595,089 | -2,662,197 | |
3.02193 % | Palo Alto Investors LP | 9,029,843 | -314,259 | |
2.38319 % | Macquarie Investment Management | 7,121,222 | 50,489 | |
2.18164 % | Geode Capital Management, L.L.C. | 6,518,945 | 308,209 | |
1.74115 % | Fiera Capital Inc. | 5,202,718 | 36,807 | |
1.51853 % | Morgan Stanley & Co. LLC | 4,537,524 | -4,377,590 | |
1.41100 % | Pictet Asset Management Ltd. | 4,216,211 | -2,551,162 | |
1.31303 % | American Century Investment Management, Inc. | 3,923,465 | -877,434 | |
1.20489 % | JPMorgan Asset Management U.K. Limited | 3,600,334 | -479,256 | |
1.01086 % | MFS Investment Management | 3,020,536 | 378,999 | |
1.00964 % | Citadel Advisors LLC | 3,016,896 | 1,665,714 | |
0.97876 % | Norges Bank Investment Management (NBIM) | 2,924,645 | 393,645 | |
0.87772 % | DWS Investments UK Limited | 2,622,723 | -1,384,742 | |
0.84020 % | Invesco Advisers, Inc. | 2,510,592 | 2,269,255 | |
0.83665 % | Novo Holdings A/S | 2,500,000 | 0 | |
0.81142 % | Charles Schwab Investment Management, Inc. | 2,424,599 | 97,672 | |
0.78861 % | Northern Trust Investments, Inc. | 2,356,437 | -104,961 | |
0.76100 % | Victory Capital Management Inc. | 2,273,959 | 345,117 | |
0.68200 % | Assenagon Asset Management S.A. | 2,037,896 | 1,192,489 | |
0.63391 % | Millennium Management LLC | 1,894,176 | 1,792,277 | |
0.63141 % | Nuveen LLC | 1,886,725 | 748,625 | |
0.59626 % | Pictet Asset Management (Japan) Ltd. | 1,781,682 | 88,689 | |
0.59601 % | abrdn Inc. | 1,780,934 | 145,227 | |
0.52856 % | BlackRock Financial Management, Inc. | 1,579,378 | 448,832 | |
0.50049 % | Great Point Partners, LLC | 1,495,500 | 0 | |
0.50033 % | StemPoint Capital LP | 1,495,047 | -52,094 | |
0.47887 % | PanAgora Asset Management Inc. | 1,430,923 | -98,239 | |
0.43380 % | Voloridge Investment Management, LLC | 1,296,235 | -16,935 | |
0.43096 % | Voya Investment Management LLC | 1,287,754 | 255,038 | |
0.41282 % | Blackstone Alternative Credit Advisors LP | 1,233,552 | 0 | |
0.41282 % | Clarus Ventures, LLC | 1,233,552 | 0 | |
0.40781 % | Rock Springs Capital Management LP | 1,218,580 | 65,924 | |
0.40676 % | T. Rowe Price Associates, Inc. | 1,215,425 | -13,234 | |
0.37385 % | Balyasny Asset Management LP | 1,117,100 | 1,117,100 | |
0.37220 % | Managed Account Advisors LLC | 1,112,171 | -61,372 | |
0.35725 % | Hudson Bay Capital Management LP | 1,067,500 | 265,000 | |
0.35333 % | Goldman Sachs & Company, Inc. | 1,055,790 | 52,152 | |
0.35223 % | PRIMECAP Management Company | 1,052,500 | -41,700 | |
0.34748 % | Fidelity Management & Research Company LLC | 1,038,307 | -709,239 | |
0.32534 % | Rice Hall James & Associates, LLC | 972,138 | -146 | |
0.30706 % | New York State Common Retirement Fund | 917,514 | -633,662 | |
0.29969 % | BofA Global Research (US) | 895,516 | 147,304 | |
0.27482 % | Granite Investment Partners, LLC | 821,178 | -97,656 | |
0.26154 % | ExodusPoint Capital Management, LP | 781,517 | 138,132 | |
0.26061 % | BlackRock Investment Management, LLC | 778,728 | 51,887 | |
0.25495 % | Neuberger Berman, LLC | 761,810 | 293,158 | |
0.25048 % | M&G Investment Management Ltd. | 748,451 | 82,728 | |
0.24926 % | Peregrine Capital Management, LLC | 744,801 | -68,137 | |
0.23943 % | BNY Mellon Asset Management | 715,448 | 44,286 | |
0.23879 % | Saturn V Capital Management LP | 713,536 | -184,845 | |
0.23072 % | Osterweis Capital Management, LLC | 689,425 | 205,365 | |
0.21772 % | Squarepoint Capital LLP | 650,555 | 399,449 | |
0.21159 % | Jane Street Capital, L.L.C. | 632,266 | 484,899 | |
0.21151 % | Renaissance Technologies LLC | 632,024 | -324,176 | |
0.20745 % | Northern Trust Global Investments | 619,888 | -2,781 | |
0.19086 % | OrbiMed Advisors, LLC | 570,300 | 0 | |
0.18096 % | Silvercrest Asset Management Group LLC | 540,738 | 165,780 | |
0.17293 % | Wells Fargo Advisors | 516,740 | -6,912 | |
0.17068 % | Schroder Investment Management Ltd. (SIM) | 510,000 | 0 | |
0.16815 % | Parkman Healthcare Partners LLC | 502,463 | 275,740 | |
0.16354 % | Mellon Investments Corporation | 488,669 | 73,739 | |
0.16290 % | UBS Financial Services, Inc. | 486,767 | -411,129 | |
0.15781 % | Campbell (Bradley Lewis) | 471,552 | 0 | |
0.15283 % | Rafferty Asset Management LLC | 456,669 | -288,905 | |
0.15087 % | Envestnet Asset Management, Inc. | 450,823 | 16,263 | |
0.15060 % | CM Management, LLC | 450,000 | 0 | |
0.14545 % | Rhumbline Advisers Ltd. Partnership | 434,612 | 19,491 | |
0.14534 % | Schweizerische Nationalbank | 434,300 | 0 | |
0.13753 % | Goldman Sachs Asset Management, L.P. | 410,950 | 105,455 | |
0.13525 % | Medical Strategy GmbH | 404,130 | -38,612 | |
0.13345 % | Barclays Bank PLC | 398,767 | 106,792 | |
0.12743 % | Columbia Threadneedle Investments (US) | 380,787 | 8,391 | |
0.12437 % | Conestoga Capital Advisors, LLC | 371,627 | -3,575 | |
0.12048 % | DWS Investment GmbH | 360,000 | 30,000 | |
0.11770 % | BlackRock Advisors (UK) Limited | 351,695 | 5,245 | |
0.11708 % | State of Wisconsin Investment Board | 349,843 | 43,229 | |
0.11520 % | AllianceBernstein L.P. | 344,229 | 21,870 | |
0.11404 % | BNP Paribas Securities Corp. North America | 340,754 | -247,881 | |
0.11233 % | JPMorgan Private Bank (United States) | 335,652 | -273 | |
0.10939 % | Transcend Capital Advisors, LLC | 326,854 | -3,473 | |
0.10155 % | Susquehanna International Group, LLP | 303,448 | 201,825 | |
0.10143 % | PGIM Quantitative Solutions LLC | 303,069 | 223,035 | |
0.10032 % | BlackRock Asset Management Ireland Limited | 299,758 | 7,785 | |
0.09426 % | Ambassador Advisors, LLC | 281,659 | 8,151 | |
0.09354 % | Quimi (Daphne) | 279,509 | 29,518 | |
0.09096 % | Hillsdale Investment Management Inc. | 271,800 | -48,000 | |
0.08994 % | Essex Investment Management Company, LLC | 268,743 | 743 | |
0.08839 % | Allianz Global Investors GmbH | 264,111 | 0 | |
0.08506 % | RBC Capital Markets Wealth Management | 254,156 | 11,020 | |
0.08382 % | UBS Fund Management (Switzerland) AG | 250,464 | -72,080 | |
0.08376 % | Mutual of America Capital Management LLC | 250,293 | 48,802 | |