18.87544 % | Fidelity Management & Research Company LLC | 5,449,340 | 176,940 | |
16.00206 % | MDV Management Company, L.L.C. | 4,619,796 | 0 | |
13.85521 % | Armistice Capital LLC | 4,000,000 | 144,000 | |
13.56057 % | Stonepine Capital Management, LLC | 3,914,938 | 1,220,643 | |
10.84841 % | Magnetar Capital Partners LP | 3,131,937 | 3,131,937 | |
6.11372 % | The Vanguard Group, Inc. | 1,765,031 | 13,211 | |
5.14375 % | Swedbank Robur Fonder AB | 1,485,000 | 0 | |
5.05715 % | Opaleye Management Inc. | 1,460,000 | -210,600 | |
3.98337 % | Point72 Asset Management, L.P. | 1,150,000 | -1,101,255 | |
3.63389 % | Medical Strategy GmbH | 1,049,103 | 0 | |
2.77139 % | Cooper Creek Partners Management LLC | 800,100 | 0 | |
2.64362 % | Renaissance Technologies LLC | 763,212 | -19,600 | |
2.43595 % | Two Sigma Investments, LP | 703,258 | -413,601 | |
2.31225 % | MAI Capital Management, LLC | 667,546 | 123,730 | |
2.16650 % | Altium Capital Management LP | 625,469 | 154,520 | |
2.16515 % | Worth Venture Partners, LLC | 625,080 | 34,350 | |
2.02017 % | BlackRock Institutional Trust Company, N.A. | 583,223 | -13,551 | |
1.82067 % | Acadian Asset Management LLC | 525,628 | -67,637 | |
1.24953 % | Geode Capital Management, L.L.C. | 360,738 | 25,632 | |
1.23398 % | McFarlane (Neil F) | 356,250 | 300,000 | |
1.01638 % | D. E. Shaw & Co., L.P. | 293,428 | -175,432 | |
0.99772 % | SilverArc Capital Management, LLC | 288,042 | -250,702 | |
0.81795 % | BMO Capital Markets (US) | 236,142 | 236,142 | |
0.79559 % | BMO Asset Management U.S. | 229,688 | -12,702 | |
0.68237 % | MacPhee (John A) | 197,000 | 5,000 | |
0.48493 % | DCF Advisers, LLC | 140,000 | 0 | |
0.39799 % | Bridgeway Capital Management, LLC | 114,900 | -150,000 | |
0.39092 % | State Street Global Advisors (US) | 112,859 | 9,700 | |
0.39065 % | Mahoney (David L) | 112,781 | 5,000 | |
0.37485 % | Prentiss (Christopher B.) | 108,219 | 72,578 | |
0.34638 % | Healthcare Value Capital, LLC | 100,000 | 0 | |
0.34568 % | Shreedhar (Vishvanath) | 99,797 | -6,200 | |
0.33907 % | Newton Investment Management North America, LLC | 97,890 | 97,890 | |
0.33061 % | Northern Trust Investments, Inc. | 95,446 | 14,876 | |
0.31629 % | Mosaic Family Wealth, LLC | 91,314 | 0 | |
0.25277 % | BlackRock Financial Management, Inc. | 72,975 | 10,338 | |
0.23900 % | Lieberburg (Ivan M) | 69,000 | 5,000 | |
0.23119 % | BofA Global Research (US) | 66,745 | 6,406 | |
0.21880 % | Principal Global Investors (Equity) | 63,167 | -474 | |
0.20824 % | Morgan Stanley & Co. LLC | 60,118 | -6,115 | |
0.15006 % | Apo Asset Management GmbH | 43,322 | 0 | |
0.13351 % | Susquehanna International Group, LLP | 38,545 | 38,545 | |
0.11802 % | SG Americas Securities, L.L.C. | 34,073 | -42 | |
0.11614 % | Jacobs Levy Equity Management, Inc. | 33,530 | -17,173 | |
0.10523 % | BNY Mellon Asset Management | 30,381 | 0 | |
0.10218 % | Campbell & Company, Inc. | 29,500 | 29,500 | |
0.09621 % | Citadel Advisors LLC | 27,776 | 12,649 | |
0.09468 % | Asset Management One Co., Ltd. | 27,333 | 33 | |
0.09006 % | T. Rowe Price Associates, Inc. | 26,000 | -7,700 | |
0.08105 % | Zebra Capital Management, LLC | 23,400 | 0 | |
0.07341 % | HighVista Strategies LLC | 21,193 | 6,437 | |
0.07265 % | Papapetropoulos (Spyridon) | 20,975 | 5,000 | |
0.06923 % | Goldman Sachs Asset Management, L.P. | 19,986 | -3,765 | |
0.06543 % | Clear Harbor Asset Management, LLC | 18,889 | -1,500 | |
0.06517 % | Goldman Sachs & Company, Inc. | 18,816 | -21,489 | |
0.06191 % | Charles Schwab Investment Management, Inc. | 17,873 | 0 | |
0.05709 % | Group One Trading, L.P. | 16,483 | 16,483 | |
0.05542 % | Dowling & Yahnke, LLC | 16,000 | 0 | |
0.05542 % | Demski (Martha J) | 16,000 | 3,000 | |
0.05520 % | Algert Global LLC | 15,936 | 15,936 | |
0.05196 % | Richo (Anna S.) | 15,000 | 5,000 | |
0.04662 % | Cubist Systematic Strategies, LLC | 13,460 | -900 | |
0.04503 % | PNC Wealth Management | 13,000 | 3,000 | |
0.04337 % | Hightower Advisors, LLC | 12,521 | 0 | |
0.03907 % | Barclays Bank PLC | 11,279 | 5,553 | |
0.03879 % | United Bank, Inc. | 11,200 | 11,200 | |
0.03817 % | Nuveen Asset Management, LLC | 11,020 | 0 | |
0.03506 % | Capstone Investment Advisors, LLC | 10,123 | 10,123 | |
0.03182 % | BlackRock Japan Co., Ltd. | 9,185 | 0 | |
0.02840 % | Blackstone Alternative Investment Advisors LLC | 8,200 | 0 | |
0.02613 % | Northern Trust Global Investments | 7,545 | 0 | |
0.02600 % | BlackRock Investment Management, LLC | 7,507 | -803 | |
0.02425 % | Morgan Stanley Smith Barney LLC | 7,000 | 0 | |
0.02212 % | BlackRock Investment Management (UK) Ltd. | 6,386 | 0 | |
0.02032 % | Mackenzie Financial Corporation | 5,865 | 5,865 | |
0.01732 % | Bigham (Michael F) | 5,000 | 5,000 | |
0.01732 % | Dier (Mardi C) | 5,000 | 5,000 | |
0.01732 % | Ericson (William) | 5,000 | 5,000 | |
0.01705 % | BlackRock Fund Advisors | 4,923 | 4,923 | |
0.01455 % | Advisor Group, Inc | 4,200 | -2,000 | |
0.01239 % | Rockefeller Capital Management | 3,576 | 0 | |
0.00786 % | UBS Financial Services, Inc. | 2,270 | 685 | |
0.00381 % | Cutler Group, LP | 1,100 | 0 | |
0.00221 % | Truvestments Capital LLC | 637 | 0 | |
0.00104 % | Clearview Wealth Advisors LLC | 300 | 0 | |
0.00104 % | Wells Fargo Advisors | 300 | 0 | |
0.00077 % | Wells Fargo Bank, N.A. | 221 | -36 | |
0.00069 % | RBC Capital Markets Wealth Management | 200 | 0 | |
0.00026 % | BNY Mellon Wealth Management | 76 | 0 | |
0.00016 % | Aperio Group, LLC | 47 | 0 | |
0.00010 % | J.P. Morgan Securities plc | 28 | 0 | |
0.00000 % | BNP Paribas Securities Corp. North America | 1 | 0 | |
0 % | Walleye Capital LLC | 0 | -16,700 | |
0 % | AIGH Capital Management, LLC. | 0 | -2,585,743 | |
0 % | Avidity Partners Management LP | 0 | -2,200,200 | |
0 % | Maven Investment Partners US Ltd. | 0 | -250,000 | |
0 % | XTX Markets LLC | 0 | -16,357 | |
0 % | Jump Financial, LLC | 0 | -23,191 | |
0 % | Voya Investment Management LLC | 0 | -40,980 | |
0 % | Franklin Mutual Advisers, LLC | 0 | -1,243 | |