19.44272 % | BVF Partners L.P. | 19,522,436 | 0 | |
16.25012 % | DH Capital GmbH & Co. KG | 16,316,742 | 0 | |
11.95100 % | Varuma AG | 11,999,999 | 0 | |
6.40185 % | Affiris AG | 6,428,100 | -150,000 | |
2.41134 % | Pfeifer (Andrea M. A Ph.D.) | 2,421,226 | 56,308 | |
1.55685 % | BlackRock Financial Management, Inc. | 1,563,230 | -379,975 | |
1.03008 % | Redmile Group, LLC | 1,034,299 | -659,868 | |
0.99157 % | Wells Fargo Advisors | 995,636 | -112,402 | |
0.94818 % | Platinum Asset Management | 952,069 | 0 | |
0.73718 % | Renaissance Technologies LLC | 740,198 | 94,191 | |
0.42350 % | BlackRock Institutional Trust Company, N.A. | 425,233 | -31,168 | |
0.40139 % | Northern Trust Global Investments Limited | 403,031 | 403,031 | |
0.31068 % | Monin (Jean-Fabien) | 311,950 | 13,794 | |
0.25234 % | DWS Investment GmbH | 253,375 | 0 | |
0.20270 % | ARIAD Asset Management GmbH | 203,532 | -6,036 | |
0.19757 % | Acadian Asset Management LLC | 198,381 | 152,369 | |
0.14939 % | Handelsbanken Kapitalförvaltning AB | 150,000 | 0 | |
0.13087 % | Dimensional Fund Advisors, L.P. | 131,410 | 74,358 | |
0.13051 % | BlackRock Investment Management (UK) Ltd. | 131,044 | -36,167 | |
0.12268 % | Lanthaler (Werner) | 123,184 | 111,278 | |
0.11855 % | Millennium Management LLC | 119,040 | -47,100 | |
0.10370 % | Morgan Stanley & Co. LLC | 104,123 | 90,095 | |
0.06605 % | Marshall Wace LLP | 66,318 | -33,056 | |
0.06383 % | Geode Capital Management, L.L.C. | 64,090 | 5,794 | |
0.06217 % | Morgan Stanley Smith Barney LLC | 62,424 | 12,356 | |
0.05401 % | Two Sigma Investments, LP | 54,228 | -3,093 | |
0.05038 % | BlackRock Advisors (UK) Limited | 50,582 | 342 | |
0.05003 % | BlackRock Asset Management Ireland Limited | 50,240 | -4,104 | |
0.04948 % | UBS Financial Services, Inc. | 49,678 | 35,050 | |
0.04361 % | Squarepoint Capital LLP | 43,784 | 43,784 | |
0.04260 % | BlackRock Investment Management, LLC | 42,775 | -10,375 | |
0.03877 % | Williams (Douglas E) | 38,929 | 26,111 | |
0.03401 % | Twyman (Roy M.D.) | 34,150 | 34,150 | |
0.02694 % | Dimensional Fund Advisors, Ltd. | 27,049 | 4,030 | |
0.02490 % | Cantor Fitzgerald, L.P | 25,000 | 25,000 | |
0.02442 % | Donati (Piergiorgio) | 24,521 | 14,974 | |
0.02418 % | Jane Street Capital, L.L.C. | 24,283 | 24,283 | |
0.02192 % | Renta 4 Gestora, S.G.I.I.C., S.A. | 22,010 | -6,009 | |
0.02088 % | China Universal Asset Management Co., Ltd. | 20,970 | 1,949 | |
0.02005 % | Donovan (Howard) | 20,136 | 15,040 | |
0.01865 % | RPO LLC | 18,728 | 18,728 | |
0.01849 % | Banque Cantonale Vaudoise | 18,562 | -6,856 | |
0.01814 % | State of Wyoming | 18,219 | 1,618 | |
0.01399 % | Boothbay Fund Management, LLC | 14,046 | 14,046 | |
0.01255 % | Roberts (Christopher) | 12,601 | 10,101 | |
0.01162 % | Cubist Systematic Strategies, LLC | 11,667 | -2,604 | |
0.01121 % | Lazard Asset Management, L.L.C. | 11,256 | 11,256 | |
0.01006 % | Quinn Opportunity Partners LLC | 10,100 | 10,100 | |
0.00996 % | Compagnie Lombard Odier SCmA | 10,000 | 0 | |
0.00996 % | Silverberg Bernstein Capital Management, LLC | 10,000 | 0 | |
0.00911 % | Shaw (Monica M.D.) | 9,150 | 9,150 | |
0.00911 % | Butler (Monika) | 9,150 | 9,150 | |
0.00911 % | June (Carl) | 9,150 | 9,150 | |
0.00839 % | J.P. Morgan Securities plc | 8,424 | -2,272 | |
0.00819 % | Mendonca (Nuno) | 8,225 | 8,225 | |
0.00783 % | Citadel Advisors LLC | 7,863 | -13,943 | |
0.00748 % | SEI Investments Canada | 7,507 | 7,507 | |
0.00688 % | Tower Research Capital LLC | 6,913 | 4,028 | |
0.00585 % | Barclays Bank PLC | 5,872 | 5,382 | |
0.00457 % | ProShare Advisors LLC | 4,586 | -98 | |
0.00431 % | MFS Investment Management | 4,330 | 4,330 | |
0.00421 % | Mirae Asset Global Investments Co., Ltd. | 4,227 | 68 | |
0.00328 % | Mirae Asset Global Investments (USA) LLC | 3,296 | -281 | |
0.00316 % | Derouazi (Madiha) | 3,175 | 3,175 | |
0.00311 % | Zürcher Kantonalbank (Asset Management) | 3,123 | -540 | |
0.00288 % | BofA Global Research (US) | 2,888 | -1,091 | |
0.00272 % | Citi Investment Research (US) | 2,727 | 971 | |
0.00199 % | BNP Paribas Securities Corp. North America | 2,003 | -262 | |
0.00186 % | GF Fund Management Co., Ltd. | 1,867 | 331 | |
0.00100 % | Activest Wealth Management LLC | 1,000 | 0 | |
0.00076 % | RBC Dominion Securities, Inc. | 760 | 0 | |
0.00070 % | BlackRock Fund Advisors | 701 | -109 | |
0.00054 % | SBI Securities Co., Ltd. | 544 | 544 | |
0.00037 % | Capital Investment Trust Corporation | 367 | 0 | |
0.00022 % | RBC Capital Markets Wealth Management | 225 | 225 | |
0.00020 % | Hoopoe Advisors | 200 | 0 | |
0.00020 % | SJS Investment Services | 200 | 0 | |
0.00001 % | Morgan Stanley & Co. International Plc | 8 | -69 | |
0 % | Qube Research & Technologies Ltd | 0 | -48 | |
0 % | Vanguard Capital Wealth Advisors, LLC. | 0 | -14,000 | |
0 % | Ergoteles Capital | 0 | -20,014 | |
0 % | Osaic Holdings, Inc. | 0 | -2,000 | |
0 % | Schonfeld Strategic Advisors LLC | 0 | -11,400 | |
0 % | Man Investments Inc | 0 | -37 | |
0 % | Watch Point Trust Company LLC | 0 | -12,850 | |
0 % | Eversept Partners, LP | 0 | -99,313 | |
0 % | Simplex Trading, LLC | 0 | -635 | |
0 % | Bruno Walter Finance SA | 0 | -5,372 | |
0 % | Group One Trading, L.P. | 0 | -24,074 | |
0 % | Belpointe Asset Management LLC | 0 | -1,000 | |
0 % | Glassman Wealth Services LLC | 0 | -26 | |
0 % | Landscape Capital Management, L.L.C. | 0 | -117,418 | |
0 % | Assenagon Asset Management S.A. | 0 | -223,880 | |
0 % | Mariner Wealth Advisors | 0 | -14,368 | |
0 % | Virtu Americas LLC | 0 | -11,552 | |
0 % | Alps Advisors, Inc. | 0 | -76,630 | |
0 % | Nixon Peabody Financial Advisors LLC | 0 | -12,850 | |
0 % | Susquehanna International Group, LLP | 0 | -71,487 | |
0 % | Man Investments, Ltd. | 0 | -19 | |
0 % | Invesco Capital Management LLC | 0 | -17,362 | |