9.83 % | EcoR1 Capital, LLC | 67,26,491 | 12,59,428 | 31/12/2023 |
7.08 % | The Vanguard Group, Inc. | 48,42,174 | 2,43,167 | 31/12/2023 |
6.16 % | RTW Investments L.P. | 42,13,483 | 42,13,483 | 31/12/2023 |
6.09 % | BlackRock Institutional Trust Company, N.A. | 41,68,085 | 3,57,244 | 31/12/2023 |
5.45 % | T. Rowe Price Associates, Inc. | 37,28,873 | 11,32,898 | 31/12/2023 |
4.36 % | Avidity Partners Management LP | 29,85,117 | 3,70,157 | 31/12/2023 |
3.66 % | Bellevue Asset Management AG | 25,07,731 | 3,82,531 | 31/12/2023 |
3.57 % | Citadel Advisors LLC | 24,39,981 | 18,15,403 | 31/12/2023 |
2.48 % | Nextech Invest, Ltd. | 16,95,645 | 14,08,394 | 31/12/2023 |
2.29 % | ArrowMark Colorado Holdings, LLC | 15,69,895 | -5,17,397 | 31/12/2023 |
1.88 % | New Leaf Venture Partners LLC | 12,89,521 | 0 | 31/12/2023 |
1.74 % | Fidelity Institutional Asset Management | 11,89,011 | -3,74,164 | 31/12/2023 |
1.73 % | State Street Global Advisors (US) | 11,86,474 | 27,022 | 31/12/2023 |
1.64 % | Geode Capital Management, L.L.C. | 11,22,627 | 65,237 | 31/12/2023 |
1.57 % | JP Morgan Asset Management | 10,73,854 | -1,38,077 | 31/12/2023 |
1.54 % | Fidelity Management & Research Company LLC | 10,55,008 | -22,50,112 | 31/12/2023 |
1.54 % | Houston (John G) | 10,54,191 | 1,19,254 | 23/2/2024 |
1.49 % | JPMorgan Asset Management U.K. Limited | 10,17,463 | 3,07,192 | 31/12/2023 |
1.46 % | Commodore Capital LP | 10,00,000 | 10,00,000 | 31/12/2023 |
1.36 % | Paradigm BioCapital Advisors LP | 9,31,303 | 9,31,303 | 31/12/2023 |
1.28 % | Norges Bank Investment Management (NBIM) | 8,77,708 | 1,75,953 | 31/12/2023 |
1.15 % | Adage Capital Management, L.P. | 7,89,485 | 7,89,485 | 31/12/2023 |
1.09 % | Holocene Advisors, LP | 7,44,465 | 7,44,465 | 31/12/2023 |
1.09 % | BlackRock Financial Management, Inc. | 7,43,728 | -6,676 | 31/12/2023 |
0.92 % | VR Adviser, LLC | 6,27,788 | 6,27,788 | 31/12/2023 |
0.89 % | Boxer Capital, L.L.C. | 6,08,614 | 6,08,614 | 31/12/2023 |
0.83 % | Morgan Stanley & Co. LLC | 5,66,003 | 2,45,460 | 31/12/2023 |
0.74 % | Finepoint Capital LP | 5,04,700 | 0 | 31/12/2023 |
0.72 % | Dimensional Fund Advisors, L.P. | 4,91,877 | 22,479 | 31/12/2023 |
0.71 % | Aquilo Capital Management, LLC | 4,89,153 | 0 | 31/12/2023 |
0.71 % | Candriam Belgium S.A. | 4,87,555 | 40,004 | 31/12/2023 |
0.69 % | Charles Schwab Investment Management, Inc. | 4,69,474 | 39,484 | 31/12/2023 |
0.68 % | Candriam Luxembourg S.A. | 4,62,536 | -25,000 | 29/2/2024 |
0.65 % | Northern Trust Investments, Inc. | 4,42,512 | 24,794 | 31/12/2023 |
0.62 % | RA Capital Management, LP | 4,21,348 | 4,21,348 | 31/12/2023 |
0.58 % | American Century Investment Management, Inc. | 3,95,367 | -4,18,102 | 31/12/2023 |
0.57 % | Woodline Partners LP | 3,87,630 | 2,15,030 | 31/12/2023 |
0.52 % | Millennium Management LLC | 3,58,813 | -4,69,314 | 31/12/2023 |
0.52 % | Nuveen LLC | 3,54,898 | 17,738 | 31/12/2023 |
0.52 % | Perceptive Advisors LLC | 3,54,082 | 3,54,082 | 31/12/2023 |
0.49 % | Gilder Gagnon Howe & Co. LLC | 3,33,524 | 1,62,674 | 31/12/2023 |
0.45 % | Voloridge Investment Management, LLC | 3,09,663 | 3,09,663 | 31/12/2023 |
0.42 % | Frazier Healthcare Partners | 2,85,331 | 0 | 31/12/2023 |
0.41 % | Nordea Funds Oy | 2,78,737 | -6,317 | 31/12/2023 |
0.39 % | Brown Advisory | 2,65,431 | -1,70,163 | 31/12/2023 |
0.39 % | Opaleye Management Inc. | 2,63,700 | 2,63,700 | 31/12/2023 |
0.38 % | UBS Financial Services, Inc. | 2,56,986 | -62,752 | 31/12/2023 |
0.36 % | Schonfeld Strategic Advisors LLC | 2,45,868 | 1,81,874 | 31/12/2023 |
0.35 % | Renaissance Technologies LLC | 2,37,573 | 1,23,873 | 31/12/2023 |
0.34 % | Great Point Partners, LLC | 2,34,082 | 2,34,082 | 31/12/2023 |
0.32 % | Goldman Sachs & Company, Inc. | 2,15,728 | 1,15,219 | 31/12/2023 |
0.31 % | BlackRock Advisors (UK) Limited | 2,08,919 | 10,242 | 31/3/2024 |
0.30 % | Wasatch Global Investors Inc | 2,07,426 | -15,516 | 31/3/2024 |
0.29 % | BNP Paribas Securities Corp. North America | 1,97,052 | 97,661 | 31/12/2023 |
0.29 % | Amundi Asset Management US, Inc. | 1,95,720 | 4,423 | 31/12/2023 |
0.27 % | Cassidy (Sean A) | 1,86,707 | -1,702 | 23/2/2024 |
0.26 % | Integral Health Asset Management, LLC | 1,75,000 | 1,75,000 | 31/12/2023 |
0.26 % | BlackRock Asset Management Ireland Limited | 1,74,728 | 974 | 31/12/2023 |
0.24 % | Parkman Healthcare Partners LLC | 1,67,001 | 62,884 | 31/12/2023 |
0.23 % | UBS Asset Management (Americas), Inc. | 1,55,129 | 45,932 | 31/12/2023 |
0.23 % | BofA Global Research (US) | 1,55,036 | 47,492 | 31/12/2023 |
0.22 % | Invesco Capital Management LLC | 1,50,516 | 1,29,312 | 31/12/2023 |
0.22 % | Taylor (Ian) | 1,50,207 | 37,549 | 23/2/2024 |
0.22 % | Wanjia Asset Management Co., Ltd. | 1,50,000 | 0 | 30/6/2023 |
0.22 % | BlackRock Investment Management, LLC | 1,49,116 | 26,694 | 31/12/2023 |
0.21 % | TD Asset Management Inc. | 1,46,948 | 52,076 | 31/12/2023 |
0.21 % | Yale University | 1,43,522 | 1,43,522 | 31/12/2023 |
0.21 % | Credit Suisse Funds AG | 1,42,108 | 86,845 | 31/12/2023 |
0.20 % | Citi Investment Research (US) | 1,38,656 | 1,33,966 | 31/12/2023 |
0.20 % | Federated MDTA LLC | 1,38,028 | 33,770 | 31/12/2023 |
0.20 % | BNY Mellon Asset Management | 1,36,085 | -2,556 | 31/12/2023 |
0.20 % | Rhenman & Partners Asset Management AB | 1,34,270 | 49,270 | 31/12/2023 |
0.19 % | Nordea Investment Management AB (Denmark) | 1,31,494 | 55 | 29/2/2024 |
0.17 % | First Trust Advisors L.P. | 1,14,105 | 1,569 | 29/2/2024 |
0.17 % | Goldman Sachs Asset Management, L.P. | 1,13,731 | 19,590 | 31/12/2023 |
0.15 % | T. Rowe Price International Ltd | 1,03,250 | 10,554 | 31/12/2023 |
0.15 % | Putnam Investment Management, L.L.C. | 1,03,118 | 87,671 | 31/12/2023 |
0.15 % | Parametric Portfolio Associates LLC | 1,01,826 | 36,189 | 31/12/2023 |
0.14 % | Jane Street Capital, L.L.C. | 97,217 | 46,894 | 31/12/2023 |
0.14 % | Banque Pictet & Cie S.A. | 92,933 | 92,933 | 31/12/2023 |
0.13 % | UBS O'Connor LLC | 91,132 | -19,050 | 31/12/2023 |
0.13 % | Schweizerische Nationalbank | 89,500 | -10,200 | 31/12/2023 |
0.13 % | Manulife Investment Management (North America) Limited | 89,228 | 21,911 | 31/12/2023 |
0.12 % | D. E. Shaw & Co., L.P. | 84,931 | 64,131 | 31/12/2023 |
0.12 % | Barclays Bank PLC | 83,621 | 49,824 | 31/12/2023 |
0.12 % | Shannon (Timothy M) | 80,643 | 0 | 31/3/2023 |
0.12 % | Tang Capital Management, LLC | 80,000 | 0 | 31/12/2023 |
0.11 % | Algert Global LLC | 74,571 | -98,847 | 31/12/2023 |
0.11 % | HOOPP Investment Management | 74,000 | 74,000 | 31/12/2023 |
0.11 % | Columbia Threadneedle Investments (US) | 73,975 | 15,190 | 31/12/2023 |
0.10 % | Zacks Investment Management, Inc. | 71,695 | 64,306 | 31/12/2023 |
0.10 % | CastleArk Management, LLC | 71,570 | 71,570 | 31/12/2023 |
0.10 % | JPMorgan Private Bank (United States) | 70,612 | 22,263 | 31/12/2023 |
0.10 % | Rhumbline Advisers Ltd. Partnership | 68,890 | -110 | 31/12/2023 |
0.10 % | Conestoga Capital Advisors, LLC | 67,640 | -1,837 | 29/2/2024 |
0.10 % | Bank Vontobel AG | 66,000 | 66,000 | 31/12/2023 |
0.10 % | Sectoral Asset Management Inc. | 66,000 | 58,990 | 31/12/2023 |
0.09 % | Berkowitz (Noah) | 63,452 | 63,452 | 18/3/2024 |
0.09 % | Hennion & Walsh Asset Management, Inc. | 61,862 | 25,778 | 31/3/2024 |
0.09 % | Trexquant Investment LP | 61,243 | 61,243 | 31/12/2023 |