5.70 % | Adage Capital Management, L.P. | 53,98,825 | 28,79,568 | 9/2/2023 |
5.09 % | BlackRock Institutional Trust Company, N.A. | 48,23,128 | 4,87,993 | 31/12/2022 |
4.35 % | The Vanguard Group, Inc. | 41,24,924 | 5,28,638 | 31/12/2022 |
2.71 % | Leon (Francisco) | 25,73,000 | 0 | 13/2/2023 |
2.71 % | Palmer (Ashleigh) | 25,70,050 | 0 | 13/2/2023 |
12.53 % | Sessa Capital | 1,18,79,023 | -30,00,000 | 18/1/2023 |
1.64 % | State Street Global Advisors (US) | 15,58,238 | 2,63,813 | 31/12/2022 |
1.39 % | Geode Capital Management, L.L.C. | 13,22,189 | 1,25,392 | 31/12/2022 |
1.21 % | D. E. Shaw & Co., L.P. | 11,43,300 | 10,38,757 | 31/12/2022 |
1.18 % | VR Adviser, LLC | 11,18,653 | 0 | 31/12/2022 |
0.95 % | BioImpact Capital LLC | 8,98,483 | 1,58,139 | 31/12/2022 |
0.88 % | Verition Fund Management LLC | 8,38,716 | -28,449 | 31/12/2022 |
0.70 % | Two Sigma Investments, LP | 6,65,730 | 5,06,008 | 31/12/2022 |
0.58 % | 683 Capital Management LLC | 5,50,000 | 5,50,000 | 31/12/2022 |
0.57 % | Northern Trust Investments, Inc. | 5,38,434 | 41,127 | 31/12/2022 |
0.54 % | Invesco Capital Management LLC | 5,12,298 | 5,09,787 | 31/12/2022 |
0.45 % | Millennium Management LLC | 4,23,295 | 4,23,295 | 31/12/2022 |
0.43 % | Nuveen LLC | 4,11,306 | 29,409 | 31/12/2022 |
0.42 % | Ghost Tree Capital, LLC | 4,00,000 | 4,00,000 | 31/12/2022 |
0.41 % | Palo Alto Investors LP | 3,90,800 | 0 | 31/12/2022 |
0.37 % | BlackRock Advisors (UK) Limited | 3,52,214 | 2,658 | 28/2/2023 |
0.35 % | Medical Strategy GmbH | 3,34,200 | 0 | 30/9/2022 |
0.35 % | BlackRock Asset Management Ireland Limited | 3,33,685 | 21,052 | 31/12/2022 |
0.34 % | Banque Lombard Odier & Cie SA | 3,22,895 | 3,22,895 | 31/12/2022 |
0.34 % | Lombard Odier Asset Management (Europe) Ltd | 3,22,792 | 1,47,734 | 31/12/2022 |
0.33 % | Voloridge Investment Management, LLC | 3,10,693 | 3,10,693 | 31/12/2022 |
0.32 % | Schonfeld Strategic Advisors LLC | 3,06,546 | 3,06,546 | 31/12/2022 |
0.30 % | Advisory Research, Inc. | 2,88,707 | 53,707 | 31/12/2022 |
0.29 % | EAM Investors, LLC | 2,76,250 | 2,76,250 | 31/12/2022 |
0.28 % | Jane Street Capital, L.L.C. | 2,61,657 | 2,50,153 | 31/12/2022 |
0.25 % | Principal Global Investors (Equity) | 2,39,073 | 2,23,922 | 31/12/2022 |
0.24 % | Cubist Systematic Strategies, LLC | 2,29,409 | 1,31,483 | 31/12/2022 |
0.22 % | EAM Global Investors LLC | 2,09,856 | 2,09,856 | 31/12/2022 |
0.21 % | Morgan Stanley & Co. LLC | 1,95,233 | -1,36,881 | 31/12/2022 |
0.21 % | BNY Mellon Asset Management | 1,94,536 | 13,234 | 31/12/2022 |
0.20 % | Group One Trading, L.P. | 1,88,342 | 43,659 | 31/12/2022 |
0.20 % | Schweizerische Nationalbank | 1,87,100 | 60,200 | 31/12/2022 |
0.19 % | Cabot Wealth Management, Inc. | 1,84,271 | 1,84,271 | 31/12/2022 |
0.19 % | Rice Hall James & Associates, LLC | 1,81,980 | -39,621 | 31/12/2022 |
0.19 % | Monticello Wealth Management, LLC | 1,80,555 | 0 | 31/12/2022 |
0.19 % | Charles Schwab Investment Management, Inc. | 1,76,464 | 11,358 | 31/12/2022 |
0.18 % | BlackRock Financial Management, Inc. | 1,68,536 | -10,213 | 31/12/2022 |
0.17 % | BlackRock Investment Management, LLC | 1,63,214 | 5,947 | 31/12/2022 |
0.16 % | Sigma Planning Corporation | 1,53,790 | 100 | 31/12/2022 |
0.16 % | Parametric Portfolio Associates LLC | 1,52,168 | 1,39,464 | 31/12/2022 |
0.14 % | Goldman Sachs & Company, Inc. | 1,28,006 | -21,008 | 31/12/2022 |
0.12 % | Susquehanna International Group, LLP | 1,14,911 | -68,229 | 31/12/2022 |
0.11 % | Qube Research & Technologies Ltd | 1,01,371 | 1,01,371 | 31/12/2022 |
0.10 % | Candriam Belgium S.A. | 97,509 | -1,10,142 | 31/12/2022 |
0.10 % | California State Teachers Retirement System | 92,471 | 22,342 | 31/12/2022 |
0.10 % | AllianceBernstein L.P. | 91,600 | 0 | 31/12/2022 |
0.10 % | Goldman Sachs Asset Management, L.P. | 91,264 | 14,955 | 31/12/2022 |
0.09 % | Credit Suisse Asset Management | 89,768 | 54,558 | 31/12/2022 |
0.09 % | ClariVest Asset Management LLC | 84,966 | 84,966 | 31/12/2022 |
0.09 % | Rhumbline Advisers Ltd. Partnership | 81,291 | 6,427 | 31/12/2022 |
0.08 % | State of Wisconsin Investment Board | 77,662 | 67,520 | 31/12/2022 |
0.08 % | Dimensional Fund Advisors, L.P. | 76,109 | -472 | 31/12/2022 |
0.07 % | Ramos (Eleanor L) | 70,000 | 0 | 21/3/2022 |
0.07 % | Macquarie Investment Management | 70,000 | 0 | 31/12/2022 |
0.07 % | Polen Capital Management, LLC | 67,333 | 0 | 31/1/2023 |
0.07 % | Russell Investments Trust Company | 67,333 | 0 | 31/12/2022 |
0.07 % | Jump Financial, LLC | 67,074 | 67,074 | 31/12/2022 |
0.07 % | Northern Trust Global Investments | 64,280 | 2,401 | 31/12/2022 |
0.06 % | State Street Global Advisors Ireland Limited | 60,275 | 267 | 31/1/2023 |
0.06 % | Wells Fargo Advisors | 59,848 | 55,738 | 31/12/2022 |
0.06 % | Mackenzie Financial Corporation | 57,141 | 47,909 | 31/12/2022 |
0.05 % | Assenagon Asset Management S.A. | 52,053 | -2,059 | 28/2/2023 |
0.05 % | BofA Global Research (US) | 49,706 | -17,471 | 31/12/2022 |
0.05 % | Victory Capital Management Inc. | 49,640 | 49,640 | 31/12/2022 |
0.05 % | Simplex Trading, LLC | 49,380 | 13,447 | 31/12/2022 |
0.05 % | LPL Financial LLC | 47,783 | 17,900 | 31/12/2022 |
0.05 % | Squarepoint Capital LLP | 44,899 | 44,899 | 31/12/2022 |
0.05 % | UBS Financial Services, Inc. | 43,249 | 11,297 | 31/12/2022 |
0.05 % | Citadel Advisors LLC | 42,764 | -1,91,162 | 31/12/2022 |
0.04 % | UBS Asset Management (Switzerland) | 41,628 | 11,912 | 31/12/2022 |
0.04 % | BlackRock Investment Management (UK) Ltd. | 41,626 | 10,970 | 31/12/2022 |
0.04 % | Morgan Stanley Smith Barney LLC | 39,846 | 537 | 31/12/2022 |
0.04 % | Mellon Investments Corporation | 39,699 | 7,186 | 31/12/2022 |
0.04 % | Bluestone (Jeffrey Ph.D.) | 39,571 | 0 | 21/3/2022 |
0.04 % | JPMorgan Private Bank (United States) | 36,850 | 4,610 | 31/12/2022 |
0.04 % | New York State Common Retirement Fund | 34,909 | 7,701 | 31/12/2022 |
0.04 % | PGIM Quantitative Solutions LLC | 33,950 | 450 | 31/12/2022 |
0.03 % | Engineers Gate Manager, L.P. | 32,148 | 32,148 | 31/12/2022 |
0.03 % | Gotham Asset Management, LLC | 31,595 | 31,595 | 31/12/2022 |
0.03 % | T. Rowe Price International Ltd | 31,137 | 1,578 | 31/12/2022 |
0.03 % | LifeSci Index Partners, LLC | 31,095 | 0 | 28/2/2023 |
0.03 % | Virtus Etf Advisers LLC | 31,095 | 31,095 | 31/12/2022 |
0.03 % | MetLife Investment Management, LLC | 30,784 | 0 | 31/12/2022 |
0.03 % | Mirae Asset Global Investments (USA) LLC | 30,005 | 5,164 | 31/12/2022 |
0.03 % | Cambridge Investment Research Advisors, Inc. | 29,895 | 13,900 | 31/12/2022 |
0.03 % | SunAmerica Asset Management, LLC | 29,840 | 1,829 | 31/12/2022 |
0.03 % | Granite Investment Partners, LLC | 28,883 | -714 | 31/1/2023 |
0.03 % | Legal & General Investment Management Ltd. | 28,154 | 7,143 | 31/12/2022 |
0.03 % | Aperio Group, LLC | 27,795 | 18,993 | 31/12/2022 |
0.03 % | DWS Investments UK Limited | 27,484 | 4,538 | 31/12/2022 |
0.03 % | SEI Investments Management Corporation | 27,341 | 1,401 | 31/1/2023 |
0.03 % | UBS Asset Management (UK) Ltd. | 26,417 | 26,417 | 31/12/2022 |
0.03 % | Hightower Advisors, LLC | 25,820 | 2,205 | 31/12/2022 |
0.03 % | Barclays Bank PLC | 24,846 | 24,846 | 31/12/2022 |
0.03 % | Manulife Investment Management (North America) Limited | 24,740 | 354 | 31/12/2022 |