8.19 % | EcoR1 Capital, LLC | 57,48,399 | 57,48,399 | 22/9/2023 |
7.92 % | Avoro Capital Advisors LLC | 55,55,555 | 0 | 30/6/2023 |
7.08 % | The Vanguard Group, Inc. | 49,69,806 | -72,295 | 30/6/2023 |
6.38 % | RTW Investments L.P. | 44,72,985 | 8,29,871 | 30/6/2023 |
5.67 % | Armistice Capital LLC | 39,78,000 | 2,86,000 | 30/6/2023 |
4.83 % | Wellington Management Company, LLP | 33,88,365 | 6,92,273 | 30/6/2023 |
4.56 % | Boxer Capital, L.L.C. | 32,01,440 | 0 | 8/10/2023 |
4.47 % | Aviva Holdings Ltd. | 31,35,966 | 0 | 8/10/2023 |
3.97 % | Morgan Stanley & Co. LLC | 27,83,869 | 10,23,058 | 30/6/2023 |
3.68 % | State Street Global Advisors (US) | 25,81,739 | 2,71,919 | 30/6/2023 |
3.03 % | BlackRock Institutional Trust Company, N.A. | 21,27,589 | -2,501 | 30/6/2023 |
2.93 % | Invus Public Equities Advisors, LLC | 20,55,181 | 5,17,472 | 30/6/2023 |
2.57 % | Camber Capital Management LP | 18,00,000 | 4,00,000 | 30/6/2023 |
2.50 % | T. Rowe Price Associates, Inc. | 17,52,033 | 6,016 | 30/6/2023 |
2.06 % | Paradigm BioCapital Advisors LP | 14,43,762 | 46,983 | 30/6/2023 |
2.01 % | Baker Bros. Advisors LP | 14,09,784 | 0 | 30/6/2023 |
1.60 % | Rock Springs Capital Management LP | 11,21,647 | 56,386 | 30/6/2023 |
1.30 % | OrbiMed Advisors, LLC | 9,13,650 | 0 | 30/6/2023 |
1.27 % | Candriam Luxembourg S.A. | 8,93,738 | 20,000 | 31/8/2023 |
1.25 % | Candriam Belgium S.A. | 8,73,763 | 1,09,498 | 30/6/2023 |
1.15 % | Assenagon Asset Management S.A. | 8,08,820 | 5,52,860 | 30/6/2023 |
1.09 % | Geode Capital Management, L.L.C. | 7,64,483 | 29,195 | 30/6/2023 |
1.07 % | Octagon Capital Advisors LP | 7,50,000 | 0 | 30/6/2023 |
1.03 % | Perceptive Advisors LLC | 7,19,103 | -8,55,031 | 30/6/2023 |
0.99 % | Fiera Capital Corporation | 6,92,033 | -17,494 | 30/6/2023 |
0.92 % | Franklin Advisers, Inc. | 6,46,837 | -5 | 30/6/2023 |
0.86 % | Eventide Asset Management, LLC | 6,00,000 | 2,28,898 | 30/6/2023 |
0.85 % | BlackRock Financial Management, Inc. | 5,93,087 | 60,997 | 30/6/2023 |
0.83 % | Marshall Wace LLP | 5,84,323 | 31,709 | 30/6/2023 |
0.76 % | Credit Suisse Funds AG | 5,29,690 | 6,335 | 30/6/2023 |
0.72 % | Millennium Management LLC | 5,05,309 | 4,86,275 | 30/6/2023 |
0.69 % | Citadel Advisors LLC | 4,81,818 | 3,91,174 | 30/6/2023 |
0.68 % | Norges Bank Investment Management (NBIM) | 4,75,992 | 62,003 | 31/12/2022 |
0.67 % | Dimensional Fund Advisors, L.P. | 4,72,468 | 1,67,874 | 30/6/2023 |
0.62 % | Charles Schwab Investment Management, Inc. | 4,36,048 | 5,554 | 30/6/2023 |
0.58 % | Voloridge Investment Management, LLC | 4,06,035 | -2,72,623 | 30/6/2023 |
0.53 % | Woodline Partners LP | 3,73,332 | 1,07,232 | 30/6/2023 |
0.41 % | MVA Investors LLC | 2,87,866 | 0 | 8/10/2023 |
0.37 % | D. E. Shaw & Co., L.P. | 2,62,938 | 17,352 | 30/6/2023 |
0.37 % | International Biotechnology Trust PLC | 2,60,000 | 16,000 | 30/6/2023 |
0.37 % | UBS Asset Management (Switzerland) | 2,57,001 | 63,265 | 31/3/2023 |
0.36 % | BlackRock Investment Management (UK) Ltd. | 2,54,032 | -6,748 | 30/6/2023 |
0.35 % | BlackRock Asset Management Ireland Limited | 2,42,715 | 6,294 | 30/6/2023 |
0.34 % | Braidwell LP | 2,40,625 | -2,11,375 | 30/6/2023 |
0.33 % | New York State Common Retirement Fund | 2,32,860 | 643 | 30/6/2023 |
0.33 % | Nuveen LLC | 2,31,885 | -28,524 | 30/6/2023 |
0.33 % | Jane Street Capital, L.L.C. | 2,29,883 | 80,755 | 30/6/2023 |
0.32 % | Susquehanna International Group, LLP | 2,25,101 | -1,37,511 | 30/6/2023 |
0.32 % | Allspring Global Investments, LLC | 2,22,737 | -10,302 | 30/6/2023 |
0.32 % | Jacobs Levy Equity Management, Inc. | 2,21,763 | 13,000 | 30/6/2023 |
0.31 % | Rafferty Asset Management LLC | 2,18,639 | 45,123 | 30/6/2023 |
0.29 % | Dissanayake (Shehan Bharath) | 2,03,754 | 0 | 8/10/2023 |
0.29 % | Ghost Tree Capital, LLC | 2,00,000 | 60,000 | 30/6/2023 |
0.29 % | DWS Investment GmbH | 2,00,000 | -15,654 | 30/6/2023 |
0.28 % | BofA Global Research (US) | 1,97,267 | -59,553 | 30/6/2023 |
0.27 % | 5AM Ventures | 1,92,500 | 1,92,500 | 30/6/2023 |
0.26 % | Edmond de Rothschild Asset Management (France) S.A. | 1,84,060 | 0 | 30/6/2023 |
0.25 % | Northern Trust Investments, Inc. | 1,78,259 | 3,052 | 30/6/2023 |
0.22 % | Oracle Investment Management, Inc. | 1,52,600 | -48,800 | 30/6/2023 |
0.21 % | Sectoral Asset Management Inc. | 1,48,553 | 20,147 | 30/6/2023 |
0.21 % | Baum (Charles M) | 1,48,268 | 54,054 | 9/8/2023 |
0.21 % | Granahan Investment Management, Inc. | 1,45,287 | 16,197 | 30/6/2023 |
0.20 % | Jefferies LLC | 1,42,969 | 92,549 | 30/6/2023 |
0.20 % | Rhenman & Partners Asset Management AB | 1,40,000 | -75,000 | 30/6/2023 |
0.20 % | AllianceBernstein L.P. | 1,39,501 | 67,858 | 30/6/2023 |
0.19 % | Managed Account Advisors LLC | 1,30,489 | 1,059 | 30/6/2023 |
0.18 % | Schonfeld Strategic Advisors LLC | 1,29,636 | 1,06,837 | 30/6/2023 |
0.18 % | UBS Financial Services, Inc. | 1,24,768 | 43,336 | 30/6/2023 |
0.18 % | Fidelity Management & Research Company LLC | 1,23,783 | -54,300 | 30/6/2023 |
0.17 % | Connor, Clark & Lunn Investment Management Ltd. | 1,17,151 | -19,335 | 30/6/2023 |
0.16 % | Numeric Investors LLC | 1,09,491 | 89,681 | 30/6/2023 |
0.15 % | Barclays Bank PLC | 1,03,206 | -22,173 | 30/6/2023 |
0.15 % | Stelzer (Laurie D) | 1,02,312 | 22,297 | 9/8/2023 |
0.14 % | ExodusPoint Capital Management, LP | 98,738 | -65,004 | 30/6/2023 |
0.14 % | Polar Asset Management Partners Inc. | 98,500 | 98,500 | 30/6/2023 |
0.13 % | Dafna Capital Management, LLC | 94,700 | 21,100 | 30/6/2023 |
0.13 % | SilverArc Capital Management, LLC | 91,213 | 91,213 | 30/6/2023 |
0.13 % | BNY Mellon Asset Management | 90,071 | 7,611 | 30/6/2023 |
0.13 % | Schweizerische Nationalbank | 88,600 | 1,600 | 30/6/2023 |
0.12 % | Mellon Investments Corporation | 84,028 | -2,256 | 30/6/2023 |
0.11 % | Tang Capital Management, LLC | 80,000 | 80,000 | 30/6/2023 |
0.10 % | Algert Global LLC | 73,516 | 10,292 | 30/6/2023 |
0.10 % | HRT Financial LP | 73,276 | -8,030 | 30/6/2023 |
0.10 % | TD Asset Management Inc. | 72,105 | 4,700 | 30/6/2023 |
0.10 % | Christensen (James G) | 71,685 | -2,388 | 8/9/2023 |
0.10 % | Moriarty (John B) | 71,660 | 22,297 | 9/8/2023 |
0.10 % | Wells Fargo Advisors | 70,642 | -1,888 | 30/6/2023 |
0.10 % | California Public Employees' Retirement System | 69,454 | 0 | 30/6/2023 |
0.10 % | Citi Investment Research (US) | 67,704 | -91,289 | 30/6/2023 |
0.09 % | Tekla Capital Management LLC | 65,490 | 0 | 30/6/2023 |
0.09 % | Florida State Board of Administration | 62,506 | -1,366 | 30/6/2023 |
0.09 % | Lombard Odier Asset Management (Europe) Ltd | 62,334 | -9,056 | 31/10/2022 |
0.09 % | Sandler (Alan B.) | 62,297 | 22,297 | 9/8/2023 |
0.09 % | Macquarie Investment Management | 60,000 | 0 | 30/6/2023 |
0.09 % | UBS O'Connor LLC | 59,698 | 12,448 | 30/6/2023 |
0.08 % | Clearline Capital LP | 56,341 | 56,341 | 30/6/2023 |
0.08 % | Manulife Investment Management (North America) Limited | 55,148 | 3,769 | 30/6/2023 |
0.08 % | Fidelity International | 53,434 | 53,434 | 30/6/2023 |
0.08 % | Aperio Group, LLC | 53,414 | 22,157 | 30/6/2023 |
0.07 % | Wellington International Management Company Pte. Ltd. | 52,050 | 13,986 | 31/12/2022 |