9.82072 % | RA Capital Management, LP | 1,24,52,574 | 10,67,000 | 31/12/2022 |
7.01191 % | Perceptive Advisors LLC | 88,91,027 | -13,56,046 | 31/12/2022 |
6.37161 % | Goldman Sachs & Company, Inc. | 80,79,140 | 8,82,090 | 31/12/2022 |
5.27497 % | Pictet Asset Management Ltd. | 66,88,609 | -16,74,685 | 31/12/2022 |
4.18265 % | Commodore Capital LP | 53,03,557 | 1,75,000 | 31/12/2022 |
3.89414 % | Power Corporation of Canada | 49,37,730 | 0 | 31/12/2022 |
3.71367 % | OrbiMed Advisors, LLC | 47,08,900 | 74,000 | 31/12/2022 |
3.62779 % | Avidity Partners Management LP | 45,99,998 | 2,53,298 | 31/12/2022 |
3.60004 % | Rocabe Investments, Inc. | 45,64,810 | 0 | 23/3/2022 |
3.28751 % | Citadel Advisors LLC | 41,68,529 | 2,21,755 | 31/12/2022 |
3.24332 % | Braidwell LP | 41,12,494 | 41,12,494 | 31/12/2022 |
2.91800 % | Invus Public Equities Advisors, LLC | 37,00,000 | -23,00,000 | 31/12/2022 |
2.82415 % | Deerfield Management Company, L.P. | 35,81,000 | 5,00,000 | 31/12/2022 |
2.52368 % | Boxer Capital, L.L.C. | 32,00,000 | 0 | 31/12/2022 |
2.39531 % | Polar Capital LLP | 30,37,225 | -5,00,000 | 31/12/2022 |
1.85881 % | First Light Asset Management, LLC | 23,56,950 | -24,907 | 31/12/2022 |
1.48092 % | Fidelity Management & Research Company LLC | 18,77,796 | -8,48,668 | 31/12/2022 |
1.36364 % | Franklin Advisers, Inc. | 17,29,081 | -1,092 | 31/12/2022 |
1.34652 % | SilverArc Capital Management, LLC | 17,07,370 | 51,595 | 31/12/2022 |
1.33919 % | Novo Holdings A/S | 16,98,084 | 16,98,084 | 31/12/2022 |
1.24777 % | Marshall Wace LLP | 15,82,165 | -76,817 | 31/12/2022 |
1.22396 % | Laurion Capital Management LP | 15,51,966 | -46,679 | 31/12/2022 |
1.07624 % | Balyasny Asset Management LP | 13,64,662 | -26,537 | 31/12/2022 |
1.04745 % | Millennium Management LLC | 13,28,161 | 2,96,392 | 31/12/2022 |
1.01007 % | Asymmetry Capital Management, L.P | 12,80,757 | 2,08,059 | 31/12/2021 |
0.97752 % | Lord, Abbett & Co. LLC | 12,39,489 | -22,623 | 31/12/2022 |
0.89275 % | Altium Capital Management LP | 11,32,000 | 0 | 31/12/2022 |
0.87264 % | Connor, Clark & Lunn Investment Management Ltd. | 11,06,500 | 400 | 31/12/2022 |
0.86270 % | Lynx1 Capital Advisors LLC | 10,93,900 | -12,88,227 | 31/12/2022 |
0.84163 % | National Bank of Canada | 10,67,180 | 10,45,639 | 31/12/2022 |
0.80218 % | Vivo Capital, LLC | 10,17,152 | 0 | 31/12/2022 |
0.79169 % | Janus Henderson Investors | 10,03,861 | 2,21,938 | 31/12/2022 |
0.69822 % | Ikarian Capital LLC | 8,85,334 | 35,200 | 31/12/2022 |
0.68034 % | BlackRock Institutional Trust Company, N.A. | 8,62,664 | 67,469 | 31/12/2022 |
0.60337 % | Bellini (Roberto) | 7,65,061 | 1,35,000 | 25/11/2022 |
0.55755 % | Medical Strategy GmbH | 7,06,970 | 0 | 30/9/2022 |
0.55120 % | Berger (Franklin Milan) | 6,98,918 | 0 | 23/3/2022 |
0.52763 % | Sectoral Asset Management Inc. | 6,69,029 | 54,600 | 31/12/2022 |
0.51833 % | FMRC Family Trust | 6,57,239 | 0 | 23/3/2022 |
0.51349 % | Nomura Asset Management Co., Ltd. | 6,51,097 | 6,51,097 | 30/11/2022 |
0.49882 % | Acuta Capital Partners, LLC | 6,32,500 | -8,06,000 | 31/12/2022 |
0.45243 % | Affinity Asset Advisors LLC | 5,73,678 | 1,00,081 | 31/12/2022 |
0.39628 % | ExodusPoint Capital Management, LP | 5,02,484 | 2,97,614 | 31/12/2022 |
0.38633 % | Sphera Funds Management Ltd. | 4,89,860 | 25,000 | 31/12/2022 |
0.35988 % | Assenagon Asset Management S.A. | 4,56,321 | -3,51,676 | 31/12/2022 |
0.34331 % | D. E. Shaw & Co., L.P. | 4,35,313 | -1,33,708 | 31/12/2022 |
0.34030 % | Tenax Capital Ltd. | 4,31,497 | 68,120 | 31/12/2022 |
0.32249 % | Ensign Peak Advisors, Inc. | 4,08,916 | 0 | 31/12/2022 |
0.29969 % | AWM Investment Company, Inc. | 3,80,000 | 0 | 31/12/2022 |
0.28882 % | Driehaus Capital Management, LLC | 3,66,226 | -4,874 | 31/12/2022 |
0.27968 % | J.P. Morgan Securities LLC | 3,54,633 | -1,68,022 | 31/12/2022 |
0.22915 % | Walleye Capital LLC | 2,90,565 | 1,07,638 | 31/12/2022 |
0.22882 % | Industrial Alliance Investment Management Inc. | 2,90,140 | 19,670 | 31/12/2022 |
0.22153 % | Bellini (Francesco) | 2,80,894 | 0 | 25/11/2022 |
0.21082 % | BMO Asset Management Inc. | 2,67,317 | -11,114 | 31/12/2022 |
0.20840 % | UBS O'Connor LLC | 2,64,249 | 24,881 | 31/12/2022 |
0.20602 % | TD Asset Management Inc. | 2,61,237 | -6,820 | 31/12/2022 |
0.19696 % | Qube Research & Technologies Ltd | 2,49,746 | 74,625 | 31/12/2022 |
0.19322 % | Monashee Investment Management, LLC | 2,45,000 | 2,15,000 | 31/12/2022 |
0.17185 % | Barclays Capital Inc. | 2,17,902 | -12,099 | 31/12/2022 |
0.17125 % | Moore Capital Management, LP | 2,17,138 | -2,02,764 | 31/12/2022 |
0.17033 % | State Street Global Advisors (US) | 2,15,982 | 693 | 28/2/2023 |
0.16650 % | PSP Investments | 2,11,120 | -60,320 | 31/12/2022 |
0.15831 % | Renaissance Technologies LLC | 2,00,738 | 2,00,738 | 31/12/2022 |
0.15331 % | Schweizerische Nationalbank | 1,94,400 | 2,700 | 31/12/2022 |
0.14635 % | J. Goldman & Co., L.P. | 1,85,575 | 1,06,717 | 31/12/2022 |
0.11830 % | Lion Point Capital, L.P. | 1,50,000 | 0 | 31/12/2022 |
0.11372 % | Two Sigma Investments, LP | 1,44,194 | 11,594 | 31/12/2022 |
0.11049 % | Morgan Stanley & Co. LLC | 1,40,099 | -1,10,701 | 31/12/2022 |
0.10376 % | Larochelle (Pierre) | 1,31,570 | 0 | 30/11/2022 |
0.10319 % | British Columbia Investment Management Corp. | 1,30,844 | 57,044 | 31/12/2022 |
0.10061 % | J O Hambro Capital Management Limited | 1,27,569 | 99,241 | 31/12/2022 |
0.09916 % | TLS Advisors LLC | 1,25,731 | 1,25,731 | 31/12/2022 |
0.09402 % | Boothbay Fund Management, LLC | 1,19,215 | 4,876 | 31/12/2022 |
0.08932 % | Geode Capital Management, L.L.C. | 1,13,260 | 0 | 31/12/2022 |
0.08647 % | Bennani (Youssef Laafiret) | 1,09,649 | 0 | 23/3/2022 |
0.08480 % | BlackRock Advisors (UK) Limited | 1,07,521 | 4,433 | 28/2/2023 |
0.07912 % | CIBC Asset Management Inc. | 1,00,329 | 6,344 | 31/12/2022 |
0.07886 % | Velan Capital Investment Management LP | 1,00,000 | 0 | 31/12/2022 |
0.07438 % | RBC Capital Markets Wealth Management | 94,308 | 91,158 | 31/12/2022 |
0.07325 % | EAM Global Investors LLC | 92,884 | -4,90,709 | 31/12/2022 |
0.07216 % | HighVista Strategies LLC | 91,493 | 14,649 | 31/12/2022 |
0.07097 % | BofA Global Research (US) | 89,992 | 23,055 | 31/12/2022 |
0.06996 % | California State Teachers Retirement System | 88,708 | 88,708 | 30/6/2022 |
0.06827 % | Morgan Stanley Canada Limited | 86,560 | -42,481 | 31/12/2022 |
0.06793 % | Nuveen LLC | 86,129 | -34,191 | 31/1/2023 |
0.06750 % | RBC Global Asset Management Inc. | 85,594 | 14,100 | 31/12/2022 |
0.06700 % | Alps Advisors, Inc. | 84,953 | 16,578 | 31/12/2022 |
0.06467 % | First Wilshire Securities Management, Inc. | 82,000 | 0 | 31/12/2022 |
0.06290 % | Manulife Investment Management (North America) Limited | 79,757 | -2,957 | 31/12/2022 |
0.06240 % | Credit Suisse Asset Management | 79,125 | 20,329 | 31/12/2022 |
0.05939 % | Sun Life Global Investments (Canada) Inc. | 75,311 | 75,311 | 30/9/2022 |
0.05938 % | Mackenzie Financial Corporation | 75,289 | 1,759 | 31/12/2022 |
0.05901 % | Cubist Systematic Strategies, LLC | 74,819 | -1,20,044 | 31/12/2022 |
0.05256 % | Vestcor Inc | 66,648 | -1,07,074 | 31/12/2021 |
0.05237 % | Jump Financial, LLC | 66,400 | -30,900 | 31/12/2022 |
0.05037 % | PFM Health Sciences, LP | 63,864 | 63,864 | 31/12/2022 |
0.04602 % | BlackRock Asset Management Ireland Limited | 58,355 | 2,470 | 31/12/2022 |
0.04516 % | Jane Street Capital, L.L.C. | 57,263 | 26,118 | 31/12/2022 |
0.04465 % | Addenda Capital, Inc. | 56,617 | 56,617 | 31/12/2022 |