| 20,06568 % | Baker Bros. Advisors LP | 7.915.792 | 170.100 | |
| 8,78594 % | BVF Partners L.P. | 3.466.000 | 0 | |
| 7,93203 % | Sullivan (Brian F) | 3.129.138 | 104.340 | |
| 7,63464 % | Soleus Capital Management, L.P. | 3.011.818 | 437.696 | |
| 6,76968 % | Perceptive Advisors LLC | 2.670.597 | 1.037.389 | |
| 5,43547 % | New Enterprise Associates (NEA) | 2.144.261 | -150.000 | |
| 4,73725 % | BlackRock Institutional Trust Company, N.A. | 1.868.815 | -157.818 | |
| 4,22766 % | The Vanguard Group, Inc. | 1.667.785 | -4457 | |
| 3,52205 % | Eventide Asset Management, LLC | 1.389.427 | 123.774 | |
| 3,16862 % | Laing (Lance G Ph.D.) | 1.250.000 | 0 | |
| 3,00517 % | Saturn V Capital Management LP | 1.185.520 | 91.843 | |
| 2,24162 % | Braidwell LP | 884.306 | 0 | |
| 1,94882 % | Columbia Threadneedle Investments (US) | 768.796 | 166.324 | |
| 1,91170 % | Citadel Advisors LLC | 754.154 | -194.275 | |
| 1,71670 % | Geode Capital Management, L.L.C. | 677.229 | -42.691 | |
| 1,54755 % | Vivo Capital, LLC | 610.500 | 0 | |
| 1,48901 % | State Street Investment Management (US) | 587.404 | 2224 | |
| 1,44601 % | CAPTRUST Financial Advisors | 570.441 | 12.838 | |
| 1,38416 % | Candriam Luxembourg S.A. | 546.043 | -200.957 | |
| 1,32435 % | Morgan Stanley & Co. LLC | 522.450 | 147.118 | |
| 1,01821 % | Artisan Partners Limited Partnership | 401.678 | -52.968 | |
| 0,88571 % | Pfizer Inc | 349.406 | 0 | |
| 0,66814 % | Candriam Belgium S.A. | 263.576 | -14 | |
| 0,66636 % | BofA Global Research (US) | 262.874 | 11.145 | |
| 0,65011 % | Northern Trust Investments, Inc. | 256.463 | -30.469 | |
| 0,61609 % | Quantinno Capital Management LP | 243.042 | 41.756 | |
| 0,60712 % | Balyasny Asset Management LP | 239.504 | 239.504 | |
| 0,59078 % | Charles Schwab Investment Management, Inc. | 233.059 | 1023 | |
| 0,57035 % | Dalvey David F | 225.000 | -9325 | |
| 0,43436 % | Hennion & Walsh Asset Management, Inc. | 171.354 | -3139 | |
| 0,42314 % | Morgan Stanley Investment Management Inc. (US) | 166.927 | -228.873 | |
| 0,31714 % | Invesco Capital Management LLC | 125.110 | 125.110 | |
| 0,28872 % | ClearBridge Investments, LLC | 113.900 | 113.900 | |
| 0,27633 % | Nigon (Richard J) | 109.010 | 7917 | |
| 0,25192 % | Wellington Management Company, LLP | 99.379 | 14.554 | |
| 0,23621 % | BlackRock Investment Management, LLC | 93.184 | 11.321 | |
| 0,22573 % | Millennium Management LLC | 89.049 | 68.698 | |
| 0,21443 % | UBS Financial Services, Inc. | 84.592 | 16.353 | |
| 0,20821 % | Paloma Partners Management Company | 82.137 | 60.849 | |
| 0,20760 % | Morgan Stanley Smith Barney LLC | 81.895 | 23.584 | |
| 0,19643 % | Principal Global Investors (Equity) | 77.489 | -254 | |
| 0,16806 % | BlackRock Financial Management, Inc. | 66.297 | -7206 | |
| 0,15896 % | Jacob Asset Management of New York, LLC | 62.707 | -502 | |
| 0,15114 % | Susquehanna International Group, LLP | 59.625 | 19.594 | |
| 0,14174 % | Nuveen LLC | 55.917 | -13.670 | |
| 0,13686 % | Gagnon Securities LLC | 53.990 | -320 | |
| 0,12595 % | Barclays Bank PLC | 49.688 | 14.312 | |
| 0,12399 % | BNY Mellon Asset Management | 48.912 | -3012 | |
| 0,11245 % | AXA Investment Managers UK Ltd. | 44.360 | 44.360 | |
| 0,11007 % | Voya Investment Management LLC | 43.423 | 36.865 | |
| 0,10823 % | Rhumbline Advisers Ltd. Partnership | 42.697 | 503 | |
| 0,10120 % | Aperio Group, LLC | 39.924 | 11.118 | |
| 0,09648 % | Goldman Sachs & Company, Inc. | 38.062 | -39.186 | |
| 0,09570 % | JNBA Financial Advisors LLC | 37.753 | -338 | |
| 0,09419 % | Healthinvest Partners AB | 37.157 | 3246 | |
| 0,09000 % | Lord, Abbett & Co. LLC | 35.504 | 829 | |
| 0,08991 % | Victory Capital Management Inc. | 35.469 | 35.469 | |
| 0,08595 % | Fred Alger Management, LLC | 33.907 | 0 | |
| 0,08054 % | Fubon Asset Management Company Ltd. | 31.774 | 1075 | |
| 0,07488 % | Allianz Global Investors GmbH | 29.540 | 16.325 | |
| 0,07197 % | New York State Common Retirement Fund | 28.391 | 0 | |
| 0,07196 % | Barclays Capital Inc. | 28.388 | 28.388 | |
| 0,07166 % | AllianceBernstein L.P. | 28.270 | 4590 | |
| 0,06873 % | Accredited Investors Wealth Management | 27.115 | -2000 | |
| 0,06689 % | HRT Financial LP | 26.386 | 26.386 | |
| 0,06537 % | Tema ETFS LLC | 25.790 | 8779 | |
| 0,06229 % | Dimensional Fund Advisors, L.P. | 24.572 | 22.777 | |
| 0,06045 % | T. Rowe Price Associates, Inc. | 23.846 | 4428 | |
| 0,05169 % | Alps Advisors, Inc. | 20.391 | -8407 | |
| 0,05037 % | MetLife Investment Management, LLC | 19.872 | 0 | |
| 0,04781 % | Hahne (Vicky) | 18.860 | 303 | |
| 0,04692 % | Cresset Asset Management, LLC | 18.510 | 0 | |
| 0,04651 % | SEI Investments Management Corporation | 18.347 | 0 | |
| 0,04524 % | M Holdings Securities, Inc. | 17.848 | 17.848 | |
| 0,04455 % | SG Americas Securities, L.L.C. | 17.576 | 17.576 | |
| 0,04312 % | NEOS Investment Management, LLC | 17.011 | 1392 | |
| 0,04269 % | Mellon Investments Corporation | 16.842 | 0 | |
| 0,04219 % | Simplex Trading, LLC | 16.642 | 16.642 | |
| 0,04061 % | Corebridge Financial Inc. | 16.019 | -237 | |
| 0,04041 % | Pale Fire Capital SE | 15.940 | -1700 | |
| 0,04003 % | Wealth Enhancement Advisory Services, LLC | 15.793 | -10.476 | |
| 0,03983 % | Mirae Asset Global Investments (USA) LLC | 15.712 | -3649 | |
| 0,03961 % | NISA Investment Advisors, L.L.C. | 15.627 | 14.930 | |
| 0,03958 % | DWS Investments UK Limited | 15.616 | -2666 | |
| 0,03849 % | T. Rowe Price International Ltd | 15.186 | 1054 | |
| 0,03805 % | Wells Fargo Bank, N.A. | 15.011 | -852 | |
| 0,03766 % | INTECH Investment Management LLC | 14.855 | 734 | |
| 0,03654 % | Goldman Sachs Asset Management, L.P. | 14.415 | 2590 | |
| 0,03438 % | JPMorgan Private Bank (United States) | 13.561 | -1902 | |
| 0,03369 % | Creative Planning, Inc. | 13.291 | 13.291 | |
| 0,03321 % | Renaissance Technologies LLC | 13.100 | 13.100 | |
| 0,03320 % | Corton Capital Inc | 13.097 | 13.097 | |
| 0,03246 % | Parametric Portfolio Associates LLC | 12.807 | 5628 | |
| 0,03201 % | XTX Markets LLC | 12.628 | 12.628 | |
| 0,03114 % | Kestra Advisory Services, LLC | 12.284 | 12.284 | |
| 0,03061 % | Metropolitan Life Insurance Co. (US) | 12.075 | 0 | |
| 0,02920 % | Manulife Investment Management (North America) Limited | 11.519 | -209 | |
| 0,02738 % | Citi Investment Research (US) | 10.802 | -12.445 | |
| 0,02725 % | Furcht (Leo M.D.) | 10.750 | 0 | |
| 0,02710 % | Focus Financial Network, Inc. | 10.691 | 0 | |