| 12,50138 % | RA Capital Management, LP | 18.202.009 | 1.000.000 | 31/12/2023 |
| 9,60423 % | GSK plc | 13.983.761 | 3.300.000 | 31/12/2023 |
| 5,80206 % | Maverick Capital, Ltd. | 8.447.804 | 1.853.485 | 31/12/2023 |
| 5,06416 % | M28 Capital Management LP | 7.373.413 | 328.913 | 31/12/2023 |
| 4,11245 % | Adage Capital Management, L.P. | 5.987.730 | 2.200.000 | 31/12/2023 |
| 3,91831 % | Shin Nippon Biomedical Laboratories Ltd | 5.705.060 | 0 | 12/6/2023 |
| 3,84615 % | 683 Capital Management LLC | 5.600.000 | -250.000 | 31/12/2023 |
| 3,36760 % | BlackRock Institutional Trust Company, N.A. | 4.903.231 | 431.425 | 31/12/2023 |
| 3,08685 % | Bellevue Asset Management AG | 4.494.458 | 0 | 31/12/2023 |
| 2,70061 % | Kynam Capital Management LP | 3.932.082 | 0 | 31/12/2023 |
| 2,58201 % | PRIMECAP Management Company | 3.759.408 | -21.100 | 31/12/2023 |
| 2,20707 % | Point72 Asset Management, L.P. | 3.213.500 | 3.213.500 | 31/12/2023 |
| 2,06552 % | Invus Public Equities Advisors, LLC | 3.007.400 | 1.007.400 | 31/12/2023 |
| 1,38728 % | Kagoshima Shinsangyo Sousei Investment, L. P. | 2.019.873 | 2.019.873 | 19/7/2022 |
| 1,36144 % | Citadel Advisors LLC | 1.982.252 | 1.982.252 | 31/12/2023 |
| 1,07788 % | T. Rowe Price Associates, Inc. | 1.569.395 | 356.463 | 31/12/2023 |
| 1,00259 % | Geode Capital Management, L.L.C. | 1.459.764 | 64.627 | 31/12/2023 |
| 0,99779 % | Maven Investment Partners US Ltd. | 1.452.778 | 1.452.778 | 31/12/2023 |
| 0,95574 % | Woodline Partners LP | 1.391.561 | 162.878 | 31/12/2023 |
| 0,89195 % | The Vanguard Group, Inc. | 1.298.677 | 116.075 | 31/12/2023 |
| 0,86795 % | State Street Global Advisors (US) | 1.263.729 | 68.982 | 31/12/2023 |
| 0,82570 % | Fidelity Management & Research Company LLC | 1.202.215 | 541.790 | 31/12/2023 |
| 0,73592 % | Laurion Capital Management LP | 1.071.500 | 200.000 | 31/12/2023 |
| 0,45009 % | Platinum Asset Management | 655.331 | 200.000 | 31/12/2023 |
| 0,40355 % | Driehaus Capital Management, LLC | 587.575 | 587.575 | 31/12/2023 |
| 0,36747 % | Northern Trust Investments, Inc. | 535.041 | 69.023 | 31/12/2023 |
| 0,35342 % | Millennium Management LLC | 514.581 | 259.687 | 31/12/2023 |
| 0,35027 % | Newtyn Management, LLC | 510.000 | 0 | 31/12/2023 |
| 0,34355 % | Marshall Wace LLP | 500.209 | 318.571 | 31/12/2023 |
| 0,29734 % | Walleye Capital LLC | 432.933 | 283.973 | 31/12/2023 |
| 0,27982 % | Bolno (Paul B. M.D.) | 407.425 | 0 | 12/6/2023 |
| 0,27579 % | JPMorgan Asset Management U.K. Limited | 401.551 | 0 | 31/12/2023 |
| 0,22952 % | Goldman Sachs & Company, Inc. | 334.175 | 41.655 | 31/12/2023 |
| 0,18825 % | Wellington Management Company, LLP | 274.093 | 9.208 | 31/12/2023 |
| 0,14586 % | Jacobs Levy Equity Management, Inc. | 212.377 | 212.377 | 31/12/2023 |
| 0,14270 % | Nuveen LLC | 207.771 | -5.067 | 31/12/2023 |
| 0,14131 % | TD Asset Management Inc. | 205.746 | 43.054 | 31/12/2023 |
| 0,13236 % | Water Street Capital, Inc. | 192.722 | 0 | 31/12/2023 |
| 0,12708 % | BlackRock Financial Management, Inc. | 185.031 | 28.315 | 31/12/2023 |
| 0,12214 % | Morgan Stanley & Co. LLC | 177.832 | 107.906 | 31/12/2023 |
| 0,11918 % | BlackRock Investment Management, LLC | 173.523 | -200 | 31/12/2023 |
| 0,11655 % | Charles Schwab Investment Management, Inc. | 169.693 | 0 | 31/12/2023 |
| 0,10467 % | Schweizerische Nationalbank | 152.400 | 152.400 | 31/12/2023 |
| 0,09826 % | BNY Mellon Asset Management | 143.067 | -1.177 | 31/12/2023 |
| 0,09163 % | Manulife Investment Management (North America) Limited | 133.406 | 51.087 | 31/12/2023 |
| 0,08443 % | Barclays Bank PLC | 122.928 | 105.401 | 31/12/2023 |
| 0,07871 % | Rhumbline Advisers Ltd. Partnership | 114.595 | 3.084 | 31/12/2023 |
| 0,07688 % | Credit Suisse Funds AG | 111.931 | 94.461 | 31/12/2023 |
| 0,07095 % | Monashee Investment Management, LLC | 103.300 | 103.300 | 31/12/2023 |
| 0,06886 % | BlackRock Advisors (UK) Limited | 100.257 | 4.241 | 31/3/2024 |
| 0,06617 % | Vargeese (Chandra) | 96.346 | 0 | 12/6/2023 |
| 0,06111 % | Balyasny Asset Management LP | 88.970 | 52.618 | 31/12/2023 |
| 0,05629 % | Macquarie Investment Management | 81.955 | 0 | 31/12/2023 |
| 0,05603 % | UBS Financial Services, Inc. | 81.584 | 56.701 | 31/12/2023 |
| 0,05537 % | Assenagon Asset Management S.A. | 80.624 | 5.873 | 29/2/2024 |
| 0,05456 % | Jane Street Capital, L.L.C. | 79.438 | 79.438 | 31/12/2023 |
| 0,05403 % | California State Teachers Retirement System | 78.661 | 65.614 | 31/12/2023 |
| 0,05331 % | a16z Perennial Management, L.P. | 77.619 | 77.619 | 31/12/2023 |
| 0,05206 % | State Teachers Retirement System of Ohio | 75.800 | 75.800 | 31/12/2023 |
| 0,04726 % | Martingale Asset Management, L.P. | 68.807 | 25.190 | 31/12/2023 |
| 0,04468 % | J. J. Burns & Company, LLC | 65.049 | 32.000 | 31/12/2023 |
| 0,04274 % | BofA Global Research (US) | 62.226 | 17.247 | 31/12/2023 |
| 0,04007 % | Barclays Capital Inc. | 58.339 | 58.339 | 31/12/2023 |
| 0,03981 % | T. Rowe Price International Ltd | 57.968 | 1.738 | 31/12/2023 |
| 0,03917 % | UBS Asset Management (Switzerland) | 57.026 | 50.287 | 31/12/2023 |
| 0,03912 % | Goldman Sachs Asset Management, L.P. | 56.957 | 7.683 | 31/12/2023 |
| 0,03541 % | Francis (Christopher John) | 51.564 | -10.258 | 16/2/2023 |
| 0,03497 % | BlackRock Asset Management Ireland Limited | 50.923 | 8.721 | 31/12/2023 |
| 0,03434 % | Capstone Investment Advisors, LLC | 50.000 | 50.000 | 31/12/2023 |
| 0,03390 % | Legal & General Investment Management Ltd. | 49.356 | 44.618 | 31/12/2023 |
| 0,03357 % | Northern Trust Global Investments | 48.884 | -8 | 31/12/2023 |
| 0,03228 % | Kraematon Investment Advisors, Inc | 47.000 | 47.000 | 31/12/2023 |
| 0,03091 % | ACCI Capital Investments SGIIC, SA | 45.000 | 45.000 | 31/12/2023 |
| 0,03045 % | UBS Asset Management (UK) Ltd. | 44.341 | 0 | 29/2/2024 |
| 0,02921 % | Putnam Investment Management, L.L.C. | 42.537 | 42.537 | 31/12/2023 |
| 0,02921 % | Northern Trust Global Investments Limited | 42.525 | 42.525 | 31/12/2023 |
| 0,02832 % | BNP Paribas Securities Corp. North America | 41.234 | 30.858 | 31/12/2023 |
| 0,02747 % | Birchview Capital, LP | 40.000 | 40.000 | 31/12/2023 |
| 0,02686 % | JPMorgan Private Bank (United States) | 39.111 | 39.111 | 31/12/2023 |
| 0,02512 % | Tudor Investment Corporation | 36.580 | 36.580 | 31/12/2023 |
| 0,02506 % | Mellon Investments Corporation | 36.491 | 3.981 | 31/12/2023 |
| 0,02440 % | Mirae Asset Global Investments (USA) LLC | 35.523 | -51.130 | 31/12/2023 |
| 0,02404 % | Deka Investment GmbH | 35.000 | 35.000 | 31/12/2022 |
| 0,02374 % | SG Americas Securities, L.L.C. | 34.562 | 8.694 | 31/12/2023 |
| 0,02365 % | Virtu Americas LLC | 34.432 | 34.432 | 31/12/2023 |
| 0,02215 % | Zürcher Kantonalbank (Asset Management) | 32.250 | 30.250 | 31/12/2023 |
| 0,02206 % | Trexquant Investment LP | 32.119 | 32.119 | 31/12/2023 |
| 0,02158 % | MetLife Investment Management, LLC | 31.423 | 0 | 31/12/2023 |
| 0,02153 % | Aperio Group, LLC | 31.347 | 12.028 | 31/12/2023 |
| 0,02060 % | Verdine Gregory L | 30.000 | 0 | 12/6/2023 |
| 0,02019 % | SunAmerica Asset Management, LLC | 29.390 | -119 | 31/12/2023 |
| 0,01992 % | SEI Investments Management Corporation | 29.000 | 0 | 31/12/2023 |
| 0,01986 % | Invesco Advisers, Inc. | 28.919 | 7.151 | 31/12/2023 |
| 0,01886 % | DWS Investments UK Limited | 27.457 | -714 | 31/12/2023 |
| 0,01842 % | Engineers Gate Manager, L.P. | 26.820 | 26.820 | 31/12/2023 |
| 0,01823 % | Two Sigma Investments, LP | 26.543 | 26.543 | 31/12/2023 |
| 0,01786 % | Columbia Threadneedle Investments (US) | 25.999 | 25.999 | 31/12/2023 |
| 0,01785 % | Conestoga Capital Advisors, LLC | 25.994 | 0 | 29/2/2024 |
| 0,01731 % | Vaughan Nelson Investment Management, L.P. | 25.203 | 0 | 31/12/2023 |
| 0,01717 % | Cinctive Capital Management LP | 25.000 | 25.000 | 31/12/2023 |
