7.93 % | RTW Investments L.P. | 4,131,045 | -259,513 | |
7.14 % | Cowen & Co., LLC | 3,721,659 | 0 | |
6.44 % | Morgan Stanley & Co. LLC | 3,358,132 | 455,474 | |
5.67 % | Lynx1 Capital Advisors LLC | 2,956,918 | 292,760 | |
5.04 % | Redmile Group, LLC | 2,625,506 | -1,247,190 | |
3.90 % | Baker Bros. Advisors LP | 2,030,134 | 544,219 | |
3.60 % | Harrison (Seth Loring) | 1,875,313 | 0 | |
3.48 % | BlackRock Institutional Trust Company, N.A. | 1,815,681 | -121,639 | |
3.16 % | The Vanguard Group, Inc. | 1,648,502 | 19,118 | |
20.81 % | Skorpios Trust | 10,843,681 | -3,600,000 | |
2.55 % | Goldman Sachs & Company, Inc. | 1,326,494 | 1,282,757 | |
2.18 % | Granahan Investment Management, LLC | 1,137,887 | 286,686 | |
2.09 % | Cormorant Asset Management, LP | 1,087,807 | 0 | |
1.18 % | Geode Capital Management, L.L.C. | 615,724 | 24,607 | |
1.04 % | State Street Global Advisors (US) | 543,533 | -42,475 | |
0.79 % | DWS Investments UK Limited | 412,778 | 399,016 | |
0.78 % | Krainer (Adrian R) | 404,718 | 0 | |
0.48 % | Victory Capital Management Inc. | 249,370 | 249,370 | |
0.46 % | HOOPP Investment Management | 239,300 | 0 | |
0.44 % | Northern Trust Investments, Inc. | 227,055 | -5,619 | |
0.41 % | Dimensional Fund Advisors, L.P. | 215,294 | -43,128 | |
0.40 % | Birchview Capital, LP | 210,000 | 125,000 | |
0.39 % | Charles Schwab Investment Management, Inc. | 205,242 | -12,097 | |
0.32 % | Jacobs Levy Equity Management, Inc. | 168,028 | -49,577 | |
0.27 % | D. E. Shaw & Co., L.P. | 142,711 | -62,455 | |
0.20 % | GSA Capital Partners LLP | 102,107 | -245,962 | |
0.18 % | BlackRock Financial Management, Inc. | 94,096 | 12,369 | |
0.17 % | State of Wisconsin Investment Board | 86,600 | 7,076 | |
0.16 % | BlackRock Investment Management, LLC | 80,950 | -1,039 | |
0.14 % | Fort Point Capital Partners, LLC | 75,429 | 0 | |
0.14 % | BofA Global Research (US) | 75,339 | 17,781 | |
0.13 % | Kaye (Edward M) | 69,350 | 24,350 | |
0.13 % | BNY Mellon Asset Management | 68,230 | -9,952 | |
0.13 % | BlackRock Asset Management Ireland Limited | 66,225 | -31,938 | |
0.12 % | Goldman Sachs Asset Management, L.P. | 64,937 | -20,631 | |
0.12 % | Nuveen LLC | 62,864 | 0 | |
0.12 % | Los Angeles Capital Management LLC | 62,257 | 0 | |
0.12 % | Gilder Gagnon Howe & Co. LLC | 62,248 | -11 | |
0.12 % | Bellecapital Partners AG | 59,980 | 0 | |
0.11 % | BlackRock Advisors (UK) Limited | 58,525 | -3,224 | |
0.11 % | Woodline Partners LP | 56,904 | 0 | |
0.10 % | Jane Street Capital, L.L.C. | 50,786 | 50,786 | |
0.09 % | Susquehanna Portfolio Strategies, LLC | 45,108 | 45,108 | |
0.08 % | Rhumbline Advisers Ltd. Partnership | 40,971 | -38 | |
0.08 % | Trexquant Investment LP | 39,800 | -87,781 | |
0.08 % | Barclays Bank PLC | 39,271 | 30,831 | |
0.07 % | AllianceBernstein L.P. | 37,340 | -3,980 | |
0.07 % | Dimensional Fund Advisors, Ltd. | 34,328 | 0 | |
0.06 % | Tzianabos (Arthur) | 31,739 | 31,739 | |
0.06 % | Northern Trust Global Investments | 30,537 | -208 | |
0.06 % | T. Rowe Price International Ltd | 29,789 | 0 | |
0.06 % | UBS Financial Services, Inc. | 29,773 | 9,498 | |
0.06 % | Avantis Investors | 29,048 | 8,696 | |
0.05 % | Acuitas Investments LLC | 28,014 | 9,034 | |
0.05 % | Mellon Investments Corporation | 24,462 | 600 | |
0.05 % | Millennium Management LLC | 23,914 | -251,425 | |
0.04 % | Two Sigma Investments, LP | 22,200 | -19,900 | |
0.04 % | Columbia Threadneedle Investments (US) | 22,054 | -10,978 | |
0.04 % | Susquehanna International Group, LLP | 21,284 | -50,957 | |
0.04 % | American Century Investment Management, Inc. | 21,036 | 4,893 | |
0.04 % | Tulipano (Stephen J) | 20,746 | 8,984 | |
0.04 % | Squarepoint Capital LLP | 19,096 | 3,886 | |
0.03 % | Levin Arthur A | 17,979 | 0 | |
0.03 % | JPMorgan Private Bank (United States) | 17,880 | 17,880 | |
0.03 % | Ohio Public Employees Retirement System | 17,283 | 948 | |
0.03 % | Bridgeway Capital Management, LLC | 17,100 | 17,100 | |
0.03 % | Citadel Advisors LLC | 15,577 | -60,543 | |
0.03 % | Numeric Investors LLC | 15,361 | -98,179 | |
0.03 % | SG Americas Securities, L.L.C. | 15,101 | 1,544 | |
0.03 % | Virginia Retirement System | 14,900 | -700 | |
0.03 % | SEI Investments Management Corporation | 14,897 | 0 | |
0.03 % | MetLife Investment Management, LLC | 14,616 | 0 | |
0.03 % | LSV Asset Management | 14,416 | 0 | |
0.03 % | Zacks Investment Management, Inc. | 14,064 | 14,064 | |
0.03 % | SunAmerica Asset Management, LLC | 13,711 | -56 | |
0.02 % | Algert Global LLC | 12,540 | -4,010 | |
0.02 % | Ikarian Capital LLC | 12,116 | 0 | |
0.02 % | Principal Global Investors (Equity) | 12,037 | -94 | |
0.02 % | Parametric Portfolio Associates LLC | 11,941 | 1,325 | |
0.02 % | Manulife Investment Management (North America) Limited | 11,916 | 0 | |
0.02 % | Vaughan Nelson Investment Management, L.P. | 11,248 | 0 | |
0.02 % | Voya Investment Management LLC | 11,175 | 0 | |
0.02 % | Mairs and Power, Inc. | 10,815 | 0 | |
0.02 % | New York State Common Retirement Fund | 10,642 | -46 | |
0.02 % | State Street Global Advisors Ireland Limited | 10,228 | -37 | |
0.02 % | Wells Fargo Bank, N.A. | 8,500 | 1,682 | |
0.02 % | Nash (Huw Michael) | 7,999 | 7,999 | |
0.02 % | Simplex Trading, LLC | 7,979 | 5,298 | |
0.01 % | BNP Paribas Securities Corp. North America | 7,694 | -20,458 | |
0.01 % | Mackenzie Financial Corporation | 7,192 | 2,793 | |
0.01 % | RBC Wealth Management, International | 5,884 | 1,252 | |
0.01 % | Lazard Asset Management, L.L.C. | 5,779 | 222 | |
0.01 % | BNY Mellon Wealth Management | 5,636 | 426 | |
0.01 % | Conestoga Capital Advisors, LLC | 5,054 | -17,000 | |
0.01 % | Tower Research Capital LLC | 5,039 | 1,298 | |
0.01 % | ProShare Advisors LLC | 5,008 | 965 | |
0.01 % | Fidelity Management & Research Company LLC | 5,000 | 1,272 | |
0.01 % | Invesco Advisers, Inc. | 4,625 | -11,646 | |
0.01 % | California State Teachers Retirement System | 4,540 | -19,111 | |
0.01 % | Horizon Kinetics LLC | 4,233 | 0 | |