| 9,45851 % | RA Capital Management, LP | 60.379.366 | 0 | |
| 6,79185 % | BlackRock Institutional Trust Company, N.A. | 43.356.429 | 300.243 | |
| 6,73601 % | Deep Track Capital LP | 43.000.000 | 4.823.749 | |
| 5,55961 % | The Vanguard Group, Inc. | 35.490.312 | 1.467.349 | |
| 4,26488 % | Vivo Capital, LLC | 27.225.292 | 0 | |
| 3,72439 % | Vestal Point Capital, LP | 23.775.000 | 1.769.660 | |
| 3,70197 % | State Street Investment Management (US) | 23.631.876 | -279.916 | |
| 2,52835 % | Soleus Capital Management, L.P. | 16.140.000 | 13.740.000 | |
| 2,25207 % | ClearBridge Investments, LLC | 14.376.311 | 5.689.169 | |
| 2,21694 % | Geode Capital Management, L.L.C. | 14.152.038 | 584.444 | |
| 2,02612 % | Morgan Stanley & Co. LLC | 12.933.955 | 6.114.874 | |
| 1,88544 % | Citadel Advisors LLC | 12.035.901 | 5.372.587 | |
| 1,83987 % | UBS Financial Services, Inc. | 11.745.012 | 6.772.529 | |
| 1,50483 % | Point72 Asset Management, L.P. | 9.606.217 | 2.479.399 | |
| 1,44794 % | Goldman Sachs & Company, Inc. | 9.243.099 | 1.599.684 | |
| 1,25293 % | Woodline Partners LP | 7.998.188 | 269.443 | |
| 1,14672 % | Eversept Partners, LP | 7.320.174 | 7.320.174 | |
| 1,12667 % | Segall Bryant & Hamill, LLC | 7.192.184 | -234.670 | |
| 1,09436 % | abrdn Inc. | 6.985.932 | 3.293.179 | |
| 1,04161 % | StemPoint Capital LP | 6.649.244 | 5.688.937 | |
| 0,95929 % | BofA Global Research (US) | 6.123.740 | -3.379.999 | |
| 0,94733 % | Millennium Management LLC | 6.047.354 | -4.759.271 | |
| 0,78312 % | Renaissance Technologies LLC | 4.999.100 | -602.000 | |
| 0,78037 % | Qube Research & Technologies Ltd | 4.981.598 | 186.043 | |
| 0,75755 % | Fidelity Management & Research Company LLC | 4.835.896 | -7.527.719 | |
| 0,73881 % | Northern Trust Investments, Inc. | 4.716.236 | -18.709 | |
| 0,73459 % | Charles Schwab Investment Management, Inc. | 4.689.314 | 238.283 | |
| 0,69688 % | Algert Global LLC | 4.448.600 | 1.187.666 | |
| 0,58007 % | DWS Investments UK Limited | 3.702.959 | -80.805 | |
| 0,56382 % | Squarepoint Capital LLP | 3.599.221 | 2.199.413 | |
| 0,54144 % | Kynam Capital Management LP | 3.456.318 | -203.208 | |
| 0,53487 % | Exome Asset Management LLC | 3.414.377 | 198.920 | |
| 0,50935 % | Ally Bridge Group NY LLC | 3.251.475 | 1.194.838 | |
| 0,48562 % | 683 Capital Management LLC | 3.100.000 | 250.000 | |
| 0,41943 % | Candriam Luxembourg S.A. | 2.677.461 | 23.698 | |
| 0,36500 % | Edmond de Rothschild Asset Management (France) S.A. | 2.330.000 | 200.000 | |
| 0,33461 % | Barclays Bank PLC | 2.136.011 | 1.004.495 | |
| 0,32600 % | Nuveen LLC | 2.081.071 | -725.596 | |
| 0,30018 % | BlackRock Advisors (UK) Limited | 1.916.200 | 29.682 | |
| 0,29699 % | Candriam Belgium S.A. | 1.895.892 | -118 | |
| 0,27555 % | BlackRock Investment Management, LLC | 1.759.000 | 274.705 | |
| 0,26871 % | BlackRock Asset Management Ireland Limited | 1.715.345 | -206.186 | |
| 0,25122 % | Susquehanna International Group, LLP | 1.603.685 | -268.815 | |
| 0,25064 % | Ikarian Capital LLC | 1.600.000 | 1.450.000 | |
| 0,24357 % | Balyasny Asset Management LP | 1.554.849 | -1.955.071 | |
| 0,24335 % | BlackRock Financial Management, Inc. | 1.553.442 | -72.543 | |
| 0,23498 % | Affinity Asset Advisors LLC | 1.500.000 | 0 | |
| 0,21517 % | Nan Fung Trinity (HK) Limited | 1.373.550 | 1.373.550 | |
| 0,18695 % | UBS Asset Management (Switzerland) | 1.193.385 | 596.614 | |
| 0,17202 % | BNY Mellon Asset Management | 1.098.122 | 57.132 | |
| 0,17003 % | Prelude Capital Management, LLC | 1.085.427 | 190.402 | |
| 0,16288 % | Pensionmark Financial Group, LLC | 1.039.779 | 7.376 | |
| 0,15665 % | Stonepine Capital Management, LLC | 1.000.000 | 500.000 | |
| 0,15250 % | Schweizerische Nationalbank | 973.500 | -22.000 | |
| 0,14800 % | Marshall Wace LLP | 944.790 | -4.195.674 | |
| 0,14109 % | Aperio Group, LLC | 900.659 | 545.519 | |
| 0,13990 % | Kodai Capital Management, L.P. | 893.091 | 893.091 | |
| 0,13690 % | Rhumbline Advisers Ltd. Partnership | 873.893 | 34.437 | |
| 0,12979 % | Rafferty Asset Management LLC | 828.509 | -53.098 | |
| 0,12532 % | Centiva Capital, LP | 800.001 | 0 | |
| 0,11216 % | Patient Square Capital, LP | 716.000 | 716.000 | |
| 0,10915 % | Columbia Threadneedle Investments (US) | 696.781 | -54.925 | |
| 0,10897 % | William Blair Investment Management, LLC | 695.620 | 0 | |
| 0,10642 % | GSA Capital Partners LLP | 679.331 | 444.725 | |
| 0,09795 % | AllianceBernstein L.P. | 625.291 | 0 | |
| 0,09736 % | Fubon Asset Management Company Ltd. | 621.525 | 21.027 | |
| 0,09030 % | Cantor Fitzgerald, L.P | 576.436 | 50.000 | |
| 0,08960 % | Boothbay Fund Management, LLC | 572.002 | 518.085 | |
| 0,08646 % | MML Investors Services, LLC | 551.915 | 800 | |
| 0,08629 % | Legal & General Investment Management Ltd. | 550.871 | 42.345 | |
| 0,08399 % | Mellon Investments Corporation | 536.178 | -27.112 | |
| 0,08007 % | Goldman Sachs Asset Management, L.P. | 511.103 | 72.984 | |
| 0,07833 % | Lion Point Capital, L.P. | 500.000 | 0 | |
| 0,07808 % | T. Rowe Price International Ltd | 498.445 | 65.038 | |
| 0,07792 % | HRT Financial LP | 497.407 | -911.867 | |
| 0,07751 % | Summit Wealth Strategies | 494.789 | -53.110 | |
| 0,07511 % | California State Teachers Retirement System | 479.503 | -5.459 | |
| 0,07430 % | UBS Fund Management (Switzerland) AG | 474.302 | -9.079 | |
| 0,07366 % | Invesco Advisers, Inc. | 470.190 | 9.059 | |
| 0,06911 % | Adar1 Capital Management LLC | 441.176 | 175.000 | |
| 0,06858 % | Schonfeld Strategic Advisors LLC | 437.795 | 152.189 | |
| 0,06755 % | BlackRock Investment Management (UK) Ltd. | 431.201 | 0 | |
| 0,06247 % | Citi Investment Research (US) | 398.775 | -721.553 | |
| 0,06221 % | Mirae Asset Global Investments (USA) LLC | 397.117 | -16.729 | |
| 0,06204 % | Northern Trust Global Investments Limited | 396.020 | 1.191 | |
| 0,06172 % | Graham Capital Management, L.P. | 393.990 | 17.230 | |
| 0,05894 % | Los Angeles Capital Management LLC | 376.272 | 342.098 | |
| 0,05708 % | Hennion & Walsh Asset Management, Inc. | 364.400 | -6.635 | |
| 0,05689 % | MetLife Investment Management, LLC | 363.137 | 57.829 | |
| 0,05687 % | UBS Asset Management (UK) Ltd. | 363.027 | 119.074 | |
| 0,05616 % | Harvest Fund Management Co., Ltd. | 358.506 | 41.612 | |
| 0,05599 % | Creative Planning, Inc. | 357.427 | 250.752 | |
| 0,05557 % | INTECH Investment Management LLC | 354.715 | -181.260 | |
| 0,05519 % | Group One Trading, L.P. | 352.342 | -91.522 | |
| 0,05443 % | Private Advisor Group LLC | 347.488 | 8.891 | |
| 0,05382 % | Alps Advisors, Inc. | 343.560 | 343.560 | |
| 0,05155 % | Inspire Investing | 329.051 | 44.327 | |
| 0,05046 % | Nvest Financial, LLC | 322.125 | 122.884 | |
| 0,05017 % | Invesco Capital Management LLC | 320.257 | -2.837.219 | |
| 0,04960 % | Manulife Investment Management (North America) Limited | 316.622 | 18.491 | |