| 9,80378 % | Pfizer Inc | 22.032.040 | 0 | |
| 8,32835 % | TPG Capital, L.P. | 18.716.306 | 0 | |
| 5,93875 % | Citadel Advisors LLC | 13.346.151 | 3.093.545 | |
| 5,03338 % | BlackRock Institutional Trust Company, N.A. | 11.311.512 | 500.602 | |
| 4,96151 % | Capital World Investors | 11.150.000 | -1.115.330 | |
| 4,92013 % | Lynx1 Capital Advisors LLC | 11.057.009 | 0 | |
| 4,66328 % | Darwin Global Management Ltd | 10.479.791 | 30.000 | |
| 3,67513 % | The Vanguard Group, Inc. | 8.259.128 | 191.575 | |
| 3,36614 % | Belldegrun (Arie S) | 7.564.727 | 0 | |
| 2,54675 % | Chang (David D) | 5.723.314 | 0 | |
| 2,54489 % | PRIMECAP Management Company | 5.719.140 | 787.300 | |
| 2,39620 % | Goldman Sachs & Company, Inc. | 5.384.973 | 48.085 | |
| 1,94038 % | Woodline Partners LP | 4.360.608 | 0 | |
| 1,72151 % | Frazier Life Sciences Management, L.P. | 3.868.750 | 0 | |
| 1,71971 % | T. Rowe Price Associates, Inc. | 3.864.702 | -184.606 | |
| 1,68862 % | Geode Capital Management, L.L.C. | 3.794.827 | 435.389 | |
| 1,51456 % | Two Sigma Investments, LP | 3.403.664 | -872.235 | |
| 1,37642 % | BlackRock Financial Management, Inc. | 3.093.218 | -234.820 | |
| 1,29969 % | Wildcat Capital Management, LLC | 2.920.787 | 0 | |
| 1,27947 % | Foresite Capital Management, LLC | 2.875.357 | -572.918 | |
| 1,21765 % | Dimensional Fund Advisors, L.P. | 2.736.419 | -443.434 | |
| 1,21156 % | State Street Investment Management (US) | 2.722.742 | -67.035 | |
| 1,17994 % | BlackRock Investment Management (UK) Ltd. | 2.651.673 | -33.884 | |
| 1,17252 % | Patient Square Capital, LP | 2.635.000 | 266.814 | |
| 0,88721 % | UBS Financial Services, Inc. | 1.993.819 | -118.247 | |
| 0,80014 % | VV Manager LLC | 1.798.163 | 0 | |
| 0,74312 % | Renaissance Technologies LLC | 1.670.012 | 113.312 | |
| 0,66868 % | Millennium Management LLC | 1.502.724 | 1.245.875 | |
| 0,61412 % | Dafna Capital Management, LLC | 1.380.118 | 0 | |
| 0,54845 % | Charles Schwab Investment Management, Inc. | 1.232.535 | 76.691 | |
| 0,53393 % | Northern Trust Investments, Inc. | 1.199.902 | 75.478 | |
| 0,51470 % | Gilead Sciences Inc | 1.156.689 | 0 | |
| 0,43941 % | BofA Global Research (US) | 987.495 | 38.686 | |
| 0,43741 % | Fidelity Management & Research Company LLC | 983.001 | -6.411.161 | |
| 0,39113 % | BNP Paribas Securities Corp. North America | 878.987 | 7.390 | |
| 0,38591 % | abrdn Inc. | 867.250 | 0 | |
| 0,37760 % | JPMorgan Asset Management U.K. Limited | 848.570 | -327.137 | |
| 0,28716 % | Barclays Bank PLC | 645.325 | -8.235 | |
| 0,28592 % | Citi Investment Research (US) | 642.542 | -45.982 | |
| 0,25820 % | BlackRock Investment Management, LLC | 580.253 | 136.616 | |
| 0,24269 % | TD Asset Management Inc. | 545.388 | 0 | |
| 0,22796 % | Zacks Investment Management, Inc. | 512.301 | -6.540 | |
| 0,22004 % | Manulife Investment Management (North America) Limited | 494.500 | 8.634 | |
| 0,21898 % | GSA Capital Partners LLP | 492.121 | 8.353 | |
| 0,20769 % | Cerity Partners LLC | 466.732 | 66.465 | |
| 0,19642 % | Parker (Geoffrey M) | 441.422 | -36.744 | |
| 0,18361 % | Jane Street Capital, L.L.C. | 412.630 | -704.051 | |
| 0,17799 % | Raiffeisen Kapitalanlage-Gesellschaft mbH | 400.000 | 0 | |
| 0,16043 % | Blue Box Wealth Management SA | 360.543 | 0 | |
| 0,15255 % | Morgan Stanley & Co. LLC | 342.833 | -1.612.867 | |
| 0,13642 % | Invesco Capital Management LLC | 306.581 | 108.611 | |
| 0,13563 % | Susquehanna International Group, LLP | 304.812 | 147.168 | |
| 0,13486 % | Kazam (Joshua A) | 303.063 | 0 | |
| 0,13450 % | Graham Capital Management, L.P. | 302.270 | 302.270 | |
| 0,13194 % | AllianceBernstein L.P. | 296.498 | 108.090 | |
| 0,13030 % | Witte (Owen N) | 292.832 | 37.281 | |
| 0,12316 % | Humer (Franz Bernhard) | 276.769 | 6.543 | |
| 0,12223 % | Numeric Investors LLC | 274.684 | 88.588 | |
| 0,11903 % | Moloney Securities Asset Management, LLC | 267.500 | -27.500 | |
| 0,10553 % | Eaton Vance Management | 237.155 | 0 | |
| 0,10375 % | BNY Mellon Asset Management | 233.157 | 28.641 | |
| 0,09954 % | Nuveen LLC | 223.687 | -28.864 | |
| 0,09837 % | Coastal Bridge Advisors, LLC | 221.059 | 0 | |
| 0,09723 % | Beneski (Benjamin Machinas) | 218.507 | 218.507 | |
| 0,09315 % | Rhumbline Advisers Ltd. Partnership | 209.336 | 25.628 | |
| 0,08367 % | Mirae Asset Global Investments (USA) LLC | 188.026 | -105.023 | |
| 0,08285 % | IEQ Capital LLC | 186.178 | 120.000 | |
| 0,07741 % | LPL Financial LLC | 173.963 | 2.250 | |
| 0,07586 % | Conestoga Capital Advisors, LLC | 170.481 | -1.640 | |
| 0,07494 % | Bellecapital AG | 168.422 | 0 | |
| 0,07394 % | T. Rowe Price International Ltd | 166.170 | 9.474 | |
| 0,07191 % | Partners Capital Investment Group, LLP | 161.597 | 0 | |
| 0,06857 % | Aperio Group, LLC | 154.102 | -169.947 | |
| 0,06765 % | Dimensional Fund Advisors, Ltd. | 152.031 | -24.553 | |
| 0,06531 % | Macquarie Investment Management | 146.779 | 0 | |
| 0,06313 % | Mellon Investments Corporation | 141.880 | 17.194 | |
| 0,06181 % | Mitsubishi UFJ Asset Management Co., Ltd. | 138.900 | -125.165 | |
| 0,06017 % | Harold Davidson & Associates, Inc. | 135.228 | -117.122 | |
| 0,05866 % | Sato (Vicki Lee) | 131.837 | 5.541 | |
| 0,05713 % | Yoshiyama (Annie) | 128.389 | -9.601 | |
| 0,05549 % | BlackRock Advisors (UK) Limited | 124.705 | 3.760 | |
| 0,05258 % | Goldman Sachs Asset Management, L.P. | 118.168 | -398.918 | |
| 0,04904 % | Douglas (Earl Martin) | 110.214 | -6.404 | |
| 0,04634 % | BlackRock Asset Management Ireland Limited | 104.136 | -226.772 | |
| 0,04534 % | Roberts (Zachary) | 101.900 | -64.269 | |
| 0,04450 % | NWI Management LP | 100.000 | 100.000 | |
| 0,04391 % | INTECH Investment Management LLC | 98.671 | -21.687 | |
| 0,04383 % | HSBC Global Asset Management (UK) Limited | 98.491 | 17.056 | |
| 0,04330 % | Wells Fargo Bank, N.A. | 97.301 | 20.254 | |
| 0,04147 % | Moore (Timothy L.) | 93.203 | -172.256 | |
| 0,04002 % | Invesco Advisers, Inc. | 89.931 | 2.694 | |
| 0,03874 % | Assenagon Asset Management S.A. | 87.069 | -1.872 | |
| 0,03814 % | Vanguard Personalized Indexing Management, LLC | 85.720 | 14.032 | |
| 0,03642 % | Brevan Howard Capital Management LP | 81.843 | -163.774 | |
| 0,03588 % | AQR Capital Management, LLC | 80.624 | 22.401 | |
| 0,03524 % | DWS Investments UK Limited | 79.202 | -20.342 | |
| 0,03188 % | JPMorgan Private Bank (United States) | 71.653 | -159.660 | |
| 0,03160 % | Tudor Investment Corporation | 71.008 | 0 | |
| 0,03136 % | Acadian Asset Management LLC | 70.466 | 70.466 | |
| 0,02989 % | Virtus Investment Advisers, Inc. | 67.166 | -14.104 | |