13.99274 % | BlackRock Institutional Trust Company, N.A. | 9,792,121 | -56,774 | |
13.02687 % | PRIMECAP Management Company | 9,116,202 | 25,495 | |
9.98182 % | The Vanguard Group, Inc. | 6,985,281 | -14,048 | |
7.61706 % | EcoR1 Capital, LLC | 5,330,416 | 0 | |
5.47694 % | T. Rowe Price Associates, Inc. | 3,832,763 | 140,779 | |
4.45740 % | State Street Global Advisors (US) | 3,119,290 | -233,086 | |
2.14347 % | Logos Global Management LLC | 1,500,000 | 850,000 | |
2.08549 % | Dimensional Fund Advisors, L.P. | 1,459,427 | 87,979 | |
2.05443 % | Geode Capital Management, L.L.C. | 1,437,692 | 87,906 | |
1.80307 % | Point72 Asset Management, L.P. | 1,261,789 | 436,389 | |
1.54632 % | Two Sigma Investments, LP | 1,082,114 | -119,299 | |
1.31635 % | Loomis, Sayles & Company, L.P. | 921,184 | -36,627 | |
1.23464 % | Armistice Capital LLC | 864,000 | -136,000 | |
1.17301 % | Millennium Management LLC | 820,871 | -2,105 | |
1.06897 % | Johnson & Johnson Innovation-JJDC, Inc. | 748,062 | 0 | |
0.95316 % | BlackRock Financial Management, Inc. | 667,023 | 234 | |
0.83767 % | Charles Schwab Investment Management, Inc. | 586,200 | 33,278 | |
0.81311 % | BofA Global Research (US) | 569,017 | 75,702 | |
0.78759 % | Northern Trust Investments, Inc. | 551,156 | -16,497 | |
0.77941 % | Baker Bros. Advisors LP | 545,431 | 0 | |
0.64243 % | Invesco Capital Management LLC | 449,573 | 289,178 | |
0.51750 % | Parametric Portfolio Associates LLC | 362,144 | 25,472 | |
0.47991 % | Goldman Sachs & Company, Inc. | 335,843 | 124,016 | |
0.44301 % | Candriam Belgium S.A. | 310,019 | -341,298 | |
0.43894 % | Principal Global Investors (Equity) | 307,167 | -16,498 | |
0.43680 % | Jacobs Levy Equity Management, Inc. | 305,673 | 97,446 | |
0.43093 % | Mellon Investments Corporation | 301,563 | 10,742 | |
0.42869 % | Hudson Bay Capital Management LP | 300,000 | 90,200 | |
0.41209 % | BlackRock Advisors (UK) Limited | 288,380 | 4,644 | |
0.38934 % | BlackRock Asset Management Ireland Limited | 272,458 | 106,144 | |
0.38379 % | Citadel Advisors LLC | 268,577 | -49,523 | |
0.37035 % | Dahiyat (Bassil Ishmael) | 259,170 | 39,269 | |
0.36620 % | Morgan Stanley & Co. LLC | 256,267 | -207,818 | |
0.33206 % | PanAgora Asset Management Inc. | 232,375 | 20,043 | |
0.31422 % | Norges Bank Investment Management (NBIM) | 219,893 | -105,546 | |
0.31259 % | Rhenman & Partners Asset Management AB | 218,750 | 0 | |
0.30891 % | ExodusPoint Capital Management, LP | 216,173 | 42,204 | |
0.29863 % | DCF Advisers, LLC | 208,979 | 0 | |
0.28580 % | Macquarie Investment Management | 200,000 | 0 | |
0.27374 % | BlackRock Investment Management, LLC | 191,563 | 6,447 | |
0.27361 % | Columbia Threadneedle Investments (US) | 191,475 | -13,464 | |
0.27011 % | D. E. Shaw & Co., L.P. | 189,023 | 139,859 | |
0.26938 % | Legal & General Investment Management Ltd. | 188,512 | 129 | |
0.26925 % | Russell Investments Trust Company | 188,421 | 17,159 | |
0.25430 % | Putnam Investment Management, L.L.C. | 177,962 | -8,529 | |
0.25199 % | Nuveen LLC | 176,340 | 26,248 | |
0.25081 % | abrdn Inc. | 175,520 | 0 | |
0.24559 % | UBS Asset Management (Americas), Inc. | 171,863 | -440 | |
0.22088 % | Rhumbline Advisers Ltd. Partnership | 154,573 | 4,265 | |
0.21625 % | BNY Mellon Asset Management | 151,335 | 7,632 | |
0.20879 % | Silvercrest Asset Management Group LLC | 146,113 | 1,878 | |
0.20813 % | TD Asset Management Inc. | 145,650 | 2,200 | |
0.20286 % | Jane Street Capital, L.L.C. | 141,958 | 126,851 | |
0.19385 % | PSP Investments | 135,657 | 10,876 | |
0.19298 % | Qube Research & Technologies Ltd | 135,047 | 11,633 | |
0.19172 % | Schonfeld Strategic Advisors LLC | 134,165 | -59,807 | |
0.18957 % | Essex LLC | 132,661 | 132,661 | |
0.18525 % | T. Rowe Price International Ltd | 129,640 | 1,968 | |
0.18429 % | Goldman Sachs Asset Management, L.P. | 128,969 | 11,417 | |
0.18304 % | Desjarlais (John R) | 128,094 | 13,671 | |
0.17146 % | Manulife Investment Management (North America) Limited | 119,988 | 22,107 | |
0.17138 % | Candriam Luxembourg S.A. | 119,934 | -187,576 | |
0.16710 % | Polen Capital Management, LLC | 116,937 | 30,532 | |
0.15362 % | Schweizerische Nationalbank | 107,500 | 0 | |
0.14526 % | Cubist Systematic Strategies, LLC | 101,653 | -91,691 | |
0.13649 % | Rafferty Asset Management LLC | 95,515 | -133,856 | |
0.13629 % | American Century Investment Management, Inc. | 95,375 | 12,083 | |
0.13231 % | Kuch John J | 92,594 | -5,323 | |
0.12745 % | Dimensional Fund Advisors, Ltd. | 89,187 | 0 | |
0.12354 % | JP Morgan Asset Management | 86,453 | -1,371 | |
0.12327 % | Trexquant Investment LP | 86,264 | -30,966 | |
0.12002 % | Northern Trust Global Investments | 83,991 | -3,432 | |
0.11888 % | UBS Financial Services, Inc. | 83,195 | -127,610 | |
0.11557 % | Canada Life Asset Management Limited | 80,876 | 2,451 | |
0.11541 % | Aperio Group, LLC | 80,763 | 2,863 | |
0.11048 % | Barclays Bank PLC | 77,317 | -20,848 | |
0.10956 % | Engineers Gate Manager, L.P. | 76,672 | -24,833 | |
0.10753 % | AllianceBernstein L.P. | 75,250 | 0 | |
0.10589 % | Numeric Investors LLC | 74,100 | 7,443 | |
0.10185 % | BlackRock Investment Management (UK) Ltd. | 71,275 | -8,551 | |
0.09418 % | PGIM Quantitative Solutions LLC | 65,905 | -2,790 | |
0.09335 % | Renaissance Technologies LLC | 65,323 | 21,723 | |
0.08352 % | Y-Intercept (Hong Kong) Ltd | 58,449 | 32,134 | |
0.08320 % | New York State Teachers' Retirement System | 58,226 | -300 | |
0.07744 % | California State Teachers Retirement System | 54,192 | -910 | |
0.07533 % | Citi Investment Research (US) | 52,718 | -176,393 | |
0.07522 % | NFJ Investment Group, LLC | 52,641 | -2,743 | |
0.07353 % | Voya Investment Management LLC | 51,453 | 17,034 | |
0.07315 % | Thrivent Asset Management, LLC | 51,189 | -1,621 | |
0.07246 % | Jump Financial, LLC | 50,706 | 18,469 | |
0.07145 % | ARIAD Asset Management GmbH | 50,000 | 0 | |
0.06998 % | Irish Life Investment Managers Ltd. | 48,972 | -2,003 | |
0.06983 % | Wellington Management Company, LLP | 48,870 | 6,554 | |
0.06873 % | Alps Advisors, Inc. | 48,097 | 4,991 | |
0.06832 % | BNY Wealth | 47,810 | -2,400 | |
0.06642 % | Winton Capital Management Ltd. | 46,481 | 1,883 | |
0.06511 % | Texas Permanent School Fund | 45,562 | -7,715 | |
0.06345 % | T. Rowe Price Japan, Inc. | 44,399 | 27,800 | |
0.06206 % | Linden Thomas Advisory Services, LLC | 43,428 | -215 | |
0.06126 % | Advantage Alpha Capital Partners LP | 42,871 | -4,504 | |