8.97078 % | RTW Investments L.P. | 3,412,486 | 140,145 | |
7.15054 % | BlackRock Institutional Trust Company, N.A. | 2,720,065 | 480,432 | |
6.40225 % | Paradigm BioCapital Advisors LP | 2,435,416 | -427,990 | |
5.92744 % | Tang Capital Management, LLC | 2,254,797 | 0 | |
5.77651 % | TD Cowen (Research) | 2,197,385 | 74,855 | |
5.29838 % | Horowitz Management, Inc. | 2,015,503 | 2,015,503 | |
5.21800 % | The Vanguard Group, Inc. | 1,984,926 | 163,061 | |
4.74304 % | Morgan Stanley & Co. LLC | 1,804,254 | -41,324 | |
4.17331 % | Frazier Life Sciences Management, L.P. | 1,587,527 | -200,000 | |
3.89029 % | Jennison Associates LLC | 1,479,868 | 148,930 | |
3.40803 % | Perceptive Advisors LLC | 1,296,416 | 0 | |
3.00012 % | Assenagon Asset Management S.A. | 1,141,247 | 77,825 | |
2.43333 % | State Street Global Advisors (US) | 925,639 | 208,549 | |
2.25174 % | Azamian (Bobak R) | 856,562 | -232,571 | |
2.10378 % | Ikarian Capital LLC | 800,277 | 90,000 | |
2.03269 % | Geode Capital Management, L.L.C. | 773,235 | 143,543 | |
1.95043 % | Two Sigma Investments, LP | 741,942 | 520,216 | |
1.76251 % | ExodusPoint Capital Management, LP | 670,459 | 454,501 | |
1.64978 % | Artisan Partners Limited Partnership | 627,578 | 148 | |
1.56237 % | Ensign Peak Advisors, Inc. | 594,325 | -133,566 | |
1.55100 % | Integral Health Asset Management, LLC | 590,000 | 0 | |
1.48672 % | Vivo Capital, LLC | 565,550 | 0 | |
1.46245 % | TCG Crossover Management, LLC | 556,317 | -237,512 | |
1.31441 % | Polygon Management Ltd. | 500,000 | 50,000 | |
1.31441 % | Cormorant Asset Management, LP | 500,000 | -1,639,102 | |
1.21777 % | Lord, Abbett & Co. LLC | 463,240 | 381,014 | |
1.19609 % | Macquarie Investment Management | 454,991 | 304,991 | |
1.10609 % | Jefferies LLC | 420,758 | 150,000 | |
1.06966 % | Dimensional Fund Advisors, L.P. | 406,899 | -17,931 | |
1.02518 % | Invesco Advisers, Inc. | 389,977 | 167,722 | |
1.02419 % | HOOPP Investment Management | 389,600 | -508,400 | |
1.01777 % | J. Goldman & Co., L.P. | 387,161 | 223,814 | |
0.99080 % | Medical Strategy GmbH | 376,899 | 58,824 | |
0.98858 % | Nuveen LLC | 376,055 | 219,538 | |
0.95810 % | Driehaus Capital Management, LLC | 364,463 | 203,300 | |
0.91637 % | Millennium Management LLC | 348,586 | 322,942 | |
0.72085 % | T. Rowe Price Associates, Inc. | 274,211 | -59,877 | |
0.70924 % | D. E. Shaw & Co., L.P. | 269,793 | 73,281 | |
0.70899 % | BlackRock Financial Management, Inc. | 269,701 | 74,372 | |
0.68843 % | Charles Schwab Investment Management, Inc. | 261,879 | 39,882 | |
0.67295 % | Emerald Advisers LLC | 255,990 | 226,886 | |
0.63910 % | BofA Global Research (US) | 243,112 | 13,620 | |
0.61777 % | Ghost Tree Capital, LLC | 235,000 | -65,000 | |
0.60854 % | Northern Trust Investments, Inc. | 231,490 | 5,784 | |
0.59642 % | Qube Research & Technologies Ltd | 226,879 | 193,516 | |
0.56795 % | Boone Capital Management LLC | 216,047 | -393,057 | |
0.55345 % | Allspring Global Investments, LLC | 210,531 | 29,465 | |
0.54545 % | Citadel Advisors LLC | 207,489 | -11,789 | |
0.52601 % | Boothbay Fund Management, LLC | 200,094 | 24,582 | |
0.47676 % | Goldman Sachs & Company, Inc. | 181,360 | 2,603 | |
0.44690 % | Sands Capital Ventures LLC | 170,000 | 0 | |
0.43927 % | Link (William J) | 167,098 | 27,116 | |
0.33472 % | Wellington Management Company, LLP | 127,328 | 15,906 | |
0.32539 % | Robert W. Baird & Co. Inc. | 123,778 | -4,494 | |
0.28889 % | Flying L Investments Xi, L.L.C. | 109,892 | -105,684 | |
0.28695 % | Essex Investment Management Company, LLC | 109,156 | 87,948 | |
0.26960 % | abrdn Inc. | 102,555 | 0 | |
0.25984 % | BlackRock Investment Management, LLC | 98,842 | 20,118 | |
0.24571 % | BlackRock Advisors (UK) Limited | 93,467 | 704 | |
0.23461 % | BNY Mellon Asset Management | 89,244 | 27,604 | |
0.22430 % | Connor, Clark & Lunn Investment Management Ltd. | 85,323 | -11,724 | |
0.22355 % | Bessemer Trust Company, N.A. (US) | 85,038 | 0 | |
0.22345 % | Hudson Bay Capital Management LP | 85,000 | 85,000 | |
0.20811 % | BlackRock Asset Management Ireland Limited | 79,165 | 14,654 | |
0.20727 % | Jane Street Capital, L.L.C. | 78,847 | 40,572 | |
0.20242 % | PGIM Securities Investment Trust Enterprise | 77,000 | 77,000 | |
0.19871 % | Walleye Capital LLC | 75,588 | -196,910 | |
0.19591 % | Baird Investment Management | 74,526 | -3,222 | |
0.18732 % | Parametric Portfolio Associates LLC | 71,255 | 8,386 | |
0.17734 % | Russell Investments Trust Company | 67,461 | 47,214 | |
0.17026 % | Neervannan (Seshadri) | 64,767 | 12,044 | |
0.14236 % | TwinBeech Capital LP | 54,152 | 54,152 | |
0.14098 % | GGM Wealth Advisors | 53,630 | 30 | |
0.13778 % | BlackRock Investment Management (UK) Ltd. | 52,413 | 23,044 | |
0.13733 % | Mottiwala (Aziz) | 52,242 | 8,172 | |
0.13055 % | Rhumbline Advisers Ltd. Partnership | 49,660 | 6,070 | |
0.12657 % | Columbia Threadneedle Investments (US) | 48,148 | -10,219 | |
0.12443 % | Schweizerische Nationalbank | 47,333 | 4,900 | |
0.12373 % | State of Wisconsin Investment Board | 47,065 | 24,227 | |
0.12350 % | Lannebo Kapitalförvaltning AB | 46,981 | 0 | |
0.12350 % | E. Ohman J:or Asset Management AB | 46,981 | 8,000 | |
0.11726 % | New York State Common Retirement Fund | 44,604 | 5,105 | |
0.10515 % | SilverArc Capital Management, LLC | 40,000 | 40,000 | |
0.10402 % | Wahl (Bryan) | 39,568 | 7,602 | |
0.10069 % | Graham Capital Management, L.P. | 38,301 | 38,301 | |
0.09940 % | Advisory Services Network, LLC | 37,811 | 37,811 | |
0.09303 % | TD Asset Management Inc. | 35,388 | -13,200 | |
0.09232 % | AllianceBernstein L.P. | 35,120 | 7,820 | |
0.09175 % | Trexquant Investment LP | 34,903 | -6,135 | |
0.08778 % | Mellon Investments Corporation | 33,390 | 1,223 | |
0.08749 % | Manulife Investment Management (North America) Limited | 33,282 | 3,112 | |
0.08467 % | Whitfield (Dianne C) | 32,208 | 7,397 | |
0.08212 % | Aperio Group, LLC | 31,240 | 1,419 | |
0.07862 % | Yeu-lin (Elizabeth M.D.) | 29,906 | 11,506 | |
0.07761 % | Jackson Creek Investment Advisors LLC | 29,524 | -53 | |
0.07747 % | Alps Advisors, Inc. | 29,468 | 3,020 | |
0.07397 % | Schonfeld Strategic Advisors LLC | 28,137 | 12,606 | |
0.07354 % | UBS Financial Services, Inc. | 27,973 | -10,367 | |
0.07315 % | Voloridge Investment Management, LLC | 27,827 | 27,827 | |
0.07114 % | Legal & General Investment Management Ltd. | 27,062 | 4,231 | |