8.91330 % | Wellington Management Company, LLP | 7,585,221 | -57,225 | |
6.73731 % | BlackRock Institutional Trust Company, N.A. | 5,733,451 | 811,058 | |
6.65100 % | Kynam Capital Management LP | 5,660,000 | 2,060,000 | |
5.89451 % | State Street Global Advisors (US) | 5,016,224 | 1,415,576 | |
5.07684 % | The Vanguard Group, Inc. | 4,320,388 | 712,749 | |
4.96148 % | Avoro Capital Advisors LLC | 4,222,222 | 1,666,667 | |
4.64160 % | Avidity Partners Management LP | 3,950,000 | 1,129,000 | |
3.97561 % | Eversept Partners, LP | 3,383,244 | 786,999 | |
3.33079 % | Point72 Asset Management, L.P. | 2,834,499 | -322,483 | |
3.18596 % | T. Rowe Price Investment Management, Inc. | 2,711,253 | 1,644,705 | |
2.46993 % | Marshall Wace LLP | 2,101,911 | 1,497,949 | |
2.20329 % | BVF Partners L.P. | 1,875,000 | 1,875,000 | |
2.05523 % | OrbiMed Advisors, LLC | 1,749,000 | 465,000 | |
1.81459 % | Woodline Partners LP | 1,544,216 | 1,510,149 | |
1.80382 % | Geode Capital Management, L.L.C. | 1,535,055 | 174,135 | |
1.64231 % | Morgan Stanley & Co. LLC | 1,397,603 | 946,055 | |
1.56819 % | Franklin Advisers, Inc. | 1,334,531 | 1,334,531 | |
1.38073 % | Cormorant Asset Management, LP | 1,175,000 | 1,175,000 | |
1.30121 % | Goldman Sachs & Company, Inc. | 1,107,330 | -74,741 | |
1.28613 % | StemPoint Capital LP | 1,094,494 | 1,094,494 | |
1.26414 % | Sofinnova Investments, Inc | 1,075,786 | 133,969 | |
1.25852 % | Candriam Luxembourg S.A. | 1,071,000 | 0 | |
1.20447 % | Aisling Capital Management LP | 1,025,000 | 0 | |
1.19980 % | Candriam Belgium S.A. | 1,021,032 | 781,022 | |
1.11875 % | BofA Global Research (US) | 952,057 | 759,276 | |
1.10769 % | Millennium Management LLC | 942,642 | 502,872 | |
1.05758 % | Adage Capital Management, L.P. | 900,000 | -100,000 | |
1.02820 % | Foresite Capital Management, LLC | 875,000 | 0 | |
0.98475 % | BlackRock Financial Management, Inc. | 838,023 | 258,358 | |
0.91657 % | HOOPP Investment Management | 780,000 | 780,000 | |
0.90830 % | Sphera Funds Management Ltd. | 772,964 | -97 | |
0.87696 % | Kingdon Capital Management, L.L.C. | 746,293 | 746,293 | |
0.87259 % | Dafna Capital Management, LLC | 742,574 | 284,201 | |
0.86791 % | Parkman Healthcare Partners LLC | 738,589 | 526,141 | |
0.80774 % | Two Sigma Investments, LP | 687,390 | 188,773 | |
0.75720 % | JP Morgan Asset Management | 644,374 | -3,761 | |
0.73118 % | Nuveen LLC | 622,237 | 462,635 | |
0.72139 % | Northern Trust Investments, Inc. | 613,904 | 72,239 | |
0.69979 % | PFM Health Sciences, LP | 595,523 | -2,119,712 | |
0.67805 % | Charles Schwab Investment Management, Inc. | 577,022 | 70,555 | |
0.62063 % | Algert Global LLC | 528,157 | 71,938 | |
0.60963 % | Saturn V Capital Management LLC | 518,799 | -289,170 | |
0.60500 % | Ensign Peak Advisors, Inc. | 514,852 | 0 | |
0.60400 % | Soleus Capital Management, L.P. | 514,000 | 394,500 | |
0.55893 % | Columbia Threadneedle Investments (US) | 475,648 | 4,459 | |
0.55535 % | Palo Alto Investors LP | 472,600 | 0 | |
0.55402 % | Schonfeld Strategic Advisors LLC | 471,475 | 253,062 | |
0.48410 % | Assenagon Asset Management S.A. | 411,965 | 21,427 | |
0.47401 % | Rafferty Asset Management LLC | 403,381 | 119,257 | |
0.42921 % | Nantahala Capital Management, LLC | 365,259 | 125,228 | |
0.41510 % | ExodusPoint Capital Management, LP | 353,252 | 197,538 | |
0.37710 % | Granahan Investment Management, LLC | 320,911 | 307,862 | |
0.34172 % | UBS Financial Services, Inc. | 290,801 | 215,444 | |
0.32327 % | Zimmer Partners, LP | 275,100 | 275,100 | |
0.29854 % | Barclays Bank PLC | 254,061 | 67,076 | |
0.28683 % | Macquarie Investment Management | 244,090 | 11,624 | |
0.28553 % | Citadel Advisors LLC | 242,985 | -192,508 | |
0.26901 % | Parametric Portfolio Associates LLC | 228,924 | 168,149 | |
0.23036 % | Peregrine Capital Management, LLC | 196,033 | -23,941 | |
0.22268 % | BlackRock Investment Management, LLC | 189,497 | 13,104 | |
0.21834 % | BNY Mellon Asset Management | 185,810 | 2,784 | |
0.20463 % | PanAgora Asset Management Inc. | 174,144 | 82,645 | |
0.19510 % | Voya Investment Management LLC | 166,033 | 117,144 | |
0.19391 % | Balyasny Asset Management LP | 165,018 | 16,494 | |
0.19261 % | Metzger (Michael A) | 163,909 | 3,750 | |
0.19143 % | BNP Paribas Securities Corp. North America | 162,905 | 44,906 | |
0.19084 % | Citi Investment Research (US) | 162,406 | 42,174 | |
0.18778 % | New Jersey Division of Investment | 159,803 | 26,769 | |
0.17626 % | Casdin Capital, LLC | 150,000 | 150,000 | |
0.16864 % | Trexquant Investment LP | 143,514 | 143,514 | |
0.16835 % | Verition Fund Management LLC | 143,266 | 128,266 | |
0.16733 % | Schweizerische Nationalbank | 142,400 | 21,400 | |
0.16427 % | Allianz Global Investors GmbH | 139,790 | 0 | |
0.16041 % | JPMorgan Private Bank (United States) | 136,509 | 55,546 | |
0.15520 % | BlackRock Advisors (UK) Limited | 132,075 | 6,237 | |
0.15228 % | Goldman Sachs Asset Management, L.P. | 129,590 | 58,629 | |
0.15033 % | Walleye Capital LLC | 127,932 | 127,932 | |
0.13458 % | Yelin Lapidot Mutual Funds Management Ltd | 114,530 | 114,530 | |
0.13458 % | Yelin Lapidot Provident Funds Management Ltd | 114,530 | 0 | |
0.12844 % | Dimensional Fund Advisors, L.P. | 109,303 | 3,163 | |
0.12581 % | Jane Street Capital, L.L.C. | 107,066 | -43,065 | |
0.12067 % | Victory Capital Management Inc. | 102,687 | 102,687 | |
0.11827 % | Crestline Investors, Inc. | 100,649 | -33,815 | |
0.11275 % | UBS O'Connor LLC | 95,949 | 95,949 | |
0.11201 % | Rhumbline Advisers Ltd. Partnership | 95,317 | -3,652 | |
0.10967 % | Podlesak (Dennis G) | 93,333 | -2,000 | |
0.10818 % | Sectoral Asset Management Inc. | 92,060 | 6,060 | |
0.10448 % | BlackRock Asset Management Ireland Limited | 88,910 | 4,125 | |
0.10126 % | Axiom Investors | 86,175 | 75,355 | |
0.10012 % | Wellington Management Japan Pte Ltd | 85,200 | -54,891 | |
0.09807 % | TwinBeech Capital LP | 83,456 | -104,654 | |
0.09255 % | State of Wisconsin Investment Board | 78,758 | 24,302 | |
0.09102 % | AllianceBernstein L.P. | 77,460 | 0 | |
0.08861 % | California State Teachers Retirement System | 75,407 | 12,215 | |
0.08552 % | Credit Suisse Funds AG | 72,775 | 3,606 | |
0.08226 % | HealthCor Management, L.P. | 70,000 | -789,240 | |
0.08106 % | Tudor Investment Corporation | 68,981 | 39,042 | |
0.08047 % | Aperio Group, LLC | 68,479 | 37,344 | |
0.08014 % | Gyon Technologies Capital Management, LP | 68,195 | 35,226 | |
0.07885 % | Polar Asset Management Partners Inc. | 67,100 | 67,100 | |