8.16 % | The Vanguard Group, Inc. | 9,293,363 | -1,600,786 | |
6.55 % | BlackRock Institutional Trust Company, N.A. | 7,451,035 | -850,122 | |
5.42 % | Boxer Capital, L.L.C. | 6,171,000 | 5,671,000 | |
4.26 % | Bellevue Asset Management AG | 4,851,579 | 0 | |
4.16 % | Point72 Asset Management, L.P. | 4,730,700 | 1,196,770 | |
3.15 % | D. E. Shaw & Co., L.P. | 3,581,979 | -1,129,685 | |
3.01 % | Two Sigma Investments, LP | 3,427,559 | -156,513 | |
2.97 % | Johnson & Johnson Innovation-JJDC, Inc. | 3,379,064 | 0 | |
2.41 % | Jacobs Levy Equity Management, Inc. | 2,741,104 | 224,452 | |
2.40 % | BlackRock Financial Management, Inc. | 2,733,253 | -160,455 | |
2.34 % | Citadel Advisors LLC | 2,666,208 | 646,576 | |
2.00 % | Acadian Asset Management LLC | 2,281,171 | 131,574 | |
11.58 % | Redmile Group, LLC | 13,180,388 | 11,331 | |
1.92 % | Monaco asset management S.A.M. | 2,183,228 | 335,284 | |
1.80 % | Casdin Capital, LLC | 2,050,000 | 0 | |
1.64 % | Geode Capital Management, L.L.C. | 1,863,485 | 88,141 | |
1.64 % | State Street Global Advisors (US) | 1,861,919 | -410,006 | |
1.63 % | Federated MDTA LLC | 1,849,872 | -601,672 | |
1.49 % | Adage Capital Management, L.P. | 1,700,000 | 1,700,000 | |
1.13 % | Vestal Point Capital, LP | 1,290,000 | 1,290,000 | |
1.00 % | JP Morgan Asset Management | 1,136,219 | -784,480 | |
0.96 % | Morgan Stanley & Co. LLC | 1,088,296 | -20,725 | |
0.86 % | Charles Schwab Investment Management, Inc. | 983,019 | 96,304 | |
0.79 % | Integral Health Asset Management, LLC | 900,000 | 900,000 | |
0.79 % | StemPoint Capital LP | 898,196 | 898,196 | |
0.79 % | Millennium Management LLC | 893,648 | -1,170,590 | |
0.74 % | Superstring Capital Management LP | 847,823 | 847,823 | |
0.74 % | Citi Investment Research (US) | 843,962 | 835,245 | |
0.64 % | Rafferty Asset Management LLC | 729,657 | 729,657 | |
0.62 % | Jane Street Capital, L.L.C. | 711,287 | -12,986 | |
0.61 % | Tang Capital Management, LLC | 700,000 | 0 | |
0.57 % | Northern Trust Investments, Inc. | 645,801 | -55,686 | |
0.53 % | Rastetter (William H) | 608,774 | -5,969 | |
0.53 % | BofA Global Research (US) | 607,004 | 414,932 | |
0.46 % | OrbiMed Advisors, LLC | 528,080 | 528,080 | |
0.44 % | Schonfeld Strategic Advisors LLC | 497,457 | 478,257 | |
0.44 % | GCM Grosvenor Holdings, LLC | 495,916 | 0 | |
0.43 % | JPMorgan Asset Management U.K. Limited | 488,879 | 0 | |
0.39 % | PGIM Quantitative Solutions LLC | 447,011 | 304,000 | |
0.37 % | BlackRock Investment Management (UK) Ltd. | 424,549 | -131,942 | |
0.37 % | Goldman Sachs & Company, Inc. | 421,089 | 124,084 | |
0.35 % | HRT Financial LP | 395,753 | -277,537 | |
0.34 % | Woodline Partners LP | 385,364 | 385,364 | |
0.33 % | Nikko Asset Management Americas, Inc. | 376,900 | -72,560 | |
0.32 % | Barclays Bank PLC | 358,708 | 253,823 | |
0.31 % | PanAgora Asset Management Inc. | 356,740 | -69,845 | |
0.28 % | Dimensional Fund Advisors, L.P. | 320,774 | -394,375 | |
0.27 % | Mendlein (John D) | 302,581 | -14,619 | |
0.26 % | Nuveen LLC | 296,528 | 9,578 | |
0.26 % | Fidelity Management & Research Company LLC | 291,172 | -16,458 | |
0.25 % | Davis (Aaron I) | 290,000 | 290,000 | |
0.25 % | BlackRock Investment Management, LLC | 284,579 | 8,006 | |
0.22 % | BlackRock Asset Management Ireland Limited | 255,355 | -120,146 | |
0.22 % | Numeric Investors LLC | 252,676 | 34,473 | |
0.22 % | Columbia Threadneedle Investments (US) | 251,649 | -23,843 | |
0.22 % | BlackRock Advisors (UK) Limited | 249,718 | -13,647 | |
0.22 % | Wolchko (John Scott) | 246,657 | -14,391 | |
0.21 % | Putnam Investment Management, L.L.C. | 244,684 | 111,434 | |
0.21 % | Conestoga Capital Advisors, LLC | 236,948 | 0 | |
0.21 % | AQR Capital Management, LLC | 235,058 | -97,853 | |
0.20 % | BNY Mellon Asset Management | 223,940 | 4,035 | |
0.19 % | Parametric Portfolio Associates LLC | 217,003 | -86,089 | |
0.19 % | Cubist Systematic Strategies, LLC | 214,446 | 101 | |
0.16 % | BIT Capital GmbH | 178,324 | 178,324 | |
0.16 % | Squarepoint Capital LLP | 176,495 | -98,306 | |
0.15 % | UBS Financial Services, Inc. | 176,305 | 109,595 | |
0.15 % | Goldman Sachs Asset Management, L.P. | 169,904 | 24,083 | |
0.15 % | J.P. Morgan Securities LLC | 169,777 | 131,849 | |
0.14 % | Assenagon Asset Management S.A. | 163,097 | -217,640 | |
0.14 % | AllianceBernstein L.P. | 160,760 | -800 | |
0.14 % | Ohio Public Employees Retirement System | 154,178 | 0 | |
0.13 % | Susquehanna International Group, LLP | 152,509 | -282,623 | |
0.13 % | Pennant Investors, LP | 146,100 | 146,100 | |
0.13 % | JPMorgan Private Bank (United States) | 145,297 | -2,371 | |
0.13 % | Bruce & Company, Inc. | 143,000 | -57,000 | |
0.12 % | Rhumbline Advisers Ltd. Partnership | 140,335 | -7 | |
0.12 % | J.P. Morgan Private Wealth Advisors LLC | 132,334 | 0 | |
0.11 % | Lombard Odier Asset Management (Europe) Ltd | 121,894 | -4,657 | |
0.10 % | Avantis Investors | 116,014 | 69,978 | |
0.10 % | PGIM Fixed Income | 113,000 | 61,100 | |
0.09 % | Royce Investment Partners | 107,318 | 76,979 | |
0.09 % | Invesco Capital Management LLC | 99,773 | -1,483 | |
0.09 % | Mellon Investments Corporation | 97,197 | 6,638 | |
0.08 % | State of Wyoming | 94,501 | 80,242 | |
0.08 % | Voya Investment Management LLC | 93,313 | 11,492 | |
0.08 % | SG Americas Securities, L.L.C. | 90,553 | 16,911 | |
0.07 % | Algert Global LLC | 80,654 | -11,210 | |
0.07 % | HSBC Global Asset Management (UK) Limited | 78,747 | -31,645 | |
0.06 % | Dimensional Fund Advisors, Ltd. | 72,545 | 31,689 | |
0.06 % | Northern Trust Global Investments | 62,788 | -425,135 | |
0.05 % | Shell Asset Management Company B.V. | 59,302 | -17,897 | |
0.05 % | Coughlin (Timothy P) | 57,632 | -5,969 | |
0.05 % | Valamehr (Bahram) | 56,877 | -11,271 | |
0.05 % | Abaris Investment Management AG | 56,000 | 15,000 | |
0.05 % | T. Rowe Price International Ltd | 54,357 | -30,637 | |
0.05 % | American Century Investment Management, Inc. | 52,982 | 15,920 | |
0.05 % | Qube Research & Technologies Ltd | 52,442 | -335,814 | |
0.04 % | Russell Investments Trust Company | 51,189 | 4,237 | |
0.04 % | BlackRock Japan Co., Ltd. | 50,471 | 0 | |
0.04 % | Engineers Gate Manager, L.P. | 46,847 | 31,460 | |