9.77004 % | Wellington Management Company, LLP | 6,476,561 | 1,044,728 | |
9.16151 % | Fidelity Management & Research Company LLC | 6,073,162 | -200,884 | |
5.47596 % | Eventide Asset Management, LLC | 3,630,013 | 2,030,013 | |
5.22432 % | RTW Investments L.P. | 3,463,201 | 0 | |
4.99849 % | BlackRock Institutional Trust Company, N.A. | 3,313,502 | 429,668 | |
4.73053 % | Polar Capital LLP | 3,135,871 | 709,115 | |
4.57939 % | The Vanguard Group, Inc. | 3,035,675 | 425,500 | |
4.53448 % | Kynam Capital Management LP | 3,005,904 | -194,096 | |
4.15767 % | Point72 Asset Management, L.P. | 2,756,122 | -866,014 | |
3.64504 % | Bellevue Asset Management AG | 2,416,296 | 516,296 | |
3.58625 % | State Street Global Advisors (US) | 2,377,326 | 84,475 | |
3.35714 % | Pictet Asset Management Ltd. | 2,225,448 | 374,478 | |
1.93104 % | Marshall Wace LLP | 1,280,084 | 741,765 | |
1.68652 % | Geode Capital Management, L.L.C. | 1,117,994 | 117,569 | |
1.49917 % | Redmile Group, LLC | 993,803 | -642,135 | |
1.47420 % | Fidelity Institutional Asset Management | 977,247 | 162,173 | |
1.46273 % | Rock Springs Capital Management LP | 969,646 | 469,545 | |
1.27321 % | Sofinnova Investments, Inc | 844,008 | 419,749 | |
1.13759 % | Eversept Partners, LP | 754,107 | 165,964 | |
1.06732 % | Octagon Capital Advisors LP | 707,526 | -52,372 | |
1.05893 % | Commodore Capital LP | 701,967 | -4,698 | |
0.93953 % | Morgan Stanley & Co. LLC | 622,813 | 119,544 | |
0.75014 % | 5AM Ventures | 497,270 | 187,000 | |
0.61758 % | Charles Schwab Investment Management, Inc. | 409,391 | 47,844 | |
0.60358 % | Northern Trust Investments, Inc. | 400,112 | 27,920 | |
0.60341 % | Affinity Asset Advisors LLC | 400,000 | 250,000 | |
0.58592 % | Goldman Sachs & Company, Inc. | 388,404 | 12,964 | |
0.58478 % | Woodline Partners LP | 387,652 | 280,156 | |
0.58200 % | T. Rowe Price Associates, Inc. | 385,809 | -47,814 | |
0.47897 % | Candriam Luxembourg S.A. | 317,509 | 0 | |
0.47897 % | Candriam Belgium S.A. | 317,509 | -5,000 | |
0.47616 % | Sphera Funds Management Ltd. | 315,644 | 135,644 | |
0.37939 % | TSP Capital Management Group, LLC | 251,495 | -200 | |
0.37358 % | Baker Bros. Advisors LP | 247,644 | 247,644 | |
0.37293 % | SilverArc Capital Management, LLC | 247,215 | 247,215 | |
0.36799 % | Medical Strategy GmbH | 243,942 | 6,400 | |
0.35543 % | Invesco Capital Management LLC | 235,612 | 217,783 | |
0.34767 % | Dimensional Fund Advisors, L.P. | 230,471 | -110,879 | |
0.32604 % | BofA Global Research (US) | 216,133 | 4,695 | |
0.27095 % | Ensign Peak Advisors, Inc. | 179,611 | 87,482 | |
0.25534 % | Walleye Capital LLC | 169,268 | 10,275 | |
0.24665 % | Nomura Asset Management Co., Ltd. | 163,501 | 163,501 | |
0.24295 % | American Century Investment Management, Inc. | 161,051 | 191 | |
0.23849 % | UBS Financial Services, Inc. | 158,092 | 136,897 | |
0.22328 % | Rafferty Asset Management LLC | 148,009 | -16,781 | |
0.21775 % | Barclays Bank PLC | 144,345 | 2,295 | |
0.21447 % | AXA Investment Managers UK Ltd. | 142,170 | -3,439 | |
0.20969 % | BlackRock Financial Management, Inc. | 139,006 | 3,916 | |
0.20898 % | Laurion Capital Management LP | 138,531 | 138,531 | |
0.20607 % | BNP Paribas Securities Corp. North America | 136,601 | 44,878 | |
0.19693 % | Schonfeld Strategic Advisors LLC | 130,542 | 130,542 | |
0.19430 % | MacKay Shields LLC | 128,803 | 0 | |
0.19333 % | Jane Street Capital, L.L.C. | 128,161 | 68,747 | |
0.19284 % | BNY Mellon Asset Management | 127,836 | 4,661 | |
0.19057 % | Citadel Advisors LLC | 126,328 | 120,403 | |
0.18614 % | BlackRock Investment Management, LLC | 123,393 | 1,115 | |
0.18114 % | Nuveen LLC | 120,076 | -204 | |
0.16790 % | Exome Asset Management LLC | 111,300 | 111,300 | |
0.15803 % | Mirador Capital Partners LP | 104,759 | -3,151 | |
0.15117 % | Monashee Investment Management, LLC | 100,209 | 100,209 | |
0.14633 % | Schweizerische Nationalbank | 97,000 | 8,700 | |
0.14225 % | Polar Asset Management Partners Inc. | 94,300 | -38,100 | |
0.12104 % | UBS Switzerland AG | 80,235 | 0 | |
0.11468 % | Rhumbline Advisers Ltd. Partnership | 76,022 | -652 | |
0.10469 % | Acuta Capital Partners, LLC | 69,400 | -52,941 | |
0.10144 % | Crestline Investors, Inc. | 67,243 | 4,133 | |
0.09633 % | BlackRock Advisors (UK) Limited | 63,854 | 1,366 | |
0.09404 % | Citi Investment Research (US) | 62,341 | -7,014 | |
0.09379 % | Kennedy Capital Management LLC | 62,172 | -25,222 | |
0.08870 % | OrbiMed Advisors, LLC | 58,800 | 58,800 | |
0.08158 % | AllianceBernstein L.P. | 54,080 | -39,201 | |
0.07893 % | TD Asset Management Inc. | 52,322 | -12,600 | |
0.07846 % | Legal & General Investment Management Ltd. | 52,012 | 11,168 | |
0.07822 % | Wellington Management Japan Pte Ltd | 51,854 | -16,384 | |
0.07765 % | California State Teachers Retirement System | 51,474 | 5,721 | |
0.07543 % | HBM Partners AG | 50,000 | 0 | |
0.07445 % | Goldman Sachs Asset Management, L.P. | 49,355 | 12,961 | |
0.07375 % | Susquehanna International Group, LLP | 48,888 | -8,572 | |
0.07256 % | International Biotechnology Trust PLC | 48,099 | 0 | |
0.07256 % | Schroder Investment Management Ltd. (SIM) | 48,099 | 48,099 | |
0.07241 % | Credit Suisse Funds AG | 47,998 | 8,352 | |
0.07107 % | Young (Diane C) | 47,115 | 0 | |
0.07063 % | BlackRock Asset Management Ireland Limited | 46,821 | 3,562 | |
0.06952 % | SG Americas Securities, L.L.C. | 46,083 | -31,928 | |
0.06861 % | Monarch Partners Asset Management LLC | 45,479 | 45,479 | |
0.06784 % | Qube Research & Technologies Ltd | 44,968 | 40,669 | |
0.06551 % | Manulife Investment Management (North America) Limited | 43,427 | -6,405 | |
0.06235 % | JPMorgan Private Bank (United States) | 41,331 | 36,735 | |
0.06223 % | Mellon Investments Corporation | 41,252 | 321 | |
0.06167 % | Atom Investors LP | 40,882 | 40,882 | |
0.06112 % | State of Wisconsin Investment Board | 40,518 | 8,569 | |
0.05989 % | Caption Management, LLC | 39,700 | 26,700 | |
0.05679 % | Alps Advisors, Inc. | 37,645 | 2,797 | |
0.05608 % | TwinBeech Capital LP | 37,177 | -25,406 | |
0.05527 % | Northern Trust Global Investments | 36,637 | -50,169 | |
0.05504 % | T. Rowe Price International Ltd | 36,484 | 2,052 | |
0.05299 % | Martin (Samuel Bates) | 35,128 | 10,750 | |
0.05280 % | PFM Health Sciences, LP | 35,000 | 35,000 | |
0.05150 % | JP Morgan Asset Management | 34,139 | -23,937 | |
0.04932 % | Kentucky Teachers' Retirement System | 32,697 | 0 | |