9.50074 % | Deerfield Management Company, L.P. | 4,695,020 | 0 | |
5.95206 % | BlackRock Institutional Trust Company, N.A. | 2,941,353 | 118,089 | |
5.50310 % | The Vanguard Group, Inc. | 2,719,487 | 160,007 | |
4.77767 % | Jefferies LLC | 2,361,000 | -15,970 | |
4.23902 % | Schroder Investment Management North America Inc. | 2,094,811 | -257,183 | |
3.73275 % | Rice Hall James & Associates, LLC | 1,844,627 | 166,018 | |
3.46161 % | UBS Financial Services, Inc. | 1,710,637 | 100,781 | |
3.32645 % | FundLogic SAS | 1,643,846 | 0 | |
2.73220 % | Easterly Investment Partners LLC | 1,350,183 | 1,350,183 | |
2.58886 % | Medical Strategy GmbH | 1,279,345 | 0 | |
2.49200 % | Rubric Capital Management LP | 1,231,483 | 1,231,483 | |
2.48602 % | Levin Capital Strategies, L.P. | 1,228,525 | -207,351 | |
2.47244 % | Jacobs Levy Equity Management, Inc. | 1,221,814 | 83,439 | |
2.33954 % | C WorldWide Asset Management Fondsmaeglerselskab A/S | 1,156,142 | 0 | |
2.33647 % | Citi Investment Research (US) | 1,154,623 | -52,683 | |
2.14411 % | Fred Alger Management, LLC | 1,059,565 | 549,357 | |
2.09208 % | Pinnacle Associates Ltd. | 1,033,852 | 2,787 | |
2.01626 % | DWS Investments UK Limited | 996,383 | 719,744 | |
1.91026 % | State Street Global Advisors (US) | 944,000 | -151,898 | |
1.84063 % | BofA Global Research (US) | 909,592 | -34,531 | |
1.82916 % | Managed Account Advisors LLC | 903,921 | -922,608 | |
1.69047 % | Geode Capital Management, L.L.C. | 835,386 | 71,654 | |
1.68871 % | Andbank Wealth Management, SGIIC, S.A.U. | 834,516 | 14,524 | |
1.43148 % | Granahan Investment Management, Inc. | 707,398 | -881,546 | |
1.41556 % | PFM Health Sciences, LP | 699,531 | -389,035 | |
1.27787 % | Walleye Capital LLC | 631,490 | 362,380 | |
1.19454 % | Renaissance Technologies LLC | 590,310 | 92,100 | |
1.17688 % | Fidelity Management & Research Company LLC | 581,585 | 397,305 | |
1.13796 % | Rhenman & Partners Asset Management AB | 562,350 | -26,850 | |
1.07066 % | Columbia Threadneedle Investments (US) | 529,094 | -549,377 | |
0.94734 % | Granite Investment Partners, LLC | 468,152 | -70,000 | |
0.90922 % | Nuveen LLC | 449,312 | 64,974 | |
0.87930 % | Marshall Wace LLP | 434,525 | 305,951 | |
0.85570 % | Weatherbie Capital, LLC | 422,863 | 0 | |
0.79187 % | Northern Trust Investments, Inc. | 391,322 | 5,592 | |
0.70835 % | Columbia Threadneedle Investments (UK) | 350,049 | 10,215 | |
0.70425 % | Charles Schwab Investment Management, Inc. | 348,021 | 7,302 | |
0.62686 % | Highland Capital Management Fund Advisors, L.P. | 309,778 | 0 | |
0.58490 % | Dafna Capital Management, LLC | 289,040 | 0 | |
0.56710 % | Kopczynski Casey C | 280,244 | 19,015 | |
0.54144 % | Wellington Management Company, LLP | 267,565 | 0 | |
0.53953 % | Victory Capital Management Inc. | 266,620 | -427,188 | |
0.50839 % | Stonepine Capital Management, LLC | 251,235 | 157,335 | |
0.50265 % | D. E. Shaw & Co., L.P. | 248,399 | 187,899 | |
0.46963 % | Highland Capital Management, L.P. | 232,078 | 232,078 | |
0.46261 % | LifeSci Fund Management LLC | 228,608 | 53,908 | |
0.45221 % | Morgan Stanley & Co. LLC | 223,471 | -1,247,404 | |
0.44960 % | NexPoint Advisors, L.P. | 222,180 | 222,180 | |
0.43665 % | Kannan (Raj) | 215,783 | 0 | |
0.42524 % | Jacob Asset Management of New York, LLC | 210,143 | -36,420 | |
0.38251 % | Stifel Nicolaus Investment Advisors | 189,026 | 5,012 | |
0.37219 % | BlackRock Financial Management, Inc. | 183,927 | 43,953 | |
0.33896 % | Endurance Wealth Management, Inc. | 167,503 | -5,000 | |
0.33827 % | DCF Advisers, LLC | 167,165 | -22,400 | |
0.31778 % | PDT Partners, LLC | 157,037 | -3,878 | |
0.30141 % | Schroder Investment Management Ltd. (SIM) | 148,947 | 0 | |
0.29398 % | Allianz Global Investors U.S. LLC | 145,275 | 15,170 | |
0.27723 % | AlphaCentric Advisors LLC. | 137,000 | 89,500 | |
0.25045 % | Voloridge Investment Management, LLC | 123,766 | -110,859 | |
0.24857 % | BlackRock Investment Management, LLC | 122,838 | 3,994 | |
0.22716 % | BNY Mellon Asset Management | 112,255 | 9,399 | |
0.22444 % | New York State Common Retirement Fund | 110,912 | 10,399 | |
0.21408 % | BlackRock Advisors (UK) Limited | 105,794 | 6,593 | |
0.20762 % | Schweizerische Nationalbank | 102,600 | -3,700 | |
0.20359 % | ARIAD Asset Management GmbH | 100,611 | 0 | |
0.20236 % | Alyeska Investment Group, L.P. | 100,000 | 0 | |
0.20082 % | BlackRock Asset Management Ireland Limited | 99,242 | -23,944 | |
0.18608 % | Citadel Advisors LLC | 91,957 | -775 | |
0.18087 % | Nordea Funds Oy | 89,379 | 51,070 | |
0.16875 % | Goldman Sachs & Company, Inc. | 83,390 | -128,802 | |
0.16476 % | Mitro (Thomas A) | 81,418 | -5,291 | |
0.16394 % | AQR Capital Management, LLC | 81,013 | 41,813 | |
0.16270 % | Acadian Asset Management LLC | 80,402 | 80,402 | |
0.15962 % | Envestnet Asset Management, Inc. | 78,879 | 35,423 | |
0.15940 % | Parametric Portfolio Associates LLC | 78,770 | -78,243 | |
0.15878 % | UBS Asset Management (Americas), Inc. | 78,466 | 12,950 | |
0.15119 % | Thompson Investment Management, Inc. | 74,712 | 0 | |
0.13815 % | Goldman Sachs Asset Management, L.P. | 68,271 | 7,035 | |
0.13653 % | Rhumbline Advisers Ltd. Partnership | 67,469 | 17,886 | |
0.13093 % | AllianceBernstein L.P. | 64,700 | 0 | |
0.12935 % | Squarepoint Capital LLP | 63,919 | 49,400 | |
0.11658 % | California State Teachers Retirement System | 57,612 | 1,517 | |
0.11426 % | Jane Street Capital, L.L.C. | 56,463 | 56,463 | |
0.10843 % | LaRocca (John) | 53,585 | -771 | |
0.10779 % | Northern Trust Global Investments | 53,266 | 4,409 | |
0.10485 % | Balyasny Asset Management LP | 51,816 | 51,816 | |
0.10370 % | IndexIQ Advisors LLC | 51,246 | 9,205 | |
0.10259 % | Geneva Capital Management LLC | 50,695 | 50,695 | |
0.10121 % | Graham Capital Management, L.P. | 50,017 | 50,017 | |
0.10084 % | Redwood Investments, LLC | 49,833 | -2,630 | |
0.09739 % | Two Sigma Investments, LP | 48,129 | -38,738 | |
0.09695 % | SEI Investments Management Corporation | 47,910 | 1,526 | |
0.09369 % | Lang Peter Frederick | 46,297 | 46,297 | |
0.09211 % | PanAgora Asset Management Inc. | 45,517 | -3,514 | |
0.09036 % | Los Angeles Capital Management And Equity Research, Inc. | 44,653 | -140 | |
0.08854 % | Morgan Stanley Smith Barney LLC | 43,754 | 11,641 | |
0.08784 % | Apo Asset Management GmbH | 43,406 | 0 | |
0.08677 % | Millennium Management LLC | 42,880 | -589,297 | |
0.08496 % | McGraw (Benjamin F III) | 41,984 | 6,245 | |
0.08302 % | Principal Global Investors (Equity) | 41,027 | 6,319 | |