8.77499 % | The Vanguard Group, Inc. | 13,660,028 | 151,833 | |
8.39913 % | Weiss (Michael S) | 13,074,929 | 500,000 | |
6.05327 % | BlackRock Institutional Trust Company, N.A. | 9,423,120 | 338,294 | |
4.30150 % | State Street Global Advisors (US) | 6,696,143 | -1,100,436 | |
2.34185 % | Soleus Capital Management, L.P. | 3,645,562 | 477,106 | |
2.08356 % | Pictet Asset Management Ltd. | 3,243,481 | -83,733 | |
2.05974 % | Geode Capital Management, L.L.C. | 3,206,390 | 98,946 | |
1.84373 % | Deep Track Capital LP | 2,870,131 | 2,870,131 | |
1.46464 % | Opaleye Management Inc. | 2,280,000 | 0 | |
1.33737 % | BofA Global Research (US) | 2,081,888 | -119,562 | |
1.31802 % | Marshall Wace LLP | 2,051,762 | 2,051,762 | |
1.19566 % | Sofinnova Investments, Inc | 1,861,277 | -123,685 | |
1.19470 % | Citadel Advisors LLC | 1,859,792 | -18,541 | |
1.07988 % | Nuveen LLC | 1,681,044 | 135,597 | |
1.01043 % | Hood River Capital Management LLC | 1,572,929 | 98,892 | |
0.98107 % | Two Sigma Investments, LP | 1,527,228 | 1,263,350 | |
0.93654 % | Millennium Management LLC | 1,457,908 | -2,026,138 | |
0.91189 % | Woodline Partners LP | 1,419,534 | 14,937 | |
0.89934 % | 683 Capital Management LLC | 1,400,000 | -225,000 | |
0.78087 % | Fidelity Management & Research Company LLC | 1,215,577 | -180,975 | |
0.76588 % | Morgan Stanley & Co. LLC | 1,192,241 | 334,728 | |
0.75587 % | Charles Schwab Investment Management, Inc. | 1,176,670 | 31,101 | |
0.72087 % | Goldman Sachs Asset Management, L.P. | 1,122,177 | 565,038 | |
0.72070 % | Northern Trust Investments, Inc. | 1,121,906 | -34,739 | |
0.70746 % | ExodusPoint Capital Management, LP | 1,101,298 | 539,706 | |
0.69832 % | Susquehanna International Group, LLP | 1,087,069 | 4,709 | |
0.62558 % | BlackRock Financial Management, Inc. | 973,843 | 228,102 | |
0.60731 % | Goldman Sachs & Company, Inc. | 945,398 | 233,764 | |
0.51519 % | Balyasny Asset Management LP | 802,003 | 802,003 | |
0.46175 % | Eventide Asset Management, LLC | 718,814 | 0 | |
0.43809 % | Power (Sean A) | 681,969 | 308,750 | |
0.43619 % | Cubist Systematic Strategies, LLC | 679,020 | -3,993 | |
0.39741 % | Group One Trading, L.P. | 618,654 | 10,372 | |
0.38370 % | Norges Bank Investment Management (NBIM) | 597,300 | -477,737 | |
0.37636 % | Point72 Asset Management, L.P. | 585,873 | 585,873 | |
0.33827 % | BlackRock Advisors (UK) Limited | 526,585 | 200,348 | |
0.32119 % | Ghost Tree Capital, LLC | 500,000 | -325,000 | |
0.27968 % | UBS Financial Services, Inc. | 435,379 | -89,240 | |
0.26663 % | Jane Street Capital, L.L.C. | 415,063 | 190,801 | |
0.26276 % | Invesco Capital Management LLC | 409,038 | -95,196 | |
0.24997 % | Capital Fund Management S.A. | 389,123 | 355,710 | |
0.24584 % | BlackRock Investment Management, LLC | 382,701 | 31,322 | |
0.22200 % | BNY Mellon Asset Management | 345,583 | 22,230 | |
0.21682 % | J.P. Morgan Securities plc | 337,529 | 81,306 | |
0.21646 % | Rafferty Asset Management LLC | 336,964 | -209,555 | |
0.19874 % | Renaissance Technologies LLC | 309,371 | -531,229 | |
0.19850 % | Jump Financial, LLC | 309,004 | 309,004 | |
0.19297 % | Goldman Sachs Asset Management International | 300,394 | 0 | |
0.18539 % | Schweizerische Nationalbank | 288,600 | 4,500 | |
0.18461 % | BlackRock Asset Management Ireland Limited | 287,387 | -129,731 | |
0.17363 % | Schonfeld Strategic Advisors LLC | 270,284 | -220,814 | |
0.17019 % | Hoberman (Kenneth) | 264,935 | 22,250 | |
0.16241 % | TwinBeech Capital LP | 252,823 | 217,093 | |
0.16174 % | GTS Securities LLC | 251,785 | 8,274 | |
0.16162 % | Exome Asset Management LLC | 251,600 | 21,300 | |
0.15680 % | Echelard (Yann) | 244,098 | 22,250 | |
0.15449 % | Hume (Daniel) | 240,489 | 22,250 | |
0.15418 % | D. E. Shaw & Co., L.P. | 240,012 | 150,410 | |
0.15255 % | Charney (Laurence Neil) | 237,479 | 22,250 | |
0.15068 % | State of Wisconsin Investment Board | 234,569 | 10,345 | |
0.14666 % | Susquehanna Portfolio Strategies, LLC | 228,304 | 0 | |
0.13815 % | Rhumbline Advisers Ltd. Partnership | 215,055 | 15,582 | |
0.13715 % | Rhenman & Partners Asset Management AB | 213,500 | 90,000 | |
0.13187 % | New Jersey Division of Investment | 205,283 | 113,683 | |
0.13176 % | BlackRock Investment Management (UK) Ltd. | 205,117 | 54,975 | |
0.12722 % | Commonwealth Financial Network | 198,037 | 11,043 | |
0.11585 % | Jacobs Levy Equity Management, Inc. | 180,338 | -344,523 | |
0.11583 % | Parkman Healthcare Partners LLC | 180,320 | 25,281 | |
0.11400 % | Morgan Stanley Smith Barney LLC | 177,468 | -9,831 | |
0.10936 % | Assenagon Asset Management S.A. | 170,234 | -318,709 | |
0.10931 % | Raymond James & Associates, Inc. | 170,160 | 44,972 | |
0.10838 % | Legal & General Investment Management Ltd. | 168,718 | 19,462 | |
0.10398 % | AllianceBernstein L.P. | 161,870 | -5,350 | |
0.10381 % | M28 Capital Management LP | 161,600 | 0 | |
0.10328 % | Point72 Europe (London) LLP | 160,769 | 160,769 | |
0.10074 % | First Trust Advisors L.P. | 156,828 | -11,734 | |
0.09598 % | Trexquant Investment LP | 149,418 | 149,418 | |
0.09514 % | Simplex Trading, LLC | 148,108 | -41,741 | |
0.09487 % | Parkwood LLC | 147,680 | 131,609 | |
0.09457 % | Algert Global LLC | 147,218 | 97,118 | |
0.09449 % | Hudson Bay Capital Management LP | 147,100 | 147,100 | |
0.09292 % | Connor, Clark & Lunn Investment Management Ltd. | 144,648 | -87,699 | |
0.09169 % | California State Teachers Retirement System | 142,727 | -594 | |
0.09163 % | BNP Paribas Securities Corp. North America | 142,646 | 56,045 | |
0.08951 % | Barclays Bank PLC | 139,334 | -17,046 | |
0.08917 % | Mellon Investments Corporation | 138,815 | 36,029 | |
0.08562 % | LPL Financial LLC | 133,280 | 18,778 | |
0.08557 % | OrbiMed Advisors, LLC | 133,200 | 133,200 | |
0.08502 % | Columbia Threadneedle Investments (US) | 132,343 | 1,925 | |
0.07914 % | Brookfield BHS Advisors LLC | 123,193 | -375,098 | |
0.07149 % | Parametric Portfolio Associates LLC | 111,294 | -9,831 | |
0.07136 % | Lighthouse Investment Partners, LLC | 111,092 | 111,092 | |
0.07000 % | Raymond James Financial Services Advisors, Inc. | 108,969 | -304 | |
0.06781 % | Bayesian Capital Management, LP | 105,567 | 61,300 | |
0.06758 % | Lonial (Sagar) | 105,195 | -3,683 | |
0.06703 % | Northern Trust Global Investments | 104,347 | 1,540 | |
0.06655 % | Quantum Private Wealth, LLC | 103,604 | 0 | |
0.06546 % | Nomura Asset Management Co., Ltd. | 101,900 | 101,900 | |
0.06424 % | Tang Capital Management, LLC | 100,000 | 0 | |
0.06336 % | Hennion & Walsh Asset Management, Inc. | 98,629 | -2,740 | |