19.42538 % | BML Capital Management LLC | 6,440,000 | 0 | |
17.83954 % | RA Capital Management, LP | 5,914,252 | 0 | |
8.42806 % | Shin Nippon Biomedical Laboratories Ltd | 2,794,113 | 0 | |
7.50648 % | New Enterprise Associates (NEA) | 2,488,587 | -504,371 | |
2.77661 % | The Vanguard Group, Inc. | 920,517 | 11,127 | |
2.46407 % | Driehaus Capital Management, LLC | 816,902 | -897,144 | |
1.41533 % | Two Sigma Investments, LP | 469,218 | 423,889 | |
1.23402 % | Geode Capital Management, L.L.C. | 409,108 | 217,663 | |
0.93769 % | Kollins (John A) | 310,869 | 3,591 | |
0.82971 % | Acadian Asset Management LLC | 275,069 | 275,069 | |
0.76646 % | Renaissance Technologies LLC | 254,100 | 244,100 | |
0.69804 % | Dimensional Fund Advisors, L.P. | 231,417 | -44,849 | |
0.53661 % | Nan Fung Group Holdings Ltd | 177,900 | 0 | |
0.52785 % | Millennium Management LLC | 174,994 | 112,878 | |
0.45245 % | Leonard (Braden Michael) | 150,000 | 150,000 | |
0.41040 % | Ikarian Capital LLC | 136,059 | 0 | |
0.38304 % | BlackRock Institutional Trust Company, N.A. | 126,987 | 252 | |
0.23694 % | Marquette Wealth Management | 78,551 | 78,551 | |
0.21205 % | Bridgeway Capital Management, LLC | 70,300 | -45,000 | |
0.19263 % | Chicago Partners Wealth Advisors | 63,863 | 63,863 | |
0.18773 % | State Street Global Advisors (US) | 62,236 | 0 | |
0.16415 % | Susquehanna International Group, LLP | 54,419 | 42,369 | |
0.15082 % | Signal Iduna Asset Management GmbH | 50,000 | -70,000 | |
0.11734 % | Northern Trust Investments, Inc. | 38,901 | -37 | |
0.09823 % | Simplex Trading, LLC | 32,565 | -35,258 | |
0.06648 % | Dimensional Fund Advisors, Ltd. | 22,039 | 0 | |
0.06509 % | Albrecht Detlef | 21,579 | 0 | |
0.05511 % | BofA Global Research (US) | 18,271 | -224 | |
0.04772 % | Barclays Bank PLC | 15,820 | -100 | |
0.04525 % | William Blair & Company, L.L.C. (Research) | 15,000 | 15,000 | |
0.03610 % | Boothbay Fund Management, LLC | 11,968 | 0 | |
0.02990 % | Citadel Advisors LLC | 9,912 | 9,912 | |
0.02397 % | Morgan Stanley & Co. LLC | 7,948 | -212,133 | |
0.01347 % | BlackRock Japan Co., Ltd. | 4,465 | 0 | |
0.01010 % | BlackRock Investment Management, LLC | 3,350 | 0 | |
0.01010 % | Lord, Abbett & Co. LLC | 3,350 | 0 | |
0.01005 % | Northern Trust Global Investments | 3,331 | 0 | |
0.00976 % | Parametric Portfolio Associates LLC | 3,235 | 0 | |
0.00859 % | O'Neil (Thomas Paul) | 2,849 | 1,482 | |
0.00452 % | BlackRock Financial Management, Inc. | 1,498 | -16,132 | |
0.00211 % | Blackstone Alternative Investment Advisors LLC | 700 | -300 | |
0.00173 % | Group One Trading, L.P. | 572 | 572 | |
0.00043 % | Wells Fargo Bank, N.A. | 144 | 10 | |
0.00022 % | Barclays Capital Inc. | 73 | -202,909 | |
0.00014 % | Fidelity Management & Research Company LLC | 45 | 45 | |
0.00011 % | Wells Fargo Advisors | 38 | 38 | |
0.00002 % | Citi Investment Research (US) | 8 | -6,577 | |
0 % | ACCI Capital Investments SGIIC, SA | 0 | -54,287 | |
0 % | ExodusPoint Capital Management, LP | 0 | -13,474 | |
0 % | LUNIS Vermögensmanagement AG | 0 | -20,000 | |
0 % | Ergoteles Capital | 0 | -42,000 | |
0 % | Advisor Group, Inc | 0 | -1,000 | |
0 % | Schonfeld Strategic Advisors LLC | 0 | -11,300 | |
0 % | Engineers Gate Manager, L.P. | 0 | -11,273 | |
0 % | PDT Partners, LLC | 0 | -15,000 | |
0 % | Ghost Tree Capital, LLC | 0 | -473,562 | |
0 % | Vericimetry Advisors LLC | 0 | -7,350 | |
0 % | Caption Management, LLC | 0 | -90,000 | |
0 % | Tibra Equities Europe, Ltd. | 0 | -35,000 | |
0 % | Monashee Investment Management, LLC | 0 | -118,027 | |
0 % | Principal Funds, Inc. | 0 | -1,178 | |
0 % | DWS Investments UK Limited | 0 | -5,952 | |
0 % | Morgan Stanley Smith Barney LLC | 0 | -500 | |
0 % | Assenagon Asset Management S.A. | 0 | -204 | |
0 % | Virtu Americas LLC | 0 | -10,096 | |
0 % | Russell Investments Trust Company | 0 | -69,351 | |
0 % | EAM Investors, LLC | 0 | -149,029 | |
0 % | ProShare Advisors LLC | 0 | -2,555 | |
0 % | Samlyn Capital, LLC | 0 | -2,929,195 | |
0 % | ClariVest Asset Management LLC | 0 | -612 | |
0 % | CAPTRUST Financial Advisors | 0 | -128 | |
0 % | GSA Capital Partners LLP | 0 | -90,665 | |
0 % | Jane Street Capital, L.L.C. | 0 | -19,257 | |
0 % | Tower Research Capital LLC | 0 | -110 | |
0 % | Vivo Capital, LLC | 0 | -1,232,394 | |
0 % | Winton Capital Management Ltd. | 0 | -13,955 | |
0 % | Morgan Stanley & Co. International Plc | 0 | -2 | |
0 % | RBC Capital Partners | 0 | -93 | |
0 % | Credit Suisse Securities (Europe) Limited | 0 | -2 | |
0 % | BNP Paribas Securities Corp. North America | 0 | -59 | |
0 % | TPG Capital, L.P. | 0 | -1,885,939 | |
0 % | BlackRock Asset Management Canada Limited | 0 | -191 | |
0 % | Marshall Wace LLP | 0 | -10,123 | |
0 % | Lemanik Invest SA | 0 | -5,500 | |
0 % | First Trust Advisors L.P. | 0 | -20,012 | |
0 % | ProFund Advisors LLC | 0 | -199 | |
0 % | Polen Capital Management, LLC | 0 | -69,351 | |
0 % | Norges Bank Investment Management (NBIM) | 0 | -33,500 | |
0 % | Point72 Asset Management, L.P. | 0 | -528,169 | |
0 % | D. E. Shaw & Co., L.P. | 0 | -11,232 | |
0 % | Federated Hermes MDTA LLC | 0 | -100 | |
0 % | Charles Schwab Investment Management, Inc. | 0 | -12,319 | |
0 % | Legal & General Investment Management Ltd. | 0 | -897 | |
0 % | Principal Global Investors (Equity) | 0 | -1,178 | |
0 % | DWS Investment Management Americas, Inc. | 0 | -20,840 | |
0 % | T. Rowe Price Associates, Inc. | 0 | -125 | |
0 % | HOOPP Investment Management | 0 | -68,600 | |
0 % | State Teachers Retirement System of Ohio | 0 | -1,100 | |
0 % | Morgan Stanley Investment Management Inc. (US) | 0 | -63 | |
0 % | BNY Mellon Wealth Management | 0 | -165 | |