9.91642 % | Farallon Capital Management, L.L.C. | 5,840,773 | 101,800 | |
8.97522 % | RTW Investments L.P. | 5,286,404 | -29,110 | |
7.17981 % | BlackRock Institutional Trust Company, N.A. | 4,228,907 | 104,598 | |
5.63547 % | BVF Partners L.P. | 3,319,290 | -436,700 | |
5.48889 % | The Vanguard Group, Inc. | 3,232,959 | 50,502 | |
5.40499 % | State Street Global Advisors (US) | 3,183,542 | 1,101,218 | |
4.15821 % | Johnson & Johnson Innovation-JJDC, Inc. | 2,449,183 | 0 | |
3.46445 % | Jefferies LLC | 2,040,561 | 860,000 | |
3.39786 % | Adage Capital Management, L.P. | 2,001,342 | -217,526 | |
2.72314 % | Adar1 Capital Management LLC | 1,603,932 | 818,277 | |
2.32796 % | Geode Capital Management, L.L.C. | 1,371,169 | 77,430 | |
2.15405 % | Perceptive Advisors LLC | 1,268,735 | 274,412 | |
2.00725 % | TD Cowen (Research) | 1,182,268 | -375,368 | |
1.99193 % | T. Rowe Price Associates, Inc. | 1,173,247 | 387,974 | |
1.85778 % | BlackRock Financial Management, Inc. | 1,094,233 | 37,441 | |
1.62697 % | Millennium Management LLC | 958,283 | 915,418 | |
1.58216 % | Fairmount Funds Management LLC | 931,890 | 0 | |
1.54454 % | Point72 Asset Management, L.P. | 909,734 | -290,168 | |
1.39588 % | Woodline Partners LP | 822,173 | 185,217 | |
1.38713 % | DWS Investments UK Limited | 817,017 | -2,125 | |
1.35823 % | Kynam Capital Management LP | 800,000 | -344,242 | |
1.04613 % | Dimensional Fund Advisors, L.P. | 616,172 | -175,172 | |
1.02623 % | 683 Capital Management LLC | 604,449 | -95,551 | |
0.97144 % | Marshall Wace LLP | 572,177 | -404,716 | |
0.94539 % | Driehaus Capital Management, LLC | 556,835 | -3,695 | |
0.89245 % | Charles Schwab Investment Management, Inc. | 525,653 | 29,091 | |
0.85880 % | Eversept Partners, LP | 505,836 | 94,358 | |
0.81734 % | Goldman Sachs & Company, Inc. | 481,412 | 35,419 | |
0.77693 % | Northern Trust Investments, Inc. | 457,614 | -24,838 | |
0.76936 % | Qube Research & Technologies Ltd | 453,152 | 390,997 | |
0.74586 % | Mangrove Partners | 439,314 | 0 | |
0.73762 % | Fidelity Management & Research Company LLC | 434,459 | -31,626 | |
0.71158 % | Patel (Dinesh V) | 419,123 | -36,000 | |
0.71026 % | Gratus Capital LLC | 418,346 | 10,173 | |
0.62909 % | Nuveen LLC | 370,534 | -305,950 | |
0.60719 % | Eagle Asset Management, Inc. | 357,633 | 357,633 | |
0.60371 % | Susquehanna International Group, LLP | 355,586 | 283,768 | |
0.60272 % | Checkpoint Capital L.P. | 355,000 | 74,699 | |
0.54524 % | JP Morgan Asset Management | 321,147 | 166,898 | |
0.50504 % | Renaissance Technologies LLC | 297,467 | 264,900 | |
0.49250 % | Kennedy Capital Management LLC | 290,082 | -7,986 | |
0.49153 % | Morgan Stanley & Co. LLC | 289,511 | -1,531,363 | |
0.46489 % | Candriam Belgium S.A. | 273,818 | -86,182 | |
0.45043 % | BofA Global Research (US) | 265,306 | 36,866 | |
0.40519 % | UBS Asset Management (Americas), Inc. | 238,655 | -1,882 | |
0.33826 % | Two Sigma Investments, LP | 199,237 | -155,057 | |
0.33626 % | Rubric Capital Management LP | 198,059 | 0 | |
0.32456 % | Silvercrest Asset Management Group LLC | 191,168 | 2,425 | |
0.31006 % | BlackRock Advisors (UK) Limited | 182,623 | 1,072 | |
0.30039 % | BlackRock Investment Management, LLC | 176,931 | 11,755 | |
0.28746 % | Jane Street Capital, L.L.C. | 169,311 | 88,041 | |
0.27588 % | Candriam Luxembourg S.A. | 162,492 | 0 | |
0.27334 % | Medical Strategy GmbH | 161,000 | 0 | |
0.26789 % | Northwestern Mutual Capital, LLC | 157,788 | 157,788 | |
0.25820 % | Algert Global LLC | 152,079 | 4,236 | |
0.25179 % | TD Asset Management Inc. | 148,302 | 39,850 | |
0.25033 % | Gupta (Suneel) | 147,443 | -24,603 | |
0.24697 % | Columbia Threadneedle Investments (US) | 145,465 | -1,539 | |
0.24104 % | BNY Mellon Asset Management | 141,971 | 11,386 | |
0.22379 % | First Trust Advisors L.P. | 131,810 | 71,147 | |
0.21903 % | Jacobs Levy Equity Management, Inc. | 129,011 | 0 | |
0.21375 % | BNP Paribas Asset Management USA, Inc. | 125,898 | 0 | |
0.21127 % | Artia Global Partners LP | 124,440 | 0 | |
0.20252 % | Moody Aldrich Partners, LLC | 119,287 | -14,928 | |
0.20129 % | Segall Bryant & Hamill, LLC | 118,562 | 118,562 | |
0.19775 % | BlackRock Investment Management (UK) Ltd. | 116,472 | 18,750 | |
0.19424 % | Manulife Investment Management (North America) Limited | 114,406 | 24,749 | |
0.19294 % | Epoch Investment Partners, Inc. | 113,640 | 0 | |
0.18565 % | Goldman Sachs Asset Management, L.P. | 109,349 | 30,302 | |
0.17827 % | Opaleye Management Inc. | 105,000 | -7,700 | |
0.17630 % | Allspring Global Investments, LLC | 103,842 | 103,414 | |
0.16452 % | Allianz Global Investors GmbH | 96,900 | 33,300 | |
0.16158 % | AllianceBernstein L.P. | 95,169 | 9,769 | |
0.15871 % | Great Lakes Advisors, LLC | 93,479 | -3,681 | |
0.15506 % | BlackRock Asset Management Ireland Limited | 91,332 | 7,428 | |
0.15280 % | DWS Investment GmbH | 90,000 | 0 | |
0.14584 % | Schweizerische Nationalbank | 85,900 | -4,800 | |
0.14427 % | Rhumbline Advisers Ltd. Partnership | 84,975 | -14 | |
0.14296 % | Cubist Systematic Strategies, LLC | 84,202 | 78,207 | |
0.14056 % | Connor, Clark & Lunn Investment Management Ltd. | 82,791 | -10,395 | |
0.13687 % | Trexquant Investment LP | 80,614 | -21,765 | |
0.12779 % | Rafferty Asset Management LLC | 75,270 | -163,938 | |
0.12427 % | UBS Asset Management (Switzerland) | 73,195 | 8,527 | |
0.11584 % | UBS O'Connor LLC | 68,231 | -41,099 | |
0.11372 % | UBS Financial Services, Inc. | 66,981 | -110,565 | |
0.11047 % | Voya Investment Management LLC | 65,066 | -4,377 | |
0.10601 % | Twin Lakes Capital | 62,439 | -380 | |
0.10535 % | Invesco Capital Management LLC | 62,049 | 59,589 | |
0.10350 % | Dark Forest Capital Management LP | 60,962 | 60,962 | |
0.10148 % | Mellon Investments Corporation | 59,773 | 10,399 | |
0.10108 % | Legal & General Investment Management Ltd. | 59,537 | 8,851 | |
0.10003 % | Old Mission Capital LLC | 58,916 | 58,916 | |
0.09813 % | PGIM Quantitative Solutions LLC | 57,800 | 0 | |
0.09499 % | State of Wisconsin Investment Board | 55,951 | 14,465 | |
0.08891 % | Knott Partners Management, LLC | 52,368 | 0 | |
0.08489 % | Swedbank Robur Fonder AB | 50,000 | 0 | |
0.08330 % | Schonfeld Strategic Advisors LLC | 49,064 | 49,064 | |
0.08249 % | Thrivent Asset Management, LLC | 48,584 | 48,584 | |
0.08234 % | JPMorgan Private Bank (United States) | 48,500 | 15,457 | |
0.08209 % | Molina (Arturo MD) | 48,350 | 25,823 | |