10.22301 % | EcoR1 Capital, LLC | 5,748,399 | 5,748,399 | |
9.88006 % | Avoro Capital Advisors LLC | 5,555,555 | 0 | |
8.83835 % | The Vanguard Group, Inc. | 4,969,806 | -72,295 | |
7.95480 % | RTW Investments L.P. | 4,472,985 | 829,871 | |
7.07452 % | Armistice Capital LLC | 3,978,000 | 286,000 | |
6.02590 % | Wellington Management Company, LLP | 3,388,365 | 692,273 | |
5.69347 % | Boxer Capital, L.L.C. | 3,201,440 | 0 | |
5.57703 % | Aviva Holdings Ltd. | 3,135,966 | 0 | |
4.95086 % | Morgan Stanley & Co. LLC | 2,783,869 | 1,023,058 | |
4.59139 % | State Street Global Advisors (US) | 2,581,739 | 271,919 | |
3.78373 % | BlackRock Institutional Trust Company, N.A. | 2,127,589 | -2,501 | |
3.65495 % | Invus Public Equities Advisors, LLC | 2,055,181 | 517,472 | |
3.20114 % | Camber Capital Management LP | 1,800,000 | 400,000 | |
3.11583 % | T. Rowe Price Associates, Inc. | 1,752,033 | 6,016 | |
2.56760 % | Paradigm BioCapital Advisors LP | 1,443,762 | 46,983 | |
2.50717 % | Baker Bros. Advisors LP | 1,409,784 | 0 | |
1.99475 % | Rock Springs Capital Management LP | 1,121,647 | 56,386 | |
1.62484 % | OrbiMed Advisors, LLC | 913,650 | 0 | |
1.58943 % | Candriam Luxembourg S.A. | 893,738 | 20,000 | |
1.55391 % | Candriam Belgium S.A. | 873,763 | 109,498 | |
1.43841 % | Assenagon Asset Management S.A. | 808,820 | 552,860 | |
1.35956 % | Geode Capital Management, L.L.C. | 764,483 | 29,195 | |
1.33381 % | Octagon Capital Advisors LP | 750,000 | 0 | |
1.27886 % | Perceptive Advisors LLC | 719,103 | -855,031 | |
1.23072 % | Fiera Capital Corporation | 692,033 | -17,494 | |
1.15034 % | Franklin Advisers, Inc. | 646,837 | -5 | |
1.06705 % | Eventide Asset Management, LLC | 600,000 | 228,898 | |
1.05475 % | BlackRock Financial Management, Inc. | 593,087 | 60,997 | |
1.03917 % | Marshall Wace LLP | 584,323 | 31,709 | |
0.94201 % | Credit Suisse Funds AG | 529,690 | 6,335 | |
0.89865 % | Millennium Management LLC | 505,309 | 486,275 | |
0.85687 % | Citadel Advisors LLC | 481,818 | 391,174 | |
0.84651 % | Norges Bank Investment Management (NBIM) | 475,992 | 62,003 | |
0.84024 % | Dimensional Fund Advisors, L.P. | 472,468 | 167,874 | |
0.77547 % | Charles Schwab Investment Management, Inc. | 436,048 | 5,554 | |
0.72210 % | Voloridge Investment Management, LLC | 406,035 | -272,623 | |
0.66394 % | Woodline Partners LP | 373,332 | 107,232 | |
0.51194 % | MVA Investors LLC | 287,866 | 0 | |
0.46761 % | D. E. Shaw & Co., L.P. | 262,938 | 17,352 | |
0.46239 % | International Biotechnology Trust PLC | 260,000 | 16,000 | |
0.45705 % | UBS Asset Management (Switzerland) | 257,001 | 63,265 | |
0.45177 % | BlackRock Investment Management (UK) Ltd. | 254,032 | -6,748 | |
0.43165 % | BlackRock Asset Management Ireland Limited | 242,715 | 6,294 | |
0.42793 % | Braidwell LP | 240,625 | -211,375 | |
0.41412 % | New York State Common Retirement Fund | 232,860 | 643 | |
0.41239 % | Nuveen LLC | 231,885 | -28,524 | |
0.40883 % | Jane Street Capital, L.L.C. | 229,883 | 80,755 | |
0.40032 % | Susquehanna International Group, LLP | 225,101 | -137,511 | |
0.39612 % | Allspring Global Investments, LLC | 222,737 | -10,302 | |
0.39439 % | Jacobs Levy Equity Management, Inc. | 221,763 | 13,000 | |
0.38883 % | Rafferty Asset Management LLC | 218,639 | 45,123 | |
0.36236 % | Dissanayake (Shehan Bharath) | 203,754 | 0 | |
0.35568 % | Ghost Tree Capital, LLC | 200,000 | 60,000 | |
0.35568 % | DWS Investment GmbH | 200,000 | -15,654 | |
0.35082 % | BofA Global Research (US) | 197,267 | -59,553 | |
0.34234 % | 5AM Ventures | 192,500 | 192,500 | |
0.32733 % | Edmond de Rothschild Asset Management (France) S.A. | 184,060 | 0 | |
0.31702 % | Northern Trust Investments, Inc. | 178,259 | 3,052 | |
0.27139 % | Oracle Investment Management, Inc. | 152,600 | -48,800 | |
0.26419 % | Sectoral Asset Management Inc. | 148,553 | 20,147 | |
0.26368 % | Baum (Charles M) | 148,268 | 54,054 | |
0.25838 % | Granahan Investment Management, Inc. | 145,287 | 16,197 | |
0.25426 % | Jefferies LLC | 142,969 | 92,549 | |
0.24898 % | Rhenman & Partners Asset Management AB | 140,000 | -75,000 | |
0.24809 % | AllianceBernstein L.P. | 139,501 | 67,858 | |
0.23206 % | Managed Account Advisors LLC | 130,489 | 1,059 | |
0.23055 % | Schonfeld Strategic Advisors LLC | 129,636 | 106,837 | |
0.22189 % | UBS Financial Services, Inc. | 124,768 | 43,336 | |
0.22014 % | Fidelity Management & Research Company LLC | 123,783 | -54,300 | |
0.20834 % | Connor, Clark & Lunn Investment Management Ltd. | 117,151 | -19,335 | |
0.19472 % | Numeric Investors LLC | 109,491 | 89,681 | |
0.18354 % | Barclays Bank PLC | 103,206 | -22,173 | |
0.18195 % | Stelzer (Laurie D) | 102,312 | 22,297 | |
0.17560 % | ExodusPoint Capital Management, LP | 98,738 | -65,004 | |
0.17517 % | Polar Asset Management Partners Inc. | 98,500 | 98,500 | |
0.16842 % | Dafna Capital Management, LLC | 94,700 | 21,100 | |
0.16221 % | SilverArc Capital Management, LLC | 91,213 | 91,213 | |
0.16018 % | BNY Mellon Asset Management | 90,071 | 7,611 | |
0.15757 % | Schweizerische Nationalbank | 88,600 | 1,600 | |
0.14944 % | Mellon Investments Corporation | 84,028 | -2,256 | |
0.14227 % | Tang Capital Management, LLC | 80,000 | 80,000 | |
0.13074 % | Algert Global LLC | 73,516 | 10,292 | |
0.13031 % | HRT Financial LP | 73,276 | -8,030 | |
0.12823 % | TD Asset Management Inc. | 72,105 | 4,700 | |
0.12749 % | Christensen (James G) | 71,685 | -2,388 | |
0.12744 % | Moriarty (John B) | 71,660 | 22,297 | |
0.12563 % | Wells Fargo Advisors | 70,642 | -1,888 | |
0.12352 % | California Public Employees' Retirement System | 69,454 | 0 | |
0.12041 % | Citi Investment Research (US) | 67,704 | -91,289 | |
0.11647 % | Tekla Capital Management LLC | 65,490 | 0 | |
0.11116 % | Florida State Board of Administration | 62,506 | -1,366 | |
0.11086 % | Lombard Odier Asset Management (Europe) Ltd | 62,334 | -9,056 | |
0.11079 % | Sandler (Alan B.) | 62,297 | 22,297 | |
0.10670 % | Macquarie Investment Management | 60,000 | 0 | |
0.10617 % | UBS O'Connor LLC | 59,698 | 12,448 | |
0.10020 % | Clearline Capital LP | 56,341 | 56,341 | |
0.09808 % | Manulife Investment Management (North America) Limited | 55,148 | 3,769 | |
0.09503 % | Fidelity International | 53,434 | 53,434 | |
0.09499 % | Aperio Group, LLC | 53,414 | 22,157 | |
0.09257 % | Wellington International Management Company Pte. Ltd. | 52,050 | 13,986 | |