8.59142 % | Franklin Advisers, Inc. | 4,598,127 | 487,708 | |
8.34533 % | Adage Capital Management, L.P. | 4,466,420 | 2,729,917 | |
7.58006 % | Suvretta Capital Management, LLC | 4,056,847 | 564,700 | |
4.61232 % | T. Rowe Price Associates, Inc. | 2,468,513 | 1,099,855 | |
4.36806 % | EW Healthcare Partners | 2,337,786 | -1,153,135 | |
3.80056 % | The Vanguard Group, Inc. | 2,034,060 | 593,336 | |
3.67848 % | BlackRock Institutional Trust Company, N.A. | 1,968,721 | 371,954 | |
2.91232 % | T. Rowe Price Investment Management, Inc. | 1,558,675 | 1,558,675 | |
2.72490 % | Columbia Threadneedle Investments (US) | 1,458,367 | 1,448,018 | |
2.29312 % | Citadel Advisors LLC | 1,227,278 | 168,231 | |
2.10882 % | Millennium Management LLC | 1,128,638 | 548,009 | |
2.10816 % | Morgan Stanley & Co. LLC | 1,128,285 | 1,060,344 | |
12.87974 % | Cormorant Asset Management, LP | 6,893,235 | 855,000 | |
1.99223 % | Jennison Associates LLC | 1,066,240 | 1,066,240 | |
1.27507 % | Geode Capital Management, L.L.C. | 682,417 | 146,842 | |
1.26088 % | Federated MDTA LLC | 674,824 | 445,289 | |
1.18350 % | Laurion Capital Management LP | 633,409 | 633,409 | |
1.10173 % | Perceptive Advisors LLC | 589,646 | 589,646 | |
1.07281 % | UBS Financial Services, Inc. | 574,169 | 47,321 | |
1.05000 % | DWS Investments UK Limited | 561,958 | 549,824 | |
1.02879 % | State Street Global Advisors (US) | 550,609 | 17,554 | |
1.01183 % | Goldman Sachs & Company, Inc. | 541,530 | -34,607 | |
0.79433 % | Acuta Capital Partners, LLC | 425,128 | 125,000 | |
0.75029 % | Oracle Investment Management, Inc. | 401,557 | 401,557 | |
0.74738 % | Woodline Partners LP | 400,000 | 400,000 | |
0.69317 % | Lord, Abbett & Co. LLC | 370,987 | 370,987 | |
0.68784 % | Ikarian Capital LLC | 368,130 | 368,130 | |
0.59232 % | First Turn Management, LLC | 317,010 | 317,010 | |
0.58857 % | Candriam Luxembourg S.A. | 315,000 | 75,000 | |
0.53652 % | AXA Investment Managers UK Ltd. | 287,143 | -6,948 | |
0.52293 % | Invesco Capital Management LLC | 279,872 | 279,872 | |
0.51332 % | Norges Bank Investment Management (NBIM) | 274,729 | 274,729 | |
0.49707 % | Susquehanna International Group, LLP | 266,031 | 140,351 | |
0.46712 % | VR Adviser, LLC | 250,000 | 250,000 | |
0.45043 % | SEB Investment Management AB | 241,072 | 190,268 | |
0.41612 % | Northern Trust Investments, Inc. | 222,705 | 29,808 | |
0.37166 % | DWS Investment S.A. | 198,915 | 198,915 | |
0.34910 % | Alyeska Investment Group, L.P. | 186,840 | 186,840 | |
0.33632 % | Schroder Investment Management Ltd. (SIM) | 180,000 | 180,000 | |
0.32698 % | Monashee Investment Management, LLC | 175,000 | 175,000 | |
0.32452 % | Two Sigma Investments, LP | 173,682 | 77,252 | |
0.31927 % | PFM Health Sciences, LP | 170,871 | 170,871 | |
0.30830 % | Ghost Tree Capital, LLC | 165,000 | -160,000 | |
0.29828 % | Barclays Bank PLC | 159,642 | 113,983 | |
0.27567 % | Essex Investment Management Company, LLC | 147,541 | -59,619 | |
0.26875 % | Paggiarino Dario A | 143,834 | 24,858 | |
0.26699 % | TD Asset Management Inc. | 142,894 | 71,094 | |
0.26290 % | Voloridge Investment Management, LLC | 140,705 | 140,705 | |
0.26158 % | Candriam Belgium S.A. | 140,000 | 140,000 | |
0.25843 % | EAM Investors, LLC | 138,310 | 138,310 | |
0.25598 % | HOOPP Investment Management | 137,000 | 137,000 | |
0.24404 % | Elston (George O) | 130,609 | 7,608 | |
0.23125 % | Connor, Clark & Lunn Investment Management Ltd. | 123,764 | 123,764 | |
0.22982 % | Nuveen LLC | 122,997 | -52,865 | |
0.21689 % | Jones (David Scott) | 116,079 | 6,311 | |
0.21674 % | PGIM Securities Investment Trust Enterprise | 116,000 | 116,000 | |
0.20534 % | Affinity Asset Advisors LLC | 109,900 | 109,900 | |
0.20514 % | Parametric Portfolio Associates LLC | 109,790 | 43,575 | |
0.20298 % | Ghisallo Capital Management LLC | 108,634 | 108,634 | |
0.18979 % | BlackRock Financial Management, Inc. | 101,578 | -49,498 | |
0.18864 % | D. E. Shaw & Co., L.P. | 100,960 | 100,960 | |
0.18726 % | Ocumension Therapeutics | 100,222 | -1,910,500 | |
0.17887 % | StemPoint Capital LP | 95,732 | 95,732 | |
0.17672 % | BNY Mellon Asset Management | 94,582 | 6,394 | |
0.17668 % | Wellington Management Company, LLP | 94,561 | 94,561 | |
0.16525 % | Boothbay Fund Management, LLC | 88,443 | 88,443 | |
0.15574 % | Lurker (Nancy S) | 83,351 | -52,090 | |
0.15164 % | Sectoral Asset Management Inc. | 81,160 | -94,920 | |
0.15093 % | PanAgora Asset Management Inc. | 80,780 | 5,541 | |
0.15058 % | Morgan Stanley Smith Barney LLC | 80,588 | 78,199 | |
0.14657 % | BofA Global Research (US) | 78,444 | 70,884 | |
0.14651 % | Charles Schwab Investment Management, Inc. | 78,410 | 6,862 | |
0.13905 % | Manulife Investment Management (North America) Limited | 74,421 | 21,482 | |
0.13640 % | Bridgeway Capital Management, LLC | 73,000 | -44,100 | |
0.13403 % | Legato Capital Management LLC | 71,734 | 12,387 | |
0.13071 % | BlackRock Investment Management, LLC | 69,957 | 314 | |
0.13060 % | Jane Street Capital, L.L.C. | 69,895 | 39,672 | |
0.10393 % | BlackRock Advisors (UK) Limited | 55,624 | 3,006 | |
0.10125 % | T. Rowe Price International Ltd | 54,191 | 48,503 | |
0.10094 % | Cubist Systematic Strategies, LLC | 54,022 | -81,137 | |
0.09947 % | Nicholas Investment Partners, L.P. | 53,236 | 53,236 | |
0.09342 % | Artia Global Partners LP | 50,000 | 50,000 | |
0.09111 % | Trexquant Investment LP | 48,760 | -55,858 | |
0.08621 % | Rhumbline Advisers Ltd. Partnership | 46,140 | 4,388 | |
0.08408 % | Ratan Capital Management LP | 45,000 | 45,000 | |
0.08177 % | Jacobs Levy Equity Management, Inc. | 43,761 | 0 | |
0.07945 % | Franklin Equity Group | 42,524 | 3,300 | |
0.06540 % | Deka Vermögensmanagement GmbH | 35,000 | 35,000 | |
0.06191 % | Assenagon Asset Management S.A. | 33,135 | 2,411 | |
0.06070 % | Fidelity Management & Research Company LLC | 32,485 | 30,088 | |
0.06012 % | Occudo Quantitative Strategies LP | 32,176 | 32,176 | |
0.05751 % | Woodstock Corporation | 30,778 | 8,525 | |
0.05607 % | Hightower Advisors, LLC | 30,007 | -222,965 | |
0.05533 % | Dimensional Fund Advisors, L.P. | 29,610 | -20,511 | |
0.05497 % | Duker (Jay S) | 29,420 | -14,066 | |
0.05331 % | Victory Capital Management Inc. | 28,530 | 28,530 | |
0.04943 % | Goldman Sachs Asset Management, L.P. | 26,456 | 2,119 | |
0.04933 % | Exome Asset Management LLC | 26,400 | 26,400 | |
0.04746 % | BMO Capital Markets (US) | 25,400 | 25,400 | |
0.04568 % | Simplex Trading, LLC | 24,450 | 24,450 | |